Details for: CRHR2

Gene ID: 1395

Symbol: CRHR2

Ensembl ID: ENSG00000106113

Description: corticotropin releasing hormone receptor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.0961
    Cell Significance Index: 13.6000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9904
    Cell Significance Index: 23.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2768
    Cell Significance Index: 54.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0828
    Cell Significance Index: 16.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0621
    Cell Significance Index: 42.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0462
    Cell Significance Index: 2.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0453
    Cell Significance Index: 16.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0019
    Cell Significance Index: -0.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0021
    Cell Significance Index: -3.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0022
    Cell Significance Index: -3.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0032
    Cell Significance Index: -4.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0047
    Cell Significance Index: -3.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0069
    Cell Significance Index: -3.8700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0070
    Cell Significance Index: -0.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0077
    Cell Significance Index: -1.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0077
    Cell Significance Index: -4.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0078
    Cell Significance Index: -4.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0099
    Cell Significance Index: -2.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0108
    Cell Significance Index: -1.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0184
    Cell Significance Index: -0.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0207
    Cell Significance Index: -2.4100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0209
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0209
    Cell Significance Index: -4.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0220
    Cell Significance Index: -0.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0221
    Cell Significance Index: -0.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0265
    Cell Significance Index: -3.8500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0290
    Cell Significance Index: -1.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0310
    Cell Significance Index: -4.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0330
    Cell Significance Index: -4.0600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0348
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0395
    Cell Significance Index: -4.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0412
    Cell Significance Index: -1.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0433
    Cell Significance Index: -4.5100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.0440
    Cell Significance Index: -0.3200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0441
    Cell Significance Index: -0.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0443
    Cell Significance Index: -3.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0443
    Cell Significance Index: -2.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0450
    Cell Significance Index: -0.8900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0482
    Cell Significance Index: -0.7000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0524
    Cell Significance Index: -0.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0528
    Cell Significance Index: -1.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0537
    Cell Significance Index: -1.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0543
    Cell Significance Index: -5.5500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0549
    Cell Significance Index: -0.5700
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0560
    Cell Significance Index: -0.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0579
    Cell Significance Index: -3.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0581
    Cell Significance Index: -3.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0592
    Cell Significance Index: -3.9800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0600
    Cell Significance Index: -0.7000
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0602
    Cell Significance Index: -0.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0617
    Cell Significance Index: -2.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0623
    Cell Significance Index: -3.8200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0644
    Cell Significance Index: -0.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0665
    Cell Significance Index: -0.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0763
    Cell Significance Index: -2.4300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0835
    Cell Significance Index: -2.6400
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0856
    Cell Significance Index: -0.7700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0904
    Cell Significance Index: -1.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0956
    Cell Significance Index: -4.5000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0957
    Cell Significance Index: -0.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0963
    Cell Significance Index: -4.2600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0995
    Cell Significance Index: -2.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1009
    Cell Significance Index: -2.8800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1018
    Cell Significance Index: -1.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1043
    Cell Significance Index: -3.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1062
    Cell Significance Index: -3.7300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.1196
    Cell Significance Index: -0.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1233
    Cell Significance Index: -2.5800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1241
    Cell Significance Index: -0.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1260
    Cell Significance Index: -2.7600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1274
    Cell Significance Index: -2.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1274
    Cell Significance Index: -3.6700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1282
    Cell Significance Index: -1.2200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1304
    Cell Significance Index: -1.7600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1322
    Cell Significance Index: -1.4400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1327
    Cell Significance Index: -1.8200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1468
    Cell Significance Index: -2.5300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1493
    Cell Significance Index: -1.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1552
    Cell Significance Index: -3.8800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1597
    Cell Significance Index: -3.2500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1626
    Cell Significance Index: -3.2000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1645
    Cell Significance Index: -2.4600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1666
    Cell Significance Index: -2.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1678
    Cell Significance Index: -4.8100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1684
    Cell Significance Index: -4.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1719
    Cell Significance Index: -4.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1734
    Cell Significance Index: -4.5600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1743
    Cell Significance Index: -2.2000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1750
    Cell Significance Index: -4.3700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1764
    Cell Significance Index: -3.6600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1771
    Cell Significance Index: -2.3200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1772
    Cell Significance Index: -4.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1788
    Cell Significance Index: -4.7900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1825
    Cell Significance Index: -4.6500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1869
    Cell Significance Index: -2.3300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1873
    Cell Significance Index: -3.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1901
    Cell Significance Index: -5.6000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1910
    Cell Significance Index: -2.4100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1946
    Cell Significance Index: -3.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CRHR2 is a G protein-coupled receptor with seven transmembrane domains, characterized by a high degree of sequence homology with other secretin family receptors. The receptor is activated by corticotropin-releasing hormone (CRH), which binding to the receptor triggers a cascade of downstream signaling events. CRHR2 is also known to interact with other neurotransmitters, such as dopamine and serotonin, and is involved in the regulation of various physiological processes, including the HPA axis, metabolism, and immune function. **Pathways and Functions** CRHR2 is involved in the regulation of various physiological processes, including: 1. **Stress Response**: CRHR2 is activated by CRH, which stimulates the HPA axis and leads to the release of glucocorticoids, such as cortisol and corticosterone. 2. **Metabolism**: CRHR2 is involved in the regulation of glucose and lipid metabolism, and is activated by CRH, which stimulates the release of glucocorticoids that promote lipolysis and gluconeogenesis. 3. **Immune Function**: CRHR2 is expressed on immune cells, such as macrophages and T cells, and is involved in the regulation of immune responses, including the production of cytokines and the activation of immune cells. 4. **Neuroinflammation**: CRHR2 is involved in the regulation of neuroinflammation, and is activated by CRH, which stimulates the release of pro-inflammatory cytokines and the activation of immune cells in the brain. 5. **Synaptic Plasticity**: CRHR2 is involved in the regulation of synaptic plasticity, and is activated by CRH, which stimulates the release of neurotransmitters and the activation of AMPA receptors. **Clinical Significance** CRHR2 has been implicated in various diseases, including: 1. **Stress-Related Disorders**: CRHR2 is involved in the regulation of the HPA axis, and dysregulation of CRHR2 has been implicated in stress-related disorders, such as post-traumatic stress disorder (PTSD) and anxiety disorders. 2. **Metabolic Disorders**: CRHR2 is involved in the regulation of glucose and lipid metabolism, and dysregulation of CRHR2 has been implicated in metabolic disorders, such as obesity and type 2 diabetes. 3. **Cardiovascular Disease**: CRHR2 is involved in the regulation of cardiovascular function, and dysregulation of CRHR2 has been implicated in cardiovascular disease, including hypertension and atherosclerosis. 4. **Neurodegenerative Disorders**: CRHR2 is involved in the regulation of synaptic plasticity, and dysregulation of CRHR2 has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CRHR2 is a crucial regulator of various physiological and pathological processes, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms of CRHR2 and its role in human disease.

