Details for: F12

Gene ID: 2161

Symbol: F12

Ensembl ID: ENSG00000131187

Description: coagulation factor XII

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 82.6126
    Cell Significance Index: -12.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.7693
    Cell Significance Index: -12.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.9227
    Cell Significance Index: -8.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.4221
    Cell Significance Index: -12.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.9793
    Cell Significance Index: -10.6600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2691
    Cell Significance Index: -12.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.2333
    Cell Significance Index: 54.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6395
    Cell Significance Index: 325.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3231
    Cell Significance Index: 79.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2194
    Cell Significance Index: 132.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9846
    Cell Significance Index: 160.1400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.8543
    Cell Significance Index: 12.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6818
    Cell Significance Index: 19.6500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.6781
    Cell Significance Index: 3.9100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.6744
    Cell Significance Index: 2.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6633
    Cell Significance Index: 14.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6364
    Cell Significance Index: 44.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6115
    Cell Significance Index: 552.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5584
    Cell Significance Index: 65.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5157
    Cell Significance Index: 51.0100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5061
    Cell Significance Index: 8.3400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.4186
    Cell Significance Index: 7.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3918
    Cell Significance Index: 17.7600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.3403
    Cell Significance Index: 4.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3050
    Cell Significance Index: 9.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2578
    Cell Significance Index: 13.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2226
    Cell Significance Index: 4.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2124
    Cell Significance Index: 40.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1549
    Cell Significance Index: 4.3300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1464
    Cell Significance Index: 0.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1419
    Cell Significance Index: 62.7500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1382
    Cell Significance Index: 1.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1304
    Cell Significance Index: 3.2600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1205
    Cell Significance Index: 1.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1028
    Cell Significance Index: 1.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1026
    Cell Significance Index: 1.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1013
    Cell Significance Index: 13.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0787
    Cell Significance Index: 15.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0706
    Cell Significance Index: 2.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0434
    Cell Significance Index: 2.0400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0430
    Cell Significance Index: 0.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0123
    Cell Significance Index: 0.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0057
    Cell Significance Index: 0.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0050
    Cell Significance Index: 2.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0038
    Cell Significance Index: 1.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0062
    Cell Significance Index: -11.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0121
    Cell Significance Index: -2.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0123
    Cell Significance Index: -1.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0135
    Cell Significance Index: -9.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0151
    Cell Significance Index: -9.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0157
    Cell Significance Index: -11.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0187
    Cell Significance Index: -11.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0194
    Cell Significance Index: -14.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0199
    Cell Significance Index: -11.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0210
    Cell Significance Index: -38.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0228
    Cell Significance Index: -6.5700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0246
    Cell Significance Index: -0.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0250
    Cell Significance Index: -38.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0274
    Cell Significance Index: -37.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0354
    Cell Significance Index: -16.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0360
    Cell Significance Index: -2.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0402
    Cell Significance Index: -6.8600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0422
    Cell Significance Index: -0.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0440
    Cell Significance Index: -1.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0453
    Cell Significance Index: -2.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0568
