Details for: MSX1

Gene ID: 4487

Symbol: MSX1

Ensembl ID: ENSG00000163132

Description: msh homeobox 1

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Gastrulation
    (R-HSA-9758941)
  • Specification of the neural plate border
    (R-HSA-9834899)
  • Activation of meiosis
    (GO:0090427)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • Bmp signaling pathway
    (GO:0030509)
  • Bone morphogenesis
    (GO:0060349)
  • Cardiac conduction system development
    (GO:0003161)
  • Cartilage morphogenesis
    (GO:0060536)
  • Cell morphogenesis
    (GO:0000902)
  • Cell surface receptor signaling pathway involved in heart development
    (GO:0061311)
  • Chromatin
    (GO:0000785)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Embryonic forelimb morphogenesis
    (GO:0035115)
  • Embryonic hindlimb morphogenesis
    (GO:0035116)
  • Embryonic morphogenesis
    (GO:0048598)
  • Embryonic nail plate morphogenesis
    (GO:0035880)
  • Epithelial to mesenchymal transition involved in endocardial cushion formation
    (GO:0003198)
  • Face morphogenesis
    (GO:0060325)
  • Forebrain development
    (GO:0030900)
  • Inner ear development
    (GO:0048839)
  • In utero embryonic development
    (GO:0001701)
  • Mammary gland epithelium development
    (GO:0061180)
  • Mesenchymal cell apoptotic process
    (GO:0097152)
  • Mesenchymal cell proliferation
    (GO:0010463)
  • Midbrain development
    (GO:0030901)
  • Middle ear morphogenesis
    (GO:0042474)
  • Muscle organ development
    (GO:0007517)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cell growth
    (GO:0030308)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of odontoblast differentiation
    (GO:1901330)
  • Negative regulation of striated muscle cell differentiation
    (GO:0051154)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nose development
    (GO:0043584)
  • Nuclear periphery
    (GO:0034399)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Odontogenesis of dentin-containing tooth
    (GO:0042475)
  • P53 binding
    (GO:0002039)
  • Positive regulation of bmp signaling pathway
    (GO:0030513)
  • Positive regulation of cell cycle
    (GO:0045787)
  • Positive regulation of dna damage response, signal transduction by p53 class mediator
    (GO:0043517)
  • Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
    (GO:1902255)
  • Positive regulation of mesenchymal cell apoptotic process
    (GO:2001055)
  • Positive regulation of odontogenesis
    (GO:0042482)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein localization to nucleus
    (GO:0034504)
  • Protein stabilization
    (GO:0050821)
  • Regulation of odontogenesis
    (GO:0042481)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Roof of mouth development
    (GO:0060021)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Signal transduction involved in regulation of gene expression
    (GO:0023019)
  • Stem cell differentiation
    (GO:0048863)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription regulator complex
    (GO:0005667)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 80.1696
    Cell Significance Index: -12.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.4539
    Cell Significance Index: -12.2900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 29.4940
    Cell Significance Index: -12.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5355
    Cell Significance Index: -12.1500
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 4.1523
    Cell Significance Index: 4.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.1568
    Cell Significance Index: 404.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1500
    Cell Significance Index: -12.4300
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.9793
    Cell Significance Index: 12.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.9679
    Cell Significance Index: 56.4100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.6391
    Cell Significance Index: 28.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0392
    Cell Significance Index: 567.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7339
    Cell Significance Index: 19.6700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.6175
    Cell Significance Index: 4.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4603
    Cell Significance Index: 87.5900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.4194
    Cell Significance Index: 4.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3753
    Cell Significance Index: 17.0100
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.3427
    Cell Significance Index: 1.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3207
    Cell Significance Index: 63.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2534
    Cell Significance Index: 7.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1994
    Cell Significance Index: 11.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1439
    Cell Significance Index: 129.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1419
    Cell Significance Index: 14.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1415
    Cell Significance Index: 15.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1100
    Cell Significance Index: 1.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0963
    Cell Significance Index: 15.6600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0944
    Cell Significance Index: 1.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0935
    Cell Significance Index: 12.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0900
    Cell Significance Index: 39.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0691
    Cell Significance Index: 12.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0580
    Cell Significance Index: 1.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0458
    Cell Significance Index: 2.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0429
    Cell Significance Index: 2.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0353
    Cell Significance Index: 1.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0255
    Cell Significance Index: 5.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0182
    Cell Significance Index: 6.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0143
    Cell Significance Index: 0.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0033
    Cell Significance Index: 0.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0038
    Cell Significance Index: -0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0054
    Cell Significance Index: -10.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0059
    Cell Significance Index: -4.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0061
    Cell Significance Index: -11.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0062
    Cell Significance Index: -9.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0063
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0066
    Cell Significance Index: -4.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0077
    Cell Significance Index: -10.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0142
    Cell Significance Index: -7.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0158
    Cell Significance Index: -10.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0160
    Cell Significance Index: -11.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0161
    Cell Significance Index: -12.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0164
