IL6 | ENSG00000136244 | NCBI 3569

Details for: IL6

Gene ID: 3569

Symbol: IL6

Ensembl ID: ENSG00000136244

Description: interleukin 6

Associated with

Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Cd163 mediating an anti-inflammatory response
(R-HSA-9662834)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-6 family signaling
(R-HSA-6783589)
Interleukin-6 signaling
(R-HSA-1059683)
Interleukin-10 signaling
(R-HSA-6783783)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Mapk1 (erk2) activation
(R-HSA-112411)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk3 (erk1) activation
(R-HSA-110056)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism of proteins
(R-HSA-392499)
Parasitic infection pathways
(R-HSA-9824443)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Raf-independent mapk1/3 activation
(R-HSA-112409)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by ventx
(R-HSA-8853884)
Acute-phase response
(GO:0006953)
Cell surface receptor signaling pathway via jak-stat
(GO:0007259)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine activity
(GO:0005125)
Endocrine pancreas development
(GO:0031018)
Germinal center b cell differentiation
(GO:0002314)
Glucose homeostasis
(GO:0042593)
Growth factor activity
(GO:0008083)
Hepatic immune response
(GO:0002384)
Humoral immune response
(GO:0006959)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Interleukin-6 receptor binding
(GO:0005138)
Maintenance of blood-brain barrier
(GO:0035633)
Monocyte chemotaxis
(GO:0002548)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of bone resorption
(GO:0045779)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of chemokine production
(GO:0032682)
Negative regulation of collagen biosynthetic process
(GO:0032966)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of lipid storage
(GO:0010888)
Neuron projection development
(GO:0031175)
Neutrophil apoptotic process
(GO:0001781)
Neutrophil mediated immunity
(GO:0002446)
Platelet activation
(GO:0030168)
Positive regulation of acute inflammatory response
(GO:0002675)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of interleukin-21 production
(GO:0032745)
Positive regulation of leukocyte chemotaxis
(GO:0002690)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of translation
(GO:0045727)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Protein binding
(GO:0005515)
Regulation of angiogenesis
(GO:0045765)
Regulation of vascular endothelial growth factor production
(GO:0010574)
Response to activity
(GO:0014823)
Response to peptidoglycan
(GO:0032494)
Vascular endothelial growth factor production
(GO:0010573)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 25.8703
Cell Significance Index: -10.5100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 11.0082
Cell Significance Index: -10.5100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 10.2276
Cell Significance Index: 180.7400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 6.9756
Cell Significance Index: 199.9600
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 6.1273
Cell Significance Index: 29.1800
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 3.6230
Cell Significance Index: 26.0200
Cell Name: decidual cell (CL2000002)
Fold Change: 3.3144
Cell Significance Index: 53.1800
Cell Name: inflammatory cell (CL0009002)
Fold Change: 3.2788
Cell Significance Index: 18.8000
Cell Name: myometrial cell (CL0002366)
Fold Change: 2.7177
Cell Significance Index: 31.3000
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.6830
Cell Significance Index: 18.5900
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.2244
Cell Significance Index: 13.3700
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.5804
Cell Significance Index: 2.6800
Cell Name: lactocyte (CL0002325)
Fold Change: 0.1385
Cell Significance Index: 17.8900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0633
Cell Significance Index: 40.1800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0607
Cell Significance Index: 0.6900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0500
Cell Significance Index: 31.2500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0245
Cell Significance Index: 13.3600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0152
Cell Significance Index: 0.7100
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0058
Cell Significance Index: 0.0900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0016
Cell Significance Index: -0.0800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0017
Cell Significance Index: -3.2800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0061
Cell Significance Index: -0.8800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0069
Cell Significance Index: -5.1100
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0078
Cell Significance Index: -0.3200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0090
Cell Significance Index: -5.0600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0102
Cell Significance Index: -18.7800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0116
Cell Significance Index: -8.7800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0122
Cell Significance Index: -18.7800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0130
Cell Significance Index: -1.7900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0165
Cell Significance Index: -7.4700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0193
Cell Significance Index: -1.4400
Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: -0.0212
Cell Significance Index: -0.2900
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0236
Cell Significance Index: -3.0300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0287
Cell Significance Index: -3.5300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0333
Cell Significance Index: -7.0100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0377
Cell Significance Index: -6.4300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0492
Cell Significance Index: -8.8700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0640
Cell Significance Index: -7.3300
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0728
Cell Significance Index: -14.4500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0786
Cell Significance Index: -15.7600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0972
Cell Significance Index: -11.0900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0973
Cell Significance Index: -9.9400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0990
Cell Significance Index: -1.7000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1010
Cell Significance Index: -11.9100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1033
Cell Significance Index: -5.3800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1144
Cell Significance Index: -13.3300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1346
Cell Significance Index: -6.3300
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1471
Cell Significance Index: -2.8700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1477
Cell Significance Index: -15.3800
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2139
