Details for: IL6

Gene ID: 3569

Symbol: IL6

Ensembl ID: ENSG00000136244

Description: interleukin 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.94
    Marker Score: 1548
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.65
    Marker Score: 90086
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.16
    Marker Score: 900
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.94
    Marker Score: 484
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.93
    Marker Score: 484
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.76
    Marker Score: 1500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.73
    Marker Score: 2930
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.56
    Marker Score: 3831
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.38
    Marker Score: 2447
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.38
    Marker Score: 1186
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.36
    Marker Score: 778
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.36
    Marker Score: 3465
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 859
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.18
    Marker Score: 1423.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.16
    Marker Score: 296
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.15
    Marker Score: 294
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.11
    Marker Score: 1610
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.1
    Marker Score: 474
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.08
    Marker Score: 2042.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.06
    Marker Score: 376
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.04
    Marker Score: 233
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71797
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48022
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.99
    Marker Score: 1421
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1975
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5330
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.91
    Marker Score: 2393
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.89
    Marker Score: 344
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.82
    Marker Score: 279
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 690
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 575.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.74
    Marker Score: 179
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.69
    Marker Score: 1429
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.69
    Marker Score: 456
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.66
    Marker Score: 141
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.66
    Marker Score: 236
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.63
    Marker Score: 288
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.61
    Marker Score: 386
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.6
    Marker Score: 649
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.59
    Marker Score: 394
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 240
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.57
    Marker Score: 1135
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.56
    Marker Score: 265
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.54
    Marker Score: 545
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.52
    Marker Score: 1190
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.52
    Marker Score: 502
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.52
    Marker Score: 128
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5
    Marker Score: 7893
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.5
    Marker Score: 291
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.48
    Marker Score: 226
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.48
    Marker Score: 699
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.48
    Marker Score: 454
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.46
    Marker Score: 157
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.45
    Marker Score: 182
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.44
    Marker Score: 183
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.43
    Marker Score: 125
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 384
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.41
    Marker Score: 2500
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.41
    Marker Score: 444
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.41
    Marker Score: 1750
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.4
    Marker Score: 618
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.4
    Marker Score: 106
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.4
    Marker Score: 146
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.4
    Marker Score: 493
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.39
    Marker Score: 224
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.39
    Marker Score: 4438
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 371
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.38
    Marker Score: 375
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.38
    Marker Score: 339
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.37
    Marker Score: 244
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.37
    Marker Score: 166
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 365
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.36
    Marker Score: 102
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.36
    Marker Score: 396
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.36
    Marker Score: 160
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.34
    Marker Score: 109
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.33
    Marker Score: 1641
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.32
    Marker Score: 94
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.32
    Marker Score: 99
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.3
    Marker Score: 270
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.29
    Marker Score: 296
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.29
    Marker Score: 205
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.29
    Marker Score: 126
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.29
    Marker Score: 120
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.29
    Marker Score: 282
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.29
    Marker Score: 82
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.28
    Marker Score: 328
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.28
    Marker Score: 64
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.28
    Marker Score: 81
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.27
    Marker Score: 124

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Other Information

**Key characteristics** * IL-6 is a cytokine that is produced by a variety of cell types, including immune cells, fibroblasts, and endothelial cells. * It is a key cytokine in the regulation of inflammation, tissue development, and differentiation. * IL-6 has both pro-inflammatory and anti-inflammatory effects, depending on the context. * It is a potent activator of the JAK/STAT signaling pathway. * It is involved in the regulation of immune responses, tissue repair, and inflammation. **Pathways and functions** * IL-6 is produced by activated T cells and macrophages and acts on a variety of cell types, including monocytes, macrophages, and lymphocytes. * It promotes the differentiation of hematopoietic stem cells into various immune cell lineages. * It stimulates the proliferation and survival of fibroblasts and endothelial cells. * It inhibits the differentiation of fibroblasts into myofibroblasts. * It promotes inflammation and tissue repair. * It has a role in the regulation of immune responses, tissue development, and differentiation. **Clinical significance** * IL-6 is a key cytokine in the pathogenesis of a variety of diseases, including asthma, rheumatoid arthritis, and cancer. * It is a potential therapeutic target for a variety of diseases, including cancer, autoimmune disorders, and inflammatory diseases. * The development of anti-IL-6 antibodies is a promising area of research for the treatment of inflammatory diseases.

