Details for: LIF

Gene ID: 3976

Symbol: LIF

Ensembl ID: ENSG00000128342

Description: LIF interleukin 6 family cytokine

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 12.1844
    Cell Significance Index: -4.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.3263
    Cell Significance Index: -6.0400
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 3.5844
    Cell Significance Index: 17.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.5656
    Cell Significance Index: 102.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9640
    Cell Significance Index: -7.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.5578
    Cell Significance Index: 201.2600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 1.3684
    Cell Significance Index: 15.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3152
    Cell Significance Index: 68.3200
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.2403
    Cell Significance Index: 13.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0461
    Cell Significance Index: 199.0800
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.9271
    Cell Significance Index: 10.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8686
    Cell Significance Index: 101.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5497
    Cell Significance Index: 300.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5149
    Cell Significance Index: 30.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4841
    Cell Significance Index: 437.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4308
    Cell Significance Index: 46.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3592
    Cell Significance Index: 16.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3522
    Cell Significance Index: 57.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3278
    Cell Significance Index: 15.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3073
    Cell Significance Index: 8.8600
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.2768
    Cell Significance Index: 1.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2337
    Cell Significance Index: 23.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2283
    Cell Significance Index: 15.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1961
    Cell Significance Index: 5.7600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1478
    Cell Significance Index: 2.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1253
    Cell Significance Index: 1.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1051
    Cell Significance Index: 7.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0928
    Cell Significance Index: 2.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0902
    Cell Significance Index: 1.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0874
    Cell Significance Index: 2.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0620
    Cell Significance Index: 38.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0525
    Cell Significance Index: 33.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0209
    Cell Significance Index: 0.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0132
    Cell Significance Index: 0.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0131
    Cell Significance Index: 1.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0120
    Cell Significance Index: 0.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0114
    Cell Significance Index: 0.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0076
    Cell Significance Index: 0.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0060
    Cell Significance Index: 1.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0023
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0042
    Cell Significance Index: -0.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0045
    Cell Significance Index: -0.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0048
    Cell Significance Index: -0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0049
    Cell Significance Index: -8.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0051
    Cell Significance Index: -2.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0051
    Cell Significance Index: -7.8100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0052
    Cell Significance Index: -0.0800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0057
    Cell Significance Index: -0.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0071
    Cell Significance Index: -0.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0073
    Cell Significance Index: -5.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0093
    Cell Significance Index: -6.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0116
    Cell Significance Index: -1.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0122
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0134
    Cell Significance Index: -2.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0139
    Cell Significance Index: -6.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0244
    Cell Significance Index: -4.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0263
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0319
    Cell Significance Index: -3.6400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0347
    Cell Significance Index: -0.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0383
    Cell Significance Index: -7.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0409
    Cell Significance Index: -1.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0426
    Cell Significance Index: -4.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0440
    Cell Significance Index: -2.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0491
    Cell Significance Index: -6.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0525
    Cell Significance Index: -1.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0674
    Cell Significance Index: -7.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0715
    Cell Significance Index: -7.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0831
    Cell Significance Index: -5.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0898
    Cell Significance Index: -4.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1061
    Cell Significance Index: -6.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1082
    Cell Significance Index: -8.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1119
    Cell Significance Index: -7.5300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1181
    Cell Significance Index: -1.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1194
    Cell Significance Index: -7.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1292
    Cell Significance Index: -3.4500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1358
    Cell Significance Index: -2.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1373
    Cell Significance Index: -1.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1384
    Cell Significance Index: -5.0800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1409
    Cell Significance Index: -2.4900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1464
    Cell Significance Index: -0.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1533
    Cell Significance Index: -4.1000
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1546
    Cell Significance Index: -1.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1583
    Cell Significance Index: -8.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1611
    Cell Significance Index: -9.0400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1672
    Cell Significance Index: -4.0500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1925
    Cell Significance Index: -1.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1948
    Cell Significance Index: -6.7700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1976
    Cell Significance Index: -3.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2008
    Cell Significance Index: -5.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2051
    Cell Significance Index: -9.0700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.2268
    Cell Significance Index: -2.0500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.2275
    Cell Significance Index: -1.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2413
    Cell Significance Index: -7.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2487
    Cell Significance Index: -7.9200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2567
    Cell Significance Index: -1.9800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2637
    Cell Significance Index: -7.5300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2640
    Cell Significance Index: -3.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** LIF is a 17-kilodalton protein with a single chain structure, consisting of a prodomain, a cytokine domain, and a transmembrane domain. 2. **Receptor Binding:** LIF binds to its receptor, LIF receptor, which is a transmembrane glycoprotein with two extracellular immunoglobulin-like domains. 3. **Signaling Pathways:** LIF activates various signaling pathways, including the JAK-STAT pathway, MAPK cascade, and PI3K/AKT pathway, which regulate cell proliferation, differentiation, and survival. 4. **Cellular Expression:** LIF is significantly expressed in various cell types, including glandular epithelial cells, fibroblasts, and immune cells. **Pathways and Functions:** 1. **Embryonic Development:** LIF plays a crucial role in embryonic development, particularly in implantation, trophoblast differentiation, and organogenesis. 2. **Immune Response:** LIF modulates immune responses by regulating the differentiation, proliferation, and survival of immune cells, including macrophages and T cells. 3. **Tissue Remodeling:** LIF is involved in tissue remodeling processes, including blood vessel remodeling, lung development, and lung alveolus formation. 4. **Cell Proliferation and Differentiation:** LIF regulates cell proliferation and differentiation in various cell types, including fibroblasts, epithelial cells, and immune cells. 5. **Fibroblast Proliferation:** LIF promotes fibroblast proliferation and differentiation, which is essential for tissue repair and remodeling. **Clinical Significance:** 1. **Cancer:** LIF has been implicated in various cancers, including leukemia, lymphoma, and solid tumors, where it promotes tumor growth, angiogenesis, and metastasis. 2. **Reproductive Disorders:** LIF plays a crucial role in reproductive disorders, including implantation failure, miscarriage, and preterm labor. 3. **Autoimmune Diseases:** LIF has been linked to autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis, where it regulates immune responses and tissue damage. 4. **Infectious Diseases:** LIF has been implicated in infectious diseases, including HIV, tuberculosis, and malaria, where it modulates immune responses and tissue damage. In conclusion, LIF is a multifaceted cytokine that regulates various biological processes, including embryonic development, immune response, tissue remodeling, and cell proliferation and differentiation. Its dysregulation has been implicated in various diseases, including cancer, reproductive disorders, autoimmune diseases, and infectious diseases. Further research is necessary to fully elucidate the mechanisms of LIF and its clinical significance.

