Details for: GPM6A

Gene ID: 2823

Symbol: GPM6A

Ensembl ID: ENSG00000150625

Description: glycoprotein M6A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 8.32
    Marker Score: 6,260
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 8.21
    Marker Score: 43,050
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 7.56
    Marker Score: 4,972
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 7.31
    Marker Score: 24,495
  • Cell Name: granule cell (CL0000120)
    Fold Change: 7.23
    Marker Score: 54,511
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 7.11
    Marker Score: 38,188
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 6.81
    Marker Score: 28,403
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 6.21
    Marker Score: 14,271
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 5.41
    Marker Score: 20,930
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.3
    Marker Score: 179,003
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 4.49
    Marker Score: 6,231
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.25
    Marker Score: 19,648
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 4
    Marker Score: 16,740
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 3.49
    Marker Score: 1,956
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.4
    Marker Score: 4,103
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.27
    Marker Score: 69,846
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.25
    Marker Score: 1,888
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.12
    Marker Score: 6,338
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.04
    Marker Score: 2,872
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.99
    Marker Score: 1,439
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.97
    Marker Score: 867
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.89
    Marker Score: 57,495
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.84
    Marker Score: 8,111
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.82
    Marker Score: 21,600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.78
    Marker Score: 2,405
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.75
    Marker Score: 41,072
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.73
    Marker Score: 4,589
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.69
    Marker Score: 102,192
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.6
    Marker Score: 10,790
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.55
    Marker Score: 806
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.42
    Marker Score: 89,292
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.34
    Marker Score: 9,047
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.34
    Marker Score: 2,890
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.28
    Marker Score: 2,627
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.21
    Marker Score: 850
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20,675
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.12
    Marker Score: 889
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127,945
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.04
    Marker Score: 21,025
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.03
    Marker Score: 8,251
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2
    Marker Score: 1,045
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.96
    Marker Score: 2,446
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.94
    Marker Score: 623
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,337
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,160
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.78
    Marker Score: 2,145
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.75
    Marker Score: 555
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.73
    Marker Score: 526
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.72
    Marker Score: 703
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.67
    Marker Score: 826
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2,546
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.62
    Marker Score: 1,959
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.62
    Marker Score: 1,788
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,160
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.49
    Marker Score: 892
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.49
    Marker Score: 408
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.48
    Marker Score: 535
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,942
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 1.42
    Marker Score: 14,394
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.37
    Marker Score: 666
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.36
    Marker Score: 2,759
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.28
    Marker Score: 608
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 1.27
    Marker Score: 428
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.24
    Marker Score: 19,908
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.22
    Marker Score: 2,864
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.21
    Marker Score: 727
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.2
    Marker Score: 1,323
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.18
    Marker Score: 735
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.17
    Marker Score: 397
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.05
    Marker Score: 1,860
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.04
    Marker Score: 395
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.04
    Marker Score: 701
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.02
    Marker Score: 318
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.01
    Marker Score: 420
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,783
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,008
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.98
    Marker Score: 2,299
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.96
    Marker Score: 883
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.94
    Marker Score: 432
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.93
    Marker Score: 638
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,297
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13,986
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.89
    Marker Score: 408
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.88
    Marker Score: 2,112
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,280
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.86
    Marker Score: 188
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.84
    Marker Score: 392
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.83
    Marker Score: 1,892
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.83
    Marker Score: 372
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.83
    Marker Score: 332
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.82
    Marker Score: 301
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.81
    Marker Score: 774
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.79
    Marker Score: 780

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** GPM6A is primarily expressed in the plasma membrane of neurons, astrocytes, and other neural cells, suggesting its role in cell-cell interactions and communication. 2. **Glycosylation:** The protein is glycosylated, which may be crucial for its function and interactions with other molecules. 3. **Multiple functions:** GPM6A is involved in various cellular processes, including axonal growth cone formation, calcium channel activity, and synapse assembly. 4. **Significant expression:** The gene is significantly expressed in photoreceptor cells, neurons, and other neural cells, indicating its widespread importance in neural development and function. **Pathways and Functions:** 1. **Axonal growth cone formation:** GPM6A is involved in the formation and stabilization of axonal growth cones, which are crucial for neuronal migration and axon outgrowth. 2. **Calcium channel activity:** The protein regulates calcium channel activity, which is essential for neurotransmission and synaptic plasticity. 3. **Synapse assembly:** GPM6A contributes to the organization and assembly of synapses, which are critical for neural circuit function. 4. **Regulation of filopodium assembly:** The protein regulates the assembly of filopodia, which are actin-based structures involved in cell migration and adhesion. 5. **Neuronal cell body and projection development:** GPM6A is involved in the development and maintenance of neuronal cell bodies and projections. **Clinical Significance:** 1. **Neurodevelopmental disorders:** Abnormalities in GPM6A expression or function may contribute to neurodevelopmental disorders, such as autism spectrum disorder, schizophrenia, and Alzheimer's disease. 2. **Neuropathic pain:** GPM6A may play a role in the development and maintenance of neuropathic pain, a common complication of various neurological conditions. 3. **Synaptic dysfunction:** Alterations in GPM6A expression or function may contribute to synaptic dysfunction, which is a hallmark of various neurological disorders. 4. **Cancer:** GPM6A has been implicated in cancer progression, particularly in the development of glioblastoma and other brain tumors. In conclusion, GPM6A is a multifunctional protein that plays a critical role in various cellular processes, including neural development, synaptic organization, and cell migration. Further research is necessary to elucidate the mechanisms by which GPM6A contributes to neural function and to explore its potential as a therapeutic target for neurodevelopmental and neurological disorders.

Genular Protein ID: 2950729633

Symbol: GPM6A_HUMAN

Name: Neuronal membrane glycoprotein M6-a

UniProtKB Accession Codes:

P51674 B7Z642 E9PHI5 Q92602

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 21 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8893821

Title: Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33-->q34.

PubMed ID: 8893821

DOI: 10.1159/000134401

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8661015

Title: Chromosomal mapping of the human M6 genes.

PubMed ID: 8661015

DOI: 10.1006/geno.1996.0231

PubMed ID: 19298174

Title: Human GPM6A is associated with differentiation and neuronal migration of neurons derived from human embryonic stem cells.

PubMed ID: 19298174

DOI: 10.1089/scd.2008.0215

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24705354

Title: The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.

PubMed ID: 24705354

DOI: 10.1093/hmg/ddu137

Sequence Information:

  • Length: 278
  • Mass: 31210
  • Checksum: DD0DB598C0E86B5D
  • Sequence:
    • MEENMEEGQT QKGCFECCIK CLGGIPYASL IATILLYAGV ALFCGCGHEA LSGTVNILQT 
YFEMARTAGD TLDVFTMIDI FKYVIYGIAA AFFVYGILLM VEGFFTTGAI KDLYGDFKIT 
TCGRCVSAWF IMLTYLFMLA WLGVTAFTSL PVYMYFNLWT ICRNTTLVEG ANLCLDLRQF 
GIVTIGEEKK ICTVSENFLR MCESTELNMT FHLFIVALAG AGAAVIAMVH YLMVLSANWA 
YVKDACRMQK YEDIKSKEEQ ELHDIHSTRS KERLNAYT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.