Details for: POU5F1B

Gene ID: 5462

Symbol: POU5F1B

Ensembl ID: ENSG00000212993

Description: POU class 5 homeobox 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.7834
    Cell Significance Index: 10.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6663
    Cell Significance Index: 14.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2203
    Cell Significance Index: 41.9200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1699
    Cell Significance Index: 2.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1608
    Cell Significance Index: 15.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1170
    Cell Significance Index: 105.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1086
    Cell Significance Index: 5.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0864
    Cell Significance Index: 14.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0816
    Cell Significance Index: 8.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0713
    Cell Significance Index: 4.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0693
    Cell Significance Index: 3.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0572
    Cell Significance Index: 5.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0549
    Cell Significance Index: 6.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0448
    Cell Significance Index: 1.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0416
    Cell Significance Index: 2.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0322
    Cell Significance Index: 1.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0275
    Cell Significance Index: 1.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0217
    Cell Significance Index: 0.4500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0215
    Cell Significance Index: 0.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0145
    Cell Significance Index: 7.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0134
    Cell Significance Index: 0.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0089
    Cell Significance Index: 0.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0034
    Cell Significance Index: 0.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0018
    Cell Significance Index: 0.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0009
    Cell Significance Index: -0.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0015
    Cell Significance Index: -0.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0018
    Cell Significance Index: -1.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0022
    Cell Significance Index: -0.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0023
    Cell Significance Index: -3.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0026
    Cell Significance Index: -1.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0026
    Cell Significance Index: -0.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0033
    Cell Significance Index: -0.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0034
    Cell Significance Index: -2.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0040
    Cell Significance Index: -2.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0040
    Cell Significance Index: -2.9400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0040
    Cell Significance Index: -0.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0062
    Cell Significance Index: -1.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0073
    Cell Significance Index: -0.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0078
    Cell Significance Index: -1.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0081
    Cell Significance Index: -1.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0088
    Cell Significance Index: -0.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0097
    Cell Significance Index: -1.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0101
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0103
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0112
    Cell Significance Index: -1.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0118
    Cell Significance Index: -0.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0122
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0146
    Cell Significance Index: -3.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0176
    Cell Significance Index: -0.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0203
    Cell Significance Index: -1.2800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0206
    Cell Significance Index: -0.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0264
    Cell Significance Index: -2.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0285
    Cell Significance Index: -2.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0295
    Cell Significance Index: -2.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0334
    Cell Significance Index: -1.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0370
    Cell Significance Index: -0.8600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0372
    Cell Significance Index: -0.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0373
    Cell Significance Index: -2.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0388
    Cell Significance Index: -2.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0408
    Cell Significance Index: -3.1300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0417
    Cell Significance Index: -0.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0426
    Cell Significance Index: -2.6200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0443
    Cell Significance Index: -0.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0467
    Cell Significance Index: -1.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0471
    Cell Significance Index: -1.5100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0488
    Cell Significance Index: -0.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0504
    Cell Significance Index: -2.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0511
    Cell Significance Index: -1.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0547
    Cell Significance Index: -1.9200
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0552
    Cell Significance Index: -0.5000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0557
    Cell Significance Index: -1.3900
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0592
    Cell Significance Index: -0.8100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0605
    Cell Significance Index: -0.9700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0606
    Cell Significance Index: -0.6600
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0606
    Cell Significance Index: -0.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0627
    Cell Significance Index: -3.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0636
    Cell Significance Index: -2.2100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0641
    Cell Significance Index: -0.4300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0659
    Cell Significance Index: -1.1100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0668
    Cell Significance Index: -1.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0681
    Cell Significance Index: -1.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0687
    Cell Significance Index: -2.2500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0694
    Cell Significance Index: -0.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0700
    Cell Significance Index: -2.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0713
    Cell Significance Index: -2.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0720
    Cell Significance Index: -1.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0726
    Cell Significance Index: -0.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0730
    Cell Significance Index: -1.4300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0739
    Cell Significance Index: -1.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0760
    Cell Significance Index: -3.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0761
    Cell Significance Index: -2.2400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0768
    Cell Significance Index: -0.8000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0770
    Cell Significance Index: -0.9800
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0778
    Cell Significance Index: -0.8700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0798
    Cell Significance Index: -0.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0818
    Cell Significance Index: -2.1500
  • Cell Name: parietal cell (CL0000162)
    Fold Change: -0.0846
    Cell Significance Index: -0.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** POU5F1B is a member of the POU domain-containing transcription factor family, which is characterized by the presence of a POU domain, a conserved DNA-binding motif. The gene is highly expressed in cells of the immune system, particularly in conventional dendritic cells and granulocyte monocyte progenitor cells, which are essential for the development and function of the immune system. POU5F1B is also expressed in epithelial cells, including intestinal epithelial cells and absorptive cells, where it regulates the expression of genes involved in epithelial homeostasis. **Pathways and Functions:** POU5F1B is involved in regulating the expression of genes involved in several cellular pathways, including: 1. **Chromatin and DNA Binding:** POU5F1B binds to specific DNA sequences, regulating the expression of genes involved in chromatin organization and DNA replication. 2. **RNA Polymerase II-Specific Transcription:** POU5F1B regulates the expression of genes involved in RNA polymerase II-mediated transcription, which is essential for the synthesis of mRNA. 3. **Regulation of DNA- Templated Transcription:** POU5F1B regulates the expression of genes involved in DNA-templated transcription, which is essential for the synthesis of proteins. 4. **Mitochondrial Regulation:** POU5F1B regulates the expression of genes involved in mitochondrial function, which is essential for energy production and cellular metabolism. **Functions:** The POU5F1B gene plays a crucial role in regulating the expression of genes involved in immune system development and function, as well as epithelial homeostasis. The gene is involved in: 1. **Immune System Development:** POU5F1B regulates the expression of genes involved in the development and function of immune cells, including conventional dendritic cells and granulocyte monocyte progenitor cells. 2. **Epithelial Homeostasis:** POU5F1B regulates the expression of genes involved in epithelial homeostasis, including the regulation of gene expression in intestinal epithelial cells and absorptive cells. **Clinical Significance:** Dysregulation of the POU5F1B gene has been implicated in several immunological and epithelial disorders, including: 1. **Autoimmune Diseases:** POU5F1B dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer:** POU5F1B dysregulation has been implicated in various types of cancer, including colon cancer and breast cancer. 3. **Gastrointestinal Disorders:** POU5F1B dysregulation has been implicated in gastrointestinal disorders, such as inflammatory bowel disease and celiac disease. In conclusion, the POU5F1B gene is a transcription factor that plays a crucial role in regulating the expression of genes involved in immune system development and function, as well as epithelial homeostasis. Dysregulation of the gene has been implicated in several immunological and epithelial disorders, highlighting the importance of further research into the role of POU5F1B in human disease.

