Details for: MOG

Gene ID: 4340

Symbol: MOG

Ensembl ID: ENSG00000204655

Description: myelin oligodendrocyte glycoprotein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.2861
    Cell Significance Index: -6.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.8255
    Cell Significance Index: 90.5000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.2190
    Cell Significance Index: 18.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3346
    Cell Significance Index: 7.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2610
    Cell Significance Index: 15.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2529
    Cell Significance Index: 41.1300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.1231
    Cell Significance Index: 1.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0327
    Cell Significance Index: 0.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0282
    Cell Significance Index: 5.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0244
    Cell Significance Index: 1.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0223
    Cell Significance Index: 8.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0190
    Cell Significance Index: 13.1300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.0109
    Cell Significance Index: 0.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0082
    Cell Significance Index: 0.1800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0071
    Cell Significance Index: 0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0022
    Cell Significance Index: -4.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0040
    Cell Significance Index: -6.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0049
    Cell Significance Index: -0.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0052
    Cell Significance Index: -7.1100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0071
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0084
    Cell Significance Index: -6.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0087
    Cell Significance Index: -6.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0095
    Cell Significance Index: -6.0400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0105
    Cell Significance Index: -0.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0108
    Cell Significance Index: -6.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0113
    Cell Significance Index: -6.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0130
    Cell Significance Index: -5.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0219
    Cell Significance Index: -4.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0224
    Cell Significance Index: -6.4400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0267
    Cell Significance Index: -1.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0286
    Cell Significance Index: -1.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0304
    Cell Significance Index: -6.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0344
    Cell Significance Index: -6.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0374
    Cell Significance Index: -6.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0382
    Cell Significance Index: -5.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0403
    Cell Significance Index: -4.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0450
    Cell Significance Index: -6.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0499
    Cell Significance Index: -5.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0525
    Cell Significance Index: -6.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0540
    Cell Significance Index: -1.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0595
    Cell Significance Index: -6.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0612
    Cell Significance Index: -7.9100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0660
    Cell Significance Index: -1.3700
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.0678
    Cell Significance Index: -0.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0681
    Cell Significance Index: -6.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0773
    Cell Significance Index: -4.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1056
    Cell Significance Index: -7.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1065
    Cell Significance Index: -5.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1124
    Cell Significance Index: -4.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1133
    Cell Significance Index: -5.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1141
    Cell Significance Index: -6.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1145
    Cell Significance Index: -4.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1313
    Cell Significance Index: -6.8400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1364
    Cell Significance Index: -2.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1377
    Cell Significance Index: -2.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1380
    Cell Significance Index: -3.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1404
    Cell Significance Index: -5.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1435
    Cell Significance Index: -4.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1448
    Cell Significance Index: -4.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1462
    Cell Significance Index: -3.9800
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1466
    Cell Significance Index: -1.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1626
    Cell Significance Index: -7.6400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1635
    Cell Significance Index: -3.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1675
    Cell Significance Index: -7.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1867
    Cell Significance Index: -6.5600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1906
    Cell Significance Index: -4.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1918
    Cell Significance Index: -4.0700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1947
    Cell Significance Index: -1.7600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1963
    Cell Significance Index: -1.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1980
    Cell Significance Index: -4.9400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1989
    Cell Significance Index: -2.2600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2039
    Cell Significance Index: -4.4100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2117
    Cell Significance Index: -4.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2169
    Cell Significance Index: -6.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2217
    Cell Significance Index: -3.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2240
    Cell Significance Index: -4.4300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2251
    Cell Significance Index: -4.5800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2252
    Cell Significance Index: -4.7000
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.2273
    Cell Significance Index: -2.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2279
    Cell Significance Index: -4.9900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2344
    Cell Significance Index: -3.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2354
    Cell Significance Index: -8.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2372
    Cell Significance Index: -5.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2398
    Cell Significance Index: -5.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2422
    Cell Significance Index: -5.0700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2426
    Cell Significance Index: -2.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2445
    Cell Significance Index: -6.4300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2474
    Cell Significance Index: -6.3200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2487
    Cell Significance Index: -2.8200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2499
    Cell Significance Index: -4.3200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2512
    Cell Significance Index: -6.4000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2520
    Cell Significance Index: -7.9700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2586
    Cell Significance Index: -5.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2760
    Cell Significance Index: -7.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2761
    Cell Significance Index: -7.9200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2782
    Cell Significance Index: -4.4600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2798
    Cell Significance Index: -4.6100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2818
    Cell Significance Index: -5.5000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2858
    Cell Significance Index: -4.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MOG is a transmembrane glycoprotein consisting of two extracellular domains (ECDs) and two intracellular domains (ICDs). The ECDs are homologous to the complement regulatory proteins, CR1 and CR2, which regulate the complement cascade and prevent excessive inflammation. MOG is also a member of the immunoglobulin superfamily, which indicates its potential role in binding to immune receptors. MOG is primarily expressed on oligodendrocytes, but it is also found on enterocytes, goblet cells, and other cells in the intestinal epithelium. **Pathways and Functions:** MOG is involved in several key pathways, including: 1. **Cell adhesion:** MOG interacts with the integrins and other adhesion molecules to regulate cell-cell interactions and maintain the integrity of the CNS. 2. **Regulation of cytokine production:** MOG modulates the production of pro-inflammatory and anti-inflammatory cytokines, which is essential for maintaining immune homeostasis in the CNS. 3. **T cell receptor signaling pathway:** MOG interacts with T cell receptors to regulate T cell activation and proliferation. 4. **Virus receptor activity:** MOG has been shown to bind to viruses, such as herpes simplex virus, and regulate viral entry into host cells. **Clinical Significance:** MOG has been implicated in several autoimmune diseases, including: 1. **Neuromyelitis optica spectrum disorder (NMOSD):** MOG antibodies have been identified as a diagnostic marker for NMOSD, a chronic and debilitating autoimmune disease affecting the optic nerve and spinal cord. 2. **Multiple sclerosis (MS):** MOG has been shown to be a target antigen in MS, a chronic autoimmune disease affecting the CNS. 3. **Gastrointestinal disorders:** MOG has been implicated in gastrointestinal disorders, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). In conclusion, MOG is a complex glycoprotein that plays a crucial role in maintaining the integrity of the CNS and modulating the immune response. Its dysregulation has been implicated in several autoimmune diseases, highlighting the importance of further research into the mechanisms of MOG-mediated immunity.

