Details for: TSPAN5

Gene ID: 10098

Symbol: TSPAN5

Ensembl ID: ENSG00000168785

Description: tetraspanin 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.29
    Marker Score: 2,474
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.28
    Marker Score: 10,995
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.04
    Marker Score: 14,087
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.75
    Marker Score: 4,621
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.68
    Marker Score: 40,128
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.67
    Marker Score: 53,120
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.64
    Marker Score: 3,553
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.62
    Marker Score: 1,368
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.59
    Marker Score: 1,244
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.57
    Marker Score: 13,488
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.55
    Marker Score: 19,538
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.52
    Marker Score: 6,035
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.49
    Marker Score: 10,326
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.39
    Marker Score: 10,003
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.34
    Marker Score: 1,312
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.32
    Marker Score: 85,685
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.3
    Marker Score: 8,908
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.3
    Marker Score: 729
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.23
    Marker Score: 11,975
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.22
    Marker Score: 1,326
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.19
    Marker Score: 6,251
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.19
    Marker Score: 46,720
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.19
    Marker Score: 917
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.17
    Marker Score: 3,060
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.17
    Marker Score: 1,073
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.16
    Marker Score: 20,312
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.14
    Marker Score: 2,587
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.1
    Marker Score: 13,673
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.06
    Marker Score: 126,664
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.03
    Marker Score: 1,750
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.01
    Marker Score: 2,501
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2
    Marker Score: 75,925
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.96
    Marker Score: 1,033
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.93
    Marker Score: 2,334
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.92
    Marker Score: 2,120
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.91
    Marker Score: 18,122
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.89
    Marker Score: 33,616
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.86
    Marker Score: 961
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.85
    Marker Score: 15,894
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.84
    Marker Score: 13,905
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.84
    Marker Score: 538
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.79
    Marker Score: 7,271
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.77
    Marker Score: 643
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.76
    Marker Score: 1,159
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.76
    Marker Score: 1,656
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.74
    Marker Score: 593
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.69
    Marker Score: 3,426
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.64
    Marker Score: 955
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.62
    Marker Score: 3,725
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.62
    Marker Score: 2,497
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.61
    Marker Score: 1,732
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.57
    Marker Score: 1,806
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.51
    Marker Score: 5,816
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.49
    Marker Score: 408
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.47
    Marker Score: 14,796
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,862
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.45
    Marker Score: 14,975
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.43
    Marker Score: 1,501
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.42
    Marker Score: 828
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.38
    Marker Score: 1,065
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.33
    Marker Score: 799
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.32
    Marker Score: 320
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.31
    Marker Score: 1,136
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.27
    Marker Score: 2,591
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.26
    Marker Score: 1,850
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.25
    Marker Score: 778
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.23
    Marker Score: 880
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.19
    Marker Score: 2,722
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.18
    Marker Score: 1,338
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.13
    Marker Score: 17,729
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.12
    Marker Score: 324
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.09
    Marker Score: 4,533
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.09
    Marker Score: 3,003
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.08
    Marker Score: 2,946
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.05
    Marker Score: 404
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.03
    Marker Score: 263
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.02
    Marker Score: 11,498
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,717
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,942
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,396
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.97
    Marker Score: 8,326
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.96
    Marker Score: 564
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.95
    Marker Score: 1,190
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.95
    Marker Score: 304
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.95
    Marker Score: 350
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.93
    Marker Score: 276
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.92
    Marker Score: 280
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,713
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.89
    Marker Score: 8,858
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.88
    Marker Score: 3,401
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.87
    Marker Score: 5,222
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.87
    Marker Score: 3,747
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,935
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.86
    Marker Score: 2,109
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.86
    Marker Score: 273

