HYAL2 | ENSG00000068001 | NCBI 8692

Details for: HYAL2

Gene ID: 8692

Symbol: HYAL2

Ensembl ID: ENSG00000068001

Description: hyaluronidase 2

Associated with

Glycosaminoglycan metabolism
(R-HSA-1630316)
Hyaluronan metabolism
(R-HSA-2142845)
Hyaluronan uptake and degradation
(R-HSA-2160916)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Apical plasma membrane
(GO:0016324)
Carbohydrate metabolic process
(GO:0005975)
Cartilage development
(GO:0051216)
Cell surface
(GO:0009986)
Cellular response to fibroblast growth factor stimulus
(GO:0044344)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular response to uv-b
(GO:0071493)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Endocytic vesicle
(GO:0030139)
Endoplasmic reticulum
(GO:0005783)
Enzyme binding
(GO:0019899)
External side of plasma membrane
(GO:0009897)
Fusion of virus membrane with host plasma membrane
(GO:0019064)
Glycosaminoglycan catabolic process
(GO:0006027)
Golgi membrane
(GO:0000139)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Hyaluronan catabolic process
(GO:0030214)
Hyaluronic acid binding
(GO:0005540)
Hyaluronoglucuronidase activity
(GO:0033906)
Hyalurononglucosaminidase activity
(GO:0004415)
Kidney development
(GO:0001822)
Lysosome
(GO:0005764)
Membrane raft
(GO:0045121)
Microvillus
(GO:0005902)
Monocyte activation
(GO:0042117)
Multicellular organismal-level iron ion homeostasis
(GO:0060586)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of fibroblast migration
(GO:0010764)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051898)
Negative regulation of protein tyrosine kinase activity
(GO:0061099)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of extrinsic apoptotic signaling pathway
(GO:2001238)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of urine volume
(GO:0035810)
Protein binding
(GO:0005515)
Receptor signaling protein tyrosine kinase inhibitor activity
(GO:0030294)
Receptor tyrosine kinase binding
(GO:0030971)
Renal water absorption
(GO:0070295)
Response to antibiotic
(GO:0046677)
Response to reactive oxygen species
(GO:0000302)
Response to virus
(GO:0009615)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Skeletal system morphogenesis
(GO:0048705)
Symbiont entry into host cell
(GO:0046718)
Transcription coactivator activity
(GO:0003713)
Transforming growth factor beta binding
(GO:0050431)
Virus receptor activity
(GO:0001618)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 166.1896
Cell Significance Index: -25.8500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 101.8950
Cell Significance Index: -25.8500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 74.8396
Cell Significance Index: -30.8300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 56.1401
Cell Significance Index: -26.5100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 55.9621
Cell Significance Index: -22.7400
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 39.5032
Cell Significance Index: -26.5100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 23.8389
Cell Significance Index: -22.7600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 21.4606
Cell Significance Index: -26.4600
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.5414
Cell Significance Index: -25.5600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.7473
Cell Significance Index: -26.6300
Cell Name: endocardial cell (CL0002350)
Fold Change: 5.4725
Cell Significance Index: 32.3100
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 4.1076
Cell Significance Index: 14.2900
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 3.6774
Cell Significance Index: 64.9900
Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 3.5069
Cell Significance Index: 13.0700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 3.3458
Cell Significance Index: 38.0100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.1206
Cell Significance Index: 162.5500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.9183
Cell Significance Index: 132.6600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.5634
Cell Significance Index: 154.6600
Cell Name: kidney cell (CL1000497)
Fold Change: 1.4529
Cell Significance Index: 11.6000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.4101
Cell Significance Index: 49.0000
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.2234
Cell Significance Index: 7.6600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0193
Cell Significance Index: 110.8700
Cell Name: peg cell (CL4033014)
Fold Change: 0.9546
Cell Significance Index: 22.0600
Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: 0.8727
Cell Significance Index: 11.9500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.8270
Cell Significance Index: 451.6700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.8174
Cell Significance Index: 17.1100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7065
Cell Significance Index: 114.9100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5291
Cell Significance Index: 72.6600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4690
Cell Significance Index: 57.6700
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.4582
Cell Significance Index: 6.5900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4561
Cell Significance Index: 411.8600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3680
Cell Significance Index: 66.3400
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.3540
Cell Significance Index: 3.6700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3257
Cell Significance Index: 64.6400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2821
Cell Significance Index: 124.7500
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.2761
Cell Significance Index: 2.1800
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.2450
Cell Significance Index: 1.4800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2381
Cell Significance Index: 45.3200
Cell Name: lactocyte (CL0002325)
Fold Change: 0.2227
Cell Significance Index: 28.7700
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.2076
Cell Significance Index: 5.4600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1807
Cell Significance Index: 13.4700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1791
Cell Significance Index: 5.1600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1408
Cell Significance Index: 18.0600
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.0863
Cell Significance Index: 0.8200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0585
Cell Significance Index: 3.0400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0440
Cell Significance Index: 3.1100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0388
Cell Significance Index: 0.6500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0344
Cell Significance Index: 1.2100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0327
Cell Significance Index: 1.4800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0238
Cell Significance Index: 1.1100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0063
Cell Significance Index: -4.7800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0109
Cell Significance Index: -20.5700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0178
Cell Significance Index: -0.3800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0186
Cell Significance Index: -13.6300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0188
Cell Significance Index: -34.6500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0226
Cell Significance Index: -34.7900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0253
Cell Significance Index: -34.4000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0268
Cell Significance Index: -0.5800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0333
Cell Significance Index: -21.1600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0348
Cell Significance Index: -25.8100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0354
Cell Significance Index: -4.0500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0360
Cell Significance Index: -3.6800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0412
Cell Significance Index: -14.7600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0419
Cell Significance Index: -8.4100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0462
Cell Significance Index: -2.1700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0469
Cell Significance Index: -29.2800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0478
Cell Significance Index: -26.9700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0578
Cell Significance Index: -26.2200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0652
Cell Significance Index: -1.7400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0802
Cell Significance Index: -9.3500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0920
Cell Significance Index: -26.4800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0947
Cell Significance Index: -1.0300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1041
Cell Significance Index: -2.1600
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.1215
Cell Significance Index: -1.8800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1441
Cell Significance Index: -24.6100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1484
Cell Significance Index: -31.2600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1633
Cell Significance Index: -23.7400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1760
Cell Significance Index: -4.7900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2071
Cell Significance Index: -24.4200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2103
Cell Significance Index: -11.8000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2257
Cell Significance Index: -7.2300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2584
Cell Significance Index: -26.9100
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.2681
Cell Significance Index: -3.7600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2941
Cell Significance Index: -22.5700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2970
Cell Significance Index: -18.7200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2994
Cell Significance Index: -23.7100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3044
Cell Significance Index: -19.6400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3123
Cell Significance Index: -9.2000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3340
Cell Significance Index: -20.5300
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3802
Cell Significance Index: -3.1000
Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.3946
Cell Significance Index: -2.4700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3969
Cell Significance Index: -26.6900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4422
Cell Significance Index: -27.1100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4619
Cell Significance Index: -11.8000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4821
Cell Significance Index: -25.3100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4974
Cell Significance Index: -13.9000
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.5279
Cell Significance Index: -7.9100
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.5534
Cell Significance Index: -7.9300
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.5567
Cell Significance Index: -7.1300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5813
Cell Significance Index: -14.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** HYAL2 is a member of the hyaluronidase family, which consists of enzymes that cleave hyaluronic acid. The HYAL2 enzyme has a high specificity for hyaluronic acid, with a Km value of 0.1 mM. The gene is located on chromosome 11q13.3 and is highly conserved across species, suggesting its essential role in cellular processes. **Pathways and Functions** HYAL2 is involved in various cellular processes, including: 1. **Cell migration**: HYAL2 helps to break down hyaluronic acid, allowing cells to migrate through the extracellular matrix. 2. **Cell proliferation**: HYAL2 regulates cell growth by controlling the availability of hyaluronic acid, a key component of the extracellular matrix. 3. **Differentiation**: HYAL2 influences the differentiation of cells, particularly in embryonic tissues. 4. **Immune responses**: HYAL2 is involved in the regulation of immune responses, including the activation of immune cells and the production of inflammatory cytokines. 5. **Endothelial function**: HYAL2 regulates endothelial cell function, including the regulation of blood vessel formation and maintenance. **Clinical Significance** Dysregulation of HYAL2 has been implicated in various diseases, including: 1. **Cancer**: HYAL2 overexpression has been linked to cancer progression and metastasis. 2. **Arthritis**: HYAL2 deficiency has been associated with arthritis, as the breakdown of hyaluronic acid contributes to joint inflammation and damage. 3. **Cardiovascular disease**: HYAL2 dysregulation has been linked to cardiovascular disease, including atherosclerosis and cardiac remodeling. 4. **Neurological disorders**: HYAL2 has been implicated in neurological disorders, including Alzheimer's disease and multiple sclerosis. In conclusion, HYAL2 is a critical gene involved in various cellular processes, including cell migration, proliferation, and differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of HYAL2 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Hyaluronidase-2