Genular Protein ID: 1842001897

Symbol: IL6_HUMAN

Name: B-cell stimulatory factor 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3491322

Title: Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.

PubMed ID: 3491322

DOI: 10.1038/324073a0

PubMed ID: 3500852

Title: Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.

PubMed ID: 3500852

DOI: 10.1002/j.1460-2075.1987.tb02598.x

PubMed ID: 3538015

Title: Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved.

PubMed ID: 3538015

DOI: 10.1073/pnas.83.23.8957

PubMed ID: 3023045

Title: Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines.

PubMed ID: 3023045

DOI: 10.1002/j.1460-2075.1986.tb04531.x

PubMed ID: 3320204

Title: Molecular cloning and expression of hybridoma growth factor in Escherichia coli.

PubMed ID: 3320204

PubMed ID: 2789513

Title: Deletion of 3' untranslated region of human BSF-2 mRNA causes stabilization of the mRNA and high-level expression in mouse NIH3T3 cells.

PubMed ID: 2789513

DOI: 10.1016/0006-291x(89)92328-0

PubMed ID: 3758081

Title: Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts.

PubMed ID: 3758081

DOI: 10.1111/j.1432-1033.1986.tb09931.x

PubMed ID: 3266463

Title: Interleukin 6: identification as a hematopoietic colony-stimulating factor.

PubMed ID: 3266463

PubMed ID: 1291290

Title: Stable and efficient expression of human interleukin-6 cDNA in mammalian cells after gene transfer.

PubMed ID: 1291290

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3279116

Title: Separation and comparison of two monokines with lymphocyte-activating factor activity: IL-1 beta and hybridoma growth factor (HGF). Identification of leukocyte-derived HGF as IL-6.

PubMed ID: 3279116

PubMed ID: 2610854

Title: Interleukin 6 is the principal cytolytic T lymphocyte differentiation factor for thymocytes in human leukocyte conditioned medium.

PubMed ID: 2610854

PubMed ID: 1883960

Title: Marked cell-type-specific differences in glycosylation of human interleukin-6.

PubMed ID: 1883960

DOI: 10.1016/1043-4666(91)90018-9

PubMed ID: 7851440

Title: Structure, stability and biological properties of a N-terminally truncated form of recombinant human interleukin-6 containing a single disulfide bond.

PubMed ID: 7851440

DOI: 10.1111/j.1432-1033.1995.tb20427.x

PubMed ID: 2472117

Title: Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor.

PubMed ID: 2472117

DOI: 10.1016/0003-9861(89)90205-1

PubMed ID: 2037043

Title: Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6.

PubMed ID: 2037043

DOI: 10.1016/0014-5793(91)80491-k

PubMed ID: 11080265

Title: Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6.

PubMed ID: 11080265

DOI: 10.1111/j.1469-7793.2000.00237.x

PubMed ID: 12794819

Title: Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.

PubMed ID: 12794819

DOI: 10.1002/art.11143

PubMed ID: 15124018

Title: IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.

PubMed ID: 15124018

DOI: 10.1172/jci20945

PubMed ID: 17075861

Title: Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system.

PubMed ID: 17075861

DOI: 10.1002/art.22175

PubMed ID: 20823453

Title: IL-6 selectively stimulates fat metabolism in human skeletal muscle.

PubMed ID: 20823453

DOI: 10.1152/ajpendo.00328.2010

PubMed ID: 22037645

Title: Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.

PubMed ID: 22037645

DOI: 10.1038/nm.2513

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25731159

Title: A gp130-Src-YAP module links inflammation to epithelial regeneration.

PubMed ID: 25731159

DOI: 10.1038/nature14228

PubMed ID: 28265003

Title: SorLA in Interleukin-6 Signaling and Turnover.