    Cell Significance Index: -0.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0189
    Cell Significance Index: -8.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0219
    Cell Significance Index: -6.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0259
    Cell Significance Index: -5.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0351
    Cell Significance Index: -6.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0448
    Cell Significance Index: -6.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0654
    Cell Significance Index: -8.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0680
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0756
    Cell Significance Index: -8.6300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0769
    Cell Significance Index: -1.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0847
    Cell Significance Index: -3.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0892
    Cell Significance Index: -9.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0909
    Cell Significance Index: -6.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0980
    Cell Significance Index: -4.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1030
    Cell Significance Index: -11.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1073
    Cell Significance Index: -12.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1094
    Cell Significance Index: -2.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1099
    Cell Significance Index: -3.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1120
    Cell Significance Index: -5.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1158
    Cell Significance Index: -12.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1404
    Cell Significance Index: -2.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1446
    Cell Significance Index: -10.7800
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: -0.1476
    Cell Significance Index: -0.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1521
    Cell Significance Index: -9.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1535
    Cell Significance Index: -10.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1600
    Cell Significance Index: -12.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1709
    Cell Significance Index: -8.8800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1751
    Cell Significance Index: -1.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1782
    Cell Significance Index: -3.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1938
    Cell Significance Index: -12.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1982
    Cell Significance Index: -5.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2076
    Cell Significance Index: -12.7600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2085
    Cell Significance Index: -1.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2142
    Cell Significance Index: -12.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2299
    Cell Significance Index: -12.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2444
    Cell Significance Index: -10.8100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2533
    Cell Significance Index: -9.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2556
    Cell Significance Index: -6.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2695
    Cell Significance Index: -9.4400
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2765
    Cell Significance Index: -2.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2780
    Cell Significance Index: -7.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2820
    Cell Significance Index: -10.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2888
    Cell Significance Index: -3.9400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3014
    Cell Significance Index: -4.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3016
    Cell Significance Index: -10.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3094
    Cell Significance Index: -10.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3178
    Cell Significance Index: -10.1200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3191
    Cell Significance Index: -5.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3313
    Cell Significance Index: -7.2600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3335
    Cell Significance Index: -1.5400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3354
    Cell Significance Index: -5.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MSX1 is a member of the homeobox gene family, which is characterized by the presence of a homeobox domain, a conserved DNA-binding motif. The MSX1 gene is highly conserved across species, with high sequence identity to its mouse and zebrafish counterparts. MSX1 is expressed in a wide range of tissues, including the nervous system, cardiovascular system, and reproductive system. It is also involved in the regulation of cell proliferation, differentiation, and survival. **Pathways and Functions** MSX1 is involved in several signaling pathways, including: 1. **BMP signaling pathway**: MSX1 is a positive regulator of the BMP signaling pathway, which is involved in embryonic development, bone morphogenesis, and cardiac conduction system development. 2. **Wnt signaling pathway**: MSX1 is also involved in the regulation of the Wnt signaling pathway, which is involved in cell proliferation, differentiation, and survival. 3. **Notch signaling pathway**: MSX1 is a negative regulator of the Notch signaling pathway, which is involved in cell fate determination and differentiation. 4. **Chromatin remodeling**: MSX1 is involved in the regulation of chromatin remodeling, which is essential for gene expression and cell differentiation. MSX1 functions as a transcription factor, regulating the expression of target genes involved in development, growth, and differentiation. It binds to specific DNA sequences, known as enhancers and promoters, and recruits co-activators or co-repressors to modulate gene expression. MSX1 is also involved in the regulation of cell cycle, apoptosis, and gene expression. **Clinical Significance** MSX1 dysregulation has been implicated in various diseases, including: 1. **Cancer**: MSX1 is often downregulated in cancer cells, leading to the loss of cell differentiation and the acquisition of a more aggressive phenotype. 2. **Cardiovascular diseases**: MSX1 is involved in the regulation of cardiac conduction system development and function. Its dysregulation has been implicated in arrhythmias and cardiac conduction disorders. 3. **Developmental disorders**: MSX1 is involved in the regulation of embryonic development and organogenesis. Its dysregulation has been implicated in developmental disorders, such as craniofacial anomalies and neural tube defects. 4. **Neurological disorders**: MSX1 is involved in the regulation of neural development and function. Its dysregulation has been implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, MSX1 is a critical transcription factor involved in various developmental processes, including embryonic development, organogenesis, and cell differentiation. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular diseases, and developmental disorders. Further studies are needed to fully understand the mechanisms of MSX1 dysregulation and its clinical significance.

