Details for: TSPAN5

Gene ID: 10098

Symbol: TSPAN5

Ensembl ID: ENSG00000168785

Description: tetraspanin 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 353.0163
    Cell Significance Index: -54.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 262.6128
    Cell Significance Index: -66.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 141.2345
    Cell Significance Index: -66.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 120.4545
    Cell Significance Index: -61.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 120.0964
    Cell Significance Index: -48.7900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.1551
    Cell Significance Index: -48.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.4250
    Cell Significance Index: -57.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.1848
    Cell Significance Index: -59.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.5770
    Cell Significance Index: -60.1300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.0417
    Cell Significance Index: -32.9200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 5.8565
    Cell Significance Index: 94.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.2806
    Cell Significance Index: 1535.3800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 4.0102
    Cell Significance Index: 49.7400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.7530
    Cell Significance Index: 107.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 3.3866
    Cell Significance Index: 81.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.2018
    Cell Significance Index: 54.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.1174
    Cell Significance Index: 191.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.0249
    Cell Significance Index: 606.7900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.0058
    Cell Significance Index: 42.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8926
    Cell Significance Index: 375.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.8560
    Cell Significance Index: 104.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.6749
    Cell Significance Index: 87.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.6063
    Cell Significance Index: 108.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.5312
    Cell Significance Index: 67.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4271
    Cell Significance Index: 166.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.3436
    Cell Significance Index: 50.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2405
    Cell Significance Index: 857.9800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.1155
    Cell Significance Index: 23.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.8209
    Cell Significance Index: 1545.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8148
    Cell Significance Index: 22.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7962
    Cell Significance Index: 59.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6794
    Cell Significance Index: 93.3000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6173
    Cell Significance Index: 7.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5427
    Cell Significance Index: 28.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5125
    Cell Significance Index: 97.5300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.4678
    Cell Significance Index: 6.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4428
    Cell Significance Index: 816.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4427
    Cell Significance Index: 72.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3648
    Cell Significance Index: 231.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3511
    Cell Significance Index: 22.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3286
    Cell Significance Index: 15.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3156
    Cell Significance Index: 485.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2779
    Cell Significance Index: 50.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1789
    Cell Significance Index: 19.4600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1585
    Cell Significance Index: 1.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0892
    Cell Significance Index: 8.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0864
    Cell Significance Index: 10.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0802
    Cell Significance Index: 4.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0801
    Cell Significance Index: 43.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0168
    Cell Significance Index: 22.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0274
    Cell Significance Index: -3.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0290
    Cell Significance Index: -1.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0312
    Cell Significance Index: -13.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0537
    Cell Significance Index: -39.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0761
    Cell Significance Index: -55.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0791
    Cell Significance Index: -2.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0807
    Cell Significance Index: -50.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0898
    Cell Significance Index: -40.7700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0925
    Cell Significance Index: -70.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1001
    Cell Significance Index: -56.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1569
    Cell Significance Index: -7.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1960
    Cell Significance Index: -13.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1980
    Cell Significance Index: -56.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2372
    Cell Significance Index: -49.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2703
    Cell Significance Index: -46.1600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2831
    Cell Significance Index: -3.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2938
    Cell Significance Index: -17.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3070
    Cell Significance Index: -6.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3502
    Cell Significance Index: -35.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3518
    Cell Significance Index: -27.0000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3717
    Cell Significance Index: -7.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4181
    Cell Significance Index: -54.0200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4534
    Cell Significance Index: -4.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.4966
    Cell Significance Index: -63.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5025
    Cell Significance Index: -52.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5280
    Cell Significance Index: -62.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6035
    Cell Significance Index: -10.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6309
    Cell Significance Index: -72.2800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6315
    Cell Significance Index: -72.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6428
    Cell Significance Index: -8.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6772
    Cell Significance Index: -22.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6820
    Cell Significance Index: -21.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7024
    Cell Significance Index: -18.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7105
    Cell Significance Index: -43.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7188
    Cell Significance Index: -56.9300
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.7301
    Cell Significance Index: -5.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7812
    Cell Significance Index: -16.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8650
    Cell Significance Index: -30.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8683
    Cell Significance Index: -61.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8686
    Cell Significance Index: -23.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8861
    Cell Significance Index: -28.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.9127
    Cell Significance Index: -58.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.9273
    Cell Significance Index: -43.5800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.9555
    Cell Significance Index: -12.0600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.9603
    Cell Significance Index: -6.0300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.9669
    Cell Significance Index: -13.5200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9750
    Cell Significance Index: -21.0700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.9940
    Cell Significance Index: -12.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.1085
    Cell Significance Index: -15.8800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -1.1568
    Cell Significance Index: -8.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TSPAN5 is a transmembrane protein with a molecular weight of approximately 28 kDa. It is highly expressed in the brain, particularly in photoreceptor cells, neuronal brush cells, and inhibitory interneurons. TSPAN5 is characterized by its ability to form tetraspanin complexes with other proteins, which are essential for maintaining cellular membrane structure and function. The protein's ectodomain is rich in cysteine residues, which are involved in protein-protein interactions and protein maturation. **Pathways and Functions:** TSPAN5 is involved in various cellular processes, including: 1. **Positive Regulation of Notch Signaling Pathway:** TSPAN5 interacts with Notch receptors to regulate the Notch signaling pathway, which plays a crucial role in cell fate determination, differentiation, and proliferation. 2. **Protein Binding:** TSPAN5 binds to various proteins, including Notch receptors, amyloid precursor protein, and synaptotagmin, which are involved in synaptic transmission and neuronal function. 3. **Protein Localization to Plasma Membrane:** TSPAN5 is localized to the plasma membrane, where it interacts with other proteins to regulate membrane protein ectodomain proteolysis. 4. **Actin Cytoskeleton Regulation:** TSPAN5 is involved in regulating the actin cytoskeleton, which is essential for maintaining cellular shape and function. 5. **Amyloid Fiber Formation:** TSPAN5 is involved in the formation of amyloid fibers, which are characteristic of neurodegenerative diseases such as Alzheimer's disease. **Clinical Significance:** TSPAN5 is implicated in various neurological disorders, including: 1. **Alzheimer's Disease:** TSPAN5 is involved in the formation of amyloid fibers, which are a hallmark of Alzheimer's disease. 2. **Amyotrophic Lateral Sclerosis (ALS):** TSPAN5 is involved in regulating the actin cytoskeleton, which is disrupted in ALS. 3. **Multiple Sclerosis:** TSPAN5 is involved in regulating the immune response, which is impaired in multiple sclerosis. 4. **Neurodegenerative Diseases:** TSPAN5 is involved in regulating protein maturation and localization to the plasma membrane, which is disrupted in neurodegenerative diseases. In conclusion, TSPAN5 is a critical component of cellular membrane structure and signaling in the brain. Its dysregulation is implicated in various neurological disorders, highlighting the importance of further research into the molecular mechanisms underlying these diseases.

