Details for: SPRR2F

Gene ID: 6705

Symbol: SPRR2F

Ensembl ID: ENSG00000244094

Description: small proline rich protein 2F

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 28.6591
    Cell Significance Index: 139.3900
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 16.7392
    Cell Significance Index: 77.3200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 5.8138
    Cell Significance Index: 74.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.9260
    Cell Significance Index: 129.5300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 2.8838
    Cell Significance Index: 32.2300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.5157
    Cell Significance Index: 14.7800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.4853
    Cell Significance Index: 6.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4746
    Cell Significance Index: 65.1700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1532
    Cell Significance Index: 2.3700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0640
    Cell Significance Index: 0.9100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0618
    Cell Significance Index: 0.4100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0229
    Cell Significance Index: 0.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0029
    Cell Significance Index: 0.0800
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.0016
    Cell Significance Index: -0.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0082
    Cell Significance Index: -0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0196
    Cell Significance Index: -14.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0218
    Cell Significance Index: -16.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0272
    Cell Significance Index: -15.3400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0289
    Cell Significance Index: -0.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0429
    Cell Significance Index: -5.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0429
    Cell Significance Index: -4.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0444
    Cell Significance Index: -7.5800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0485
    Cell Significance Index: -0.5600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0512
    Cell Significance Index: -0.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0757
    Cell Significance Index: -15.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0772
    Cell Significance Index: -13.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0806
    Cell Significance Index: -2.6400
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0941
    Cell Significance Index: -0.7200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1028
    Cell Significance Index: -1.9000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1129
    Cell Significance Index: -1.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1131
    Cell Significance Index: -13.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1143
    Cell Significance Index: -2.2300
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.1201
    Cell Significance Index: -1.1500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1392
    Cell Significance Index: -2.3700
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.1549
    Cell Significance Index: -1.8100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1605
    Cell Significance Index: -2.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1720
    Cell Significance Index: -3.6000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1781
    Cell Significance Index: -2.1300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1916
    Cell Significance Index: -2.4200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.2055
    Cell Significance Index: -2.7400
  • Cell Name: obsolete somatic cell (CL0002371)
    Fold Change: -0.2178
    Cell Significance Index: -1.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2381
    Cell Significance Index: -8.7400
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.2445
    Cell Significance Index: -3.0800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2500
    Cell Significance Index: -1.6900
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.2562
    Cell Significance Index: -3.2800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2628
    Cell Significance Index: -2.0900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2655
    Cell Significance Index: -3.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2757
    Cell Significance Index: -7.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2772
    Cell Significance Index: -14.4000
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.2838
    Cell Significance Index: -2.6800
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.3260
    Cell Significance Index: -2.9100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3284
    Cell Significance Index: -3.5700
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.3385
    Cell Significance Index: -3.3100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3396
    Cell Significance Index: -4.0100
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.3542
    Cell Significance Index: -2.4700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.3713
    Cell Significance Index: -3.5800
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.3721
    Cell Significance Index: -3.6100
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.3753
    Cell Significance Index: -3.5900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3894
    Cell Significance Index: -9.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4136
    Cell Significance Index: -19.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4498
    Cell Significance Index: -20.9700
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.4557
    Cell Significance Index: -3.6200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.4560
    Cell Significance Index: -6.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4597
    Cell Significance Index: -13.5400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.4911
    Cell Significance Index: -7.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5008
    Cell Significance Index: -13.4200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.5075