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TSPAN5 is a transmembrane protein with a molecular weight of approximately 28 kDa. It is highly expressed in the brain, particularly in photoreceptor cells, neuronal brush cells, and inhibitory interneurons. TSPAN5 is characterized by its ability to form tetraspanin complexes with other proteins, which are essential for maintaining cellular membrane structure and function. The protein's ectodomain is rich in cysteine residues, which are involved in protein-protein interactions and protein maturation. **Pathways and Functions:** TSPAN5 is involved in various cellular processes, including: 1. **Positive Regulation of Notch Signaling Pathway:** TSPAN5 interacts with Notch receptors to regulate the Notch signaling pathway, which plays a crucial role in cell fate determination, differentiation, and proliferation. 2. **Protein Binding:** TSPAN5 binds to various proteins, including Notch receptors, amyloid precursor protein, and synaptotagmin, which are involved in synaptic transmission and neuronal function. 3. **Protein Localization to Plasma Membrane:** TSPAN5 is localized to the plasma membrane, where it interacts with other proteins to regulate membrane protein ectodomain proteolysis. 4. **Actin Cytoskeleton Regulation:** TSPAN5 is involved in regulating the actin cytoskeleton, which is essential for maintaining cellular shape and function. 5. **Amyloid Fiber Formation:** TSPAN5 is involved in the formation of amyloid fibers, which are characteristic of neurodegenerative diseases such as Alzheimer's disease. **Clinical Significance:** TSPAN5 is implicated in various neurological disorders, including: 1. **Alzheimer's Disease:** TSPAN5 is involved in the formation of amyloid fibers, which are a hallmark of Alzheimer's disease. 2. **Amyotrophic Lateral Sclerosis (ALS):** TSPAN5 is involved in regulating the actin cytoskeleton, which is disrupted in ALS. 3. **Multiple Sclerosis:** TSPAN5 is involved in regulating the immune response, which is impaired in multiple sclerosis. 4. **Neurodegenerative Diseases:** TSPAN5 is involved in regulating protein maturation and localization to the plasma membrane, which is disrupted in neurodegenerative diseases. In conclusion, TSPAN5 is a critical component of cellular membrane structure and signaling in the brain. Its dysregulation is implicated in various neurological disorders, highlighting the importance of further research into the molecular mechanisms underlying these diseases.

Genular Protein ID: 2560475236

Symbol: TSN5_HUMAN

Name: Tetraspanin-5

UniProtKB Accession Codes:

P62079 B2RDY2 O60628 O60746 Q6FHE5 Q9JLY1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9714763

Title: Sequences and expression of six new members of the tetraspanin/TM4SF family.

PubMed ID: 9714763

DOI: 10.1016/s0167-4781(98)00087-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26686862

Title: TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization.

PubMed ID: 26686862

DOI: 10.1007/s00018-015-2111-z

PubMed ID: 28600292

Title: ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration.

PubMed ID: 28600292

DOI: 10.4049/jimmunol.1600713

PubMed ID: 31792032

Title: TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life.

PubMed ID: 31792032

DOI: 10.26508/lsa.201900444

PubMed ID: 37516108

Title: Structural basis for membrane-proximal proteolysis of substrates by ADAM10.

PubMed ID: 37516108

DOI: 10.1016/j.cell.2023.06.026

Sequence Information:

  • Length: 268
  • Mass: 30337
  • Checksum: 7F4480BD0FA6192D
  • Sequence:
    • MSGKHYKGPE VSCCIKYFIF GFNVIFWFLG ITFLGIGLWA WNEKGVLSNI SSITDLGGFD 
PVWLFLVVGG VMFILGFAGC IGALRENTFL LKFFSVFLGI IFFLELTAGV LAFVFKDWIK 
DQLYFFINNN IRAYRDDIDL QNLIDFTQEY WQCCGAFGAD DWNLNIYFNC TDSNASRERC 
GVPFSCCTKD PAEDVINTQC GYDARQKPEV DQQIVIYTKG CVPQFEKWLQ DNLTIVAGIF 
IGIALLQIFG ICLAQNLVSD IEAVRASW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.