Details for: PDE6G

Gene ID: 5148

Symbol: PDE6G

Ensembl ID: ENSG00000185527

Description: phosphodiesterase 6G

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 70.0761
    Cell Significance Index: -10.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.6406
    Cell Significance Index: -9.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 11.6449
    Cell Significance Index: 733.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.9298
    Cell Significance Index: -11.0100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.7794
    Cell Significance Index: 28.2300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 1.4656
    Cell Significance Index: 12.9100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.7505
    Cell Significance Index: 10.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6822
    Cell Significance Index: 44.0200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.5655
    Cell Significance Index: 6.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3938
    Cell Significance Index: 10.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2743
    Cell Significance Index: 3.2700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.2470
    Cell Significance Index: 1.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.1919
    Cell Significance Index: -0.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1053
    Cell Significance Index: 5.5300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0540
    Cell Significance Index: 0.8200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0485
    Cell Significance Index: 0.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0413
    Cell Significance Index: 77.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0413
    Cell Significance Index: 1.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0368
    Cell Significance Index: 1.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0269
    Cell Significance Index: 0.7200
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0020
    Cell Significance Index: -0.2500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0036
    Cell Significance Index: -0.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0054
    Cell Significance Index: -3.7500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0055
    Cell Significance Index: -0.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0067
    Cell Significance Index: -1.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0077
    Cell Significance Index: -0.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0081
    Cell Significance Index: -5.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0084
    Cell Significance Index: -6.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0150
    Cell Significance Index: -8.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0157
    Cell Significance Index: -11.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0166
    Cell Significance Index: -4.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0187
    Cell Significance Index: -34.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0215
    Cell Significance Index: -7.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0218
    Cell Significance Index: -9.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0218
    Cell Significance Index: -16.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0229
    Cell Significance Index: -35.2600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0230
    Cell Significance Index: -0.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0250
    Cell Significance Index: -3.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0265
    Cell Significance Index: -36.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0270
    Cell Significance Index: -3.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0273
    Cell Significance Index: -5.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0343
    Cell Significance Index: -6.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0350
    Cell Significance Index: -19.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0366
    Cell Significance Index: -3.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0425
    Cell Significance Index: -2.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0434
    Cell Significance Index: -5.0600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0443
    Cell Significance Index: -0.6300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0465
    Cell Significance Index: -1.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0497
    Cell Significance Index: -1.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0541
    Cell Significance Index: -6.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0601
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0606
    Cell Significance Index: -10.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0617
    Cell Significance Index: -7.9700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0659
    Cell Significance Index: -0.4500
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0687
    Cell Significance Index: -0.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0703
    Cell Significance Index: -9.6600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0717
    Cell Significance Index: -0.8100
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0764
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0778
    Cell Significance Index: -16.3900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0795
    Cell Significance Index: -0.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0812
    Cell Significance Index: -2.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0899
    Cell Significance Index: -10.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0907
    Cell Significance Index: -1.7700
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0994
    Cell Significance Index: -1.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1023
    Cell Significance Index: -4.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1049
    Cell Significance Index: -10.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1079
    Cell Significance Index: -8.0400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1153
    Cell Significance Index: -1.8500
  • Cell Name: MHC-II-positive classical monocyte (CL0002470)
    Fold Change: -0.1280
    Cell Significance Index: -0.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1297
