Details for: LGALSL

Gene ID: 29094

Symbol: LGALSL

Ensembl ID: ENSG00000119862

Description: galectin like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 104.0855
    Cell Significance Index: -16.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 64.1846
    Cell Significance Index: -16.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 30.6191
    Cell Significance Index: -15.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.1310
    Cell Significance Index: -16.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.0100
    Cell Significance Index: -16.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.8800
    Cell Significance Index: 307.5700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 4.4931
    Cell Significance Index: 63.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1383
    Cell Significance Index: -16.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.7909
    Cell Significance Index: 45.1900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.3036
    Cell Significance Index: 27.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9856
    Cell Significance Index: 90.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.8393
    Cell Significance Index: 27.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6345
    Cell Significance Index: 22.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1636
    Cell Significance Index: 25.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0693
    Cell Significance Index: 124.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9258
    Cell Significance Index: 55.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8377
    Cell Significance Index: 91.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8205
    Cell Significance Index: 21.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6914
    Cell Significance Index: 89.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6877
    Cell Significance Index: 111.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4789
    Cell Significance Index: 13.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4534
    Cell Significance Index: 409.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4008
    Cell Significance Index: 177.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3608
    Cell Significance Index: 18.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3355
    Cell Significance Index: 23.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3272
    Cell Significance Index: 23.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2713
    Cell Significance Index: 12.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2639
    Cell Significance Index: 12.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2337
    Cell Significance Index: 46.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2287
    Cell Significance Index: 4.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2158
    Cell Significance Index: 42.8200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.2129
    Cell Significance Index: 0.4800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1794
    Cell Significance Index: 3.1700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1764
    Cell Significance Index: 1.3600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.1754
    Cell Significance Index: 0.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1712
    Cell Significance Index: 32.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1596
    Cell Significance Index: 15.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1546
    Cell Significance Index: 84.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1472
    Cell Significance Index: 4.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1021
    Cell Significance Index: 1.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0975
    Cell Significance Index: 5.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0881
    Cell Significance Index: 10.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0832
    Cell Significance Index: 29.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0823
    Cell Significance Index: 11.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0668
    Cell Significance Index: 4.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0657
    Cell Significance Index: 2.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0631
    Cell Significance Index: 11.3800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0591
    Cell Significance Index: 0.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0367
    Cell Significance Index: 27.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0335
    Cell Significance Index: 4.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0047
    Cell Significance Index: -8.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0093
    Cell Significance Index: -17.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0093
    Cell Significance Index: -12.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0100
    Cell Significance Index: -7.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0102
    Cell Significance Index: -15.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0117
    Cell Significance Index: -7.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0135
    Cell Significance Index: -10.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0157
    Cell Significance Index: -0.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0203
    Cell Significance Index: -5.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0248
    Cell Significance Index: -4.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0255
    Cell Significance Index: -14.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0272
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0286
    Cell Significance Index: -17.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0293
    Cell Significance Index: -13.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0322
    Cell Significance Index: -0.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0434
    Cell Significance Index: -1.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0628
    Cell Significance Index: -6.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0702
    Cell Significance Index: -10.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0758
    Cell Significance Index: -4.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0815
    Cell Significance Index: -17.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0862
    Cell Significance Index: -9.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0941
    Cell Significance Index: -2.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0965
    Cell Significance Index: -1.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0979
    Cell Significance Index: -6.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1084
    Cell Significance Index: -12.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1298
    Cell Significance Index: -7.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1404
    Cell Significance Index: -3.5100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1513
    Cell Significance Index: -2.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1554
    Cell Significance Index: -12.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1564
    Cell Significance Index: -16.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1914
    Cell Significance Index: -3.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1976
    Cell Significance Index: -15.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2092
    Cell Significance Index: -11.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2107
    Cell Significance Index: -4.3700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2159
    Cell Significance Index: -2.2400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.2176
    Cell Significance Index: -1.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2227
    Cell Significance Index: -7.7400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2242
    Cell Significance Index: -1.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2247
    Cell Significance Index: -6.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2415
    Cell Significance Index: -10.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2440
    Cell Significance Index: -15.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2792
    Cell Significance Index: -10.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2952
    Cell Significance Index: -14.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3034
    Cell Significance Index: -11.4900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3247
    Cell Significance Index: -7.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3487
    Cell Significance Index: -9.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3609
    Cell Significance Index: -10.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3610
    Cell Significance Index: -11.8200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3670
    Cell Significance Index: -5.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3725
    Cell Significance Index: -13.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The LGALSL gene belongs to the galectin family of proteins, which are carbohydrate-binding proteins that play crucial roles in various biological processes, including cell adhesion, proliferation, and differentiation. The LGALSL gene is characterized by its high expression in specific cell types, including respiratory basal cells, eye photoreceptor cells, retinal rod cells, germ cells, corneal epithelial cells, pulmonary interstitial fibroblasts, cardiac endothelial cells, pancreatic acinar cells, immature innate lymphoid cells, and pneumocytes. This widespread expression suggests that LGALSL may be involved in tissue development, maintenance, and immune homeostasis. **Pathways and Functions:** The LGALSL gene is involved in carbohydrate binding and protein binding pathways, which are critical for cellular interactions and immune responses. The carbohydrate-binding activity of LGALSL may facilitate cell-cell interactions, cell adhesion, and migration, while its protein-binding activity may modulate signaling pathways and regulate cellular behavior. Specifically, LGALSL has been shown to interact with various proteins, including integrins, cadherins, and other galectins, to regulate cell adhesion, proliferation, and differentiation. **Clinical Significance:** The discovery of LGALSL's role in carbohydrate binding and protein binding pathways has significant implications for our understanding of various diseases, including cancer, autoimmune disorders, and immune-mediated inflammatory conditions. For example, alterations in LGALSL expression or function may contribute to the development of cancer, as it can regulate cell adhesion and migration, which are critical steps in tumor progression. Additionally, LGALSL's involvement in immune homeostasis suggests that dysregulation of this gene may contribute to autoimmune disorders, such as rheumatoid arthritis or multiple sclerosis. Furthermore, LGALSL's expression in specific cell types, including innate lymphoid cells, suggests that this gene may play a role in the regulation of innate immunity. Understanding the functions of LGALSL in the immune system may provide new insights into the pathogenesis of immune-mediated diseases and the development of novel therapeutic strategies. In conclusion, the LGALSL gene is a galectin-like gene with significant implications for our understanding of carbohydrate binding and protein binding pathways. Its widespread expression in various cell types and its potential role in immune homeostasis make it an attractive candidate for further investigation. Further research is needed to elucidate the functions of LGALSL in disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3227169137

