Details for: FCN2

Gene ID: 2220

Symbol: FCN2

Ensembl ID: ENSG00000160339

Description: ficolin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.4871
    Cell Significance Index: 19.6400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.9815
    Cell Significance Index: 18.3900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.0299
    Cell Significance Index: 9.7900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7854
    Cell Significance Index: 19.0300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.3188
    Cell Significance Index: 4.5300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1843
    Cell Significance Index: 2.6500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1293
    Cell Significance Index: 1.6700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0111
    Cell Significance Index: 0.1200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.0042
    Cell Significance Index: 0.0300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0017
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0032
    Cell Significance Index: -0.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0176
    Cell Significance Index: -33.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0228
    Cell Significance Index: -0.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0241
    Cell Significance Index: -15.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0283
    Cell Significance Index: -1.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0394
    Cell Significance Index: -0.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0400
    Cell Significance Index: -73.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0445
    Cell Significance Index: -33.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0480
    Cell Significance Index: -73.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0546
    Cell Significance Index: -74.2200
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0652
    Cell Significance Index: -0.7400
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0655
    Cell Significance Index: -0.7000
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0796
    Cell Significance Index: -0.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0815
    Cell Significance Index: -1.5900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0843
    Cell Significance Index: -0.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0864
    Cell Significance Index: -15.5800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0889
    Cell Significance Index: -0.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0892
    Cell Significance Index: -17.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0893
    Cell Significance Index: -1.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1061
    Cell Significance Index: -15.4200
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1066
    Cell Significance Index: -0.7100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1194
    Cell Significance Index: -0.9500
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1210
    Cell Significance Index: -1.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1255
    Cell Significance Index: -15.4300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1276
    Cell Significance Index: -0.7900
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1281
    Cell Significance Index: -1.6400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1285
    Cell Significance Index: -1.4900
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1331
    Cell Significance Index: -1.5400
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.1413
    Cell Significance Index: -1.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1473
    Cell Significance Index: -29.2300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1571
    Cell Significance Index: -1.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1720
    Cell Significance Index: -29.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1780
    Cell Significance Index: -18.1900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1814
    Cell Significance Index: -1.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1845
    Cell Significance Index: -8.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1938
    Cell Significance Index: -26.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2333
    Cell Significance Index: -26.7300
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.2362
    Cell Significance Index: -1.1300
  • Cell Name: metallothionein-positive alveolar macrophage (CL4033042)
    Fold Change: -0.2538
    Cell Significance Index: -1.5400
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.2626
    Cell Significance Index: -1.6200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3939
    Cell Significance Index: -6.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4390
    Cell Significance Index: -19.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4645
    Cell Significance Index: -31.2300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.5208
    Cell Significance Index: -7.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5353
    Cell Significance Index: -69.1600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.5432
    Cell Significance Index: -10.8300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.5436
    Cell Significance Index: -7.9500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.5537
    Cell Significance Index: -7.9400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.5592
    Cell Significance Index: -5.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5677
    Cell Significance Index: -16.7200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6033
    Cell Significance Index: -15.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6543
    Cell Significance Index: -22.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6624
    Cell Significance Index: -31.1300
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.6799
    Cell Significance Index: -1.5700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6823
    Cell Significance Index: -13.4300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.6828
    Cell Significance Index: -7.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6972
    Cell Significance Index: -22.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7127
    Cell Significance Index: -22.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7312
    Cell Significance Index: -14.6800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.7760
    Cell Significance Index: -10.7300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.7836
    Cell Significance Index: -6.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7908
    Cell Significance Index: -21.1900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8531
    Cell Significance Index: -14.7500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.9018
    Cell Significance Index: -11.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.9241
    Cell Significance Index: -68.8700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9322
    Cell Significance Index: -20.1400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9328
    Cell Significance Index: -18.4500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9824
    Cell Significance Index: -21.5100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.0680
    Cell Significance Index: -17.9900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.0711
    Cell Significance Index: -15.8100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.0727
    Cell Significance Index: -27.3300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -1.0884
    Cell Significance Index: -11.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0947
    Cell Significance Index: -31.2400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -1.1075
    Cell Significance Index: -15.3600
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: -1.1151
    Cell Significance Index: -0.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.1301
    Cell Significance Index: -42.8000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -1.1327
    Cell Significance Index: -12.5500
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -1.1362
    Cell Significance Index: -11.3700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.1383
    Cell Significance Index: -22.2600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -1.1575
    Cell Significance Index: -14.8700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -1.1921
    Cell Significance Index: -17.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.2015
    Cell Significance Index: -32.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.2034
    Cell Significance Index: -25.5400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.2314
    Cell Significance Index: -25.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.2356
    Cell Significance Index: -32.4900
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -1.2363
    Cell Significance Index: -12.1000
  • Cell Name: T cell (CL0000084)
    Fold Change: -1.2544
    Cell Significance Index: -14.8100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -1.2907
    Cell Significance Index: -16.3300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -1.2929
    Cell Significance Index: -17.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Ficolin 2 exhibits several key characteristics that enable it to perform its immune functions effectively: 1. **Carbohydrate binding**: Ficolin 2 binds to repetitive carbohydrate structures on the surface of pathogens, such as mannans, which are common in gram-positive and gram-negative bacteria. 2. **Lectin pathway activation**: Upon binding to pathogens, ficolin 2 triggers the activation of the lectin pathway of complement, which leads to the formation of C3 convertase and the subsequent opsonization of pathogens. 3. **Opsonization**: Ficolin 2-bound pathogens are recognized by the immune system as targets for phagocytosis, marking them for destruction by immune cells such as neutrophils and macrophages. 4. **Cell surface expression**: Ficolin 2 is expressed on the surface of various cells, including microglial cells, endothelial cells, and granulocyte-monocyte progenitor cells, allowing it to interact with pathogens and other immune cells. **Pathways and Functions** Ficolin 2 is involved in several key pathways and functions: 1. **Lectin pathway of complement activation**: Ficolin 2 triggers the activation of the lectin pathway of complement, which leads to the formation of C3 convertase and the subsequent opsonization of pathogens. 2. **Innate immune response**: Ficolin 2 plays a critical role in the innate immune response, recognizing pathogens and triggering the activation of the complement system. 3. **Defense against gram-negative and gram-positive bacteria**: Ficolin 2 is involved in the recognition and elimination of gram-negative and gram-positive bacteria, including those that cause sepsis and other life-threatening infections. 4. **Recognition of apoptotic cells**: Ficolin 2 can bind to apoptotic cells, marking them for phagocytosis and preventing the release of pro-inflammatory mediators. **Clinical Significance** Dysregulation of ficolin 2 has been implicated in various diseases, including: 1. **Sepsis**: Ficolin 2 deficiency has been associated with increased susceptibility to sepsis, a life-threatening condition characterized by an overwhelming immune response to infection. 2. **Autoimmune disorders**: Ficolin 2 has been implicated in the pathogenesis of autoimmune disorders, such as lupus and rheumatoid arthritis, where dysregulation of the complement system contributes to disease progression. 3. **Infectious diseases**: Ficolin 2 plays a critical role in the recognition and elimination of pathogens, and its dysregulation can contribute to the development of infectious diseases, such as pneumonia and meningitis. 4. **Cancer**: Ficolin 2 has been implicated in the recognition and elimination of tumor cells, and its dysregulation may contribute to cancer progression. In summary, ficolin 2 is a critical component of the innate immune system that plays a pivotal role in the recognition and elimination of pathogens. Its dysregulation has been implicated in various diseases, highlighting the importance of ficolin 2 in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 1263134108

