Details for: FAM156A

Gene ID: 29057

Symbol: FAM156A

Ensembl ID: ENSG00000268350

Description: family with sequence similarity 156 member A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.8942
    Cell Significance Index: -12.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8522
    Cell Significance Index: 32.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8346
    Cell Significance Index: 36.9200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.6698
    Cell Significance Index: 9.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6656
    Cell Significance Index: 133.5100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.5447
    Cell Significance Index: 3.3700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.5382
    Cell Significance Index: 7.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3085
    Cell Significance Index: 110.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2774
    Cell Significance Index: 55.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2444
    Cell Significance Index: 15.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2174
    Cell Significance Index: 16.6800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.2011
    Cell Significance Index: 6.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1907
    Cell Significance Index: 12.8300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1801
    Cell Significance Index: 4.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1686
    Cell Significance Index: 4.8100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1426
    Cell Significance Index: 2.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1222
    Cell Significance Index: 6.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1101
    Cell Significance Index: 2.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0598
    Cell Significance Index: 1.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0574
    Cell Significance Index: 31.3300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.0526
    Cell Significance Index: 0.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0444
    Cell Significance Index: 83.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0403
    Cell Significance Index: 0.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0341
    Cell Significance Index: 46.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0303
    Cell Significance Index: 46.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0251
    Cell Significance Index: 15.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0243
    Cell Significance Index: 44.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0174
    Cell Significance Index: 7.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0162
    Cell Significance Index: 2.9200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0139
    Cell Significance Index: 0.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0092
    Cell Significance Index: 0.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0021
    Cell Significance Index: -0.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0028
    Cell Significance Index: -0.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0094
    Cell Significance Index: -0.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0105
    Cell Significance Index: -1.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0112
    Cell Significance Index: -8.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0137
    Cell Significance Index: -10.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0185
    Cell Significance Index: -10.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0188
    Cell Significance Index: -2.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0303
    Cell Significance Index: -13.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0329
    Cell Significance Index: -4.0500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0463
    Cell Significance Index: -0.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0484
    Cell Significance Index: -5.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0498
    Cell Significance Index: -10.4900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0512
    Cell Significance Index: -0.6900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0539
    Cell Significance Index: -2.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0570
    Cell Significance Index: -9.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0627
    Cell Significance Index: -6.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0758
    Cell Significance Index: -7.8900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0772
    Cell Significance Index: -1.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0797
    Cell Significance Index: -8.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0865
    Cell Significance Index: -8.8400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0887
    Cell Significance Index: -1.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0945
    Cell Significance Index: -10.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0993
    Cell Significance Index: -2.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1030
    Cell Significance Index: -12.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1103
    Cell Significance Index: -6.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1189
    Cell Significance Index: -3.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1204
    Cell Significance Index: -8.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1228
    Cell Significance Index: -3.2300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1234
    Cell Significance Index: -2.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1291
    Cell Significance Index: -5.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1450
    Cell Significance Index: -4.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1479
    Cell Significance Index: -9.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1485
    Cell Significance Index: -4.7300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1579
    Cell Significance Index: -3.1700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1628
    Cell Significance Index: -2.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1659
    Cell Significance Index: -10.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1666
    Cell Significance Index: -7.8300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1689
    Cell Significance Index: -2.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1697
    Cell Significance Index: -2.4300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1805
    Cell Significance Index: -3.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1914
    Cell Significance Index: -13.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1938
    Cell Significance Index: -6.7900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2015
    Cell Significance Index: -1.9100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2041
    Cell Significance Index: -4.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2044
    Cell Significance Index: -12.8800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2078
    Cell Significance Index: -4.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2141
    Cell Significance Index: -11.2400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2147
    Cell Significance Index: -2.7100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2185
    Cell Significance Index: -5.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2225
    Cell Significance Index: -11.5600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2361
    Cell Significance Index: -5.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2439
    Cell Significance Index: -3.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2514
    Cell Significance Index: -8.8400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2538
    Cell Significance Index: -6.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2604
    Cell Significance Index: -6.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2757
    Cell Significance Index: -9.5800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2791
    Cell Significance Index: -3.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2908
    Cell Significance Index: -13.5600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3107
    Cell Significance Index: -7.5800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3182
    Cell Significance Index: -4.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3211
    Cell Significance Index: -10.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3317
    Cell Significance Index: -9.7700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3354
    Cell Significance Index: -4.1600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3401
    Cell Significance Index: -6.9200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3484
    Cell Significance Index: -6.8600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3543
    Cell Significance Index: -4.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3560
    Cell Significance Index: -10.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3578
    Cell Significance Index: -10.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FAM156A is a non-coding gene that is part of the family with sequence similarity 156 (FAM) family. The gene consists of 12 exons and is located on chromosome 14q24.1. FAM156A is a pseudogene, meaning that it does not encode a protein but instead produces a non-functional RNA that can be used as a decoy for microRNAs. Despite its non-coding nature, FAM156A has been shown to play a role in regulating gene expression through various mechanisms, including transcriptional regulation and epigenetic modification. FAM156A is also known as FAM156B, and the two genes are thought to be pseudogenes that arose from a common ancestral gene. The protein encoded by FAM156B is a member of the FAM family, which is characterized by a conserved domain that is involved in protein-protein interactions. **Pathways and Functions** FAM156A is involved in several biological pathways, including: 1. **Membrane trafficking**: FAM156A has been shown to regulate the trafficking of proteins and lipids within the cell membrane. This involves the interaction with other proteins and the regulation of membrane fluidity and structure. 2. **Methylated histone binding**: FAM156A has been implicated in the regulation of histone modification, which is a key process in gene expression. FAM156A binds to methylated histones, which can either activate or repress gene expression. 3. **Nuclear envelope**: FAM156A has been shown to interact with the nuclear envelope, which is a complex structure that regulates the flow of materials in and out of the nucleus. 4. **Protein binding**: FAM156A has been shown to interact with various proteins, including those involved in cell growth, differentiation, and survival. **Clinical Significance** Dysregulation of FAM156A has been associated with several diseases, including: 1. **Cancer**: FAM156A has been implicated in the development and progression of various types of cancer, including breast, lung, and colon cancer. 2. **Cardiovascular disease**: FAM156A has been shown to play a role in the regulation of cardiovascular function, and its dysregulation has been associated with cardiovascular disease. 3. **Inflammatory disorders**: FAM156A has been implicated in the regulation of immune responses, and its dysregulation has been associated with inflammatory disorders, including rheumatoid arthritis and atherosclerosis. In conclusion, FAM156A is a complex gene that plays a critical role in various cellular processes, including cell growth, differentiation, and survival. Its dysregulation has been associated with several diseases, and further research is needed to fully understand its role in human health and disease.