Symbol: LEGL_HUMAN

Name: Galectin-related protein

UniProtKB Accession Codes:

Q3ZCW2 B2RBG8 D6W5E8 Q6P5T6 Q9P005

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16682780

Title: Expression, purification, crystallization and preliminary X-ray characterization of the GRP carbohydrate-recognition domain from Homo sapiens.

PubMed ID: 16682780

DOI: 10.1107/s1744309106012875

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 18320588

Title: Crystal structure of the C-terminal conserved domain of human GRP, a galectin-related protein, reveals a function mode different from those of galectins.

PubMed ID: 18320588

DOI: 10.1002/prot.22003

PubMed ID: 18433051

Title: Crystal structure of the putative carbohydrate recognition domain of human galectin-related protein.

PubMed ID: 18433051

DOI: 10.1002/prot.22078

Sequence Information:

  • Length: 172
  • Mass: 18986
  • Checksum: E2D41EA68EF44DEC
  • Sequence:
    • MAGSVADSDA VVKLDDGHLN NSLSSPVQAD VYFPRLIVPF CGHIKGGMRP GKKVLVMGIV 
DLNPESFAIS LTCGDSEDPP ADVAIELKAV FTDRQLLRNS CISGERGEEQ SAIPYFPFIP 
DQPFRVEILC EHPRFRVFVD GHQLFDFYHR IQTLSAIDTI KINGDLQITK LG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.