Details for: HYAL2

Gene ID: 8692

Symbol: HYAL2

Ensembl ID: ENSG00000068001

Description: hyaluronidase 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.22
    Marker Score: 13,278
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.22
    Marker Score: 6,104
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.03
    Marker Score: 2,611
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.61
    Marker Score: 606
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.59
    Marker Score: 5,179
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.52
    Marker Score: 1,426
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.36
    Marker Score: 2,471
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.12
    Marker Score: 18,572
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.96
    Marker Score: 1,843
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.93
    Marker Score: 1,720
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.73
    Marker Score: 368
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.67
    Marker Score: 999
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.66
    Marker Score: 1,327
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.6
    Marker Score: 406
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.57
    Marker Score: 1,415
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.4
    Marker Score: 340
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.4
    Marker Score: 2,372
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.39
    Marker Score: 2,904
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.39
    Marker Score: 334
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.36
    Marker Score: 427
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.34
    Marker Score: 897
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.28
    Marker Score: 44,287
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.23
    Marker Score: 509
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.22
    Marker Score: 2,069
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.16
    Marker Score: 333
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.15
    Marker Score: 573
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.14
    Marker Score: 14,987
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.13
    Marker Score: 1,636
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.12
    Marker Score: 4,848
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.12
    Marker Score: 261
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.11
    Marker Score: 1,196
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.1
    Marker Score: 241
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.06
    Marker Score: 582
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.05
    Marker Score: 1,180
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,754
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.99
    Marker Score: 11,203
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.99
    Marker Score: 1,879
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.99
    Marker Score: 525
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.99
    Marker Score: 615
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.98
    Marker Score: 1,994
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.96
    Marker Score: 278
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.96
    Marker Score: 253
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.96
    Marker Score: 224
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.94
    Marker Score: 1,007
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14,530
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.92
    Marker Score: 294
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,722
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.89
    Marker Score: 3,491
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.88
    Marker Score: 1,290
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.87
    Marker Score: 823
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.87
    Marker Score: 240
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,975
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.87
    Marker Score: 2,049
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.87
    Marker Score: 1,092
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.87
    Marker Score: 1,412
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,267
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.86
    Marker Score: 897
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.86
    Marker Score: 219
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.83
    Marker Score: 1,003
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.81
    Marker Score: 812
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.8
    Marker Score: 714
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 311
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.76
    Marker Score: 482
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.76
    Marker Score: 420
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.74
    Marker Score: 6,373
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.73
    Marker Score: 283
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.73
    Marker Score: 1,835
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.72
    Marker Score: 455
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 659
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.71
    Marker Score: 767
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.71
    Marker Score: 351
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.71
    Marker Score: 1,172
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.7
    Marker Score: 262
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.7
    Marker Score: 713
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.7
    Marker Score: 199
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.7
    Marker Score: 4,556
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.7
    Marker Score: 334
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7
    Marker Score: 7,023
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.7
    Marker Score: 168
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.69
    Marker Score: 462
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,882
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.69
    Marker Score: 439
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.67
    Marker Score: 281
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.67
    Marker Score: 717
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.66
    Marker Score: 706
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.66
    Marker Score: 223
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.66
    Marker Score: 1,558
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.66
    Marker Score: 659
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.65
    Marker Score: 3,877
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.64
    Marker Score: 304
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 382
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.63
    Marker Score: 1,508

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HYAL2 is a member of the hyaluronidase family, which consists of enzymes that cleave hyaluronic acid. The HYAL2 enzyme has a high specificity for hyaluronic acid, with a Km value of 0.1 mM. The gene is located on chromosome 11q13.3 and is highly conserved across species, suggesting its essential role in cellular processes. **Pathways and Functions** HYAL2 is involved in various cellular processes, including: 1. **Cell migration**: HYAL2 helps to break down hyaluronic acid, allowing cells to migrate through the extracellular matrix. 2. **Cell proliferation**: HYAL2 regulates cell growth by controlling the availability of hyaluronic acid, a key component of the extracellular matrix. 3. **Differentiation**: HYAL2 influences the differentiation of cells, particularly in embryonic tissues. 4. **Immune responses**: HYAL2 is involved in the regulation of immune responses, including the activation of immune cells and the production of inflammatory cytokines. 5. **Endothelial function**: HYAL2 regulates endothelial cell function, including the regulation of blood vessel formation and maintenance. **Clinical Significance** Dysregulation of HYAL2 has been implicated in various diseases, including: 1. **Cancer**: HYAL2 overexpression has been linked to cancer progression and metastasis. 2. **Arthritis**: HYAL2 deficiency has been associated with arthritis, as the breakdown of hyaluronic acid contributes to joint inflammation and damage. 3. **Cardiovascular disease**: HYAL2 dysregulation has been linked to cardiovascular disease, including atherosclerosis and cardiac remodeling. 4. **Neurological disorders**: HYAL2 has been implicated in neurological disorders, including Alzheimer's disease and multiple sclerosis. In conclusion, HYAL2 is a critical gene involved in various cellular processes, including cell migration, proliferation, and differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of HYAL2 in human health and disease.

Genular Protein ID: 3661777102

Symbol: HYAL2_HUMAN

Name: Hyaluronidase-2

UniProtKB Accession Codes:

Q12891 B3KRZ2 O15177 Q9BW29

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 8 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 57 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9712871

Title: HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity.

PubMed ID: 9712871

DOI: 10.1074/jbc.273.35.22466

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11731268

Title: Hyal2 -- less active, but more versatile?

PubMed ID: 11731268

DOI: 10.1016/s0945-053x(01)00170-6

PubMed ID: 11296287

Title: Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation.

PubMed ID: 11296287

DOI: 10.1073/pnas.071572898

PubMed ID: 12676986

Title: Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus.

PubMed ID: 12676986

DOI: 10.1073/pnas.0837136100

Sequence Information:

  • Length: 473
  • Mass: 53860
  • Checksum: A8302738478BFE61
  • Sequence:
    • MRAGPGPTVT LALVLAVSWA MELKPTAPPI FTGRPFVVAW DVPTQDCGPR LKVPLDLNAF 
DVQASPNEGF VNQNITIFYR DRLGLYPRFD SAGRSVHGGV PQNVSLWAHR KMLQKRVEHY 
IRTQESAGLA VIDWEDWRPV WVRNWQDKDV YRRLSRQLVA SRHPDWPPDR IVKQAQYEFE 
FAAQQFMLET LRYVKAVRPR HLWGFYLFPD CYNHDYVQNW ESYTGRCPDV EVARNDQLAW 
LWAESTALFP SVYLDETLAS SRHGRNFVSF RVQEALRVAR THHANHALPV YVFTRPTYSR 
RLTGLSEMDL ISTIGESAAL GAAGVILWGD AGYTTSTETC QYLKDYLTRL LVPYVVNVSW 
ATQYCSRAQC HGHGRCVRRN PSASTFLHLS TNSFRLVPGH APGEPQLRPV GELSWADIDH 
LQTHFRCQCY LGWSGEQCQW DHRQAAGGAS EAWAGSHLTS LLALAALAFT WTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.