Details for: MEX3C

Gene ID: 51320

Symbol: MEX3C

Ensembl ID: ENSG00000176624

Description: mex-3 RNA binding family member C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 122.8582
    Cell Significance Index: -19.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.5572
    Cell Significance Index: -18.1500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 51.0259
    Cell Significance Index: -21.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.2146
    Cell Significance Index: -17.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.0153
    Cell Significance Index: -17.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.8643
    Cell Significance Index: -19.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.9433
    Cell Significance Index: -18.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0151
    Cell Significance Index: -19.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.1025
    Cell Significance Index: -6.7900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.7342
    Cell Significance Index: 29.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.5733
    Cell Significance Index: 108.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4402
    Cell Significance Index: 19.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8644
    Cell Significance Index: 55.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8458
    Cell Significance Index: 50.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8119
    Cell Significance Index: 21.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7514
    Cell Significance Index: 122.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7408
    Cell Significance Index: 16.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5730
    Cell Significance Index: 16.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4940
    Cell Significance Index: 22.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4674
    Cell Significance Index: 24.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4082
    Cell Significance Index: 21.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3960
    Cell Significance Index: 8.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3954
    Cell Significance Index: 22.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3933
    Cell Significance Index: 48.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3326
    Cell Significance Index: 66.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3313
    Cell Significance Index: 66.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3242
    Cell Significance Index: 8.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2936
    Cell Significance Index: 52.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2453
    Cell Significance Index: 108.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2436
    Cell Significance Index: 6.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2427
    Cell Significance Index: 132.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2306
    Cell Significance Index: 31.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1854
    Cell Significance Index: 18.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1808
    Cell Significance Index: 34.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1705
    Cell Significance Index: 21.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1502
    Cell Significance Index: 7.0600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1248
    Cell Significance Index: 1.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1217
    Cell Significance Index: 43.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0820
    Cell Significance Index: 5.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0802
    Cell Significance Index: 3.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0698
    Cell Significance Index: 4.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0549
    Cell Significance Index: 1.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0527
    Cell Significance Index: 1.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0498
    Cell Significance Index: 34.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0478
    Cell Significance Index: 0.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0147
    Cell Significance Index: 0.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0130
    Cell Significance Index: 0.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0080
    Cell Significance Index: 0.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0059
    Cell Significance Index: 0.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0043
    Cell Significance Index: 7.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0029
    Cell Significance Index: 5.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0016
    Cell Significance Index: 2.4600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0021
    Cell Significance Index: -2.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0046
    Cell Significance Index: -0.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0089
    Cell Significance Index: -1.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0099
    Cell Significance Index: -0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0138
    Cell Significance Index: -8.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0174
    Cell Significance Index: -12.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0182
    Cell Significance Index: -13.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0187
    Cell Significance Index: -14.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0239
    Cell Significance Index: -0.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0246
    Cell Significance Index: -11.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0284
    Cell Significance Index: -2.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0299
    Cell Significance Index: -5.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0313
    Cell Significance Index: -17.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0358
    Cell Significance Index: -22.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0479
    Cell Significance Index: -1.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0496
    Cell Significance Index: -0.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0523
    Cell Significance Index: -15.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0570
    Cell Significance Index: -8.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0594
    Cell Significance Index: -6.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0620
    Cell Significance Index: -4.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0635
    Cell Significance Index: -6.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0916
    Cell Significance Index: -10.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1021
    Cell Significance Index: -21.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1030
    Cell Significance Index: -2.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1246
    Cell Significance Index: -5.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1392
    Cell Significance Index: -3.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1424
    Cell Significance Index: -2.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1458
    Cell Significance Index: -4.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1624
    Cell Significance Index: -6.1500
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1781
    Cell Significance Index: -1.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1797
    Cell Significance Index: -18.7100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2006
    Cell Significance Index: -3.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2124
    Cell Significance Index: -16.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2553
    Cell Significance Index: -15.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3011
    Cell Significance Index: -7.2200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3245
    Cell Significance Index: -4.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3356
    Cell Significance Index: -17.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3507
    Cell Significance Index: -9.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3692
    Cell Significance Index: -9.4900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3703
    Cell Significance Index: -3.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3781
    Cell Significance Index: -5.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3826
    Cell Significance Index: -14.0500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3841
    Cell Significance Index: -10.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3989
    Cell Significance Index: -10.1900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4061
    Cell Significance Index: -5.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4198
    Cell Significance Index: -13.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4378
    Cell Significance Index: -13.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MEX3C is a single-codon frame shift mutation gene, encoded by the ENSG00000176624 gene in humans. It belongs to the mex-3 RNA binding family, which is characterized by the presence of a conserved RNA-binding motif. The MEX3C protein is a large, multifunctional protein with a molecular weight of approximately 60 kDa. It exhibits two distinct domains: an RNA-binding domain and a ubiquitin ligase domain, which are essential for its biological functions. **Pathways and Functions:** MEX3C is involved in various cellular processes, including: 1. **Adaptive Immune System**: MEX3C plays a crucial role in the adaptive immune system, particularly in the regulation of antigen presentation and processing. It interacts with Class I MHC molecules, facilitating the presentation of antigens to CD8+ T cells. 2. **Antigen Processing: Ubiquitination & Proteasome Degradation**: MEX3C is involved in the ubiquitination and proteasome degradation of antigens, which is essential for their presentation by MHC molecules. 3. **Chondrocyte Hypertrophy**: MEX3C is also expressed in chondrocytes, where it regulates the hypertrophy of these cells, which is a critical process in bone development. 4. **Energy Homeostasis**: MEX3C is involved in the regulation of energy homeostasis, particularly in the context of adipocyte differentiation. 5. **Regulation of Fat Cell Differentiation**: MEX3C regulates the differentiation of adipocytes, which is essential for energy homeostasis and metabolic health. **Clinical Significance:** The dysregulation of MEX3C has been implicated in various diseases, including: 1. **Autoimmune Disorders**: MEX3C dysfunction has been linked to autoimmune disorders, such as rheumatoid arthritis and lupus, where the immune system is dysregulated. 2. **Cancer**: MEX3C is often downregulated in cancer cells, leading to impaired antigen presentation and immune evasion. 3. **Metabolic Disorders**: MEX3C dysfunction has been linked to metabolic disorders, such as obesity and type 2 diabetes, where energy homeostasis is disrupted. In conclusion, MEX3C is a multifunctional protein that plays a critical role in immune regulation, cellular differentiation, and energy homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is necessary to fully elucidate the mechanisms by which MEX3C regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 704895031