Genular Protein ID: 1239763902

Symbol: CRFR2_HUMAN

Name: Corticotropin-releasing factor receptor 2

UniProtKB Accession Codes:

Q13324 B2R967 B3SXS6 B3SXS7 B3SXS8 B3SXT0 F8WA81 O43461 Q4QRJ4 Q99431

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 14 EMDB 3 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRINTS 3 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 3 RefSeq 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8536644

Title: Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid.

PubMed ID: 8536644

DOI: 10.1210/endo.137.1.8536644

PubMed ID: 9717834

Title: Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2gamma receptor.

PubMed ID: 9717834

DOI: 10.1210/mend.12.8.0145

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9199241

Title: A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor.

PubMed ID: 9199241

DOI: 10.1016/s0167-4781(97)00047-x

PubMed ID: 22689579

Title: The Pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization.

PubMed ID: 22689579

DOI: 10.1074/jbc.m112.360594

PubMed ID: 20966082

Title: Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor.

PubMed ID: 20966082

DOI: 10.1074/jbc.m110.186072

Sequence Information:

  • Length: 411
  • Mass: 47688
  • Checksum: 96B99A93594CF07F
  • Sequence:
    • MDAALLHSLL EANCSLALAE ELLLDGWGPP LDPEGPYSYC NTTLDQIGTC WPRSAAGALV 
ERPCPEYFNG VKYNTTRNAY RECLENGTWA SKINYSQCEP ILDDKQRKYD LHYRIALVVN 
YLGHCVSVAA LVAAFLLFLA LRSIRCLRNV IHWNLITTFI LRNVMWFLLQ LVDHEVHESN 
EVWCRCITTI FNYFVVTNFF WMFVEGCYLH TAIVMTYSTE RLRKCLFLFI GWCIPFPIIV 
AWAIGKLYYE NEQCWFGKEP GDLVDYIYQG PIILVLLINF VFLFNIVRIL MTKLRASTTS 
ETIQYRKAVK ATLVLLPLLG ITYMLFFVNP GEDDLSQIMF IYFNSFLQSF QGFFVSVFYC 
FFNGEVRSAV RKRWHRWQDH HSLRVPMARA MSIPTSPTRI SFHSIKQTAA V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.