PubMed ID: 28265003

DOI: 10.1128/mcb.00641-16

PubMed ID: 30995492

Title: Targeting Interleukin-6 Signaling in Clinic.

PubMed ID: 30995492

DOI: 10.1016/j.immuni.2019.03.026

PubMed ID: 8555185

Title: Folding topologies of human interleukin-6 and its mutants as studied by NMR spectroscopy.

PubMed ID: 8555185

DOI: 10.1021/bi951949e

PubMed ID: 9159484

Title: Solution structure of recombinant human interleukin-6.

PubMed ID: 9159484

DOI: 10.1006/jmbi.1997.0933

PubMed ID: 9118960

Title: 1.9-A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling.

PubMed ID: 9118960

DOI: 10.1093/emboj/16.5.989

PubMed ID: 12829785

Title: Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex.

PubMed ID: 12829785

DOI: 10.1126/science.1083901

PubMed ID: 9769329

Title: The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.

PubMed ID: 9769329

DOI: 10.1172/jci2629

PubMed ID: 11001912

Title: An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus.

PubMed ID: 11001912

PubMed ID: 11355017

Title: A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density.

PubMed ID: 11355017

DOI: 10.1007/s100380170077

PubMed ID: 12768442

Title: Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women.

PubMed ID: 12768442

DOI: 10.1007/s10038-003-0020-8

Sequence Information:

  • Length: 212
  • Mass: 23718
  • Checksum: 1F1ED1FE1B734079
  • Sequence:
  • MNSFSTSAFG PVAFSLGLLL VLPAAFPAPV PPGEDSKDVA APHRQPLTSS ERIDKQIRYI 
    LDGISALRKE TCNKSNMCES SKEALAENNL NLPKMAEKDG CFQSGFNEET CLVKIITGLL 
    EFEVYLEYLQ NRFESSEEQA RAVQMSTKVL IQFLQKKAKN LDAITTPDPT TNASLLTKLQ 
    AQNQWLQDMT THLILRSFKE FLQSSLRALR QM

Genular Protein ID: 2969460870

Symbol: B5MC21_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

Sequence Information:

  • Length: 136
  • Mass: 15596
  • Checksum: DE6D1905F32FF15E
  • Sequence:
  • MCESSKEALA ENNLNLPKMA EKDGCFQSGF NEETCLVKII TGLLEFEVYL EYLQNRFESS 
    EEQARAVQMS TKVLIQFLQK KAKNLDAITT PDPTTNASLL TKLQAQNQWL QDMTTHLILR 
    SFKEFLQSSL RALRQM

Genular Protein ID: 684579229

Symbol: B4DVM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 198
  • Mass: 21954
  • Checksum: 549E4F5C85E70BD0
  • Sequence:
  • MNSFSTSAFG PVAFSLGLLL VLPAAFPAPV PPGEDSKDVA APHRQPLTSS ERIDKQIRYI 
    LDGISALRKE TCNKSNMCES SKEALAENNL NLPKMAEKDG CFQSGFNEET CLVKIITGLL 
    EFEVYLEYLQ NRFESGEGQA RAVQMSTKVL IQFLQKKVGV SSFPQLGVGE DRLKDSVLDN 
    SGMQCHFQKR RLHVNKRV

Genular Protein ID: 3988121719

Symbol: B4DNQ5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 252
  • Mass: 27459
  • Checksum: A5EC09716F313477
  • Sequence:
  • MNSFSTSKCR KSLALELPAA VEPCVREGCV AQGGLAGGQQ QRQAPSCAVS SPLRSLPSGT 
    GAFGPVAFSL GLLLVLPAAF PAPVPPGEDS KDVAAPHRQP LTSSERIDKQ IRYILDGISA 
    LRKETCNKSN MCESSKEALA ENNLNLPKMA EKDGCFQSGF NEETCLVKII TGLLEFEVYL 
    EYLQNRFESS EEQARAVQMS TKVLIQFLQK KVGVSSFPQL GVGEDRLKDS VLDNSGMQCH 
    FQKRRLHVNK RV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.