    Cell Significance Index: -2.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0577
    Cell Significance Index: -6.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0602
    Cell Significance Index: -6.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0612
    Cell Significance Index: -3.8600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0639
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0781
    Cell Significance Index: -16.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0806
    Cell Significance Index: -6.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0819
    Cell Significance Index: -11.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0929
    Cell Significance Index: -10.9500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1021
    Cell Significance Index: -2.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1022
    Cell Significance Index: -14.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1232
    Cell Significance Index: -9.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1302
    Cell Significance Index: -13.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1452
    Cell Significance Index: -9.7600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1506
    Cell Significance Index: -1.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1511
    Cell Significance Index: -9.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1561
    Cell Significance Index: -8.1300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1638
    Cell Significance Index: -1.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1646
    Cell Significance Index: -10.1200
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1661
    Cell Significance Index: -0.8700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1687
    Cell Significance Index: -1.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1768
    Cell Significance Index: -3.7000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1866
    Cell Significance Index: -3.0000
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.1907
    Cell Significance Index: -1.4200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1915
    Cell Significance Index: -1.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1946
    Cell Significance Index: -4.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1997
    Cell Significance Index: -5.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2060
    Cell Significance Index: -4.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2542
    Cell Significance Index: -6.9200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2632
    Cell Significance Index: -3.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2641
    Cell Significance Index: -11.6800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2651
    Cell Significance Index: -6.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2676
    Cell Significance Index: -9.3000
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.2759
    Cell Significance Index: -2.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2856
    Cell Significance Index: -9.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Coagulation factor XII is a zymogen that is activated by contact activation, a process triggered by the binding of negatively charged surfaces, such as collagen, and the presence of negatively charged ions, like calcium. Once activated, F12 initiates a cascade of reactions that ultimately lead to the formation of fibrin clots. The F12 protein exhibits a unique ability to form a complex with the protein C inhibitor, which regulates the activity of protein C, a critical regulator of coagulation and fibrinolysis. **Pathways and Functions:** F12 is integral to the intrinsic pathway of blood coagulation, which is triggered by the contact of blood with negatively charged surfaces. This pathway involves the activation of factor XII, which in turn activates factor XI, leading to the activation of factor IX and ultimately the formation of thrombin and fibrin. F12 also plays a role in the regulation of fibrinolysis, as it interacts with the protein C inhibitor to modulate the activity of protein C. Furthermore, F12 is involved in the activation of the contact activation system (CAS) and the kallikrein-kinin system (KKS), which are critical components of the innate immune response. The F12 protein also exhibits serine-type endopeptidase activity, which allows it to process and activate other proteins. **Clinical Significance:** Dysregulation of F12 has been implicated in various pathological conditions, including hereditary angioedema, a disorder characterized by recurrent episodes of severe edema. Defects in the F12 gene or the serping1 gene, which encodes a binding protein for F12, have been identified as the primary causes of hereditary angioedema. Additionally, alterations in F12 expression have been linked to various cardiovascular and autoimmune diseases, highlighting the protein's potential as a therapeutic target. **Implications for Immunology:** The study of F12 has significant implications for our understanding of the immune response and the regulation of coagulation and fibrinolysis. The protein's involvement in the activation of the CAS and KKS highlights its role in the innate immune response, while its interaction with the protein C inhibitor suggests a complex regulatory mechanism that modulates coagulation and fibrinolysis. Further research is needed to fully elucidate the mechanisms by which F12 regulates these processes and to explore its potential as a therapeutic target for various diseases. **Conclusion:** In conclusion, coagulation factor XII is a multifaceted protein that plays a critical role in the regulation of coagulation, fibrinolysis, and the immune response. Its dysregulation has been implicated in various pathological conditions, highlighting the need for further research into the mechanisms by which F12 regulates these processes. As our understanding of F12 continues to evolve, it is likely that this protein will emerge as a key player in the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 856038412

