ERVK3 1 | ENSG00000142396 | NCBI 105372481

Details for: ERVK3 1

Gene ID: 105372481

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ERVK3 1

Ensembl ID: ENSG00000142396

Description: endogenous retrovirus group K3 member 1

Cell Significance Landscape

Display Count:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

CD14-positive monocyte CL0001054

CSI 4.62

rCSI 5.76%

PRS 97.74
epithelial cell of lung CL0000082

CSI 4.02

rCSI 3.33%

PRS 95.05
T-helper 17 cell CL0000899

CSI 3.98

rCSI 3.16%

PRS 98.91
mature T cell CL0002419

CSI 3.23

rCSI 2.51%

PRS 98.32
secretory cell CL0000151

CSI 3.09

rCSI 3.23%

PRS 93.32
pro-B cell CL0000826

CSI 3.02

rCSI 2.5%

PRS 94.82
neural crest cell CL0011012

CSI 2.97

rCSI 2.34%

PRS 89.19
activated type II NK T cell CL0000931

CSI 2.95

rCSI 3.32%

PRS 98.3
perivascular cell CL4033054

CSI 2.89

rCSI 3.95%

PRS 96.28
class switched memory B cell CL0000972

CSI 2.86

rCSI 2.14%

PRS 97.7
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 2.86

rCSI 3.3%

PRS 87.85
CD4-positive helper T cell CL0000492

CSI 2.79

rCSI 2.11%

PRS 98.63
alpha-beta T cell CL0000789

CSI 2.74

rCSI 3.21%

PRS 98.24
choroid plexus epithelial cell CL0000706

CSI 2.72

rCSI 4.46%

PRS 88.96
group 3 innate lymphoid cell CL0001071

CSI 2.71

rCSI 2.03%

PRS 95.9
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 2.69

rCSI 1.79%

PRS 97.41
epithelial cell of lower respiratory tract CL0002632

CSI 2.65

rCSI 2.05%

PRS 95.83
myofibroblast cell CL0000186

CSI 2.63

rCSI 3.65%

PRS 91.71
rod bipolar cell CL0000751

CSI 2.62

rCSI 4.7%

PRS 90.24
ciliated epithelial cell CL0000067

CSI 2.57

rCSI 2.26%

PRS 87.2
bronchus fibroblast of lung CL2000093

CSI 2.56

rCSI 2.08%

PRS 93.81
retina horizontal cell CL0000745

CSI 2.5

rCSI 3.81%

PRS 91.54
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 2.19

rCSI 11%

PRS 98.27
CD14-low, CD16-positive monocyte CL0002396

CSI 2.17

rCSI 1.67%

PRS 96.36
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.98

rCSI 1.79%

PRS 93.12
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.9

rCSI 3.35%

PRS 84.17
common dendritic progenitor CL0001029

CSI 1.87

rCSI 2.35%

PRS 96.98
retinal cone cell CL0000573

CSI 1.84

rCSI 2.96%

PRS 87.72
radial glial cell CL0000681

CSI 1.74

rCSI 2.41%

PRS 92.63
glioblast CL0000030

CSI 1.67

rCSI 2.66%

PRS 88.08
primitive red blood cell CL0002355

CSI 1.6

rCSI 8.65%

PRS 94.39
endothelial cell of lymphatic vessel CL0002138

CSI 1.57

rCSI 3.1%

PRS 94.44
cytotoxic T cell CL0000910

CSI 0.34

rCSI 1.96%

PRS 91.89
lung microvascular endothelial cell CL2000016

CSI 0.33

rCSI 6.4%

PRS 96.41

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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- High
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- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description

