Details for: AGAP5

Gene ID: 729092

Symbol: AGAP5

Ensembl ID: ENSG00000172650

Description: ArfGAP with GTPase domain, ankyrin repeat and PH domain 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.5535
    Cell Significance Index: -8.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.7353
    Cell Significance Index: -8.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.5265
    Cell Significance Index: 80.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3897
    Cell Significance Index: -5.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7335
    Cell Significance Index: 139.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4551
    Cell Significance Index: 45.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3865
    Cell Significance Index: 349.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3425
    Cell Significance Index: 7.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2928
    Cell Significance Index: 58.7400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.2753
    Cell Significance Index: 2.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2477
    Cell Significance Index: 40.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2361
    Cell Significance Index: 6.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2333
    Cell Significance Index: 25.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2032
    Cell Significance Index: 5.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1919
    Cell Significance Index: 11.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1820
    Cell Significance Index: 36.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1485
    Cell Significance Index: 11.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1462
    Cell Significance Index: 52.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1260
    Cell Significance Index: 3.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1085
    Cell Significance Index: 7.5100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1057
    Cell Significance Index: 1.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0996
    Cell Significance Index: 2.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0895
    Cell Significance Index: 16.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0732
    Cell Significance Index: 1.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0710
    Cell Significance Index: 8.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0267
    Cell Significance Index: 14.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0166
    Cell Significance Index: 0.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0053
    Cell Significance Index: 0.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0009
    Cell Significance Index: 0.4100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0003
    Cell Significance Index: 0.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0085
    Cell Significance Index: -1.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0087
    Cell Significance Index: -6.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0094
    Cell Significance Index: -0.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0098
    Cell Significance Index: -1.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0127
    Cell Significance Index: -9.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0142
    Cell Significance Index: -9.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0148
    Cell Significance Index: -1.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0155
    Cell Significance Index: -28.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0188
    Cell Significance Index: -11.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0197
    Cell Significance Index: -14.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0200
    Cell Significance Index: -9.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0225
    Cell Significance Index: -0.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0264
    Cell Significance Index: -14.9000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0287
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0305
    Cell Significance Index: -5.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0382
    Cell Significance Index: -2.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0424
    Cell Significance Index: -12.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0600
    Cell Significance Index: -3.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0638
    Cell Significance Index: -2.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0666
    Cell Significance Index: -6.8000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0669
    Cell Significance Index: -0.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0673
    Cell Significance Index: -8.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0771
    Cell Significance Index: -5.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0771
    Cell Significance Index: -3.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0791
    Cell Significance Index: -16.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0792
    Cell Significance Index: -9.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0795
    Cell Significance Index: -1.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0819
    Cell Significance Index: -3.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0865
    Cell Significance Index: -2.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0939
    Cell Significance Index: -3.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0990
    Cell Significance Index: -6.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1108
    Cell Significance Index: -8.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1108
    Cell Significance Index: -13.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1216
    Cell Significance Index: -6.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1259
    Cell Significance Index: -5.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1412
    Cell Significance Index: -3.0600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1416
    Cell Significance Index: -2.1500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1514
    Cell Significance Index: -2.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1542
    Cell Significance Index: -8.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1635
    Cell Significance Index: -10.3100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1691
    Cell Significance Index: -1.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1738
    Cell Significance Index: -4.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1770
    Cell Significance Index: -6.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1805
    Cell Significance Index: -3.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1868
    Cell Significance Index: -3.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2063
    Cell Significance Index: -10.8300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2121
    Cell Significance Index: -2.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2199
    Cell Significance Index: -3.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2284
    Cell Significance Index: -8.0000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2287
    Cell Significance Index: -3.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2297
    Cell Significance Index: -7.5200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2332
    Cell Significance Index: -3.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2372
    Cell Significance Index: -4.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2452
    Cell Significance Index: -6.6800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2456
    Cell Significance Index: -2.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2565
    Cell Significance Index: -8.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2601
    Cell Significance Index: -7.6600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2668
    Cell Significance Index: -3.7400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2807
    Cell Significance Index: -4.2300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2865
    Cell Significance Index: -4.2300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2923
    Cell Significance Index: -6.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2979
    Cell Significance Index: -8.5400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.2991
    Cell Significance Index: -2.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2994
    Cell Significance Index: -7.1800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2998
    Cell Significance Index: -4.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3129
    Cell Significance Index: -6.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3197
    Cell Significance Index: -9.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3245
    Cell Significance Index: -8.2900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3258
    Cell Significance Index: -6.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3260
    Cell Significance Index: -6.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Multifunctional protein**: AGAP5 possesses a unique combination of domains, including an ArfGAP (ADP-ribosylation factor GTPase activating protein) domain, ankyrin repeat, and a PH (pleckstrin homology) domain. 2. **GTPase regulation**: AGAP5 acts as a GTPase activator, modulating the activity of GTPases, which are essential for various cellular processes, including signaling pathways and protein regulation. 3. **Metal ion binding**: AGAP5 exhibits metal ion binding capabilities, which may contribute to its regulatory functions in cellular processes. 4. **Tissue-specific expression**: AGAP5 is highly expressed in specific cell types, such as retinal cone cells, intestinal crypt stem cells, and cerebral cortex GABAergic interneurons. **Pathways and Functions:** AGAP5 is implicated in several cellular pathways, including: 1. **GTPase activation**: AGAP5 modulates the activity of GTPases, influencing various cellular processes, such as signaling pathways, protein regulation, and membrane trafficking. 2. **Cell signaling**: AGAP5's involvement in GTPase activation and metal ion binding suggests its potential role in cell signaling pathways, including those involved in development, differentiation, and homeostasis. 3. **Membrane trafficking**: The PH domain of AGAP5 may participate in membrane trafficking processes, such as vesicle transport and endocytosis. **Clinical Significance:** AGAP5's involvement in tissue homeostasis and its potential implications in disease states make it an attractive subject for further investigation. Dysregulation of AGAP5 may contribute to various diseases, including: 1. **Neurological disorders**: AGAP5's role in cerebral cortex GABAergic interneurons and its potential involvement in neurological disorders, such as epilepsy or neurodegenerative diseases. 2. **Gastrointestinal diseases**: AGAP5's expression in intestinal crypt stem cells and its potential role in maintaining intestinal homeostasis may contribute to gastrointestinal diseases, such as inflammatory bowel disease or cancer. 3. **Eye diseases**: AGAP5's expression in retinal cone cells and its potential involvement in eye diseases, such as retinitis pigmentosa or age-related macular degeneration. In conclusion, AGAP5 is a complex gene involved in various cellular processes, including GTPase regulation, metal ion binding, and cell signaling pathways. Its tissue-specific expression and potential implications in disease states make it an attractive subject for further investigation, and further studies are needed to elucidate the full significance of AGAP5 in human health and disease.

