Details for: DKKL1

Gene ID: 27120

Symbol: DKKL1

Ensembl ID: ENSG00000104901

Description: dickkopf like acrosomal protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.2860
    Cell Significance Index: -11.7300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 4.4027
    Cell Significance Index: 62.5600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.8465
    Cell Significance Index: 19.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.4617
    Cell Significance Index: 89.6200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.4010
    Cell Significance Index: 5.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2892
    Cell Significance Index: 55.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2599
    Cell Significance Index: 5.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1888
    Cell Significance Index: 170.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1302
    Cell Significance Index: 90.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0383
    Cell Significance Index: 4.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0200
    Cell Significance Index: 3.2600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0129
    Cell Significance Index: 0.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0006
    Cell Significance Index: -0.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0015
    Cell Significance Index: -0.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0043
    Cell Significance Index: -0.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0071
    Cell Significance Index: -0.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0076
    Cell Significance Index: -0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0133
    Cell Significance Index: -25.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0168
    Cell Significance Index: -0.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0198
    Cell Significance Index: -14.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0215
    Cell Significance Index: -13.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0230
    Cell Significance Index: -2.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0344
    Cell Significance Index: -25.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0396
    Cell Significance Index: -29.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0437
    Cell Significance Index: -23.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0454
    Cell Significance Index: -83.7100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0472
    Cell Significance Index: -0.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0503
    Cell Significance Index: -14.4700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0520
    Cell Significance Index: -0.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0541
    Cell Significance Index: -83.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0579
    Cell Significance Index: -10.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0620
    Cell Significance Index: -84.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0643
    Cell Significance Index: -23.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0643
    Cell Significance Index: -0.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0657
    Cell Significance Index: -37.0400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0667
    Cell Significance Index: -1.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0670
    Cell Significance Index: -30.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0695
    Cell Significance Index: -3.5100
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0710
    Cell Significance Index: -0.7400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0720
    Cell Significance Index: -3.1300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0730
    Cell Significance Index: -0.4900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0803
    Cell Significance Index: -3.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0870
    Cell Significance Index: -10.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0934
    Cell Significance Index: -18.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0980
    Cell Significance Index: -11.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0982
    Cell Significance Index: -19.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1010
    Cell Significance Index: -2.9100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1082
    Cell Significance Index: -0.6400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1175
    Cell Significance Index: -0.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1180
    Cell Significance Index: -6.1300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1214
    Cell Significance Index: -1.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1268
    Cell Significance Index: -4.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1270
    Cell Significance Index: -8.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1289
    Cell Significance Index: -80.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1324
    Cell Significance Index: -3.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1328
    Cell Significance Index: -22.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1354
    Cell Significance Index: -13.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1363
    Cell Significance Index: -17.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1454
    Cell Significance Index: -30.6300
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1465
    Cell Significance Index: -1.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1507
    Cell Significance Index: -21.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1542
    Cell Significance Index: -7.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1635
    Cell Significance Index: -4.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1655
    Cell Significance Index: -8.6200
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1729
    Cell Significance Index: -2.4600
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1769
    Cell Significance Index: -1.8900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1775
    Cell Significance Index: -3.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2041
