Details for: GPM6A

Gene ID: 2823

Symbol: GPM6A

Ensembl ID: ENSG00000150625

Description: glycoprotein M6A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 8.32
    Marker Score: 6260
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 8.21
    Marker Score: 43050
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 7.56
    Marker Score: 4972
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 7.31
    Marker Score: 24495
  • Cell Name: granule cell (CL0000120)
    Fold Change: 7.23
    Marker Score: 54511
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 7.11
    Marker Score: 38188
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 6.81
    Marker Score: 28403
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 6.21
    Marker Score: 14271
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 5.41
    Marker Score: 20930
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.3
    Marker Score: 179003
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 4.49
    Marker Score: 6230.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.25
    Marker Score: 19648
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 4
    Marker Score: 16740
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 3.49
    Marker Score: 1956
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.4
    Marker Score: 4103
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.27
    Marker Score: 69846
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.25
    Marker Score: 1888
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.12
    Marker Score: 6338
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.04
    Marker Score: 2872
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.99
    Marker Score: 1439
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.97
    Marker Score: 867
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.89
    Marker Score: 57495
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.84
    Marker Score: 8111
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.82
    Marker Score: 21600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.78
    Marker Score: 2405
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.75
    Marker Score: 41072
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.73
    Marker Score: 4589
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.69
    Marker Score: 102192
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.6
    Marker Score: 10790
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.55
    Marker Score: 806
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.42
    Marker Score: 89292
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.34
    Marker Score: 9047
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.34
    Marker Score: 2890
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.28
    Marker Score: 2627
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.21
    Marker Score: 850
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20675
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.12
    Marker Score: 889
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127945
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.04
    Marker Score: 21025
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.03
    Marker Score: 8251
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2
    Marker Score: 1044.5
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.96
    Marker Score: 2446
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.94
    Marker Score: 623
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18337
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16160
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.78
    Marker Score: 2145
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.75
    Marker Score: 555
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.73
    Marker Score: 526
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.72
    Marker Score: 703
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.67
    Marker Score: 826
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2546
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.62
    Marker Score: 1959
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.62
    Marker Score: 1788
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1160
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.49
    Marker Score: 892
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.49
    Marker Score: 408
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.48
    Marker Score: 535
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167942
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 1.42
    Marker Score: 14394
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.37
    Marker Score: 666
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.36
    Marker Score: 2759
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.28
    Marker Score: 608
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 1.27
    Marker Score: 428
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.24
    Marker Score: 19908
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.22
    Marker Score: 2864
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.21
    Marker Score: 727
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.2
    Marker Score: 1323
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.18
    Marker Score: 735
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.17
    Marker Score: 397
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.05
    Marker Score: 1860
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.04
    Marker Score: 395
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.04
    Marker Score: 701
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.02
    Marker Score: 318
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.01
    Marker Score: 419.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71783
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48008
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.98
    Marker Score: 2299
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.96
    Marker Score: 883
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.94
    Marker Score: 432
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.93
    Marker Score: 638
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5297
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13986
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.89
    Marker Score: 408
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.88
    Marker Score: 2112
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.86
    Marker Score: 188
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.84
    Marker Score: 392
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.83
    Marker Score: 1892
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.83
    Marker Score: 372
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.83
    Marker Score: 332
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.82
    Marker Score: 301
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.81
    Marker Score: 774
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.79
    Marker Score: 780

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Other Information

**Key characteristics** - GPM6A is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in a variety of cell types, including photoreceptor cells, neurons, astrocytes, and oligodendrocytes. - GPM6A is a key component of the axonal growth cone, where it is involved in the assembly of the axon. - It is also involved in the regulation of calcium channel activity, calcium ion transmembrane transport, dendritic spine, and neural retina development. - GPM6A is a positive regulator of filopodium assembly, presynaptic active zone membrane, and synapse assembly. **Pathways and functions** - GPM6A is involved in the assembly of the axonal growth cone. - It is a key component of the presynaptic active zone membrane, where it is involved in the formation of the synaptic cleft. - It is also involved in the regulation of calcium channel activity and calcium ion transmembrane transport. - GPM6A is a positive regulator of filopodium assembly, where it is involved in the extension of the filopodium. - It is also involved in the regulation of synapse organization and the response to bacteria. **Clinical significance** - Mutations in the GPM6A gene have been linked to a number of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. - GPM6A is a promising target for the treatment of neurodegenerative diseases, as it is involved in the assembly and function of neural structures that are affected in these diseases.

Genular Protein ID: 2950729633

Symbol: GPM6A_HUMAN

Name: Neuronal membrane glycoprotein M6-a

UniProtKB Accession Codes:

P51674 B7Z642 E9PHI5 Q92602

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 21 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8893821

Title: Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33-->q34.

PubMed ID: 8893821

DOI: 10.1159/000134401

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8661015

Title: Chromosomal mapping of the human M6 genes.

PubMed ID: 8661015

DOI: 10.1006/geno.1996.0231

PubMed ID: 19298174

Title: Human GPM6A is associated with differentiation and neuronal migration of neurons derived from human embryonic stem cells.

PubMed ID: 19298174

DOI: 10.1089/scd.2008.0215

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24705354

Title: The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.

PubMed ID: 24705354

DOI: 10.1093/hmg/ddu137

Sequence Information:

  • Length: 278
  • Mass: 31210
  • Checksum: DD0DB598C0E86B5D
  • Sequence:
    • MEENMEEGQT QKGCFECCIK CLGGIPYASL IATILLYAGV ALFCGCGHEA LSGTVNILQT 
YFEMARTAGD TLDVFTMIDI FKYVIYGIAA AFFVYGILLM VEGFFTTGAI KDLYGDFKIT 
TCGRCVSAWF IMLTYLFMLA WLGVTAFTSL PVYMYFNLWT ICRNTTLVEG ANLCLDLRQF 
GIVTIGEEKK ICTVSENFLR MCESTELNMT FHLFIVALAG AGAAVIAMVH YLMVLSANWA 
YVKDACRMQK YEDIKSKEEQ ELHDIHSTRS KERLNAYT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.