Genular Protein ID: 89355654

Symbol: MOG_HUMAN

Name: Myelin-oligodendrocyte glycoprotein

UniProtKB Accession Codes:

Q16653 A6NDR4 A6NNJ9 A8MY31 B0UZR9 E9PGF0 F8W9D5 O00713 O00714 O00715 Q13054 Q13055 Q14855 Q29ZN8 Q56UY0 Q5JNX7 Q5JNY1 Q5JNY2 Q5JNY4 Q5SSB5 Q5SSB6 Q5STL9 Q5STM0 Q5STM1 Q5STM2 Q5STM5 Q5SUK5 Q5SUK7 Q5SUK8 Q5SUK9 Q5SUL0 Q5SUL1 Q8IYG5 Q92891 Q92892 Q92893 Q92894 Q92895 Q93053 Q96KU9 Q96KV0 Q96KV1 Q99605

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 10 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 39 Ensembl 59 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 15 RNAct 1 RefSeq 10 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7790876

Title: Characterization of cDNA and genomic clones encoding human myelin oligodendrocyte glycoprotein.

PubMed ID: 7790876

DOI: 10.1046/j.1471-4159.1995.65010309.x

PubMed ID: 7964757

Title: Characterization and expression of the cDNA coding for the human myelin/oligodendrocyte glycoprotein.

PubMed ID: 7964757

DOI: 10.1046/j.1471-4159.1994.63062353.x

PubMed ID: 8530032

Title: The human myelin oligodendrocyte glycoprotein (MOG) gene: complete nucleotide sequence and structural characterization.

PubMed ID: 8530032

DOI: 10.1006/geno.1995.1137

PubMed ID: 8666381

Title: Structure of the human myelin/oligodendrocyte glycoprotein gene and multiple alternative spliced isoforms.

PubMed ID: 8666381

DOI: 10.1006/geno.1995.9995

PubMed ID: 8915905

Title: Myelin/oligodendrocyte glycoprotein is alternatively spliced in humans but not mice.

PubMed ID: 8915905

DOI: 10.1002/(sici)1097-4547(19961015)46:2<271::aid-jnr16>3.0.co;2-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21880773

Title: Identification of the myelin oligodendrocyte glycoprotein as a cellular receptor for rubella virus.

PubMed ID: 21880773

DOI: 10.1128/jvi.05398-11

PubMed ID: 9210466

Title: A conformational study of the human and rat encephalitogenic myelin oligodendrocyte glycoprotein peptides 35-55.

PubMed ID: 9210466

DOI: 10.1111/j.1432-1033.1997.t01-2-00059.x

PubMed ID: 21907016

Title: A missense mutation in myelin oligodendrocyte glycoprotein as a cause of familial narcolepsy with cataplexy.

PubMed ID: 21907016

DOI: 10.1016/j.ajhg.2011.08.007

Sequence Information:

  • Length: 247
  • Mass: 28193
  • Checksum: 846EBA5D412C080C
  • Sequence:
    • MASLSRPSLP SCLCSFLLLL LLQVSSSYAG QFRVIGPRHP IRALVGDEVE LPCRISPGKN 
ATGMEVGWYR PPFSRVVHLY RNGKDQDGDQ APEYRGRTEL LKDAIGEGKV TLRIRNVRFS 
DEGGFTCFFR DHSYQEEAAM ELKVEDPFYW VSPGVLVLLA VLPVLLLQIT VGLIFLCLQY 
RLRGKLRAEI ENLHRTFDPH FLRVPCWKIT LFVIVPVLGP LVALIICYNW LHRRLAGQFL 
EELRNPF

Genular Protein ID: 1503249015

Symbol: Q5SSB8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5SSB8

Database IDs:

ARBA 3 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 7 GO 2 Gene3D 1 HGNC 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 2 SUPFAM 1 UCSC 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 252
  • Mass: 28633
  • Checksum: 38D840DC80BA808C
  • Sequence:
    • MASLSRPSLP SCLCSFLLLL LLQVSSSYAG QFRVIGPRHP IRALVGDEVE LPCRISPGKN 
ATGMEVGWYR PPFSRVVHLY RNGKDQDGDQ APEYRGRTEL LKDAIGEGKV TLRIRNVRFS 
DEGGFTCFFR DHSYQEEAAM ELKVEDPFYW VSPGVLVLLA VLPVLLLQIT VGLVFLCLQY 
RLRGKLRAEI ENLHRTFDPH FLRVPCWKIT LFVIVPVLGP LVALIICYNW LHRRLAGQFL 
EELLFHLEAL SG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.