Symbol: FA12_HUMAN

Name: Coagulation factor XII

UniProtKB Accession Codes:

P00748 P78339

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 5 CPTAC 2 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EC 2 EMBL 9 EMDB 1 Ensembl 1 EvolutionaryTrace 1 GO 22 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MEROPS 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PIR 1 PIRSF 1 PRINTS 3 PRO 1 PROSITE 12 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2888762

Title: Characterization of the human blood coagulation factor XII gene. Intron/exon gene organization and analysis of the 5'-flanking region.

PubMed ID: 2888762

DOI: 10.1016/s0021-9258(19)76478-3

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 3754331

Title: cDNA sequence coding for human coagulation factor XII (Hageman).

PubMed ID: 3754331

DOI: 10.1093/nar/14.7.3146

PubMed ID: 3877053

Title: Characterization of human blood coagulation factor XII cDNA. Prediction of the primary structure of factor XII and the tertiary structure of beta-factor XIIa.

PubMed ID: 3877053

DOI: 10.1016/s0021-9258(17)38776-8

PubMed ID: 3011063

Title: Characterization of a cDNA coding for human factor XII (Hageman factor).

PubMed ID: 3011063

DOI: 10.1021/bi00355a009

PubMed ID: 3886654

Title: Amino acid sequence of the heavy chain of human alpha-factor XIIa (activated Hageman factor).

PubMed ID: 3886654

DOI: 10.1016/s0021-9258(18)89026-3

PubMed ID: 6604055

Title: Amino acid sequence of human beta-factor XIIa.

PubMed ID: 6604055

DOI: 10.1016/s0021-9258(17)44364-x

PubMed ID: 8528215

Title: The novel acceptor splice site mutation 11396(G-->A) in the factor XII gene causes a truncated transcript in cross-reacting material negative patients.

PubMed ID: 8528215

DOI: 10.1093/hmg/4.7.1235

PubMed ID: 1544894

Title: O-linked fucose is present in the first epidermal growth factor domain of factor XII but not protein C.

PubMed ID: 1544894

DOI: 10.1016/s0021-9258(18)42736-6

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 2882793

Title: Factor XII gene alteration in Hageman trait detected by TaqI restriction enzyme.

PubMed ID: 2882793

PubMed ID: 21304106

Title: Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation.

PubMed ID: 21304106

DOI: 10.1182/blood-2010-07-290551

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 34502392

Title: Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement.

PubMed ID: 34502392

DOI: 10.3390/ijms22179480

PubMed ID: 35460690

Title: Novel salivary antihemostatic activities of long-form D7 proteins from the malaria vector Anopheles gambiae facilitate hematophagy.

PubMed ID: 35460690

DOI: 10.1016/j.jbc.2022.101971

PubMed ID: 23385745

Title: The structure of the FnI-EGF-like tandem domain of coagulation factor XII solved using SIRAS.

PubMed ID: 23385745

DOI: 10.1107/s1744309113000286

PubMed ID: 2510163

Title: Coagulation factor XII (Hageman factor) Washington D.C.: inactive factor XIIa results from Cys-571-->Ser substitution.

PubMed ID: 2510163

DOI: 10.1073/pnas.86.21.8319

PubMed ID: 8049433

Title: Coagulation factor XII Locarno: the functional defect is caused by the amino acid substitution Arg-353-->Pro leading to loss of a kallikrein cleavage site.

PubMed ID: 8049433

PubMed ID: 9354665

Title: Mutations in the human factor XII gene.

PubMed ID: 9354665

PubMed ID: 10361128

Title: Factor XII Tenri, a novel cross-reacting material negative factor XII deficiency, occurs through a proteasome-mediated degradation.

PubMed ID: 10361128

PubMed ID: 11776307

Title: Identification and characterization of two novel mutations (Q421K and R123P) in congenital factor XII deficiency.

PubMed ID: 11776307

PubMed ID: 15205584

Title: Genetic analyses and expression studies identified a novel mutation (W486C) as a molecular basis of congenital coagulation factor XII deficiency.

PubMed ID: 15205584

DOI: 10.1097/01.mbc.0000114447.59147.d1

PubMed ID: 15617741

Title: Factor XII Shizuoka, a novel mutation (Ala392Thr) identified and characterized in a patient with congenital coagulation factor XII deficiency.

PubMed ID: 15617741

DOI: 10.1016/j.thromres.2004.08.027

PubMed ID: 16638441

Title: Missense mutations in the coagulation factor XII (Hageman factor) gene in hereditary angioedema with normal C1 inhibitor.

PubMed ID: 16638441

DOI: 10.1016/j.bbrc.2006.03.092

PubMed ID: 17186468

Title: Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III.

