Details for: MICB

Gene ID: 4277

Symbol: MICB

Ensembl ID: ENSG00000204516

Description: MHC class I polypeptide-related sequence B

Associated with

  • Adaptive immune system
    (R-HSA-1280218)
  • Immune system
    (R-HSA-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-HSA-198933)
  • Adaptive immune response
    (GO:0002250)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class ib
    (GO:0002476)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-independent
    (GO:0002486)
  • Cell surface
    (GO:0009986)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular space
    (GO:0005615)
  • Gamma-delta t cell activation
    (GO:0046629)
  • Immune response
    (GO:0006955)
  • Immune response-activating cell surface receptor signaling pathway
    (GO:0002429)
  • Killing of cells of another organism
    (GO:0031640)
  • Natural killer cell lectin-like receptor binding
    (GO:0046703)
  • Negative regulation of defense response to virus by host
    (GO:0050689)
  • Peptide antigen binding
    (GO:0042605)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Response to heat
    (GO:0009408)
  • Response to oxidative stress
    (GO:0006979)
  • Response to retinoic acid
    (GO:0032526)
  • Signaling receptor binding
    (GO:0005102)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 42.9457
    Cell Significance Index: -6.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.4795
    Cell Significance Index: -6.9700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.7976
    Cell Significance Index: -6.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.0667
    Cell Significance Index: -7.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.7138
    Cell Significance Index: -7.2700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 2.0909
    Cell Significance Index: 29.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9310
    Cell Significance Index: -7.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.4923
    Cell Significance Index: 91.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6127
    Cell Significance Index: 16.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5939
    Cell Significance Index: 113.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5858
    Cell Significance Index: 12.4800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.5026
    Cell Significance Index: -1.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4464
    Cell Significance Index: 44.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3946
    Cell Significance Index: 11.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2960
    Cell Significance Index: 17.7700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.2761
    Cell Significance Index: 3.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2694
    Cell Significance Index: 29.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2504
    Cell Significance Index: 226.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2367
    Cell Significance Index: 27.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2358
    Cell Significance Index: 38.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1591
    Cell Significance Index: 2.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1440
    Cell Significance Index: 7.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1134
    Cell Significance Index: 7.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0809
    Cell Significance Index: 5.2200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0631
    Cell Significance Index: 0.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0352
    Cell Significance Index: 4.1000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0339
    Cell Significance Index: 0.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0327
    Cell Significance Index: 1.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0191
    Cell Significance Index: 0.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0098
    Cell Significance Index: 1.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0067
    Cell Significance Index: 1.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0065
    Cell Significance Index: 1.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0049
    Cell Significance Index: 2.6700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0043
    Cell Significance Index: 0.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0010
    Cell Significance Index: 0.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0006
    Cell Significance Index: 0.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0020
    Cell Significance Index: -0.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0029
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -7.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0046
    Cell Significance Index: -0.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0068
    Cell Significance Index: -12.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0071
    Cell Significance Index: -5.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0086
    Cell Significance Index: -6.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0088
    Cell Significance Index: -13.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0105
    Cell Significance Index: -6.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0106
    Cell Significance Index: -14.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0114
    Cell Significance Index: -1.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0123
    Cell Significance Index: -1.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0129
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0153
    Cell Significance Index: -11.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0178
    Cell Significance Index: -6.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0191
    Cell Significance Index: -8.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0193
    Cell Significance Index: -10.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0318
    Cell Significance Index: -3.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0344
    Cell Significance Index: -1.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0380
    Cell Significance Index: -2.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0418
    Cell Significance Index: -6.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0427
    Cell Significance Index: -5.8600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0493
    Cell Significance Index: -0.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0503