Genular Protein ID: 2560475236

Symbol: TSN5_HUMAN

Name: Tetraspanin-5

UniProtKB Accession Codes:

P62079 B2RDY2 O60628 O60746 Q6FHE5 Q9JLY1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9714763

Title: Sequences and expression of six new members of the tetraspanin/TM4SF family.

PubMed ID: 9714763

DOI: 10.1016/s0167-4781(98)00087-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26686862

Title: TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization.

PubMed ID: 26686862

DOI: 10.1007/s00018-015-2111-z

PubMed ID: 28600292

Title: ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration.

PubMed ID: 28600292

DOI: 10.4049/jimmunol.1600713

PubMed ID: 31792032

Title: TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life.

PubMed ID: 31792032

DOI: 10.26508/lsa.201900444

PubMed ID: 37516108

Title: Structural basis for membrane-proximal proteolysis of substrates by ADAM10.

PubMed ID: 37516108

DOI: 10.1016/j.cell.2023.06.026

Sequence Information:

  • Length: 268
  • Mass: 30337
  • Checksum: 7F4480BD0FA6192D
  • Sequence:
    • MSGKHYKGPE VSCCIKYFIF GFNVIFWFLG ITFLGIGLWA WNEKGVLSNI SSITDLGGFD 
PVWLFLVVGG VMFILGFAGC IGALRENTFL LKFFSVFLGI IFFLELTAGV LAFVFKDWIK 
DQLYFFINNN IRAYRDDIDL QNLIDFTQEY WQCCGAFGAD DWNLNIYFNC TDSNASRERC 
GVPFSCCTKD PAEDVINTQC GYDARQKPEV DQQIVIYTKG CVPQFEKWLQ DNLTIVAGIF 
IGIALLQIFG ICLAQNLVSD IEAVRASW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.