Details for: HCCS

Gene ID: 3052

Symbol: HCCS

Ensembl ID: ENSG00000004961

Description: holocytochrome c synthase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.58
    Marker Score: 2268
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.22
    Marker Score: 959
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.09
    Marker Score: 2296
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.07
    Marker Score: 36237
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.04
    Marker Score: 1536
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71731
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47955
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.97
    Marker Score: 656
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.97
    Marker Score: 2360.5
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.95
    Marker Score: 234
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2396
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9
    Marker Score: 952.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2705
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.89
    Marker Score: 884
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.89
    Marker Score: 441
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5040
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.87
    Marker Score: 3409
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5243
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.86
    Marker Score: 7435
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.86
    Marker Score: 4113
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.84
    Marker Score: 2625
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.81
    Marker Score: 444
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.8
    Marker Score: 1910
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.79
    Marker Score: 989
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.78
    Marker Score: 1300
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.78
    Marker Score: 277
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 582
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.75
    Marker Score: 563
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.74
    Marker Score: 2834
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.73
    Marker Score: 3577.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.72
    Marker Score: 208
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.7
    Marker Score: 734
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.7
    Marker Score: 17883
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.69
    Marker Score: 915
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.69
    Marker Score: 725
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.68
    Marker Score: 230
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.67
    Marker Score: 429
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2783.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 601
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.66
    Marker Score: 1165
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.65
    Marker Score: 254
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.65
    Marker Score: 1604.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.64
    Marker Score: 1121
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.63
    Marker Score: 1436
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.63
    Marker Score: 257
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.62
    Marker Score: 382
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.62
    Marker Score: 1541.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.61
    Marker Score: 2277
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.61
    Marker Score: 153
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.61
    Marker Score: 4761.5
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.61
    Marker Score: 153
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.6
    Marker Score: 3676
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6
    Marker Score: 593.5
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.59
    Marker Score: 144
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.57
    Marker Score: 1166
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.57
    Marker Score: 1560
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.57
    Marker Score: 511
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.57
    Marker Score: 19834
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 378
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.57
    Marker Score: 134
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.57
    Marker Score: 607
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.57
    Marker Score: 269
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.57
    Marker Score: 569
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.56
    Marker Score: 382
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.56
    Marker Score: 210
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.56
    Marker Score: 371
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.56
    Marker Score: 6461
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.56
    Marker Score: 3544
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.54
    Marker Score: 632
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.54
    Marker Score: 137
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.54
    Marker Score: 447
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 426
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.53
    Marker Score: 336.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.53
    Marker Score: 1112
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.52
    Marker Score: 259
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.52
    Marker Score: 240
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.52
    Marker Score: 347
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.52
    Marker Score: 217
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.52
    Marker Score: 464.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.52
    Marker Score: 8136
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.52
    Marker Score: 215
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.51
    Marker Score: 377
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.51
    Marker Score: 1165
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.51
    Marker Score: 154
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.51
    Marker Score: 482
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.51
    Marker Score: 934
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.51
    Marker Score: 2197
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.51
    Marker Score: 3231
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.5
    Marker Score: 544
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 211
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.5
    Marker Score: 145
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.5
    Marker Score: 1261

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Other Information

## Summary HCCS is a protein that is involved in the assembly and function of cytochrome c, a protein that is a key component of the electron transport chain. Cytochrome c is responsible for transferring electrons from one protein to another in the mitochondrial inner membrane, where they are used to generate ATP. ## Key characteristics * HCCS is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is found in a variety of cell types, including oogonial cells, epithelial cells of the urethra, pancreatic acinar cells, fibroblasts of the mammary gland, bladder urothelial cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, proerythroblasts, and basal cells of the prostate epithelium. * It is significantly expressed in the oogonial cell, epithelial cell of the urethra, pancreatic acinar cell, fibroblast of the mammary gland, bladder urothelial cell, and cerebral cortex GABAergic interneuron. ## Pathways and functions HCCS is involved in the following pathways and functions: * Cytochrome c-heme linkage * Cytosol * Heme binding * Holocytochrome-c synthase activity * Membrane * Metal ion binding * Mitochondrial inner membrane * Mitochondrial outer membrane * Protein binding ## Clinical significance HCCS is a gene that is involved in the assembly and function of cytochrome c, a protein that is a key component of the electron transport chain. Mutations in HCCS genes have been linked to a number of human diseases, including mitochondrial disorders and cancer.

Genular Protein ID: 1921740438

Symbol: CCHL_HUMAN

Name: N/A

UniProtKB Accession Codes:

P53701 B3KUS1 Q502X8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 9 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 Rhea 4 SAM 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8661044

Title: Cloning and characterization of a putative human holocytochrome c-type synthetase gene (HCCS) isolated from the critical region for microphthalmia with linear skin defects (MLS).

PubMed ID: 8661044

DOI: 10.1006/geno.1996.0261

PubMed ID: 9674913

Title: Genomic structure of a human holocytochrome c-type synthetase gene in Xp22.3 and mutation analysis in patients with Rett syndrome.

PubMed ID: 9674913

DOI: 10.1002/(sici)1096-8628(19980630)78:2<179::aid-ajmg17>3.3.co;2-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23150584

Title: Human mitochondrial holocytochrome c synthase's heme binding, maturation determinants, and complex formation with cytochrome c.

PubMed ID: 23150584

DOI: 10.1073/pnas.1213897109

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25807930

Title: Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

PubMed ID: 25807930

DOI: 10.1002/anie.201500342

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 17033964

Title: Mutations of the mitochondrial holocytochrome c-type synthase in X-linked dominant microphthalmia with linear skin defects syndrome.

PubMed ID: 17033964

DOI: 10.1086/508474

Sequence Information:

  • Length: 268
  • Mass: 30602
  • Checksum: 8DC4DA47E444B2FB
  • Sequence:
    • MGLSPSAPAV AVQASNASAS PPSGCPMHEG KMKGCPVNTE PSGPTCEKKT YSVPAHQERA 
YEYVECPIRG TAAENKENLD PSNLMPPPNQ TPAPDQPFAL STVREESSIP RADSEKKWVY 
PSEQMFWNAM LKKGWKWKDE DISQKDMYNI IRIHNQNNEQ AWKEILKWEA LHAAECPCGP 
SLIRFGGKAK EYSPRARIRS WMGYELPFDR HDWIINRCGT EVRYVIDYYD GGEVNKDYQF 
TILDVRPALD SLSAVWDRMK VAWWRWTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.