Symbol: FCN2_HUMAN

Name: Ficolin-2

UniProtKB Accession Codes:

Q15485 A6NFG7 A8K478 Q6IS69 Q7M4P4 Q9UC57

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8884275

Title: Cloning and characterization of the human lectin P35 gene and its related gene.

PubMed ID: 8884275

DOI: 10.1006/geno.1996.0497

PubMed ID: 8576206

Title: A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin.

PubMed ID: 8576206

DOI: 10.1074/jbc.271.5.2448

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7498469

Title: Hucolin, a new corticosteroid-binding protein from human plasma with structural similarities to ficolins, transforming growth factor-beta 1-binding proteins.

PubMed ID: 7498469

DOI: 10.1016/0014-5793(95)01205-s

PubMed ID: 8586615

Title: EBP-37, a new elastin-binding protein in human plasma: structural similarity to ficolins, transforming growth factor-beta 1-binding proteins.

PubMed ID: 8586615

DOI: 10.1093/oxfordjournals.jbchem.a124802

PubMed ID: 10679061

Title: Complement-activating complex of ficolin and mannose-binding lectin-associated serine protease.

PubMed ID: 10679061

DOI: 10.4049/jimmunol.164.5.2281

PubMed ID: 23460739

Title: Deciphering complement receptor type 1 interactions with recognition proteins of the lectin complement pathway.

PubMed ID: 23460739

DOI: 10.4049/jimmunol.1202451

PubMed ID: 17215869

Title: Structural insights into the innate immune recognition specificities of L- and H-ficolins.

PubMed ID: 17215869

DOI: 10.1038/sj.emboj.7601500

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 313
  • Mass: 34001
  • Checksum: D363029846CCB3C9
  • Sequence:
    • MELDRAVGVL GAATLLLSFL GMAWALQAAD TCPEVKMVGL EGSDKLTILR GCPGLPGAPG 
PKGEAGTNGK RGERGPPGPP GKAGPPGPNG APGEPQPCLT GPRTCKDLLD RGHFLSGWHT 
IYLPDCRPLT VLCDMDTDGG GWTVFQRRVD GSVDFYRDWA TYKQGFGSRL GEFWLGNDNI 
HALTAQGTSE LRVDLVDFED NYQFAKYRSF KVADEAEKYN LVLGAFVEGS AGDSLTFHNN 
QSFSTKDQDN DLNTGNCAVM FQGAWWYKNC HVSNLNGRYL RGTHGSFANG INWKSGKGYN 
YSYKVSEMKV RPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.