Genular Protein ID: 2734624317

Symbol: LIF_HUMAN

Name: Leukemia inhibitory factor

UniProtKB Accession Codes:

P15018 B2RCW7 B5MC23 Q52LZ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 1 Ensembl 2 EvolutionaryTrace 1 GO 47 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3143918

Title: Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells.

PubMed ID: 3143918

DOI: 10.1038/336690a0

PubMed ID: 2475312

Title: Genomic cloning and heterologous expression of human differentiation-stimulating factor.

PubMed ID: 2475312

DOI: 10.1089/dna.1.1989.8.351

PubMed ID: 15146197

Title: Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

PubMed ID: 15146197

DOI: 10.1038/nbt971

PubMed ID: 1692837

Title: Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions.

PubMed ID: 1692837

DOI: 10.1016/s0021-9258(19)38963-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3128791

Title: Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor.

PubMed ID: 3128791

DOI: 10.1073/pnas.85.8.2623

PubMed ID: 2730639

Title: Purification of a lipoprotein lipase-inhibiting protein produced by a melanoma cell line associated with cancer cachexia.

PubMed ID: 2730639

DOI: 10.1016/s0006-291x(89)80114-7

PubMed ID: 8489250

Title: Glycosylation pattern and disulfide assignments of recombinant human differentiation-stimulating factor.

PubMed ID: 8489250

DOI: 10.1006/abbi.1993.1243

PubMed ID: 14527405

Title: Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130.

PubMed ID: 14527405

DOI: 10.1016/s1097-2765(03)00365-4

PubMed ID: 17652170

Title: An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor.

PubMed ID: 17652170

DOI: 10.1073/pnas.0705577104

Sequence Information:

  • Length: 202
  • Mass: 22008
  • Checksum: 634CD10BFF67A217
  • Sequence:
    • MKVLAAGVVP LLLVLHWKHG AGSPLPITPV NATCAIRHPC HNNLMNQIRS QLAQLNGSAN 
ALFILYYTAQ GEPFPNNLDK LCGPNVTDFP PFHANGTEKA KLVELYRIVV YLGTSLGNIT 
RDQKILNPSA LSLHSKLNAT ADILRGLLSN VLCRLCSKYH VGHVDVTYGP DTSGKDVFQK 
KKLGCQLLGK YKQIIAVLAQ AF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.