Cell Significance Index: -13.8000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2266
Cell Significance Index: -13.9300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2340
Cell Significance Index: -14.7500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2397
Cell Significance Index: -18.4000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2773
Cell Significance Index: -7.4100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2801
Cell Significance Index: -17.1700
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2920
Cell Significance Index: -10.7200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2961
Cell Significance Index: -7.6100
Cell Name: muscle cell (CL0000187)
Fold Change: -0.3220
Cell Significance Index: -3.0800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3451
Cell Significance Index: -18.1200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3464
Cell Significance Index: -15.3200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3470
Cell Significance Index: -19.4700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3511
Cell Significance Index: -18.2400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3575
Cell Significance Index: -9.7300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3597
Cell Significance Index: -12.5000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3628
Cell Significance Index: -9.7100
Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: -0.3690
Cell Significance Index: -6.3400
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3716
Cell Significance Index: -3.0300
Cell Name: vasa recta descending limb cell (CL1001285)
Fold Change: -0.4023
Cell Significance Index: -2.9200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4046
Cell Significance Index: -15.3200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4091
Cell Significance Index: -12.0500
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.4306
Cell Significance Index: -18.7300
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.4321
Cell Significance Index: -6.2200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4336
Cell Significance Index: -9.0800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4442
Cell Significance Index: -8.2100
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.4448
Cell Significance Index: -9.0500
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4475
Cell Significance Index: -14.6500
Cell Name: keratocyte (CL0002363)
Fold Change: -0.4488
Cell Significance Index: -7.1200
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4573
Cell Significance Index: -16.0200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4634
Cell Significance Index: -13.6100
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.4732
Cell Significance Index: -11.8000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4864
Cell Significance Index: -15.4900
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.5275
Cell Significance Index: -13.4400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.5340
Cell Significance Index: -14.3100
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5379
Cell Significance Index: -15.3500
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.5493
Cell Significance Index: -13.7200
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.5714
Cell Significance Index: -13.8400
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5861
Cell Significance Index: -14.0600
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5914
Cell Significance Index: -15.5500
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.5961
Cell Significance Index: -10.1900
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.6099
Cell Significance Index: -15.5800
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.6158
Cell Significance Index: -8.9400
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.6274
Cell Significance Index: -15.6500
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.6314
Cell Significance Index: -12.3500
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.6325
Cell Significance Index: -13.8500
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.6356
Cell Significance Index: -3.8400
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: -0.6434
Cell Significance Index: -6.9900
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -0.6598
Cell Significance Index: -5.2500
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.6600
Cell Significance Index: -10.6900
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.6707
Cell Significance Index: -14.4900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.6725
Cell Significance Index: -11.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** IL6 is a 22-kDa glycoprotein that belongs to the interleukin family of cytokines. It is produced by cells of the immune system, including B cells, macrophages, and dendritic cells, as well as by non-immune cells such as fibroblasts and endothelial cells. IL6 is characterized by its ability to stimulate the proliferation and differentiation of B cells, as well as its role in the regulation of inflammation and immune responses. It is also involved in the regulation of acute-phase response, which is a systemic response to tissue damage or infection. **Pathways and Functions:** IL6 is involved in a wide range of signaling pathways, including: 1. **Acute-phase response**: IL6 is a key mediator of the acute-phase response, which is a systemic response to tissue damage or infection. 2. **Anti-inflammatory response**: IL6 has anti-inflammatory properties, which are mediated by its ability to inhibit the production of pro-inflammatory cytokines such as TNF-α and IL-1β. 3. **Immune system regulation**: IL6 is involved in the regulation of immune responses, including the activation of B cells and the production of antibodies. 4. **Inflammatory response**: IL6 is also involved in the regulation of inflammatory responses, including the production of pro-inflammatory cytokines and the recruitment of immune cells to sites of inflammation. 5. **Cellular responses to stimuli**: IL6 is involved in the regulation of cellular responses to stimuli, including the production of growth factors and the regulation of cell proliferation and differentiation. **Clinical Significance:** IL6 has been implicated in numerous diseases, including: 1. **Autoimmune disorders**: IL6 has been implicated in autoimmune disorders such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer**: IL6 has been implicated in various types of cancer, including breast cancer, lung cancer, and liver cancer. 3. **Metabolic disorders**: IL6 has been implicated in metabolic disorders such as obesity, insulin resistance, and type 2 diabetes. 4. **Cardiovascular disease**: IL6 has been implicated in cardiovascular disease, including atherosclerosis and heart failure. In conclusion, IL6 is a multifunctional cytokine that plays a crucial role in the immune response and beyond. Its dysregulation has been implicated in numerous diseases, and it is an important target for therapeutic interventions. Further research is needed to fully understand the role of IL6 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 1842001897