    Cell Significance Index: -2.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0524
    Cell Significance Index: -8.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0543
    Cell Significance Index: -7.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0584
    Cell Significance Index: -6.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0615
    Cell Significance Index: -1.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0634
    Cell Significance Index: -1.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0656
    Cell Significance Index: -4.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0663
    Cell Significance Index: -13.9600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0667
    Cell Significance Index: -0.7600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0672
    Cell Significance Index: -2.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0723
    Cell Significance Index: -7.5300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0823
    Cell Significance Index: -1.3200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0841
    Cell Significance Index: -1.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0859
    Cell Significance Index: -6.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0955
    Cell Significance Index: -2.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1016
    Cell Significance Index: -5.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1109
    Cell Significance Index: -3.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1141
    Cell Significance Index: -5.3200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1172
    Cell Significance Index: -1.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1212
    Cell Significance Index: -3.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1215
    Cell Significance Index: -3.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1260
    Cell Significance Index: -4.1300
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1275
    Cell Significance Index: -2.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1291
    Cell Significance Index: -2.5200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1340
    Cell Significance Index: -2.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1353
    Cell Significance Index: -10.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1433
    Cell Significance Index: -8.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1438
    Cell Significance Index: -3.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1520
    Cell Significance Index: -7.9800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1579
    Cell Significance Index: -1.0700
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1604
    Cell Significance Index: -0.8400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1632
    Cell Significance Index: -3.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1750
    Cell Significance Index: -7.7400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1758
    Cell Significance Index: -2.6300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1763
    Cell Significance Index: -2.0300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2000
    Cell Significance Index: -2.8500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2000
    Cell Significance Index: -2.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2012
    Cell Significance Index: -6.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2012
    Cell Significance Index: -7.6200
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.2089
    Cell Significance Index: -2.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2106
    Cell Significance Index: -6.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** The MICB gene encodes a transmembrane protein that is related to the MHC class I molecule. It contains a cytoplasmic tail and a transmembrane domain, which allows it to interact with T cells. 2. **Expression:** MICB is highly expressed in thymocytes, kidney proximal convoluted tubule epithelial cells, and intestinal crypt stem cells. Its expression is also detected in other tissues, including the respiratory basal cell and goblet cell. 3. **Function:** MICB is involved in the presentation of endogenous peptides to cytotoxic T cells. It is also involved in the activation of gamma-delta T cells and the regulation of T cell-mediated cytotoxicity. 4. **Signal Transduction:** MICB interacts with T cells through its cytoplasmic tail, which triggers signal transduction pathways that lead to T cell activation and proliferation. **Pathways and Functions:** 1. **Antigen Processing and Presentation:** MICB is involved in the presentation of endogenous peptides to cytotoxic T cells via the MHC class I pathway. It is also involved in the presentation of endogenous peptides to T cells via the ER pathway. 2. **Gamma-Delta T Cell Activation:** MICB is involved in the activation of gamma-delta T cells, which are a subset of T cells that play a key role in the regulation of the immune response. 3. **T Cell-Mediated Cytotoxicity:** MICB is involved in the regulation of T cell-mediated cytotoxicity, which is a critical component of the adaptive immune response. 4. **Immune Response-Activating Cell Surface Receptor Signaling Pathway:** MICB interacts with T cells through its cytoplasmic tail, which triggers signal transduction pathways that lead to T cell activation and proliferation. **Clinical Significance:** 1. **Infectious Diseases:** MICB has been implicated in the pathogenesis of various infectious diseases, including viral and bacterial infections. 2. **Autoimmune Diseases:** MICB has been implicated in the pathogenesis of autoimmune diseases, including multiple sclerosis and type 1 diabetes. 3. **Cancer:** MICB has been implicated in the pathogenesis of various cancers, including leukemia and lymphoma. 4. **Immunodeficiency Diseases:** MICB has been implicated in the pathogenesis of immunodeficiency diseases, including severe combined immunodeficiency (SCID) and chronic granulomatous disease (CGD). In conclusion, the MICB gene plays a critical role in the adaptive immune response, particularly in the context of antigen presentation and T cell activation. Its expression is highly regulated, and its dysregulation has been implicated in various diseases, including infectious diseases, autoimmune diseases, cancer, and immunodeficiency diseases. Further research is needed to fully understand the function of MICB in the immune system and its role in human disease.