    Cell Significance Index: -3.8200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1324
    Cell Significance Index: -1.0800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1341
    Cell Significance Index: -0.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1381
    Cell Significance Index: -1.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1426
    Cell Significance Index: -6.7000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1453
    Cell Significance Index: -1.3500
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1535
    Cell Significance Index: -2.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1560
    Cell Significance Index: -9.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1612
    Cell Significance Index: -5.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1652
    Cell Significance Index: -11.1100
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1726
    Cell Significance Index: -2.2100
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1730
    Cell Significance Index: -2.1300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1818
    Cell Significance Index: -2.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1847
    Cell Significance Index: -14.1700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1858
    Cell Significance Index: -2.0200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1945
    Cell Significance Index: -2.4400
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1970
    Cell Significance Index: -2.2800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1994
    Cell Significance Index: -1.7700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2005
    Cell Significance Index: -5.0000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2020
    Cell Significance Index: -2.0900
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.2034
    Cell Significance Index: -2.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2067
    Cell Significance Index: -11.6000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2102
    Cell Significance Index: -2.0800
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2118
    Cell Significance Index: -2.3400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2144
    Cell Significance Index: -2.3400
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.2178
    Cell Significance Index: -2.1400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2199
    Cell Significance Index: -2.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2316
    Cell Significance Index: -4.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2337
    Cell Significance Index: -12.1400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2338
    Cell Significance Index: -2.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PDE6G is a subunit of the PDE6 enzyme, which is composed of four subunits: alpha, beta-gamma, epsilon, and theta. The beta-gamma subunit, which includes PDE6G, is responsible for the hydrolysis of cGMP to 5'-GMP. This enzyme plays a critical role in regulating the phototransduction cascade, which is essential for visual perception. PDE6G is specifically expressed in photoreceptor cells, bipolar cells, and other neuronal cells, suggesting its involvement in various signaling pathways beyond photoreception. **Pathways and Functions:** PDE6G is involved in several signaling pathways, including: 1. **Phototransduction cascade:** PDE6G is essential for the regulation of the phototransduction cascade, which converts light into electrical signals in photoreceptor cells. 2. **Ca2+ pathway:** PDE6G has been shown to interact with the Ca2+ pathway, which is involved in various cellular processes, including cell signaling and neurotransmission. 3. **Wnt signaling:** PDE6G has been implicated in the regulation of Wnt signaling, a critical pathway involved in development, cell proliferation, and differentiation. 4. **G protein-coupled receptor signaling pathway:** PDE6G has been shown to regulate the activity of G protein-coupled receptors, which are involved in various signaling pathways. 5. **MapK cascade:** PDE6G has been implicated in the regulation of the MAPK cascade, a critical pathway involved in cell signaling and response to stimuli. **Clinical Significance:** Dysregulation of the PDE6G gene has been implicated in various diseases, including: 1. **Retinitis pigmentosa:** A group of genetic disorders characterized by progressive vision loss due to photoreceptor degeneration. 2. **Leber congenital amaurosis:** A rare form of inherited retinal degeneration that affects the photoreceptors and leads to severe visual impairment. 3. **Gastrointestinal disorders:** PDE6G has been implicated in the regulation of gut motility and secretion, suggesting its potential role in gastrointestinal disorders. In conclusion, the PDE6G gene plays a critical role in regulating the phototransduction cascade and is involved in various cellular processes, including signal transduction, cell signaling, and the regulation of growth factor receptor signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of this gene.

Genular Protein ID: 2776398939

Symbol: CNRG_HUMAN

Name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

UniProtKB Accession Codes:

P18545 Q3KP63 Q7Z3U8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChEMBL 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 2 EMBL 7 Ensembl 3 EvolutionaryTrace 1 GO 11 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 4 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2161380

Title: Isolation and characterization of cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina.

PubMed ID: 2161380

DOI: 10.1016/0378-1119(90)90035-p

PubMed ID: 1965799

Title: The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase.

PubMed ID: 1965799

PubMed ID: 8125719

Title: Evaluation of the gene encoding the gamma subunit of rod phosphodiesterase in retinitis pigmentosa.

PubMed ID: 8125719

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20655036

Title: Autosomal-recessive early-onset retinitis pigmentosa caused by a mutation in PDE6G, the gene encoding the gamma subunit of rod cGMP phosphodiesterase.

PubMed ID: 20655036

DOI: 10.1016/j.ajhg.2010.06.016

Sequence Information:

  • Length: 87
  • Mass: 9643
  • Checksum: 5D7DEE59D7DDB9E0
  • Sequence:
    • MNLEPPKAEF RSATRVAGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF GDDIPGMEGL 
GTDITVICPW EAFNHLELHE LAQYGII

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.