Details for: KCNJ14

Gene ID: 3770

Symbol: KCNJ14

Ensembl ID: ENSG00000182324

Description: potassium inwardly rectifying channel subfamily J member 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 45.1959
    Cell Significance Index: -7.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.8290
    Cell Significance Index: -6.8100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.9659
    Cell Significance Index: -6.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 9.0943
    Cell Significance Index: 108.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 8.5484
    Cell Significance Index: 538.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.3577
    Cell Significance Index: -6.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.8558
    Cell Significance Index: -7.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.7213
    Cell Significance Index: -7.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6860
    Cell Significance Index: 9.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4010
    Cell Significance Index: 76.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3192
    Cell Significance Index: 8.9200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.3091
    Cell Significance Index: 3.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2999
    Cell Significance Index: 8.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2679
    Cell Significance Index: 26.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2634
    Cell Significance Index: 7.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2131
    Cell Significance Index: 42.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1970
    Cell Significance Index: 177.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1609
    Cell Significance Index: 8.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1507
    Cell Significance Index: 24.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1488
    Cell Significance Index: 29.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1403
    Cell Significance Index: 15.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1360
    Cell Significance Index: 6.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1178
    Cell Significance Index: 7.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1097
    Cell Significance Index: 1.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1092
    Cell Significance Index: 2.3900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0782
    Cell Significance Index: 1.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0742
    Cell Significance Index: 2.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0674
    Cell Significance Index: 1.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0670
    Cell Significance Index: 7.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0612
    Cell Significance Index: 1.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0566
    Cell Significance Index: 20.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0526
    Cell Significance Index: 3.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0503
    Cell Significance Index: 2.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0465
    Cell Significance Index: 20.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0389
    Cell Significance Index: 5.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0386
    Cell Significance Index: 26.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0205
    Cell Significance Index: 3.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0197
    Cell Significance Index: 2.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0191
    Cell Significance Index: 10.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0154
    Cell Significance Index: 0.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0061
    Cell Significance Index: 0.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0060
    Cell Significance Index: 0.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0035
    Cell Significance Index: 0.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0023
    Cell Significance Index: 4.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0014
    Cell Significance Index: -2.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0021
    Cell Significance Index: -3.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0037
    Cell Significance Index: -5.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0048
    Cell Significance Index: -0.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0052
    Cell Significance Index: -3.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0057
    Cell Significance Index: -0.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0078
    Cell Significance Index: -5.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0082
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0088
    Cell Significance Index: -6.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0096
    Cell Significance Index: -7.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0123
    Cell Significance Index: -7.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0124
    Cell Significance Index: -5.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0124
    Cell Significance Index: -6.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0135
    Cell Significance Index: -1.7300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0140
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0144
    Cell Significance Index: -2.4600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0192
    Cell Significance Index: -0.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0205
    Cell Significance Index: -5.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0284
    Cell Significance Index: -1.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0286
    Cell Significance Index: -1.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0320
    Cell Significance Index: -1.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0324
    Cell Significance Index: -3.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0391
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0410
    Cell Significance Index: -8.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0417
    Cell Significance Index: -4.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0436
    Cell Significance Index: -2.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0455
    Cell Significance Index: -3.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0492
    Cell Significance Index: -1.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0509
    Cell Significance Index: -1.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0522
    Cell Significance Index: -3.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0543
    Cell Significance Index: -6.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0591
    Cell Significance Index: -3.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0668
    Cell Significance Index: -6.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0689
    Cell Significance Index: -1.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0753
    Cell Significance Index: -3.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0841
    Cell Significance Index: -6.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0959
    Cell Significance Index: -3.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0965
    Cell Significance Index: -2.4800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1028
    Cell Significance Index: -1.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1091
    Cell Significance Index: -2.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1132
    Cell Significance Index: -6.9600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1154
    Cell Significance Index: -1.6400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1196
    Cell Significance Index: -1.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1214
    Cell Significance Index: -3.4800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1323
    Cell Significance Index: -1.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1330
    Cell Significance Index: -4.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1379
    Cell Significance Index: -3.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1381
    Cell Significance Index: -2.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1419
    Cell Significance Index: -4.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1424
    Cell Significance Index: -2.9800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1535
    Cell Significance Index: -1.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1556
    Cell Significance Index: -5.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1680
    Cell Significance Index: -5.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1680
    Cell Significance Index: -5.5000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1773
    Cell Significance Index: -3.5600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1812
    Cell Significance Index: -2.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Inwardly rectifying potassium channel**: KCNJ14 encodes a protein that functions as an inwardly rectifying potassium channel, allowing potassium ions to flow into the cell more easily than out of the cell. 2. **Highly expressed in multiple tissues**: KCNJ14 is expressed in a wide range of tissues, including the eye, brain, gastrointestinal tract, and muscle cells. 3. **Critical role in neuronal function**: KCNJ14 is essential for the proper functioning of neurons, particularly in the regulation of the resting membrane potential and the flow of potassium ions. 4. **Involved in muscle contraction**: KCNJ14 is also involved in muscle contraction, particularly in the regulation of the resting membrane potential and the flow of potassium ions. **Pathways and Functions** 1. **Cardiac conduction**: KCNJ14 is involved in the regulation of cardiac conduction, particularly in the maintenance of the resting membrane potential and the flow of potassium ions. 2. **Classical Kir channels**: KCNJ14 is a member of the classical inwardly rectifying potassium channel (Kir) family, which plays a crucial role in maintaining the resting membrane potential and regulating the flow of potassium ions. 3. **Dendrite and neuronal system**: KCNJ14 is highly expressed in the cerebral cortex and is involved in the regulation of the resting membrane potential and the flow of potassium ions in dendrite and neuronal cells. 4. **Muscle contraction**: KCNJ14 is involved in the regulation of muscle contraction, particularly in the maintenance of the resting membrane potential and the flow of potassium ions. 5. **Ion homeostasis**: KCNJ14 plays a crucial role in maintaining ion homeostasis, particularly in the regulation of potassium ions across the plasma membrane. **Clinical Significance** 1. **Neurological disorders**: Mutations in the KCNJ14 gene have been associated with various neurological disorders, including epilepsy, Parkinson's disease, and Alzheimer's disease. 2. **Cardiac arrhythmias**: KCNJ14 is involved in the regulation of cardiac conduction, and mutations in the KCNJ14 gene have been associated with cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. 3. **Gastrointestinal disorders**: KCNJ14 is highly expressed in the gastrointestinal tract, and mutations in the KCNJ14 gene have been associated with gastrointestinal disorders, including inflammatory bowel disease and irritable bowel syndrome. 4. **Cancer**: KCNJ14 is involved in the regulation of ion homeostasis, and mutations in the KCNJ14 gene have been associated with various types of cancer, including colorectal cancer and breast cancer. In conclusion, KCNJ14 is a crucial gene involved in various cellular processes, including neuronal function, muscle contraction, and ion homeostasis. Its dysregulation has been associated with various neurological, cardiac, and gastrointestinal disorders, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 1101184119

