Details for: GZMK

Gene ID: 3003

Symbol: GZMK

Ensembl ID: ENSG00000113088

Description: granzyme K

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.2
    Marker Score: 11790
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.64
    Marker Score: 3240
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.4
    Marker Score: 33636
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.89
    Marker Score: 2433
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.87
    Marker Score: 3194
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.52
    Marker Score: 828
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.29
    Marker Score: 1411
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.19
    Marker Score: 5351
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.99
    Marker Score: 1986
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.9
    Marker Score: 589
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.88
    Marker Score: 477
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.87
    Marker Score: 5910
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.87
    Marker Score: 1806
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.87
    Marker Score: 1074
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.79
    Marker Score: 4944
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1161
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.47
    Marker Score: 630
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.41
    Marker Score: 458
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.3
    Marker Score: 1101
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 850
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 482
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.15
    Marker Score: 2932
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4804
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1
    Marker Score: 602
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71812
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.99
    Marker Score: 725
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.99
    Marker Score: 545
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30373
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1510
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.91
    Marker Score: 241
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2699
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.88
    Marker Score: 405.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4901
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5205
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.85
    Marker Score: 747
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.83
    Marker Score: 650
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 617
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.78
    Marker Score: 563
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.77
    Marker Score: 450
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.76
    Marker Score: 328
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.75
    Marker Score: 613
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.72
    Marker Score: 1168
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 458
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.68
    Marker Score: 599
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 539
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.62
    Marker Score: 201
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.6
    Marker Score: 777
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.6
    Marker Score: 302.5
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.59
    Marker Score: 1163
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.57
    Marker Score: 535
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.55
    Marker Score: 1034
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.54
    Marker Score: 6310
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.53
    Marker Score: 2288
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.53
    Marker Score: 300.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.52
    Marker Score: 714.5
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.51
    Marker Score: 551
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.5
    Marker Score: 338
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.5
    Marker Score: 132
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.48
    Marker Score: 362
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.43
    Marker Score: 149
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.42
    Marker Score: 756
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.41
    Marker Score: 191
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.41
    Marker Score: 607
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.39
    Marker Score: 424
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.39
    Marker Score: 786.5
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.37
    Marker Score: 193
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.37
    Marker Score: 83
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.36
    Marker Score: 813
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 360
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.35
    Marker Score: 219
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.34
    Marker Score: 330
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.34
    Marker Score: 17996
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.33
    Marker Score: 445
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.32
    Marker Score: 167
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.32
    Marker Score: 353
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.31
    Marker Score: 94
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.3
    Marker Score: 861
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.29
    Marker Score: 4588
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.29
    Marker Score: 192.5
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.28
    Marker Score: 110
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.26
    Marker Score: 190
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.26
    Marker Score: 212
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.25
    Marker Score: 70
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.24
    Marker Score: 86
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.22
    Marker Score: 129
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.22
    Marker Score: 87
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.22
    Marker Score: 1425
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.22
    Marker Score: 380
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73

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Other Information

**Key characteristics:** - GZMK is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in high levels in activated CD8+ T cells, natural killer (NK) cells, and macrophages. - It is also expressed in epithelial cells of the gut and other tissues. - GZMK is a potent activator of the complement system. - It is involved in the regulation of inflammation through the activation of the complement system. - It is also involved in the regulation of cell migration and tumor growth. **Pathways and functions:** - GZMK is involved in the regulation of inflammation through the activation of the complement system. - It is a key activator of the C1q/C1r complex, which is a central component of the innate immune system. - The C1q/C1r complex is expressed on the surface of immune cells, and it binds to complement proteins to initiate the complement cascade. - Activation of the complement cascade leads to the formation of membrane attack complexes (MACs), which can kill target cells. - GZMK is also involved in the regulation of cell migration and tumor growth. - It is a key regulator of the migration of immune cells to sites of inflammation. - It is also involved in the migration of tumor cells to sites of metastasis. **Clinical significance:** - GZMK is a potential therapeutic target for inflammatory diseases. - Inhibition of GZMK can suppress inflammation and tumor growth. - GZMK is a promising target for the treatment of inflammatory diseases such as rheumatoid arthritis, Crohn's disease, and cancer.

Genular Protein ID: 1266905700

Symbol: GRAK_HUMAN

Name: Granzyme K

UniProtKB Accession Codes:

P49863 B2R563

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7758581

Title: Cloning of cDNA for human granzyme 3.

PubMed ID: 7758581

DOI: 10.1016/0014-5793(95)00407-z

PubMed ID: 8656064

Title: Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3.

PubMed ID: 8656064

DOI: 10.1002/jlb.59.5.763

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3262682

Title: Characterization of three serine esterases isolated from human IL-2 activated killer cells.

PubMed ID: 3262682

PubMed ID: 1460416

Title: Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

PubMed ID: 1460416

DOI: 10.1084/jem.176.6.1521

PubMed ID: 12384499

Title: The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features.

PubMed ID: 12384499

DOI: 10.1074/jbc.m207962200

Sequence Information:

  • Length: 264
  • Mass: 28882
  • Checksum: 2A93FDBAF9286CC5
  • Sequence:
    • MTKFSSFSLF FLIVGAYMTH VCFNMEIIGG KEVSPHSRPF MASIQYGGHH VCGGVLIDPQ 
WVLTAAHCQY RFTKGQSPTV VLGAHSLSKN EASKQTLEIK KFIPFSRVTS DPQSNDIMLV 
KLQTAAKLNK HVKMLHIRSK TSLRSGTKCK VTGWGATDPD SLRPSDTLRE VTVTVLSRKL 
CNSQSYYNGD PFITKDMVCA GDAKGQKDSC KGDSGGPLIC KGVFHAIVSG GHECGVATKP 
GIYTLLTKKY QTWIKSNLVP PHTN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.