Details for: SERF1A

Gene ID: 8293

Symbol: SERF1A

Ensembl ID: ENSG00000172058

Description: small EDRK-rich factor 1A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 50.9820
    Cell Significance Index: -7.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 29.8451
    Cell Significance Index: -7.5700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 6.6182
    Cell Significance Index: 165.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.4479
    Cell Significance Index: -7.9500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.0386
    Cell Significance Index: 12.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2147
    Cell Significance Index: 76.5600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.9643
    Cell Significance Index: 15.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8156
    Cell Significance Index: 155.2100
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.7159
    Cell Significance Index: 4.2900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.6461
    Cell Significance Index: 9.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4186
    Cell Significance Index: 8.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4172
    Cell Significance Index: 227.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3115
    Cell Significance Index: 18.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3044
    Cell Significance Index: 30.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2279
    Cell Significance Index: 24.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2136
    Cell Significance Index: 192.8700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2106
    Cell Significance Index: 2.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1680
    Cell Significance Index: 27.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1170
    Cell Significance Index: 6.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1076
    Cell Significance Index: 4.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0897
    Cell Significance Index: 6.2100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0879
    Cell Significance Index: 0.8500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0632
    Cell Significance Index: 0.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0531
    Cell Significance Index: 1.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0404
    Cell Significance Index: 1.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0364
    Cell Significance Index: 7.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0237
    Cell Significance Index: 2.7600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0185
    Cell Significance Index: 0.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0169
    Cell Significance Index: 6.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0159
    Cell Significance Index: 1.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0150
    Cell Significance Index: 2.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0142
    Cell Significance Index: 6.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0106
    Cell Significance Index: 1.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0102
    Cell Significance Index: 0.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0097
    Cell Significance Index: 0.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0078
    Cell Significance Index: 2.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0030
    Cell Significance Index: 0.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0014
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0053
    Cell Significance Index: -0.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0070
    Cell Significance Index: -5.1200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0084
    Cell Significance Index: -0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0089
    Cell Significance Index: -5.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0089
    Cell Significance Index: -6.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0090
    Cell Significance Index: -16.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0094
    Cell Significance Index: -7.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0103
    Cell Significance Index: -15.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0120
    Cell Significance Index: -16.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0130
    Cell Significance Index: -7.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0168
    Cell Significance Index: -0.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0173
    Cell Significance Index: -2.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0179
    Cell Significance Index: -1.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0180
    Cell Significance Index: -8.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0200
    Cell Significance Index: -1.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0234
    Cell Significance Index: -1.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0243
    Cell Significance Index: -4.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0248
    Cell Significance Index: -1.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0250
    Cell Significance Index: -1.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0255
    Cell Significance Index: -15.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0307
    Cell Significance Index: -2.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0334
    Cell Significance Index: -4.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0408
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0421
    Cell Significance Index: -7.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0430
    Cell Significance Index: -4.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0440
    Cell Significance Index: -9.2700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0506
    Cell Significance Index: -0.7100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0527
    Cell Significance Index: -2.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0576
    Cell Significance Index: -1.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0592
    Cell Significance Index: -1.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0719
    Cell Significance Index: -2.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0737
    Cell Significance Index: -2.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0739
    Cell Significance Index: -1.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0748
    Cell Significance Index: -5.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0751
    Cell Significance Index: -7.8200
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0880
    Cell Significance Index: -0.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0979
    Cell Significance Index: -11.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1053
    Cell Significance Index: -4.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1089
    Cell Significance Index: -5.7200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1181
    Cell Significance Index: -0.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1187
    Cell Significance Index: -2.6000
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1222
    Cell Significance Index: -0.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1226
    Cell Significance Index: -9.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1247
    Cell Significance Index: -4.3700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1270
    Cell Significance Index: -1.9000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1305
    Cell Significance Index: -1.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1353
    Cell Significance Index: -2.2700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1449
    Cell Significance Index: -6.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1523
    Cell Significance Index: -3.1600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1564
    Cell Significance Index: -1.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1630
    Cell Significance Index: -5.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1641
    Cell Significance Index: -7.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1722
    Cell Significance Index: -4.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1722
    Cell Significance Index: -3.3600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1786
    Cell Significance Index: -4.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1805
    Cell Significance Index: -5.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1873
    Cell Significance Index: -5.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1928
    Cell Significance Index: -7.3000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1986
    Cell Significance Index: -2.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2013
    Cell Significance Index: -5.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2013
    Cell Significance Index: -5.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **EDRK-rich motif**: SERF1A contains an EDRK-rich motif, which is a characteristic feature of a subset of proteins involved in various cellular processes, including protein binding and destabilization. 2. **Small protein**: SERF1A is a small protein, which suggests its potential for rapid response to cellular cues and adaptation to changing environments. 3. **Multiple cellular expressions**: SERF1A is significantly expressed in a wide range of cell types, including those involved in respiratory, nervous, and immune system functions. 4. **Pathway involvement**: SERF1A has been implicated in several key pathways, including amyloid fibril formation, nervous system development, and protein binding, highlighting its potential role in regulating cellular homeostasis. **Pathways and Functions:** 1. **Amyloid fibril formation**: SERF1A has been linked to amyloid fibril formation, a process that is critical in the pathogenesis of various neurodegenerative diseases. Understanding the role of SERF1A in this process may provide valuable insights into the development of novel therapeutic strategies. 2. **Nervous system development**: SERF1A has been shown to play a role in nervous system development, highlighting its potential involvement in regulating neural cell fate and differentiation. 3. **Protein binding**: SERF1A has been implicated in protein binding, which is a critical process for regulating protein function, localization, and stability. 4. **Protein destabilization**: SERF1A has been shown to regulate protein stability, which is essential for maintaining cellular homeostasis and responding to changes in the cellular environment. **Clinical Significance:** 1. **Respiratory diseases**: SERF1A's involvement in amyloid fibril formation and protein binding suggests its potential role in the pathogenesis of respiratory diseases, such as amyotrophic lateral sclerosis (ALS) and chronic obstructive pulmonary disease (COPD). 2. **Neurological disorders**: SERF1A's involvement in nervous system development and protein binding may also contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: SERF1A's role in regulating protein stability and binding may also have implications for cancer biology, particularly in the context of protein homeostasis and tumor progression. 4. **Immunology**: SERF1A's involvement in B-cell development and function suggests its potential role in immunological processes, including autoimmune diseases and immune system regulation. In conclusion, SERF1A is a multifaceted gene that plays a critical role in regulating various cellular processes, including amyloid fibril formation, nervous system development, and protein binding. Further research is needed to fully elucidate the mechanisms by which SERF1A regulates cellular homeostasis and to explore its potential therapeutic applications in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.