Genular Protein ID: 2501990343

Symbol: FA156_HUMAN

Name: Protein FAM156A/FAM156B

UniProtKB Accession Codes:

Q8NDB6 B3KQ92 Q5JPL2 Q5JPL3 Q5JPL4 Q5JPL5 Q5JPL6 Q68D17 Q6NVY3 Q9UI49

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 2 Bgee 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 2 CTD 2 ChiTaRS 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 22 ExpressionAtlas 1 GO 3 GeneCards 2 GeneTree 1 GeneWiki 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 IntAct 1 InterPro 1 KEGG 2 MANE-Select 2 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 30 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 2 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16382448

Title: Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome.

PubMed ID: 16382448

DOI: 10.1002/gcc.20298

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 213
  • Mass: 24412
  • Checksum: 185A88E823B5E9FC
  • Sequence:
    • MDPLQKRNPA SPSKSSPMTA AETSQEGPAP SQPSYSEQPM MGLSNLSPGP GPSQAVPLPE 
GLLRQRYREE KTLEERRWER LEFLQRKKAF LRHVRRRHRD HMAPYAVGRE ARISPLGDRS 
QNRFRCECRY CQSHRPNLSG IPGESNRAPH PSSWETLVQG LSGLTLSLGT NQPGPLPEAA 
LQPQETEEKR QRERQQESKI MFQRLLKQWL EEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.