Symbol: IL6_HUMAN

Name: B-cell stimulatory factor 2

UniProtKB Accession Codes:

P05231 Q9UCU2 Q9UCU3 Q9UCU4

Database IDs:

Citations:

PubMed ID: 3491322

Title: Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.

PubMed ID: 3491322

DOI: 10.1038/324073a0

PubMed ID: 3500852

Title: Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.

PubMed ID: 3500852

DOI: 10.1002/j.1460-2075.1987.tb02598.x

PubMed ID: 3538015

Title: Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved.

PubMed ID: 3538015

DOI: 10.1073/pnas.83.23.8957

PubMed ID: 3023045

Title: Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines.

PubMed ID: 3023045

DOI: 10.1002/j.1460-2075.1986.tb04531.x

PubMed ID: 3320204

Title: Molecular cloning and expression of hybridoma growth factor in Escherichia coli.

PubMed ID: 3320204

PubMed ID: 2789513

Title: Deletion of 3' untranslated region of human BSF-2 mRNA causes stabilization of the mRNA and high-level expression in mouse NIH3T3 cells.

PubMed ID: 2789513

DOI: 10.1016/0006-291x(89)92328-0

PubMed ID: 3758081

Title: Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts.

PubMed ID: 3758081

DOI: 10.1111/j.1432-1033.1986.tb09931.x

PubMed ID: 3266463

Title: Interleukin 6: identification as a hematopoietic colony-stimulating factor.

PubMed ID: 3266463

PubMed ID: 1291290

Title: Stable and efficient expression of human interleukin-6 cDNA in mammalian cells after gene transfer.

PubMed ID: 1291290

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3279116

Title: Separation and comparison of two monokines with lymphocyte-activating factor activity: IL-1 beta and hybridoma growth factor (HGF). Identification of leukocyte-derived HGF as IL-6.

PubMed ID: 3279116

PubMed ID: 2610854

Title: Interleukin 6 is the principal cytolytic T lymphocyte differentiation factor for thymocytes in human leukocyte conditioned medium.

PubMed ID: 2610854

PubMed ID: 1883960

Title: Marked cell-type-specific differences in glycosylation of human interleukin-6.

PubMed ID: 1883960

DOI: 10.1016/1043-4666(91)90018-9

PubMed ID: 7851440

Title: Structure, stability and biological properties of a N-terminally truncated form of recombinant human interleukin-6 containing a single disulfide bond.

PubMed ID: 7851440

DOI: 10.1111/j.1432-1033.1995.tb20427.x

PubMed ID: 2472117

Title: Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor.

PubMed ID: 2472117

DOI: 10.1016/0003-9861(89)90205-1

PubMed ID: 2037043

Title: Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6.

PubMed ID: 2037043

DOI: 10.1016/0014-5793(91)80491-k

PubMed ID: 11080265

Title: Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6.

PubMed ID: 11080265

DOI: 10.1111/j.1469-7793.2000.00237.x

PubMed ID: 12794819

Title: Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.

PubMed ID: 12794819

DOI: 10.1002/art.11143

PubMed ID: 15124018

Title: IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.

PubMed ID: 15124018

DOI: 10.1172/jci20945

PubMed ID: 17075861

Title: Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system.

