Details for: LIF

Gene ID: 3976

Symbol: LIF

Ensembl ID: ENSG00000128342

Description: LIF interleukin 6 family cytokine

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.85
    Marker Score: 6997
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.16
    Marker Score: 901
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.11
    Marker Score: 1802
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.69
    Marker Score: 57443
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.69
    Marker Score: 420
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.67
    Marker Score: 420
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.63
    Marker Score: 578
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.33
    Marker Score: 6528
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.22
    Marker Score: 763
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.17
    Marker Score: 2212
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.15
    Marker Score: 654
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48040
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5299
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.86
    Marker Score: 542
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.83
    Marker Score: 28719
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.74
    Marker Score: 663
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.74
    Marker Score: 352
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.73
    Marker Score: 347
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 649
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.71
    Marker Score: 317
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.7
    Marker Score: 538
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2868
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.68
    Marker Score: 410
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.68
    Marker Score: 10640
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.67
    Marker Score: 152
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.58
    Marker Score: 300
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.58
    Marker Score: 147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 323
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 129
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.47
    Marker Score: 696
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.46
    Marker Score: 264
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.45
    Marker Score: 263
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.45
    Marker Score: 927
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.44
    Marker Score: 514
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 184
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.41
    Marker Score: 181
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.39
    Marker Score: 283
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.39
    Marker Score: 195
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 370
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.38
    Marker Score: 688
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.35
    Marker Score: 81
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.35
    Marker Score: 141
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.34
    Marker Score: 226
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.32
    Marker Score: 2039
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.32
    Marker Score: 774
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.32
    Marker Score: 193
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.32
    Marker Score: 391
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.31
    Marker Score: 326
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.31
    Marker Score: 90
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.3
    Marker Score: 142
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3
    Marker Score: 188
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.29
    Marker Score: 288
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.29
    Marker Score: 308
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.28
    Marker Score: 281
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.28
    Marker Score: 176
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 0.27
    Marker Score: 84
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.26
    Marker Score: 3473.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.25
    Marker Score: 195
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.24
    Marker Score: 260
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.24
    Marker Score: 149
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.24
    Marker Score: 239
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.24
    Marker Score: 166
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.24
    Marker Score: 81
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.23
    Marker Score: 107
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.23
    Marker Score: 104
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.23
    Marker Score: 112
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.23
    Marker Score: 95
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.22
    Marker Score: 72
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.22
    Marker Score: 93
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.22
    Marker Score: 208
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.21
    Marker Score: 826
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.21
    Marker Score: 326
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.21
    Marker Score: 428
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.21
    Marker Score: 66
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.21
    Marker Score: 161
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.2
    Marker Score: 45
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2
    Marker Score: 200
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.2
    Marker Score: 277
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.19
    Marker Score: 443
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.19
    Marker Score: 262
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.19
    Marker Score: 125
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.19
    Marker Score: 424

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Other Information

**Key characteristics:** - LIF is a cytokine belonging to the interleukin-6 (IL-6) family. - It is a pleiotropic cytokine with multiple effects on various cell types. - It is produced in high levels in inflammatory and tumor microenvironments. **Pathways and functions:** - LIF signaling pathway is involved in promoting epithelial cell proliferation, survival, and migration. - It stimulates fibroblast growth and migration, contributing to tissue remodeling and fibrosis. - LIF also inhibits apoptosis in epithelial cells, promoting tumor growth and metastasis. - It plays a role in regulating immune responses by promoting the differentiation and survival of regulatory T cells. - LIF signaling is also involved in maintaining the integrity and function of blood vessels. **Clinical significance:** - LIF is a potential therapeutic target for various diseases, including cancer, fibrosis, and cardiovascular diseases. - It is often used as a biomarker for cancer diagnosis and prognosis. - Blockade of LIF signaling has shown promising results in preclinical models of cancer and fibrosis. **Other important points:** - LIF is a highly conserved cytokine with significant expression in humans. - It is produced in high levels in many human cancers. - Dysregulation of LIF signaling has been linked to various diseases, including cancer, autoimmune disorders, and cardiovascular diseases.

Genular Protein ID: 2734624317

Symbol: LIF_HUMAN

Name: Leukemia inhibitory factor

UniProtKB Accession Codes:

P15018 B2RCW7 B5MC23 Q52LZ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 1 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 47 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3143918

Title: Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells.

PubMed ID: 3143918

DOI: 10.1038/336690a0

PubMed ID: 2475312

Title: Genomic cloning and heterologous expression of human differentiation-stimulating factor.

PubMed ID: 2475312

DOI: 10.1089/dna.1.1989.8.351

PubMed ID: 15146197

Title: Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

PubMed ID: 15146197

DOI: 10.1038/nbt971

PubMed ID: 1692837

Title: Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions.

PubMed ID: 1692837

DOI: 10.1016/s0021-9258(19)38963-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3128791

Title: Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor.

PubMed ID: 3128791

DOI: 10.1073/pnas.85.8.2623

PubMed ID: 2730639

Title: Purification of a lipoprotein lipase-inhibiting protein produced by a melanoma cell line associated with cancer cachexia.

PubMed ID: 2730639

DOI: 10.1016/s0006-291x(89)80114-7

PubMed ID: 8489250

Title: Glycosylation pattern and disulfide assignments of recombinant human differentiation-stimulating factor.

PubMed ID: 8489250

DOI: 10.1006/abbi.1993.1243

PubMed ID: 14527405

Title: Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130.

PubMed ID: 14527405

DOI: 10.1016/s1097-2765(03)00365-4

PubMed ID: 17652170

Title: An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor.

PubMed ID: 17652170

DOI: 10.1073/pnas.0705577104

Sequence Information:

  • Length: 202
  • Mass: 22008
  • Checksum: 634CD10BFF67A217
  • Sequence:
    • MKVLAAGVVP LLLVLHWKHG AGSPLPITPV NATCAIRHPC HNNLMNQIRS QLAQLNGSAN 
ALFILYYTAQ GEPFPNNLDK LCGPNVTDFP PFHANGTEKA KLVELYRIVV YLGTSLGNIT 
RDQKILNPSA LSLHSKLNAT ADILRGLLSN VLCRLCSKYH VGHVDVTYGP DTSGKDVFQK 
KKLGCQLLGK YKQIIAVLAQ AF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.