Details for: CXCL11

Gene ID: 6373

Symbol: CXCL11

Ensembl ID: ENSG00000169248

Description: C-X-C motif chemokine ligand 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 15.8394
    Cell Significance Index: -6.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.9816
    Cell Significance Index: 121.4900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.1032
    Cell Significance Index: 9.4800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.8102
    Cell Significance Index: 12.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6154
    Cell Significance Index: 117.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4562
    Cell Significance Index: 53.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4087
    Cell Significance Index: 40.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3203
    Cell Significance Index: 289.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1984
    Cell Significance Index: 32.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1577
    Cell Significance Index: 17.1500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1523
    Cell Significance Index: 1.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0704
    Cell Significance Index: 4.8700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0613
    Cell Significance Index: 0.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0568
    Cell Significance Index: 3.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0375
    Cell Significance Index: 1.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0206
    Cell Significance Index: 9.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0159
    Cell Significance Index: 0.5600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0129
    Cell Significance Index: 0.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0095
    Cell Significance Index: 0.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0029
    Cell Significance Index: -0.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0046
    Cell Significance Index: -0.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0059
    Cell Significance Index: -0.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0062
    Cell Significance Index: -11.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0064
    Cell Significance Index: -0.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0102
    Cell Significance Index: -6.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0107
    Cell Significance Index: -7.8300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0114
    Cell Significance Index: -0.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0122
    Cell Significance Index: -22.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0147
    Cell Significance Index: -22.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0152
    Cell Significance Index: -2.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0153
    Cell Significance Index: -11.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0167
    Cell Significance Index: -22.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0168
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0177
    Cell Significance Index: -13.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0199
    Cell Significance Index: -9.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0199
    Cell Significance Index: -10.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0224
    Cell Significance Index: -12.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0227
    Cell Significance Index: -2.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0255
    Cell Significance Index: -7.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0288
    Cell Significance Index: -10.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0300
    Cell Significance Index: -0.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0302
    Cell Significance Index: -5.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0323
    Cell Significance Index: -0.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0353
    Cell Significance Index: -0.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0393
    Cell Significance Index: -1.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0438
    Cell Significance Index: -6.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0463
    Cell Significance Index: -9.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0473
    Cell Significance Index: -9.3900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0500
    Cell Significance Index: -0.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0566
    Cell Significance Index: -6.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0600
    Cell Significance Index: -12.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0624
    Cell Significance Index: -7.3600
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0639
    Cell Significance Index: -0.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0750
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0797
    Cell Significance Index: -9.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0885
    Cell Significance Index: -12.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0950
    Cell Significance Index: -1.3600
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1058
    Cell Significance Index: -0.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1156
    Cell Significance Index: -14.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1225
    Cell Significance Index: -7.5300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1232
    Cell Significance Index: -0.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1336
    Cell Significance Index: -6.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1359
    Cell Significance Index: -3.6400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1453
    Cell Significance Index: -1.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1479
    Cell Significance Index: -3.1500
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1526
    Cell Significance Index: -1.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1614
    Cell Significance Index: -3.1500
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1618
    Cell Significance Index: -1.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1707
    Cell Significance Index: -13.1000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1809
    Cell Significance Index: -7.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1853
    Cell Significance Index: -12.4600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1890
    Cell Significance Index: -1.9600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1945
    Cell Significance Index: -3.1200
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1992
    Cell Significance Index: -1.9200
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.2002
    Cell Significance Index: -1.5900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2011
    Cell Significance Index: -1.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2099
    Cell Significance Index: -9.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2100
    Cell Significance Index: -15.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2142
    Cell Significance Index: -6.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2213
    Cell Significance Index: -4.0900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2263
    Cell Significance Index: -5.7700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2268
    Cell Significance Index: -2.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2468
    Cell Significance Index: -13.8500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2564
    Cell Significance Index: -7.5300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2589
    Cell Significance Index: -1.5200
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.2600
    Cell Significance Index: -3.5600
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.2686
    Cell Significance Index: -1.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2741
    Cell Significance Index: -7.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2768
    Cell Significance Index: -7.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2794
    Cell Significance Index: -8.9000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2851
    Cell Significance Index: -3.8000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2927
    Cell Significance Index: -4.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3006
    Cell Significance Index: -10.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3050
    Cell Significance Index: -9.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3064
    Cell Significance Index: -6.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3070
    Cell Significance Index: -13.5800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3096
    Cell Significance Index: -7.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3211
    Cell Significance Index: -7.7000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.3351
    Cell Significance Index: -4.2400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3409
    Cell Significance Index: -5.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CXCL11 is a small, secreted chemokine belonging to the CXC chemokine family, which is characterized by the presence of two adjacent CXC motifs. This chemokine exhibits a high degree of stability and resistance to degradation, allowing it to maintain its biological activity over extended periods. CXCL11 is predominantly expressed in the brain, lungs, and gastrointestinal tract, where it plays a critical role in the regulation of immune responses and tissue homeostasis. **Pathways and Functions:** CXCL11 exerts its biological effects through interaction with its specific receptor, CXCR3, which is expressed on various immune cells, including T cells, natural killer cells, and monocytes. The CXCL11/CXCR3 axis is involved in several key immune-related pathways, including: 1. **Chemotaxis:** CXCL11 attracts immune cells to sites of inflammation, promoting the recruitment of immune cells to the affected area. 2. **Cell-cell signaling:** CXCL11 interacts with CXCR3, triggering signaling events that regulate immune cell activation, proliferation, and differentiation. 3. **Antimicrobial response:** CXCL11 is involved in the recruitment of immune cells to the site of infection, where it contributes to the clearance of pathogens. 4. **Inflammation regulation:** CXCL11 modulates the inflammatory response by regulating the expression of pro-inflammatory cytokines and chemokines. **Clinical Significance:** CXCL11 has been implicated in various immune-related disorders, including: 1. **Multiple sclerosis:** Elevated levels of CXCL11 have been observed in patients with multiple sclerosis, suggesting a potential role in the pathogenesis of the disease. 2. **Rheumatoid arthritis:** CXCL11 has been shown to contribute to the recruitment of immune cells to the joint, exacerbating inflammation and tissue damage. 3. **Cancer:** CXCL11 has been implicated in the recruitment of immune cells to tumor sites, where it may contribute to tumor progression and metastasis. 4. **Neurological disorders:** CXCL11 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. In conclusion, CXCL11 is a crucial chemokine involved in the regulation of immune responses, particularly in the context of inflammation and immune cell trafficking. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of CXCL11 in maintaining immune homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which CXCL11 regulates immune responses and to explore its therapeutic potential in treating immune-related disorders.