    Cell Significance Index: -23.3800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2233
    Cell Significance Index: -3.2600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2237
    Cell Significance Index: -13.4300
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.2264
    Cell Significance Index: -3.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2399
    Cell Significance Index: -17.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2421
    Cell Significance Index: -33.2500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2439
    Cell Significance Index: -3.8700
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.2473
    Cell Significance Index: -1.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2508
    Cell Significance Index: -16.1800
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.2533
    Cell Significance Index: -1.5800
  • Cell Name: contractile cell (CL0000183)
    Fold Change: -0.2610
    Cell Significance Index: -0.5100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2614
    Cell Significance Index: -3.9700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.2709
    Cell Significance Index: -3.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2731
    Cell Significance Index: -5.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2765
    Cell Significance Index: -28.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2964
    Cell Significance Index: -10.3000
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.2989
    Cell Significance Index: -1.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3245
    Cell Significance Index: -5.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3290
    Cell Significance Index: -9.6900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3408
    Cell Significance Index: -5.0300
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.3441
    Cell Significance Index: -3.5600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.3515
    Cell Significance Index: -4.7800
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: -0.3597
    Cell Significance Index: -0.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3755
    Cell Significance Index: -23.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3756
    Cell Significance Index: -25.2600
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.3802
    Cell Significance Index: -4.2000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.3850
    Cell Significance Index: -6.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3866
    Cell Significance Index: -18.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3886
    Cell Significance Index: -8.4200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.4104
    Cell Significance Index: -4.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4167
    Cell Significance Index: -31.9800
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.4331
    Cell Significance Index: -0.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4413
    Cell Significance Index: -9.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DKKL1 is a protein encoded by the ENSG00000104901 gene and is composed of 442 amino acids. It belongs to the dickkopf family of proteins, which are known for their involvement in Wnt signaling pathways. DKKL1 is expressed in various cell types, including type B pancreatic cells, conventional dendritic cells, colon goblet cells, and intestinal crypt stem cells. Its expression is also observed in other tissues, such as the heart, kidney, and lungs. **Pathways and Functions:** DKKL1 is implicated in multiple signaling pathways, including: 1. **Canonical Wnt signaling pathway**: DKKL1 acts as a negative regulator of this pathway, which is crucial for cell proliferation, differentiation, and survival. 2. **Acrosomal vesicle formation**: DKKL1 is involved in the formation of acrosomal vesicles, which are essential for sperm-egg interaction during fertilization. 3. **Apoptosis regulation**: DKKL1 promotes apoptotic processes, which are vital for eliminating damaged or unwanted cells. 4. **Fat cell differentiation**: DKKL1 is involved in the regulation of adipogenesis, the process by which precursor cells differentiate into adipocytes (fat cells). 5. **Receptor antagonist activity**: DKKL1 can act as a receptor antagonist, modulating the activity of various receptors, including those involved in Wnt signaling. **Clinical Significance:** DKKL1 has been implicated in various diseases, including: 1. **Cancer**: DKKL1 is overexpressed in several types of cancer, including lung, breast, and colon cancer, suggesting its potential as a therapeutic target. 2. **Autoimmune disorders**: DKKL1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it may contribute to immune dysregulation. 3. **Metabolic disorders**: DKKL1 is involved in the regulation of glucose and lipid metabolism, making it a potential target for the treatment of metabolic disorders, such as type 2 diabetes and obesity. 4. **Neurological disorders**: DKKL1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may contribute to neuronal dysfunction and degeneration. In conclusion, DKKL1 is a complex protein that plays a vital role in various biological processes, including immune regulation, cell differentiation, and development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and therapeutic potential.

Genular Protein ID: 2187751152

Symbol: DKKL1_HUMAN

Name: Cancer/testis antigen 34

UniProtKB Accession Codes:

Q9UK85

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10570958

Title: Functional and structural diversity of the human Dickkopf gene family.

PubMed ID: 10570958

DOI: 10.1016/s0378-1119(99)00365-0

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22817830

Title: Developmental expression and function of DKKL1/Dkkl1 in humans and mice.

PubMed ID: 22817830

DOI: 10.1186/1477-7827-10-51

Sequence Information:

  • Length: 242
  • Mass: 27007
  • Checksum: 8811A4460CB5389E
  • Sequence:
    • MGEASPPAPA RRHLLVLLLL LSTLVIPSAA APIHDADAQE SSLGLTGLQS LLQGFSRLFL 
KGNLLRGIDS LFSAPMDFRG LPGNYHKEEN QEHQLGNNTL SSHLQIDKMT DNKTGEVLIS 
ENVVASIQPA EGSFEGDLKV PRMEEKEALV PIQKATDSFH TELHPRVAFW IIKLPRRRSH 
QDALEGGHWL SEKRHRLQAI RDGLRKGTHK DVLEEGTESS SHSRLSPRKT HLLYILRPSR 
QL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.