Details for: GPM6A

Gene ID: 2823

Symbol: GPM6A

Ensembl ID: ENSG00000150625

Description: glycoprotein M6A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 822.0760
    Cell Significance Index: -127.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 501.3732
    Cell Significance Index: -127.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 103.7345
    Cell Significance Index: -127.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 42.5592
    Cell Significance Index: -114.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 32.5059
    Cell Significance Index: -128.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.6082
    Cell Significance Index: -34.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 13.8008
    Cell Significance Index: 774.4300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 11.4364
    Cell Significance Index: 159.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 8.6893
    Cell Significance Index: 148.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 6.9409
    Cell Significance Index: 166.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 6.6877
    Cell Significance Index: 411.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 5.3101
    Cell Significance Index: 357.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.5938
    Cell Significance Index: 1647.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 4.2740
    Cell Significance Index: 8047.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.6084
    Cell Significance Index: 723.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.5277
    Cell Significance Index: 185.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.8749
    Cell Significance Index: 82.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.7593
    Cell Significance Index: 1908.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.0623
    Cell Significance Index: 91.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.7576
    Cell Significance Index: 66.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.5131
    Cell Significance Index: 960.9500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.8498
    Cell Significance Index: 6.5500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6351
    Cell Significance Index: 13.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.4799
    Cell Significance Index: 49.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2548
    Cell Significance Index: 392.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0054
    Cell Significance Index: 9.8700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0037
    Cell Significance Index: 0.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0081
    Cell Significance Index: -1.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0864
    Cell Significance Index: -117.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1010
    Cell Significance Index: -74.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1375
    Cell Significance Index: -77.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1426
    Cell Significance Index: -104.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1475
    Cell Significance Index: -66.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1818
    Cell Significance Index: -113.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1843
    Cell Significance Index: -139.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.2298
    Cell Significance Index: -125.5000
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.2592
    Cell Significance Index: -2.8800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2645
    Cell Significance Index: -5.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3491
    Cell Significance Index: -100.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.3944
    Cell Significance Index: -71.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5402
    Cell Significance Index: -113.7700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.5706
    Cell Significance Index: -4.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.5950
    Cell Significance Index: -118.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.6047
    Cell Significance Index: -115.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.6253
    Cell Significance Index: -101.7000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.6519
    Cell Significance Index: -6.4500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.7079
    Cell Significance Index: -12.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.7404
    Cell Significance Index: -126.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.7501
    Cell Significance Index: -92.2300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.8283
    Cell Significance Index: -9.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.8718
    Cell Significance Index: -112.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.8935
    Cell Significance Index: -122.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9517
    Cell Significance Index: -44.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.9789
    Cell Significance Index: -115.4500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.9815
    Cell Significance Index: -11.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.9862
    Cell Significance Index: -100.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9927
    Cell Significance Index: -32.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -1.0011
    Cell Significance Index: -128.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.0335
    Cell Significance Index: -120.4500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.0375
    Cell Significance Index: -13.8400
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -1.0412
    Cell Significance Index: -7.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.1379
    Cell Significance Index: -31.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2079
    Cell Significance Index: -38.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.2308
    Cell Significance Index: -26.9500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.2477
    Cell Significance Index: -142.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.2512
    Cell Significance Index: -143.3400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -1.2565
    Cell Significance Index: -7.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.3235
    Cell Significance Index: -104.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.3425
    Cell Significance Index: -60.8500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.4183
    Cell Significance Index: -13.5000
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.4796
    Cell Significance Index: -14.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.5073
    Cell Significance Index: -112.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.5280
    Cell Significance Index: -32.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.5405
    Cell Significance Index: -97.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.5794
    Cell Significance Index: -109.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.6718
    Cell Significance Index: -87.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.7115
    Cell Significance Index: -131.3400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.7150
    Cell Significance Index: -34.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.8100
    Cell Significance Index: -116.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.8101
    Cell Significance Index: -108.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.8246
    Cell Significance Index: -26.1300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.9356
    Cell Significance Index: -24.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.9397
    Cell Significance Index: -100.7600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.9519
    Cell Significance Index: -24.3400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -2.0057
    Cell Significance Index: -24.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.0300
    Cell Significance Index: -124.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.1378
    Cell Significance Index: -74.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -2.3177
    Cell Significance Index: -108.9300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -2.3218
    Cell Significance Index: -30.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -2.3693
    Cell Significance Index: -59.1000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -2.5760
    Cell Significance Index: -55.6600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -2.7184
    Cell Significance Index: -17.6900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -2.7804
    Cell Significance Index: -58.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -3.0423
    Cell Significance Index: -105.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.1090
    Cell Significance Index: -114.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -3.2705
    Cell Significance Index: -104.7500
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -3.3304
    Cell Significance Index: -34.2400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -3.4253
    Cell Significance Index: -41.5200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -3.5356
    Cell Significance Index: -50.3300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -3.5416
    Cell Significance Index: -44.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** GPM6A is primarily expressed in the plasma membrane of neurons, astrocytes, and other neural cells, suggesting its role in cell-cell interactions and communication. 2. **Glycosylation:** The protein is glycosylated, which may be crucial for its function and interactions with other molecules. 3. **Multiple functions:** GPM6A is involved in various cellular processes, including axonal growth cone formation, calcium channel activity, and synapse assembly. 4. **Significant expression:** The gene is significantly expressed in photoreceptor cells, neurons, and other neural cells, indicating its widespread importance in neural development and function. **Pathways and Functions:** 1. **Axonal growth cone formation:** GPM6A is involved in the formation and stabilization of axonal growth cones, which are crucial for neuronal migration and axon outgrowth. 2. **Calcium channel activity:** The protein regulates calcium channel activity, which is essential for neurotransmission and synaptic plasticity. 3. **Synapse assembly:** GPM6A contributes to the organization and assembly of synapses, which are critical for neural circuit function. 4. **Regulation of filopodium assembly:** The protein regulates the assembly of filopodia, which are actin-based structures involved in cell migration and adhesion. 5. **Neuronal cell body and projection development:** GPM6A is involved in the development and maintenance of neuronal cell bodies and projections. **Clinical Significance:** 1. **Neurodevelopmental disorders:** Abnormalities in GPM6A expression or function may contribute to neurodevelopmental disorders, such as autism spectrum disorder, schizophrenia, and Alzheimer's disease. 2. **Neuropathic pain:** GPM6A may play a role in the development and maintenance of neuropathic pain, a common complication of various neurological conditions. 3. **Synaptic dysfunction:** Alterations in GPM6A expression or function may contribute to synaptic dysfunction, which is a hallmark of various neurological disorders. 4. **Cancer:** GPM6A has been implicated in cancer progression, particularly in the development of glioblastoma and other brain tumors. In conclusion, GPM6A is a multifunctional protein that plays a critical role in various cellular processes, including neural development, synaptic organization, and cell migration. Further research is necessary to elucidate the mechanisms by which GPM6A contributes to neural function and to explore its potential as a therapeutic target for neurodevelopmental and neurological disorders.