PubMed ID: 17075861

DOI: 10.1002/art.22175

PubMed ID: 20823453

Title: IL-6 selectively stimulates fat metabolism in human skeletal muscle.

PubMed ID: 20823453

DOI: 10.1152/ajpendo.00328.2010

PubMed ID: 22037645

Title: Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.

PubMed ID: 22037645

DOI: 10.1038/nm.2513

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25731159

Title: A gp130-Src-YAP module links inflammation to epithelial regeneration.

PubMed ID: 25731159

DOI: 10.1038/nature14228

PubMed ID: 28265003

Title: SorLA in Interleukin-6 Signaling and Turnover.

PubMed ID: 28265003

DOI: 10.1128/mcb.00641-16

PubMed ID: 30995492

Title: Targeting Interleukin-6 Signaling in Clinic.

PubMed ID: 30995492

DOI: 10.1016/j.immuni.2019.03.026

PubMed ID: 34831181

Title: Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1.

PubMed ID: 34831181

DOI: 10.3390/cells10112958

PubMed ID: 8555185

Title: Folding topologies of human interleukin-6 and its mutants as studied by NMR spectroscopy.

PubMed ID: 8555185

DOI: 10.1021/bi951949e

PubMed ID: 9159484

Title: Solution structure of recombinant human interleukin-6.

PubMed ID: 9159484

DOI: 10.1006/jmbi.1997.0933

PubMed ID: 9118960

Title: 1.9-A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling.

PubMed ID: 9118960

DOI: 10.1093/emboj/16.5.989

PubMed ID: 12829785

Title: Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex.

PubMed ID: 12829785

DOI: 10.1126/science.1083901

PubMed ID: 9769329

Title: The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.

PubMed ID: 9769329

DOI: 10.1172/jci2629

PubMed ID: 11001912

Title: An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus.

PubMed ID: 11001912

PubMed ID: 11355017

Title: A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density.

PubMed ID: 11355017

DOI: 10.1007/s100380170077

PubMed ID: 12768442

Title: Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women.

PubMed ID: 12768442

DOI: 10.1007/s10038-003-0020-8

Sequence Information:

Length: 212
Mass: 23718
Checksum: 1F1ED1FE1B734079
Sequence:

MNSFSTSAFG PVAFSLGLLL VLPAAFPAPV PPGEDSKDVA APHRQPLTSS ERIDKQIRYI 
LDGISALRKE TCNKSNMCES SKEALAENNL NLPKMAEKDG CFQSGFNEET CLVKIITGLL 
EFEVYLEYLQ NRFESSEEQA RAVQMSTKVL IQFLQKKAKN LDAITTPDPT TNASLLTKLQ 
AQNQWLQDMT THLILRSFKE FLQSSLRALR QM

Genular Protein ID: 684579229

Symbol: B4DVM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DVM1

Database IDs:

Sequence Information:

Length: 198
Mass: 21954
Checksum: 549E4F5C85E70BD0
Sequence:

MNSFSTSAFG PVAFSLGLLL VLPAAFPAPV PPGEDSKDVA APHRQPLTSS ERIDKQIRYI 
LDGISALRKE TCNKSNMCES SKEALAENNL NLPKMAEKDG CFQSGFNEET CLVKIITGLL 
EFEVYLEYLQ NRFESGEGQA RAVQMSTKVL IQFLQKKVGV SSFPQLGVGE DRLKDSVLDN 
SGMQCHFQKR RLHVNKRV

Genular Protein ID: 2969460870

Symbol: B5MC21_HUMAN

Name: N/A

UniProtKB Accession Codes:

B5MC21

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

Length: 136
Mass: 15596
Checksum: DE6D1905F32FF15E
Sequence:

MCESSKEALA ENNLNLPKMA EKDGCFQSGF NEETCLVKII TGLLEFEVYL EYLQNRFESS 
EEQARAVQMS TKVLIQFLQK KAKNLDAITT PDPTTNASLL TKLQAQNQWL QDMTTHLILR 
SFKEFLQSSL RALRQM

Genular Protein ID: 3988121719

Symbol: B4DNQ5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DNQ5

Database IDs:

Sequence Information:

Length: 252
Mass: 27459
Checksum: A5EC09716F313477
Sequence:

MNSFSTSKCR KSLALELPAA VEPCVREGCV AQGGLAGGQQ QRQAPSCAVS SPLRSLPSGT 
GAFGPVAFSL GLLLVLPAAF PAPVPPGEDS KDVAAPHRQP LTSSERIDKQ IRYILDGISA 
LRKETCNKSN MCESSKEALA ENNLNLPKMA EKDGCFQSGF NEETCLVKII TGLLEFEVYL 
EYLQNRFESS EEQARAVQMS TKVLIQFLQK KVGVSSFPQL GVGEDRLKDS VLDNSGMQCH 
FQKRRLHVNK RV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: IL6

Associated with

Cells (max top 100)

Other Information

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. PubMed ID: 3491322

Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene. PubMed ID: 3500852

Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved. PubMed ID: 3538015

Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines. PubMed ID: 3023045

Molecular cloning and expression of hybridoma growth factor in Escherichia coli. PubMed ID: 3320204

Deletion of 3' untranslated region of human BSF-2 mRNA causes stabilization of the mRNA and high-level expression in mouse NIH3T3 cells. PubMed ID: 2789513

Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts. PubMed ID: 3758081

Interleukin 6: identification as a hematopoietic colony-stimulating factor. PubMed ID: 3266463

Stable and efficient expression of human interleukin-6 cDNA in mammalian cells after gene transfer. PubMed ID: 1291290

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Separation and comparison of two monokines with lymphocyte-activating factor activity: IL-1 beta and hybridoma growth factor (HGF). Identification of leukocyte-derived HGF as IL-6. PubMed ID: 3279116

Interleukin 6 is the principal cytolytic T lymphocyte differentiation factor for thymocytes in human leukocyte conditioned medium. PubMed ID: 2610854

Marked cell-type-specific differences in glycosylation of human interleukin-6. PubMed ID: 1883960

Structure, stability and biological properties of a N-terminally truncated form of recombinant human interleukin-6 containing a single disulfide bond. PubMed ID: 7851440

Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor. PubMed ID: 2472117

Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6. PubMed ID: 2037043

Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. PubMed ID: 11080265

Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. PubMed ID: 12794819

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. PubMed ID: 15124018

Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system. PubMed ID: 17075861

IL-6 selectively stimulates fat metabolism in human skeletal muscle. PubMed ID: 20823453

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. PubMed ID: 22037645

A single kinase generates the majority of the secreted phosphoproteome. PubMed ID: 26091039

A gp130-Src-YAP module links inflammation to epithelial regeneration. PubMed ID: 25731159

SorLA in Interleukin-6 Signaling and Turnover. PubMed ID: 28265003

Targeting Interleukin-6 Signaling in Clinic. PubMed ID: 30995492

Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1. PubMed ID: 34831181

Folding topologies of human interleukin-6 and its mutants as studied by NMR spectroscopy. PubMed ID: 8555185

Solution structure of recombinant human interleukin-6. PubMed ID: 9159484

1.9-A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling. PubMed ID: 9118960

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. PubMed ID: 12829785

The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. PubMed ID: 9769329

An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus. PubMed ID: 11001912

A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density. PubMed ID: 11355017

Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women. PubMed ID: 12768442

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The DNA sequence of human chromosome 7. PubMed ID: 12853948

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Database document:

PubMed ID: 3491322

PubMed ID: 3500852

PubMed ID: 3538015

PubMed ID: 3023045

PubMed ID: 3320204

PubMed ID: 2789513

PubMed ID: 3758081

PubMed ID: 3266463

PubMed ID: 1291290

PubMed ID: 15489334

PubMed ID: 3279116

PubMed ID: 2610854

PubMed ID: 1883960

PubMed ID: 7851440

PubMed ID: 2472117

PubMed ID: 2037043

PubMed ID: 11080265

PubMed ID: 12794819

PubMed ID: 15124018

PubMed ID: 17075861

PubMed ID: 20823453

PubMed ID: 22037645

PubMed ID: 26091039

PubMed ID: 25731159

PubMed ID: 28265003

PubMed ID: 30995492

PubMed ID: 34831181

PubMed ID: 8555185

PubMed ID: 9159484

PubMed ID: 9118960

PubMed ID: 12829785

PubMed ID: 9769329

PubMed ID: 11001912

PubMed ID: 11355017

PubMed ID: 12768442

PubMed ID: 11237011

PubMed ID: 12853948

PubMed ID: 15496913