Details for: CRHR2

Gene ID: 1395

Symbol: CRHR2

Ensembl ID: ENSG00000106113

Description: corticotropin releasing hormone receptor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 5.74
    Marker Score: 3180.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.01
    Marker Score: 4159
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.37
    Marker Score: 1250
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.36
    Marker Score: 2379
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.57
    Marker Score: 14793
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.1
    Marker Score: 7306
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.03
    Marker Score: 684
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.97
    Marker Score: 8335.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.87
    Marker Score: 1799
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.86
    Marker Score: 1632.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 495
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.67
    Marker Score: 10409
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 503
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.62
    Marker Score: 297
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.59
    Marker Score: 943
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.53
    Marker Score: 1070
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.52
    Marker Score: 799
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.5
    Marker Score: 176
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.46
    Marker Score: 240
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.42
    Marker Score: 389
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.42
    Marker Score: 8418.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.38
    Marker Score: 228
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.38
    Marker Score: 119
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.36
    Marker Score: 13541
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.35
    Marker Score: 388
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.34
    Marker Score: 106
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.32
    Marker Score: 193
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.31
    Marker Score: 347
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.3
    Marker Score: 110
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.3
    Marker Score: 229.5
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.29
    Marker Score: 134
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.26
    Marker Score: 247
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.25
    Marker Score: 1013
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 101
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.24
    Marker Score: 382
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.23
    Marker Score: 98
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.22
    Marker Score: 442
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.22
    Marker Score: 511
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.21
    Marker Score: 55
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.21
    Marker Score: 362
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2
    Marker Score: 111.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.2
    Marker Score: 7210
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.18
    Marker Score: 57
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.17
    Marker Score: 162
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.16
    Marker Score: 675
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.16
    Marker Score: 257.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.16
    Marker Score: 1608
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.15
    Marker Score: 321
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.15
    Marker Score: 67
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.15
    Marker Score: 111
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.12
    Marker Score: 1851
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.12
    Marker Score: 7472.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.12
    Marker Score: 46
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.12
    Marker Score: 448
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.11
    Marker Score: 877
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.11
    Marker Score: 42
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.11
    Marker Score: 68
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.11
    Marker Score: 114
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.11
    Marker Score: 107
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.09
    Marker Score: 60
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.09
    Marker Score: 160
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.08
    Marker Score: 741
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.08
    Marker Score: 360
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.08
    Marker Score: 38
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.07
    Marker Score: 93
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.07
    Marker Score: 79
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.07
    Marker Score: 167
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.07
    Marker Score: 24

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Other Information

**Key characteristics:** - The CRHR2 gene is a single-exon gene. - It is located on chromosome 17q21.1. - The protein encoded by the CRHR2 gene is a G protein-coupled receptor. - It is a member of the class b/2 (secretin family receptors). - It is expressed in high levels in the brain. **Pathways and functions:** The CRHR2 gene is involved in a variety of pathways, including the adenylate cyclase-modulating g protein-coupled receptor signaling pathway, the cell surface receptor signaling pathway, and the cellular response to CRH stimulus. CRHR2 is a key regulator of blood pressure. It is expressed in the blood vessels of the brain and is stimulated by CRH released from the pituitary gland. This stimulation of CRHR2 leads to the release of vasopressin, which is a hormone that helps to regulate water balance in the body. **Clinical significance:** Mutations in the CRHR2 gene have been linked to a number of human diseases, including hypertension, diabetes, and obesity. These diseases are caused by mutations that disrupt the function of the CRHR2 protein.

Genular Protein ID: 1239763902

Symbol: CRFR2_HUMAN

Name: Corticotropin-releasing factor receptor 2

UniProtKB Accession Codes:

Q13324 B2R967 B3SXS6 B3SXS7 B3SXS8 B3SXT0 F8WA81 O43461 Q4QRJ4 Q99431

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 14 EMDB 3 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 6 PRINTS 3 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 3 RefSeq 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8536644

Title: Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid.

PubMed ID: 8536644

DOI: 10.1210/endo.137.1.8536644

PubMed ID: 9717834

Title: Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2gamma receptor.

PubMed ID: 9717834

DOI: 10.1210/mend.12.8.0145

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9199241

Title: A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor.

PubMed ID: 9199241

DOI: 10.1016/s0167-4781(97)00047-x

PubMed ID: 22689579

Title: The Pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization.

PubMed ID: 22689579

DOI: 10.1074/jbc.m112.360594

PubMed ID: 20966082

Title: Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor.

PubMed ID: 20966082

DOI: 10.1074/jbc.m110.186072

Sequence Information:

  • Length: 411
  • Mass: 47688
  • Checksum: 96B99A93594CF07F
  • Sequence:
    • MDAALLHSLL EANCSLALAE ELLLDGWGPP LDPEGPYSYC NTTLDQIGTC WPRSAAGALV 
ERPCPEYFNG VKYNTTRNAY RECLENGTWA SKINYSQCEP ILDDKQRKYD LHYRIALVVN 
YLGHCVSVAA LVAAFLLFLA LRSIRCLRNV IHWNLITTFI LRNVMWFLLQ LVDHEVHESN 
EVWCRCITTI FNYFVVTNFF WMFVEGCYLH TAIVMTYSTE RLRKCLFLFI GWCIPFPIIV 
AWAIGKLYYE NEQCWFGKEP GDLVDYIYQG PIILVLLINF VFLFNIVRIL MTKLRASTTS 
ETIQYRKAVK ATLVLLPLLG ITYMLFFVNP GEDDLSQIMF IYFNSFLQSF QGFFVSVFYC 
FFNGEVRSAV RKRWHRWQDH HSLRVPMARA MSIPTSPTRI SFHSIKQTAA V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.