PubMed ID: 17186468

DOI: 10.1086/509899

Sequence Information:

  • Length: 615
  • Mass: 67792
  • Checksum: F5B861BF635EB480
  • Sequence:
    • MRALLLLGFL LVSLESTLSI PPWEAPKEHK YKAEEHTVVL TVTGEPCHFP FQYHRQLYHK 
CTHKGRPGPQ PWCATTPNFD QDQRWGYCLE PKKVKDHCSK HSPCQKGGTC VNMPSGPHCL 
CPQHLTGNHC QKEKCFEPQL LRFFHKNEIW YRTEQAAVAR CQCKGPDAHC QRLASQACRT 
NPCLHGGRCL EVEGHRLCHC PVGYTGAFCD VDTKASCYDG RGLSYRGLAR TTLSGAPCQP 
WASEATYRNV TAEQARNWGL GGHAFCRNPD NDIRPWCFVL NRDRLSWEYC DLAQCQTPTQ 
AAPPTPVSPR LHVPLMPAQP APPKPQPTTR TPPQSQTPGA LPAKREQPPS LTRNGPLSCG 
QRLRKSLSSM TRVVGGLVAL RGAHPYIAAL YWGHSFCAGS LIAPCWVLTA AHCLQDRPAP 
EDLTVVLGQE RRNHSCEPCQ TLAVRSYRLH EAFSPVSYQH DLALLRLQED ADGSCALLSP 
YVQPVCLPSG AARPSETTLC QVAGWGHQFE GAEEYASFLQ EAQVPFLSLE RCSAPDVHGS 
SILPGMLCAG FLEGGTDACQ GDSGGPLVCE DQAAERRLTL QGIISWGSGC GDRNKPGVYT 
DVAYYLAWIR EHTVS

Genular Protein ID: 1025429362

Symbol: Q8IZZ5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IZZ5

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 5 CTD 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 4 Gene3D 4 InterPro 17 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PIRSF 1 PIRSR 1 PRINTS 3 PROSITE 17 PROSITE-ProRule 3 PeptideAtlas 1 Pfam 5 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 6 SMR 1 SUPFAM 3

Citations:

PubMed ID: 32559765

Title: Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery.

PubMed ID: 32559765

DOI: 10.1182/blood.2020004818

Sequence Information:

  • Length: 615
  • Mass: 67735
  • Checksum: 030508870A0C7EDB
  • Sequence:
    • MRALLLLGFL LVSLESTLSI PPWEAPKEHK YKAEEHTVVL TVTGEPCHFP FQYHRQLYHK 
CTHKGRPGPQ PWCATTPNFD QDQRWGYCLE PKKVKDHCSK HSPCQKGGTC VNMPSGPHCL 
CPQHLTGNHC QKEKCFEPQL LRFFHKNEIW YRTEQAAVAR CQCKGPDAHC QRLASQACRT 
NPCLHGGRCL EVEGHRLCHC PVGYTGPFCD VDTKASCYDG RGLSYRGLAR TTLSGAPCQP 
WASEATYRNV TAEQARNWGL GGHAFCRNPD NDIRPWCFVL NRDRLSWEYC DLAQCQTPTQ 
AAPPTPVSPR LHVPLMPAQP APPKPQPTTR TPPQSQTPGA LPAKREQPPS LTRNGPLSCG 
QRLRKSLSSM TRVVGGLVAL RGAHPYIAAL YWGHSFCAGS LIAPCWVLTA AHCLQDRPAP 
EDLTVVLGQE RRNHSCEPCQ TLAVRSYRLH EAFSPVSYQH DLALLRLQED ADGSCALLSP 
YVQPVCLPSG AARPSETTLC QVAGCGHQFE GAEEYASFLQ EAQVPFLSLE RCSAPDVHGS 
SILPGMLCAG FLEGGTDACQ GDSGGPLVCE DQAAERRLTL QGIISWGSGC GDRNKPGVYT 
DVAYYLAWIR EHTVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.