    Cell Significance Index: -5.8400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.5159
    Cell Significance Index: -5.8400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.5572
    Cell Significance Index: -7.5800
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.5746
    Cell Significance Index: -3.5200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.5758
    Cell Significance Index: -5.9400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5809
    Cell Significance Index: -14.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5876
    Cell Significance Index: -15.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5908
    Cell Significance Index: -8.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6119
    Cell Significance Index: -15.2600
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.6167
    Cell Significance Index: -3.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6646
    Cell Significance Index: -19.0500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.6804
    Cell Significance Index: -9.3300
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: -0.6881
    Cell Significance Index: -3.6200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.7269
    Cell Significance Index: -12.4300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.7643
    Cell Significance Index: -10.7200
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: -0.7693
    Cell Significance Index: -4.7500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.7734
    Cell Significance Index: -6.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7825
    Cell Significance Index: -13.1000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.8004
    Cell Significance Index: -13.1900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.8119
    Cell Significance Index: -15.8800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.8292
    Cell Significance Index: -9.8000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.8528
    Cell Significance Index: -9.6100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.9259
    Cell Significance Index: -10.7400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.9385
    Cell Significance Index: -15.2000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.9481
    Cell Significance Index: -11.1600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.9489
    Cell Significance Index: -12.1900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.9566
    Cell Significance Index: -11.9500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.9817
    Cell Significance Index: -15.5800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.9833
    Cell Significance Index: -11.9600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.9958
    Cell Significance Index: -14.1800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.0113
    Cell Significance Index: -14.9300
  • Cell Name: B cell (CL0000236)
    Fold Change: -1.0129
    Cell Significance Index: -11.9700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.0265
    Cell Significance Index: -20.4700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -1.0266
    Cell Significance Index: -11.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** SPRR2F is significantly expressed in a variety of cell types, including glutamatergic neurons, oligodendrocyte precursor cells, supporting cells, microglial cells, granulosa cells, ovarian surface epithelial cells, blood vessel endothelial cells, and conventional dendritic cells. 2. **Protein Structure:** SPRR2F is a small, proline-rich protein with a conserved domain structure, suggesting its involvement in protein-protein interactions and cell-cell adhesion. 3. **Cellular Localization:** SPRR2F is primarily localized to the cytosol and cell surface, where it may interact with other proteins and lipids to regulate cellular processes. **Pathways and Functions:** 1. **Epidermal Differentiation:** SPRR2F plays a crucial role in keratinocyte differentiation, a process essential for the development and maintenance of the epidermis. It interacts with other proteins, such as keratins and cornified envelope proteins, to regulate the assembly of the cornified envelope, a key structure in the epidermis. 2. **Cytoskeletal Organization:** SPRR2F may contribute to the regulation of cytoskeletal organization and dynamics, influencing cell shape, migration, and adhesion. 3. **Cell Signaling:** SPRR2F may interact with signaling pathways, such as the MAPK and PI3K/AKT pathways, to regulate cellular responses to external stimuli. 4. **Apoptosis and Cell Survival:** SPRR2F may influence apoptosis and cell survival by interacting with pro-survival and pro-apoptotic proteins. **Clinical Significance:** 1. **Skin Disorders:** Alterations in SPRR2F expression have been linked to skin disorders, such as epidermolysis bullosa, a condition characterized by blistering and skin fragility. 2. **Ovarian Cancers:** SPRR2F expression has been observed in ovarian cancer cells, suggesting its potential role as a biomarker for diagnosis and prognosis. 3. **Neurological Disorders:** SPRR2F may be involved in the pathogenesis of neurological disorders, such as multiple sclerosis, where oligodendrocyte precursor cells are affected. 4. **Immunological Disorders:** SPRR2F may play a role in immunological disorders, such as inflammatory bowel disease, where conventional dendritic cells are involved. In conclusion, SPRR2F is a multifunctional protein with significant implications for epithelial differentiation, development, and disease. Further studies are necessary to elucidate the complex mechanisms by which SPRR2F regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3529939078

Symbol: SPR2F_HUMAN

Name: Small proline-rich protein 2F

UniProtKB Accession Codes:

Q96RM1 Q5T9T3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 UCSC 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11279051

Title: Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function.

PubMed ID: 11279051

DOI: 10.1074/jbc.m100336200

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 72
  • Mass: 7805
  • Checksum: 72B6BF255123E752
  • Sequence:
    • MSYQQQQCKQ PCQPPPVCPA PKCPEPCPPP KCPEPCPPSK CPQSCPPQQC QQKCPPVTPS 
PPCQPKCPPK SK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.