Genular Protein ID: 1792119560

Symbol: MICB_HUMAN

Name: MHC class I polypeptide-related sequence B

UniProtKB Accession Codes:

Q29980 A2AC57 A6NP85 B0UZ10 B2RAK2 O14499 O14500 O19798 O19799 O19800 O19801 O19802 O19803 O78099 O78100 O78101 O78102 O78103 O78104 P79525 P79541 Q5GR31 Q5GR37 Q5GR41 Q5GR42 Q5GR43 Q5GR44 Q5GR46 Q5GR48 Q5RIY6 Q5SSK1 Q5ST25 Q7JK51 Q7YQ89 Q861E6 Q9MY18 Q9MY19 Q9MY20 Q9UBH4 Q9UBZ8 Q9UEJ0 X6R344

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 65 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8575823

Title: Nucleotide sequence of a human MHC class I MICB cDNA.

PubMed ID: 8575823

DOI: 10.1007/bf00587305

PubMed ID: 8952966

Title: Genomic structure of the human MHC class I MICB gene.

PubMed ID: 8952966

DOI: 10.1007/s002510050184

PubMed ID: 17678727

Title: The allele MICB*0050204, over-represented in the Caucasian population, has an additional exon resulting from a new splice junction sequence.

PubMed ID: 17678727

DOI: 10.1016/j.humimm.2007.05.003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8995188

Title: Allelic and interlocus comparison of the PERB11 multigene family in the MHC.

PubMed ID: 8995188

DOI: 10.1007/s002510050191

PubMed ID: 9271635

Title: Allelic repertoire of the human MICB gene.

PubMed ID: 9271635

DOI: 10.1007/s002510050299

PubMed ID: 15191526

Title: A novel major histocompatibility complex class I-related chain allele.

PubMed ID: 15191526

DOI: 10.1111/j.1399-0039.2004.00242.x

PubMed ID: 9694358

Title: Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles.

PubMed ID: 9694358

DOI: 10.1111/j.1399-0039.1998.tb03008.x

PubMed ID: 9321430

Title: Allelic variants of the human MHC class I chain-related B gene (MICB).

PubMed ID: 9321430

DOI: 10.1007/s002510050311

PubMed ID: 10746790

Title: Three novel MICB alleles.

PubMed ID: 10746790

DOI: 10.1034/j.1399-0039.2000.550210.x

PubMed ID: 15304008

Title: Eight novel MICB alleles, including a null allele, identified in gastric MALT lymphoma patients.

PubMed ID: 15304008

DOI: 10.1111/j.1399-0039.2004.00286.x

PubMed ID: 9497295

Title: Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells.

PubMed ID: 9497295

DOI: 10.1126/science.279.5357.1737

PubMed ID: 10359807

Title: Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB.

PubMed ID: 10359807

DOI: 10.1073/pnas.96.12.6879

PubMed ID: 11287116

Title: Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2).

PubMed ID: 11287116

DOI: 10.1016/s0304-4165(01)00099-x

PubMed ID: 11239445

Title: ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.

PubMed ID: 11239445

DOI: 10.1016/s1074-7613(01)00095-4

PubMed ID: 11491531

Title: Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family.

PubMed ID: 11491531

DOI: 10.1007/s002510100325

PubMed ID: 12466900

Title: Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells.

PubMed ID: 12466900

DOI: 10.1007/s00251-002-0496-y

PubMed ID: 11777960

Title: UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.

PubMed ID: 11777960

DOI: 10.4049/jimmunol.168.2.671

PubMed ID: 12569559

Title: Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid.

PubMed ID: 12569559

DOI: 10.1002/ijc.10966

PubMed ID: 12782710

Title: Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity.

PubMed ID: 12782710

DOI: 10.1084/jem.20022059

PubMed ID: 12538683

Title: Critical role of MHC class I-related chain A and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection.

PubMed ID: 12538683

DOI: 10.4049/jimmunol.170.3.1249

PubMed ID: 16698441

Title: Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients.

PubMed ID: 16698441

DOI: 10.1016/j.humimm.2006.02.008

PubMed ID: 16849432

Title: Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function.

PubMed ID: 16849432

DOI: 10.1073/pnas.0600721103

PubMed ID: 17565371

Title: In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer.

PubMed ID: 17565371

DOI: 10.1371/journal.pone.0000518

PubMed ID: 17003176

Title: MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility.

PubMed ID: 17003176

DOI: 10.1093/rheumatology/kel331

PubMed ID: 17561376

Title: Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk.

PubMed ID: 17561376

DOI: 10.1016/j.schres.2007.04.021

PubMed ID: 17641203

Title: Host immune system gene targeting by a viral miRNA.

PubMed ID: 17641203

DOI: 10.1126/science.1140956

PubMed ID: 18395517

Title: Induction of MHC class I-related chain B (MICB) by 5-aza-2'-deoxycytidine.

PubMed ID: 18395517

DOI: 10.1016/j.bbrc.2008.03.131

PubMed ID: 32153595

Title: High-Throughput MICA/B Genotyping of Over Two Million Samples: Workflow and Allele Frequencies.

PubMed ID: 32153595

DOI: 10.3389/fimmu.2020.00314

PubMed ID: 12133964

Title: Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D.

PubMed ID: 12133964

DOI: 10.4049/jimmunol.169.3.1395

Sequence Information:

  • Length: 383
  • Mass: 42575
  • Checksum: 1309E571B48CDF9C
  • Sequence:
    • MGLGRVLLFL AVAFPFAPPA AAAEPHSLRY NLMVLSQDGS VQSGFLAEGH LDGQPFLRYD 
RQKRRAKPQG QWAENVLGAK TWDTETEDLT ENGQDLRRTL THIKDQKGGL HSLQEIRVCE 
IHEDSSTRGS RHFYYDGELF LSQNLETQES TVPQSSRAQT LAMNVTNFWK EDAMKTKTHY 
RAMQADCLQK LQRYLKSGVA IRRTVPPMVN VTCSEVSEGN ITVTCRASSF YPRNITLTWR 
QDGVSLSHNT QQWGDVLPDG NGTYQTWVAT RIRQGEEQRF TCYMEHSGNH GTHPVPSGKA 
LVLQSQRTDF PYVSAAMPCF VIIIILCVPC CKKKTSAAEG PELVSLQVLD QHPVGTGDHR 
DAAQLGFQPL MSATGSTGST EGT