Genular Protein ID: 3228540030

Symbol: MSX1_HUMAN

Name: Homeobox protein Hox-7

UniProtKB Accession Codes:

P28360 A0SZU5 A8K3M1 Q96NY4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 GO 59 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1685479

Title: Structure and sequence of the human homeobox gene HOX7.

PubMed ID: 1685479

DOI: 10.1016/0888-7543(91)90074-o

PubMed ID: 1284527

Title: Characterization of the human HOX 7 cDNA and identification of polymorphic markers.

PubMed ID: 1284527

DOI: 10.1093/hmg/1.6.407

PubMed ID: 12807959

Title: Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate.

PubMed ID: 12807959

DOI: 10.1136/jmg.40.6.399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1969845

Title: The human homeobox gene HOX7 maps to chromosome 4p16.1 and may be implicated in Wolf-Hirschhorn syndrome.

PubMed ID: 1969845

DOI: 10.1007/bf00195823

PubMed ID: 16600910

Title: PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein.

PubMed ID: 16600910

DOI: 10.1101/gad.1392006

PubMed ID: 8696335

Title: A human MSX1 homeodomain missense mutation causes selective tooth agenesis.

PubMed ID: 8696335

DOI: 10.1038/ng0896-417

PubMed ID: 11369996

Title: A nonsense mutation in MSX1 causes Witkop syndrome.

PubMed ID: 11369996

DOI: 10.1086/321271

PubMed ID: 12097313

Title: The role of MSX1 in human tooth agenesis.

PubMed ID: 12097313

DOI: 10.1177/154405910208100410

Sequence Information:

  • Length: 303
  • Mass: 31496
  • Checksum: 1B5F01B35920E64F
  • Sequence:
    • MAPAADMTSL PLGVKVEDSA FGKPAGGGAG QAPSAAAATA AAMGADEEGA KPKVSPSLLP 
FSVEALMADH RKPGAKESAL APSEGVQAAG GSAQPLGVPP GSLGAPDAPS SPRPLGHFSV 
GGLLKLPEDA LVKAESPEKP ERTPWMQSPR FSPPPARRLS PPACTLRKHK TNRKPRTPFT 
TAQLLALERK FRQKQYLSIA ERAEFSSSLS LTETQVKIWF QNRRAKAKRL QEAELEKLKM 
AAKPMLPPAA FGLSFPLGGP AAVAAAAGAS LYGASGPFQR AALPVAPVGL YTAHVGYSMY 
HLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.