Genular Protein ID: 2869800740

Symbol: AGAP5_HUMAN

Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5

UniProtKB Accession Codes:

A6NIR3 A8MSN5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 3 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 686
  • Mass: 75492
  • Checksum: C51D1E96C6179B24
  • Sequence:
    • MGNILTCCVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ PAEVTVEVGE 
DLHMHHIRDQ EMPEALEFSL SANPEASTIF QRNSQTDALE FNPSANPEAS TIFQRNSQTD 
VVEIRRSNCT NHVSTERFSQ QYSSCSTIFL DDSTASQHYL TMTIISVTLE IPHHITQRDA 
DRSLSIPDEQ LHSFAVSTVH ITKNRNGGGS LNNYSSSIPS TPSTSQEDPQ FSVPPTANTP 
TPVCKRSMRW SNLFTSEKGS HPDKERKAPE NHADTIGSGR AIPIKQGMLL KRSGKWLKTW 
KKKYVTLCSN GVLTYYSSLG DYMKNIHKKE IDLRTSTIKV PGKWPSLATS ACAPISSSKS 
NGLSKDMDTG LGDSICFSPS ISSTTSPKLN PPPSPHANKK KHLKKKSTNN FMIVSATGQT 
WHFEATTYEE RDAWVQAIQS QILASLQSCE SSKSKSQLTS QSEAMALQSI QNMRGNAHCV 
DYETQNPKWA SLNLGVLMCI ECSGIHRSLG TRLSRVRSLE LDDWPVELRK VMSSIGNDLA 
NSIWEGSSQG QTKPSVKSTR EEKERWIRSK YEEKLFLAPL PCTELSLGQH LLRATADEDL 
QTAILLLAHG SREEVNETCG EGDGCTALHL ACRKGNVVLA QLLIWYGVDV MARDAHGNTA 
LTYARQASSQ ECINVLLQYG CPDECV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.