Details for: ZNF200

Gene ID: 7752

Symbol: ZNF200

Ensembl ID: ENSG00000010539

Description: zinc finger protein 200

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 60.0468
    Cell Significance Index: -9.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 37.8878
    Cell Significance Index: -9.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 21.8799
    Cell Significance Index: -10.3300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.7996
    Cell Significance Index: -8.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.9343
    Cell Significance Index: -8.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.1349
    Cell Significance Index: -10.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5649
    Cell Significance Index: -9.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.5747
    Cell Significance Index: -10.1600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.7923
    Cell Significance Index: 29.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4393
    Cell Significance Index: -3.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9772
    Cell Significance Index: 67.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5572
    Cell Significance Index: 33.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5447
    Cell Significance Index: 491.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4706
    Cell Significance Index: 51.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4403
    Cell Significance Index: 27.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3732
    Cell Significance Index: 60.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2757
    Cell Significance Index: 52.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2248
    Cell Significance Index: 45.1000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.2172
    Cell Significance Index: 1.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2160
    Cell Significance Index: 21.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2088
    Cell Significance Index: 5.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2076
    Cell Significance Index: 41.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1140
    Cell Significance Index: 2.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1081
    Cell Significance Index: 4.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0934
    Cell Significance Index: 2.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0924
    Cell Significance Index: 33.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0825
    Cell Significance Index: 2.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0674
    Cell Significance Index: 12.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0667
    Cell Significance Index: 36.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0655
    Cell Significance Index: 3.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0584
    Cell Significance Index: 7.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0524
    Cell Significance Index: 1.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0518
    Cell Significance Index: 22.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0488
    Cell Significance Index: 33.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0425
    Cell Significance Index: 5.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0404
    Cell Significance Index: 5.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0301
    Cell Significance Index: 0.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0105
    Cell Significance Index: 0.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0071
    Cell Significance Index: 0.3300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0031
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0038
    Cell Significance Index: -7.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0065
    Cell Significance Index: -12.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0069
    Cell Significance Index: -5.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0079
    Cell Significance Index: -0.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0082
    Cell Significance Index: -12.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0097
    Cell Significance Index: -13.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0103
    Cell Significance Index: -6.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0116
    Cell Significance Index: -0.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0118
    Cell Significance Index: -8.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0130
    Cell Significance Index: -9.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0148
    Cell Significance Index: -1.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0156
    Cell Significance Index: -7.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0168
    Cell Significance Index: -9.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0196
    Cell Significance Index: -2.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0250
    Cell Significance Index: -0.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0281
    Cell Significance Index: -8.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0297
    Cell Significance Index: -5.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0341
    Cell Significance Index: -2.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0360
    Cell Significance Index: -4.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0377
    Cell Significance Index: -4.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0399
    Cell Significance Index: -4.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0407
    Cell Significance Index: -2.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0465
    Cell Significance Index: -6.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0472
    Cell Significance Index: -0.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0523
    Cell Significance Index: -3.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0561
    Cell Significance Index: -11.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0570
    Cell Significance Index: -2.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0573
    Cell Significance Index: -4.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0620
    Cell Significance Index: -1.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0634
    Cell Significance Index: -2.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0655
    Cell Significance Index: -3.6800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0668
    Cell Significance Index: -0.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0803
    Cell Significance Index: -1.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0814
    Cell Significance Index: -3.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0821
    Cell Significance Index: -3.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0884
    Cell Significance Index: -1.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0924
    Cell Significance Index: -3.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0975
    Cell Significance Index: -10.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0995
    Cell Significance Index: -6.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1027
    Cell Significance Index: -5.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1073
    Cell Significance Index: -8.5000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1085
    Cell Significance Index: -1.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1106
    Cell Significance Index: -6.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1107
    Cell Significance Index: -3.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1126
    Cell Significance Index: -2.9600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1329
    Cell Significance Index: -2.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1347
    Cell Significance Index: -3.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1429
    Cell Significance Index: -4.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1562
    Cell Significance Index: -3.2700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1601
    Cell Significance Index: -2.2800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1653
    Cell Significance Index: -2.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1748
    Cell Significance Index: -8.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1850
    Cell Significance Index: -5.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1920
    Cell Significance Index: -3.2900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2024
    Cell Significance Index: -3.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2148
    Cell Significance Index: -6.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2164
    Cell Significance Index: -7.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2208
    Cell Significance Index: -7.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2221
    Cell Significance Index: -5.9400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2290
    Cell Significance Index: -2.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain:** ZN200 contains a characteristic zinc finger domain, which is essential for its DNA-binding activity and interaction with target gene promoters. 2. **Transcriptional Regulation:** As a transcription factor, ZN200 regulates gene expression by binding to specific DNA sequences and modulating the activity of RNA polymerase II. 3. **Cellular Expression:** ZN200 is expressed in various cell types, including GABAergic interneurons, radial glial cells, absorptive cells, and intestinal epithelial cells, highlighting its diverse roles in different tissues. 4. **Metal Ion Binding:** ZN200's ability to bind metal ions, such as zinc, is crucial for its stability and function. **Pathways and Functions:** ZN200 is involved in several biological processes, including: 1. **Gene Expression:** ZN200 regulates the expression of target genes involved in cellular differentiation, proliferation, and survival. 2. **Transcriptional Regulation:** ZN200 interacts with RNA polymerase II to modulate transcriptional activity and influence the expression of specific genes. 3. **Cell Signaling:** ZN200 may participate in cell signaling pathways, influencing cellular responses to external stimuli. 4. **Metabolic Processes:** ZN200 is expressed in absorptive cells, suggesting its involvement in metabolic processes, such as nutrient uptake and storage. **Clinical Significance:** ZN200's dysregulation has been implicated in various diseases, including: 1. **Neurological Disorders:** Abnormal expression of ZN200 in GABAergic interneurons has been linked to neurological disorders, such as epilepsy and schizophrenia. 2. **Cancer:** ZN200's role in regulating cell proliferation and survival makes it a potential target for cancer therapy. 3. **Metabolic Disorders:** Alterations in ZN200 expression in absorptive cells may contribute to metabolic disorders, such as diabetes and obesity. In conclusion, ZNF200 is a critical transcription factor that regulates gene expression and cellular processes in various tissues. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 105300583