Genular Protein ID: 3661777102

Symbol: HYAL2_HUMAN

Name: Hyaluronidase-2

UniProtKB Accession Codes:

Q12891 B3KRZ2 O15177 Q9BW29

Database IDs:

Citations:

PubMed ID: 9712871

Title: HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity.

PubMed ID: 9712871

DOI: 10.1074/jbc.273.35.22466

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11731268

Title: Hyal2 -- less active, but more versatile?

PubMed ID: 11731268

DOI: 10.1016/s0945-053x(01)00170-6

PubMed ID: 11296287

Title: Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation.

PubMed ID: 11296287

DOI: 10.1073/pnas.071572898

PubMed ID: 12676986

Title: Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus.

PubMed ID: 12676986

DOI: 10.1073/pnas.0837136100

Sequence Information:

Length: 473
Mass: 53860
Checksum: A8302738478BFE61
Sequence:

MRAGPGPTVT LALVLAVSWA MELKPTAPPI FTGRPFVVAW DVPTQDCGPR LKVPLDLNAF 
DVQASPNEGF VNQNITIFYR DRLGLYPRFD SAGRSVHGGV PQNVSLWAHR KMLQKRVEHY 
IRTQESAGLA VIDWEDWRPV WVRNWQDKDV YRRLSRQLVA SRHPDWPPDR IVKQAQYEFE 
FAAQQFMLET LRYVKAVRPR HLWGFYLFPD CYNHDYVQNW ESYTGRCPDV EVARNDQLAW 
LWAESTALFP SVYLDETLAS SRHGRNFVSF RVQEALRVAR THHANHALPV YVFTRPTYSR 
RLTGLSEMDL ISTIGESAAL GAAGVILWGD AGYTTSTETC QYLKDYLTRL LVPYVVNVSW 
ATQYCSRAQC HGHGRCVRRN PSASTFLHLS TNSFRLVPGH APGEPQLRPV GELSWADIDH 
LQTHFRCQCY LGWSGEQCQW DHRQAAGGAS EAWAGSHLTS LLALAALAFT WTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: HYAL2

Associated with

Cells (max top 100)

Other Information

HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity. PubMed ID: 9712871

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Hyal2 -- less active, but more versatile? PubMed ID: 11731268

Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation. PubMed ID: 11296287

Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus. PubMed ID: 12676986