Symbol: MEX3C_HUMAN

Name: RNA-binding E3 ubiquitin-protein ligase MEX3C

UniProtKB Accession Codes:

Q5U5Q3 A1L022 Q9NZE3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 17267406

Title: Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.

PubMed ID: 17267406

DOI: 10.1093/nar/gkm016

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17015768

Title: Implication of chromosome 18 in hypertension by sibling pair and association analyses: putative involvement of the RKHD2 gene.

PubMed ID: 17015768

DOI: 10.1161/01.hyp.0000244085.52918.a0

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22863774

Title: The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation.

PubMed ID: 22863774

DOI: 10.1038/emboj.2012.218

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23446422

Title: Replication stress links structural and numerical cancer chromosomal instability.

PubMed ID: 23446422

DOI: 10.1038/nature11935

Sequence Information:

  • Length: 659
  • Mass: 69366
  • Checksum: BAFDB7AD4B331471
  • Sequence:
    • MPSGSSAALA LAAAPAPLPQ PPPPPPPPPP PLPPPSGGPE LEGDGLLLRE RLAALGLDDP 
SPAEPGAPAL RAPAAAAQGQ ARRAAELSPE ERAPPGRPGA PEAAELELEE DEEEGEEAEL 
DGDLLEEEEL EEAEEEDRSS LLLLSPPAAT ASQTQQIPGG SLGSVLLPAA RFDAREAAAA 
AAAAGVLYGG DDAQGMMAAM LSHAYGPGGC GAAAAALNGE QAALLRRKSV NTTECVPVPS 
SEHVAEIVGR QGCKIKALRA KTNTYIKTPV RGEEPIFVVT GRKEDVAMAK REILSAAEHF 
SMIRASRNKN GPALGGLSCS PNLPGQTTVQ VRVPYRVVGL VVGPKGATIK RIQQQTHTYI 
VTPSRDKEPV FEVTGMPENV DRAREEIEMH IAMRTGNYIE LNEENDFHYN GTDVSFEGGT 
LGSAWLSSNP VPPSRARMIS NYRNDSSSSL GSGSTDSYFG SNRLADFSPT SPFSTGNFWF 
GDTLPSVGSE DLAVDSPAFD SLPTSAQTIW TPFEPVNPLS GFGSDPSGNM KTQRRGSQPS 
TPRLSPTFPE SIEHPLARRV RSDPPSTGNH VGLPIYIPAF SNGTNSYSSS NGGSTSSSPP 
ESRRKHDCVI CFENEVIAAL VPCGHNLFCM ECANKICEKR TPSCPVCQTA VTQAIQIHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.