Symbol: ZN200_HUMAN

Name: Zinc finger protein 200

UniProtKB Accession Codes:

P98182 D3DUB7 D3DUB8 O15361 Q5XKM5 Q7Z5V1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 6 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 10 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9787081

Title: Identification of two Kruppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3.

PubMed ID: 9787081

DOI: 10.1006/geno.1998.5430

PubMed ID: 9288094

Title: A candidate gene for familial Mediterranean fever.

PubMed ID: 9288094

DOI: 10.1038/ng0997-25

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 395
  • Mass: 45534
  • Checksum: 6E0B8FC5702A159A
  • Sequence:
    • MMAAKVVPMP PKPKQSFILR VPPDSKLGQD LLRDATNGPK TIHQLVLEHF LTFLPKPSLV 
QPSQKVKETL VIMKDVSSSL QNRVHPRPLV KLLPKGVQKE QETVSLYLKA NPEELVVFED 
LNVFHCQEEC VSLDPTQQLT SEKEDDSSVG EMMLLAVNGS NPEGEDPERE PVENEDYREK 
SSDDDEMDSS LVSQQPPDNQ EKERLNTSIP QKRKMRNLLV TIENDTPLEE LSKYVDISII 
ALTRNRRTRR WYTCPLCGKQ FNESSYLISH QRTHTGEKPY DCNHCGKSFN HKTNLNKHER 
IHTGEKPYSC SQCGKNFRQN SHRSRHEGIH IREKIFKCPE CGKTFPKNEE FVLHLQSHEA 
ERPYGCKKCG RRFGRLSNCT RHEKTHSACK TRKQK

Genular Protein ID: 2181825354

Symbol: B3KP91_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KP91

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 394
  • Mass: 45489
  • Checksum: 88175FB9C1DC20AA
  • Sequence:
    • MMAAKVVPMP PKPKQSFILR VPPDSKLGQD LLRDATNGPK TIHQLVLEHF LTFLPKPSLV 
QPSQKVKETL VIMKDVSSSL QNRVHPRPLV KLLPKGVQKE QETVSLYLKA NPEELVVFED 
LNVFHCQEEC VSLDPTQQLT SEKEDDSSVG EMMLLVNGSN PEGEDPEREP VENEDYREKS 
SDDDEMDSSL VSQQPPDNQE KERLNTSIPQ KRKMRNLLVT IENDTPLEEL SKYVDISIIA 
LTRNRRTRRW YTCPLCGKQF NESSYLISHQ RTHTGEKPYD CNHCGKIFNH KTNLNKHERI 
HTGEKPYSCS QCGKNFRQNS HRSRHEGIHI REKIFKCPEC GKTFPKNEEF VLHLQSHEAE 
RPYGCKKCGR RFGRLSNCTR HEKTHSACKT RKQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.