Details for: NKX3 1

Gene ID: 4824

Symbol: NKX3 1

Ensembl ID: ENSG00000167034

Description: NK3 homeobox 1

Associated with

  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Androgen receptor signaling pathway
    (GO:0030521)
  • Apoptotic process
    (GO:0006915)
  • Branching involved in prostate gland morphogenesis
    (GO:0060442)
  • Branching morphogenesis of an epithelial tube
    (GO:0048754)
  • Cell differentiation
    (GO:0030154)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cellular response to interleukin-1
    (GO:0071347)
  • Cellular response to steroid hormone stimulus
    (GO:0071383)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Cellular response to xenobiotic stimulus
    (GO:0071466)
  • Chromatin
    (GO:0000785)
  • Cysteine-type endopeptidase activator activity involved in apoptotic process
    (GO:0008656)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna damage response
    (GO:0006974)
  • Dorsal aorta development
    (GO:0035907)
  • Epithelial cell proliferation involved in prostate gland development
    (GO:0060767)
  • Epithelial cell proliferation involved in salivary gland morphogenesis
    (GO:0060664)
  • Heart development
    (GO:0007507)
  • Histone deacetylase binding
    (GO:0042826)
  • Mads box domain binding
    (GO:0097162)
  • Male gonad development
    (GO:0008584)
  • Metanephros development
    (GO:0001656)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of epithelial cell proliferation
    (GO:0050680)
  • Negative regulation of epithelial cell proliferation involved in prostate gland development
    (GO:0060770)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043569)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear estrogen receptor binding
    (GO:0030331)
  • Nuclear receptor activity
    (GO:0004879)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Pharyngeal system development
    (GO:0060037)
  • Positive regulation of androgen secretion
    (GO:2000836)
  • Positive regulation of apoptotic signaling pathway
    (GO:2001235)
  • Positive regulation of cell division
    (GO:0051781)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of mitotic cell cycle
    (GO:0045931)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of protein localization
    (GO:0032880)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to testosterone
    (GO:0033574)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Salivary gland development
    (GO:0007431)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Site of dna damage
    (GO:0090734)
  • Somitogenesis
    (GO:0001756)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription regulator inhibitor activity
    (GO:0140416)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 38.8954
    Cell Significance Index: -6.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.0495
    Cell Significance Index: -6.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 12.5290
    Cell Significance Index: -5.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.3313
    Cell Significance Index: -5.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.0529
    Cell Significance Index: -6.2300
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 3.0026
    Cell Significance Index: 20.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9386
    Cell Significance Index: 26.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.5965
    Cell Significance Index: -6.3000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.1557
    Cell Significance Index: 11.9600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.0430
    Cell Significance Index: 14.6300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.6612
    Cell Significance Index: 7.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4483
    Cell Significance Index: 85.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4090
    Cell Significance Index: 10.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4084
    Cell Significance Index: 19.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3016
    Cell Significance Index: 29.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2999
    Cell Significance Index: 22.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2953
    Cell Significance Index: 38.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2422
    Cell Significance Index: 14.5400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.2259
    Cell Significance Index: 1.3900
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.2123
    Cell Significance Index: 1.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1961
    Cell Significance Index: 5.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1953
    Cell Significance Index: 21.2500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1877
    Cell Significance Index: 1.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1753
    Cell Significance Index: 158.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1675
    Cell Significance Index: 20.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1577
    Cell Significance Index: 25.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1480
    Cell Significance Index: 9.3300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1456
    Cell Significance Index: 2.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1366
    Cell Significance Index: 2.9600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.1128
    Cell Significance Index: 0.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1029
    Cell Significance Index: 4.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0981
    Cell Significance Index: 2.6700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0895
    Cell Significance Index: 0.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0832
    Cell Significance Index: 5.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0821
    Cell Significance Index: 10.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0812
    Cell Significance Index: 4.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0805
    Cell Significance Index: 14.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0628
    Cell Significance Index: 1.8000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0606
    Cell Significance Index: 1.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0543
    Cell Significance Index: 24.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0534
    Cell Significance Index: 2.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0474
    Cell Significance Index: 5.5200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.0366
    Cell Significance Index: 0.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0311
    Cell Significance Index: 8.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0208
    Cell Significance Index: 0.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0192
    Cell Significance Index: 0.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0151
    Cell Significance Index: 1.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0100
    Cell Significance Index: 5.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0053
    Cell Significance Index: 0.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0015
    Cell Significance Index: 0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0032
    Cell Significance Index: -6.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.1200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0039
    Cell Significance Index: -0.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0042
    Cell Significance Index: -6.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0048
    Cell Significance Index: -6.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0052
    Cell Significance Index: -0.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0055
    Cell Significance Index: -0.2800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0060
    Cell Significance Index: -0.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0065
    Cell Significance Index: -4.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0073
    Cell Significance Index: -5.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0074
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0077
    Cell Significance Index: -5.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0085
    Cell Significance Index: -5.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0095
    Cell Significance Index: -5.3800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0097
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0101
    Cell Significance Index: -6.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0119
    Cell Significance Index: -5.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0127
    Cell Significance Index: -4.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0134
    Cell Significance Index: -2.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0153
    Cell Significance Index: -0.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0163
    Cell Significance Index: -3.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0186
    Cell Significance Index: -0.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0193
    Cell Significance Index: -3.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0225
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0296
    Cell Significance Index: -6.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0326
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0326
    Cell Significance Index: -3.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0336
    Cell Significance Index: -3.4300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0339
    Cell Significance Index: -0.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0347
    Cell Significance Index: -5.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0358
    Cell Significance Index: -4.2200
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.0389
    Cell Significance Index: -0.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0467
    Cell Significance Index: -3.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0493
    Cell Significance Index: -0.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0599
    Cell Significance Index: -6.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0697
    Cell Significance Index: -5.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0710
    Cell Significance Index: -3.7000
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0815
    Cell Significance Index: -0.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0873
    Cell Significance Index: -5.8700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0894
    Cell Significance Index: -0.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0905
    Cell Significance Index: -5.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1012
    Cell Significance Index: -6.2200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1018
    Cell Significance Index: -0.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1028
    Cell Significance Index: -5.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1032
    Cell Significance Index: -3.7900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1072
    Cell Significance Index: -1.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1138
    Cell Significance Index: -6.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1183
    Cell Significance Index: -3.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1309
    Cell Significance Index: -4.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1353
    Cell Significance Index: -3.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NKX3.1 is a transcription factor that belongs to the NKX homeobox family, which is characterized by the presence of a homeodomain and a DNA-binding domain. The gene is highly conserved across species, with high sequence identity to its murine and zebrafish counterparts. NKX3.1 is also known as NKX3.1_HUMAN, and its protein product, NKX3.1, is a transcription factor that regulates the expression of target genes involved in various cellular processes. **Pathways and Functions** NKX3.1 is involved in several signaling pathways and cellular processes, including: 1. **Androgen receptor signaling pathway**: NKX3.1 is a positive regulator of androgen receptor signaling, which is essential for the development and maintenance of male reproductive tissues, such as the prostate gland. 2. **Apoptotic process**: NKX3.1 is involved in regulating the apoptotic process, which is crucial for maintaining tissue homeostasis and preventing cancer. 3. **Cell differentiation**: NKX3.1 regulates the differentiation of various cell types, including prostate epithelial cells and Sertoli cells. 4. **Cell proliferation**: NKX3.1 is a negative regulator of cell proliferation, which is essential for preventing uncontrolled cell growth and tumorigenesis. 5. **Chromatin regulation**: NKX3.1 regulates chromatin structure and function, which is essential for gene expression and transcriptional regulation. **Clinical Significance** Dysregulation of NKX3.1 has been implicated in various diseases, including: 1. **Prostate cancer**: NKX3.1 is a tumor suppressor gene that is often downregulated in prostate cancer, leading to uncontrolled cell proliferation and tumorigenesis. 2. **Androgen insensitivity syndrome**: NKX3.1 is involved in the regulation of androgen receptor signaling, and mutations in the NKX3.1 gene have been implicated in androgen insensitivity syndrome. 3. **Infertility**: NKX3.1 is involved in the regulation of Sertoli cell function, and dysregulation of the NKX3.1 gene has been implicated in male infertility. 4. **Neurological disorders**: NKX3.1 is expressed in the cerebral cortex and is involved in regulating neuronal development and function, and dysregulation of the NKX3.1 gene has been implicated in neurological disorders, such as schizophrenia and autism. In conclusion, NKX3.1 is a transcription factor gene that plays a crucial role in regulating cell proliferation, differentiation, and survival, and is also implicated in the regulation of androgen secretion and the apoptotic process. The gene is highly expressed in various cell types, and dysregulation of NKX3.1 has been implicated in various diseases, including prostate cancer, androgen insensitivity syndrome, infertility, and neurological disorders.