Symbol: KCJ14_HUMAN

Name: ATP-sensitive inward rectifier potassium channel 14

UniProtKB Accession Codes:

Q9UNX9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 3 Ensembl 2 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10942728

Title: Cloning and functional expression of human retinal Kir2.4, a pH-sensitive inwardly rectifying K+ channel.

PubMed ID: 10942728

DOI: 10.1152/ajpcell.2000.279.3.c771

PubMed ID: 10723734

Title: Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14).

PubMed ID: 10723734

DOI: 10.1007/s003350010047

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 436
  • Mass: 47846
  • Checksum: 9442E664007D1B7C
  • Sequence:
    • MGLARALRRL SGALDSGDSR AGDEEEAGPG LCRNGWAPAP VQSPVGRRRG RFVKKDGHCN 
VRFVNLGGQG ARYLSDLFTT CVDVRWRWMC LLFSCSFLAS WLLFGLAFWL IASLHGDLAA 
PPPPAPCFSH VASFLAAFLF ALETQTSIGY GVRSVTEECP AAVAAVVLQC IAGCVLDAFV 
VGAVMAKMAK PKKRNETLVF SENAVVALRD HRLCLMWRVG NLRRSHLVEA HVRAQLLQPR 
VTPEGEYIPL DHQDVDVGFD GGTDRIFLVS PITIVHEIDS ASPLYELGRA ELARADFELV 
VILEGMVEAT AMTTQCRSSY LPGELLWGHR FEPVLFQRGS QYEVDYRHFH RTYEVPGTPV 
CSAKELDERA EQASHSLKSS FPGSLTAFCY ENELALSCCQ EEDEDDETEE GNGVETEDGA 
ASPRVLTPTL ALTLPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.