Genular Protein ID: 2950729633

Symbol: GPM6A_HUMAN

Name: Neuronal membrane glycoprotein M6-a

UniProtKB Accession Codes:

P51674 B7Z642 E9PHI5 Q92602

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 21 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8893821

Title: Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33-->q34.

PubMed ID: 8893821

DOI: 10.1159/000134401

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8661015

Title: Chromosomal mapping of the human M6 genes.

PubMed ID: 8661015

DOI: 10.1006/geno.1996.0231

PubMed ID: 19298174

Title: Human GPM6A is associated with differentiation and neuronal migration of neurons derived from human embryonic stem cells.

PubMed ID: 19298174

DOI: 10.1089/scd.2008.0215

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24705354

Title: The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.

PubMed ID: 24705354

DOI: 10.1093/hmg/ddu137

Sequence Information:

  • Length: 278
  • Mass: 31210
  • Checksum: DD0DB598C0E86B5D
  • Sequence:
    • MEENMEEGQT QKGCFECCIK CLGGIPYASL IATILLYAGV ALFCGCGHEA LSGTVNILQT 
YFEMARTAGD TLDVFTMIDI FKYVIYGIAA AFFVYGILLM VEGFFTTGAI KDLYGDFKIT 
TCGRCVSAWF IMLTYLFMLA WLGVTAFTSL PVYMYFNLWT ICRNTTLVEG ANLCLDLRQF 
GIVTIGEEKK ICTVSENFLR MCESTELNMT FHLFIVALAG AGAAVIAMVH YLMVLSANWA 
YVKDACRMQK YEDIKSKEEQ ELHDIHSTRS KERLNAYT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.