Details for: JMJD7 PLA2G4B

Gene ID: 8681

Symbol: JMJD7 PLA2G4B

Ensembl ID: ENSG00000168970

Description: JMJD7-PLA2G4B readthrough

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 8.6152
    Cell Significance Index: -3.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 5.6472
    Cell Significance Index: 117.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 3.5716
    Cell Significance Index: -3.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.5639
    Cell Significance Index: 64.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6808
    Cell Significance Index: 129.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6643
    Cell Significance Index: 65.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6190
    Cell Significance Index: 13.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4513
    Cell Significance Index: 407.4800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3849
    Cell Significance Index: 5.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3567
    Cell Significance Index: 18.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3163
    Cell Significance Index: 51.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2424
    Cell Significance Index: 26.3700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.2272
    Cell Significance Index: 3.1900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.2179
    Cell Significance Index: 2.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1231
    Cell Significance Index: 6.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1208
    Cell Significance Index: 3.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1104
    Cell Significance Index: 6.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1011
    Cell Significance Index: 7.0000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0900
    Cell Significance Index: 1.2000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0656
    Cell Significance Index: 0.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0468
    Cell Significance Index: 2.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0340
    Cell Significance Index: 0.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0338
    Cell Significance Index: 0.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0285
    Cell Significance Index: 1.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0216
    Cell Significance Index: 0.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0046
    Cell Significance Index: 1.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0032
    Cell Significance Index: 1.4300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0028
    Cell Significance Index: -0.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0032
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0041
    Cell Significance Index: -7.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0048
    Cell Significance Index: -7.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0055
    Cell Significance Index: -0.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0056
    Cell Significance Index: -7.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0057
    Cell Significance Index: -4.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0059
    Cell Significance Index: -3.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0065
    Cell Significance Index: -3.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0068
    Cell Significance Index: -5.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0072
    Cell Significance Index: -0.9300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0077
    Cell Significance Index: -0.1100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0087
    Cell Significance Index: -0.0900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0088
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0094
    Cell Significance Index: -6.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0110
    Cell Significance Index: -0.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0112
    Cell Significance Index: -5.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0112
    Cell Significance Index: -6.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0143
    Cell Significance Index: -0.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0144
    Cell Significance Index: -2.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0178
    Cell Significance Index: -0.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0179
    Cell Significance Index: -1.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0199
    Cell Significance Index: -0.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0228
    Cell Significance Index: -4.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0246
    Cell Significance Index: -3.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0250
    Cell Significance Index: -0.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0298
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0312
    Cell Significance Index: -5.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0322
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0360
    Cell Significance Index: -4.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0377
    Cell Significance Index: -3.8500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0396
    Cell Significance Index: -0.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0397
    Cell Significance Index: -5.4500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0407
    Cell Significance Index: -0.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0446
    Cell Significance Index: -0.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0505
    Cell Significance Index: -3.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0506
    Cell Significance Index: -1.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0535
    Cell Significance Index: -1.1200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0547
    Cell Significance Index: -2.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0555
    Cell Significance Index: -5.7800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0595
    Cell Significance Index: -1.2100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0642
    Cell Significance Index: -1.2800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0642
    Cell Significance Index: -1.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0685
    Cell Significance Index: -1.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0748
    Cell Significance Index: -1.4600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0784
    Cell Significance Index: -1.3200
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0841
    Cell Significance Index: -0.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0849
    Cell Significance Index: -5.7100
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0851
    Cell Significance Index: -1.0100
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0852
    Cell Significance Index: -1.0200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0896
    Cell Significance Index: -1.4400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0908
    Cell Significance Index: -1.3400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0918
    Cell Significance Index: -1.0000
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0956
    Cell Significance Index: -0.8500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0957
    Cell Significance Index: -1.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0962
    Cell Significance Index: -3.3700
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1015
    Cell Significance Index: -1.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1027
    Cell Significance Index: -3.5700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1039
    Cell Significance Index: -2.5900
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1044
    Cell Significance Index: -1.4300
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.1058
    Cell Significance Index: -1.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1063
    Cell Significance Index: -5.5800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1085
    Cell Significance Index: -1.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1107
    Cell Significance Index: -2.9600
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1111
    Cell Significance Index: -1.1900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1120
    Cell Significance Index: -0.7300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.1120
    Cell Significance Index: -0.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1139
    Cell Significance Index: -3.7300
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.1157
    Cell Significance Index: -1.0500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1169
    Cell Significance Index: -1.7800
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.1180
    Cell Significance Index: -1.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **JMJD7-PLA2G4B readthrough:** A novel gene expression phenomenon where PLA2G4B is aberrantly expressed in the context of the JMJD7 gene. 2. **Significant expression in various cell types:** PLA2G4B is expressed in blood vessel endothelial cells, kidney proximal convoluted tubule epithelial cells, intestinal crypt stem cells, early T lineage precursors, colon goblet cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and tuft cells of the colon. 3. **Tissue specificity:** The expression of PLA2G4B is restricted to specific tissue types, suggesting a specialized role in maintaining tissue homeostasis and immune function. **Pathways and Functions:** 1. **Lipid metabolism:** PLA2G4B is involved in the regulation of lipid metabolism, specifically in the hydrolysis of phospholipids and the production of lysophospholipids. 2. **Immune function:** The expression of PLA2G4B in immune cells, such as T lineage precursors and goblet cells, suggests a role in modulating immune responses and maintaining epithelial barrier function. 3. **Cell signaling:** PLA2G4B may participate in cell signaling pathways, including the regulation of G-protein coupled receptor signaling and the modulation of ion channels. 4. **Tissue homeostasis:** The expression of PLA2G4B in various tissue types suggests a role in maintaining tissue homeostasis, including the regulation of cell proliferation, differentiation, and survival. **Clinical Significance:** 1. **Immunological disorders:** The aberrant expression of PLA2G4B in immune cells may contribute to the pathogenesis of immunological disorders, such as autoimmune diseases and inflammatory conditions. 2. **Cancer:** The expression of PLA2G4B in tumor cells may influence cancer progression and metastasis. 3. **Neurological disorders:** The expression of PLA2G4B in cerebral cortex GABAergic interneurons and forebrain radial glial cells suggests a role in the pathogenesis of neurological disorders, such as epilepsy and neurodegenerative diseases. 4. **Pharmacological applications:** The identification of PLA2G4B as a novel gene expression phenomenon has implications for the development of novel therapeutic strategies, including the targeting of PLA2G4B for the treatment of immunological and neurological disorders. In conclusion, the JMJD7-PLA2G4B readthrough is a novel gene expression phenomenon that highlights the complex and dynamic nature of gene regulation in human tissue. Further research is necessary to fully elucidate the functional significance of PLA2G4B and its role in maintaining tissue homeostasis and immune function.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.