Genular Protein ID: 1833666990

Symbol: NKX31_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99801 O15465 Q9H2P4 Q9H2P5 Q9H2P6 Q9H2P7 Q9HBG0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 GO 62 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9226374

Title: A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer.

PubMed ID: 9226374

DOI: 10.1006/geno.1997.4715

PubMed ID: 9537602

Title: Isolation and androgen regulation of the human homeobox cDNA, NKX3.1.

PubMed ID: 9537602

DOI: 10.1002/(sici)1097-0045(19980401)35:1<71::aid-pros10>3.0.co;2-h

PubMed ID: 11137288

Title: Full-length cDNA sequence and genomic organization of human NKX3A -- alternative mRNA forms and regulation by both androgens and estrogens.

PubMed ID: 11137288

DOI: 10.1016/s0378-1119(00)00453-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11809674

Title: NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter.

PubMed ID: 11809674

PubMed ID: 12972618

Title: Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription.

PubMed ID: 12972618

DOI: 10.1128/mcb.23.19.7019-7029.2003

PubMed ID: 18077445

Title: Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1.

PubMed ID: 18077445

DOI: 10.1074/jbc.m708630200

PubMed ID: 19462257

Title: Gene expression profiles in the PC-3 human prostate cancer cells induced by NKX3.1.

PubMed ID: 19462257

DOI: 10.1007/s11033-009-9549-8

PubMed ID: 9377551

Title: Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers.

PubMed ID: 9377551

Sequence Information:

  • Length: 234
  • Mass: 26350
  • Checksum: C99A0943E15B2A55
  • Sequence:
    • MLRVPEPRPG EAKAEGAAPP TPSKPLTSFL IQDILRDGAQ RQGGRTSSQR QRDPEPEPEP 
EPEGGRSRAG AQNDQLSTGP RAAPEEAETL AETEPERHLG SYLLDSENTS GALPRLPQTP 
KQPQKRSRAA FSHTQVIELE RKFSHQKYLS APERAHLAKN LKLTETQVKI WFQNRRYKTK 
RKQLSSELGD LEKHSSLPAL KEEAFSRASL VSVYNSYPYY PYLYCVGSWS PAFW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.