## Summary [ERVK3 1](/details-gene/105372481) is a protein-coding gene identified as an endogenous retrovirus group K3 member 1, located on human chromosome 19q13.43. **Overall**, expression data indicates a significant role for this gene within the immune system, particularly in myeloid cells, as evidenced by its highest significance score in [CD14-positive monocytes](/details-cell/CL0001054). The gene also demonstrates notable expression in various lymphocyte subsets, including [T-helper 17 cells](/details-cell/CL0000899) and [mature T cells](/details-cell/CL0002419), as well as in non-hematopoietic lineages such as [epithelial cells of the lung](/details-cell/CL0000082), suggesting a broad but specific functional profile spanning both immunity and tissue-specific biology. ## Cellular Roles and Expression Landscape The expression profile of [ERVK3 1](/details-gene/105372481) highlights its prominent role in both the innate and adaptive immune systems, alongside functions in specific structural and secretory tissues. The gene's highest significance is observed in [CD14-positive monocytes](/details-cell/CL0001054) (CSI: 4.62), suggesting it may be a key component of monocyte identity or function. Its functional footprint extends broadly across the adaptive immune system, with significant expression in multiple T and B cell lineages. This includes high relevance in pro-inflammatory [T-helper 17 cells](/details-cell/CL0000899) (CSI: 3.98), as well as in [mature T cells](/details-cell/CL0002419), [pro-B cells](/details-cell/CL0000826), [activated type II NK T cells](/details-cell/CL0000931), and [class switched memory B cells](/details-cell/CL0000972). This pattern implies that [ERVK3 1](/details-gene/105372481) may be involved in the general biology of lymphocytes, with a potentially specialized role in certain effector subsets. Beyond the immune system, [ERVK3 1](/details-gene/105372481) shows a strong signal in [epithelial cells of the lung](/details-cell/CL0000082) (CSI: 4.02) and [secretory cells](/details-cell/CL0000151) (CSI: 3.09). Its presence in diverse cell types, including those of neural lineage like [neural crest cells](/details-cell/CL0011012) and [neuroblasts](/details-cell/CL0000338), points towards pleiotropic functions that are likely context-dependent. The collective expression data portrays [ERVK3 1](/details-gene/105372481) as a gene with a dual identity, deeply embedded in immune processes while also contributing to the biology of specific non-immune tissues. ## Pathways and Molecular Function Detailed functional annotations, such as Gene Ontology (GO) or Reactome pathway data, were not provided in the dataset. Therefore, the specific molecular functions and biochemical pathways involving [ERVK3 1](/details-gene/105372481) cannot be precisely determined from this analysis. As an endogenous retrovirus (ERV)-derived gene, its protein product could potentially function as a structural component, an enzyme, or a regulatory element, roles that have been described for other co-opted ERV genes in human biology. Its high expression in immune cells suggests a possible involvement in host defense, immune regulation, or, if dysregulated, autoimmune responses. ## Research Directions The widespread yet specific expression pattern of [ERVK3 1](/details-gene/105372481) in both immune and non-immune cells presents several avenues for future investigation. Its identity as an endogenous retroviral element, coupled with its expression in inflammatory cell types, makes it a compelling candidate for studies on host-pathogen interactions and sterile inflammation. **Testable Hypotheses:** 1. Given its high significance in [CD14-positive monocytes](/details-cell/CL0001054) and [T-helper 17 cells](/details-cell/CL0000899), [ERVK3 1](/details-gene/105372481) may function as a regulator of pro-inflammatory responses. Its expression could be induced by inflammatory stimuli (e.g., LPS or viral components) and may be required for the production of key cytokines like IL-17 or TNF-alpha. 2. The high expression of [ERVK3 1](/details-gene/105372481) in [epithelial cells of the lung](/details-cell/CL0000082) suggests a role in pulmonary biology, potentially related to maintaining the epithelial barrier or participating in the innate immune response to inhaled pathogens. **Proposed Experiment:** To test the hypothesis that [ERVK3 1](/details-gene/105372481) regulates monocyte inflammatory function, one could perform a loss-of-function study. CRISPR-Cas9 or siRNA could be used to knock down [ERVK3 1](/details-gene/105372481) expression in a human monocyte cell line (e.g., THP-1) or in primary human [CD14-positive monocytes](/details-cell/CL0001054). Following knockdown, cells would be challenged with an inflammatory stimulus like lipopolysaccharide (LPS). The functional consequences would be assessed by measuring the secretion of key inflammatory cytokines (e.g., TNF-alpha, IL-6, IL-1beta) via ELISA and by analyzing changes in the cellular transcriptome using RNA-sequencing to identify downstream pathways modulated by [ERVK3 1](/details-gene/105372481). **Therapeutic Potential:** The potential of [ERVK3 1](/details-gene/105372481) as a therapeutic target is contingent on its precise function. If its activity promotes excessive inflammation in autoimmune or infectious diseases, it could be a target for **inhibition**. Its high expression in key inflammatory cells like [monocytes](/details-cell/CL0001054) and [Th17 cells](/details-cell/CL0000899) makes it an attractive candidate for targeted therapies in conditions such as rheumatoid arthritis or inflammatory bowel disease. Depending on whether its protein product is intracellular or a cell-surface receptor, therapeutic modalities could range from small molecule inhibitors to targeted biologics like monoclonal antibodies. Conversely, if it plays a protective role in host defense, strategies for its **activation** could be explored.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.