Genular Protein ID: 2220247449

Symbol: B7Z8M1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z8M1

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 263
  • Mass: 29167
  • Checksum: 6BA89E27C3FAB588
  • Sequence:
    • MHEDSSTRGS RHFYYNGELF LSQNLETQES TVPQSSRAQT LAMNVTNFWK EDAMKTKTHY 
RAMQADCLQK LQRYLKSGVA IRRTVPPMVN VTCSEVSEGN ITVTCRASSF YPRNITLTWR 
QDGVSLSHNT QQWGDVLPDG NGTYQTWVAT RIRQGEEQRF TCYMEHSGNH GTHPVPSGKA 
LVLQSQRTDF PYVSAAMPCF VIIIILCVPC CKKKTSAAEG PELVSLQVLD QHPVGTGDHR 
DAAQLGFQPL MSATGSTGST EGA

Genular Protein ID: 580025981

Symbol: B4DUT9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DUT9

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 2 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 351
  • Mass: 39155
  • Checksum: D060262651EEF492
  • Sequence:
    • MVLSQDGSVQ SGFLAEGHLD GQPFLRYDRQ KRRAKPQGQW AEDVLGAETW DTETEDLTEN 
GQDLRRTLTH IKDQKGGLHS LQEIRVCEMH EDSSTRGSRH FYYNGELFLS QNLETQESTV 
PQSSRAQTLA MNVTNFWKED AMKTKTHYRA MQADCLQKLQ RYLKSGVAIR RTVPPMVNVT 
CSEVSEGNIT VTCRASSFYP RNITLTWRQD GVSLSHNTQQ WGDVLPDGNG TYQTWVATRI 
RQGEEQRFTC YMEHSGNHGT HPVPSGKALV LQSQRTDFPY VSAAMPCFVI IIILCVPCCK 
KKTSAAEGPE LVSPQVLDQH PVGTGDHRDA AQLGFQPLMS ATGSTGSTEG A

Genular Protein ID: 3639486535

Symbol: A0A0G2JHB5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0G2JHB5

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 Gene3D 2 HGNC 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 340
  • Mass: 37580
  • Checksum: 988732A5C354E210
  • Sequence:
    • MGLGRVLLFL AVAFPFAPPA AAAEPHSLRY NLMVLSQDGS VQSGFLAEGH LDGQPFLRYD 
RQKRRAKPQG QWAENVLGAK TWDTETEDLT ENGQDLRRTL THIKDQKGVP QSSRAQTLAM 
NVTNFWKEDA MKTKTHYRAM QADCLQKLQR YLKSGVAIRR TVPPMVNVTC SEVSEGNITV 
TCRASSFYPR NITLTWRQDG VSLSHNTQQW GDVLPDGNGT YQTWVATRIR QGEEQRFTCY 
MEHSGNHGTH PVPSGKALVL QSQRTDFPYV SAAMPCFVII IILCVPCCKK KTSAAEGPEL 
VSLQVLDQHP VGTGDHRDAA QLGFQPLMSA TGSTGSTEGT

Genular Protein ID: 3775475101

Symbol: F5H7Q8_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H7Q8

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 3 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 8 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMART 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 351
  • Mass: 39182
  • Checksum: EA76C6D3184A3930
  • Sequence:
    • MVLSQDGSVQ SGFLAEGHLD GQPFLRYDRQ KRRAKPQGQW AENVLGAKTW DTETEDLTEN 
GQDLRRTLTH IKDQKGGLHS LQEIRVCEIH EDSSTRGSRH FYYDGELFLS QNLETQESTV 
PQSSRAQTLA MNVTNFWKED AMKTKTHYRA MQADCLQKLQ RYLKSGVAIR RTVPPMVNVT 
CSEVSEGNIT VTCRASSFYP RNITLTWRQD GVSLSHNTQQ WGDVLPDGNG TYQTWVATRI 
RQGEEQRFTC YMEHSGNHGT HPVPSGKALV LQSQRTDFPY VSAAMPCFVI IIILCVPCCK 
KKTSAAEGPE LVSLQVLDQH PVGTGDHRDA AQLGFQPLMS ATGSTGSTEG T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.