Genular Protein ID: 3191404460

Symbol: CXL11_HUMAN

Name: C-X-C motif chemokine 11

UniProtKB Accession Codes:

O14625 Q53YA3 Q92840

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 1 Ensembl 2 EvolutionaryTrace 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8798467

Title: Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha.

PubMed ID: 8798467

DOI: 10.1074/jbc.271.37.22878

PubMed ID: 9370294

Title: A genetic selection for isolating cDNAs encoding secreted proteins.

PubMed ID: 9370294

DOI: 10.1016/s0378-1119(97)00330-2

PubMed ID: 9625760

Title: Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3.

PubMed ID: 9625760

DOI: 10.1084/jem.187.12.2009

PubMed ID: 10233762

Title: Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3).

PubMed ID: 10233762

DOI: 10.1046/j.1523-1747.1999.00581.x

PubMed ID: 10386863

Title: Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN-gamma-treated human monocytes (THP-1).

PubMed ID: 10386863

DOI: 10.1089/107999099313956

PubMed ID: 10395932

Title: Genomic organization, sequence and transcriptional regulation of the human CXCL 11 gene.

PubMed ID: 10395932

DOI: 10.1016/s0167-4781(99)00084-6

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9730616

Title: The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10).

PubMed ID: 9730616

DOI: 10.1159/000015043

PubMed ID: 18645041

Title: Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation.

PubMed ID: 18645041

DOI: 10.1182/blood-2008-04-149039

PubMed ID: 27044744

Title: The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions.

PubMed ID: 27044744

DOI: 10.1074/jbc.m116.720953

PubMed ID: 15273303

Title: NMR structure of CXCR3 binding chemokine CXCL11 (ITAC).

PubMed ID: 15273303

DOI: 10.1110/ps.04791404

Sequence Information:

  • Length: 94
  • Mass: 10365
  • Checksum: 9D9D8585749EA4CE
  • Sequence:
    • MSVKGMAIAL AVILCATVVQ GFPMFKRGRC LCIGPGVKAV KVADIEKASI MYPSNNCDKI 
EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.