Genular Protein ID: 3591370713

Symbol: P5F1B_HUMAN

Name: Putative POU domain, class 5, transcription factor 1B

UniProtKB Accession Codes:

Q06416 D5K9S4 D5K9S9 D5K9T0 D5K9T1 D5K9T3 D5K9U3 D5K9U6 D5K9V4 D5K9V6 D5K9W0 D5K9W2 D5K9W7 D5K9X2 D5K9X3 D5K9X5 D5K9X8 D5K9X9 E9LRB1 E9LRB2 E9LRH5 E9LRH6 E9LRH7 E9LRK4 E9LRK5 E9LRK7 E9LRK8 E9LRM7 E9LRM9 E9LRN2 E9LRN4 E9LRN5 E9LRP8 E9LRQ0 E9LRQ2 E9LRQ3 E9LRQ4 E9LRQ5 E9LRS3 Q2VIK6 Q9BZV7 Q9BZV9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 100 Ensembl 3 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1408763

Title: Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues.

PubMed ID: 1408763

DOI: 10.1093/nar/20.17.4613

PubMed ID: 16201836

Title: Emergence of young human genes after a burst of retroposition in primates.

PubMed ID: 16201836

DOI: 10.1371/journal.pbio.0030357

PubMed ID: 21341266

Title: Expression of OCT4 pseudogenes in human tumours: lessons from glioma and breast carcinoma.

PubMed ID: 21341266

DOI: 10.1002/path.2827

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 16229821

Title: Oct4 pseudogenes are transcribed in cancers.

PubMed ID: 16229821

DOI: 10.1016/j.bbrc.2005.09.157

PubMed ID: 18949397

Title: The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1.

PubMed ID: 18949397

Sequence Information:

  • Length: 359
  • Mass: 38588
  • Checksum: 9AF853B116FCB75A
  • Sequence:
    • MAGHLASDFA FSPPPGGGGD GPWGAEPGWV DPLTWLSFQG PPGGPGIGPG VGPGSEVWGI 
PPCPPPYELC GGMAYCGPQV GVGLVPQGGL ETSQPESEAG VGVESNSNGA SPEPCTVPPG 
AVKLEKEKLE QNPEKSQDIK ALQKELEQFA KLLKQKRITL GYTQADVGLI LGVLFGKVFS 
QKTICRFEAL QLSFKNMCKL RPLLQKWVEE ADNNENLQEI CKAETLMQAR KRKRTSIENR 
VRGNLENLFL QCPKPTLQIS HIAQQLGLEK DVVRVWFCNR RQKGKRSSSD YAQREDFEAA 
GSPFSGGPVS FPPAPGPHFG TPGYGSPHFT ALYSSVPFPE GEVFPPVSVI TLGSPMHSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.