Details for: GZMA

Gene ID: 3001

Symbol: GZMA

Ensembl ID: ENSG00000145649

Description: granzyme A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.95
    Marker Score: 14460
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.48
    Marker Score: 4974
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.46
    Marker Score: 14074
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.27
    Marker Score: 11806
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.23
    Marker Score: 41872
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.87
    Marker Score: 10846
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.55
    Marker Score: 5224
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.25
    Marker Score: 1400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.18
    Marker Score: 1753
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.08
    Marker Score: 2981
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.99
    Marker Score: 2659
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.98
    Marker Score: 2504
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.78
    Marker Score: 704
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.73
    Marker Score: 1978
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.68
    Marker Score: 1540
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.64
    Marker Score: 1135
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.58
    Marker Score: 1587
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.48
    Marker Score: 805
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.33
    Marker Score: 717
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.26
    Marker Score: 743
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.08
    Marker Score: 13314
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.07
    Marker Score: 643
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.98
    Marker Score: 1973
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.93
    Marker Score: 437
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.92
    Marker Score: 1488
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.89
    Marker Score: 2609
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.54
    Marker Score: 1990
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.53
    Marker Score: 1032
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.5
    Marker Score: 882
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.46
    Marker Score: 748
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.42
    Marker Score: 1208
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.34
    Marker Score: 15551
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 843
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.24
    Marker Score: 904
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.19
    Marker Score: 614.5
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.18
    Marker Score: 1920
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4783
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.13
    Marker Score: 887
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.08
    Marker Score: 2114
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.08
    Marker Score: 372
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.04
    Marker Score: 915
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.01
    Marker Score: 733
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71786
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48012
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.99
    Marker Score: 2236
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.99
    Marker Score: 408.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5261
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.89
    Marker Score: 782
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.85
    Marker Score: 430
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.85
    Marker Score: 2073
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 643
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.83
    Marker Score: 386
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.83
    Marker Score: 678
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.82
    Marker Score: 3509.5
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.79
    Marker Score: 257
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1253
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.76
    Marker Score: 573
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 678
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 454
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.7
    Marker Score: 185
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.69
    Marker Score: 247
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.67
    Marker Score: 148
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.66
    Marker Score: 396
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.62
    Marker Score: 32748
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.6
    Marker Score: 653
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.58
    Marker Score: 267
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.58
    Marker Score: 542
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.54
    Marker Score: 956
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.5
    Marker Score: 292
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.5
    Marker Score: 195
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 127
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.47
    Marker Score: 133
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.46
    Marker Score: 500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.45
    Marker Score: 141
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.43
    Marker Score: 740
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.43
    Marker Score: 279
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.42
    Marker Score: 793
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.42
    Marker Score: 453
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.42
    Marker Score: 305
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.4
    Marker Score: 403
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.38
    Marker Score: 205
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.38
    Marker Score: 213
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.35
    Marker Score: 395
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.35
    Marker Score: 68
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.34
    Marker Score: 347
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.34
    Marker Score: 224.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.33
    Marker Score: 572
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.33
    Marker Score: 195
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.32
    Marker Score: 421

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * GZMA is a secreted protein that is expressed in high levels in NKp46-positive innate lymphoid cell, human, intraepithelial lymphocyte, mature gamma-delta T cell, decidual natural killer cell, human, mature T cell, CD8-positive, alpha-beta memory T cell, CD45RO-positive, effector memory CD8-positive, alpha-beta T cell, terminally differentiated, CD8-positive, alpha-beta cytokine secreting effector T cell, CD8-positive, alpha-beta thymocyte. * It is a glycoprotein with a molecular weight of approximately 125 kDa. * It is a key effector of NKp46 cells and is involved in the regulation of innate immunity. **Pathways and functions:** * GZMA is a key effector of NKp46 cells and is involved in the regulation of innate immunity. * It is expressed in high levels in NKp46-positive innate lymphoid cells, which are the first cells to respond to infection. * GZMA is also expressed in other immune cells, including macrophages and dendritic cells, where it exerts its cytotoxic effects. * It is involved in the activation of macrophages and dendritic cells, promoting the production of inflammatory cytokines. * It is also involved in the regulation of T cell responses, promoting the activation of CD8+ cytotoxic T cells and the regulation of immune responses to pathogens. **Clinical significance:** * Mutations in the GZMA gene have been linked to human diseases, including cancer and autoimmune disorders. * Targeting GZMA with antibodies or small molecules is a potential therapeutic strategy for these diseases.

Genular Protein ID: 881266553

Symbol: GRAA_HUMAN

Name: Fragmentin-1

UniProtKB Accession Codes:

P12544 A4PHN1 Q6IB36

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3257574

Title: Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease.

PubMed ID: 3257574

DOI: 10.1073/pnas.85.4.1184

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17180578

Title: Glucocorticoid-induced alternative promoter usage for a novel 5' variant of granzyme A.

PubMed ID: 17180578

DOI: 10.1007/s10038-006-0099-9

PubMed ID: 3047119

Title: Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity.

PubMed ID: 3047119

DOI: 10.1016/s0021-9258(18)37694-4

PubMed ID: 3262682

Title: Characterization of three serine esterases isolated from human IL-2 activated killer cells.

PubMed ID: 3262682

PubMed ID: 3263427

Title: Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes.

PubMed ID: 3263427

PubMed ID: 11555662

Title: Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks.

PubMed ID: 11555662

DOI: 10.1074/jbc.m108137200

PubMed ID: 12628186

Title: Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.

PubMed ID: 12628186

DOI: 10.1016/s0092-8674(03)00150-8

PubMed ID: 12524539

Title: Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.

PubMed ID: 12524539

DOI: 10.1038/ni885

PubMed ID: 16818237

Title: The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.

PubMed ID: 16818237

DOI: 10.1016/j.molcel.2006.06.005

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20038786

Title: Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis.

PubMed ID: 20038786

DOI: 10.1182/blood-2009-10-246116

PubMed ID: 32299851

Title: Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells.

PubMed ID: 32299851

DOI: 10.1126/science.aaz7548

PubMed ID: 34022140

Title: Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions.

PubMed ID: 34022140

DOI: 10.1016/j.cell.2021.04.036

PubMed ID: 36157507

Title: GSDMB N-terminal assembles in plasma membrane to execute pyroptotic cell death.

PubMed ID: 36157507

DOI: 10.1016/j.gendis.2021.12.022

PubMed ID: 36899106

Title: Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells.

PubMed ID: 36899106

DOI: 10.1038/s41418-023-01143-y

PubMed ID: 3237717

Title: Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes.

PubMed ID: 3237717

DOI: 10.1002/prot.340040306

PubMed ID: 12819769

Title: The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity.

PubMed ID: 12819769

DOI: 10.1038/nsb944

PubMed ID: 12819770

Title: Crystal structure of the apoptosis-inducing human granzyme A dimer.

PubMed ID: 12819770

DOI: 10.1038/nsb945

Sequence Information:

  • Length: 262
  • Mass: 28999
  • Checksum: FD773628BA6F301B
  • Sequence:
    • MRNSYRFLAS SLSVVVSLLL IPEDVCEKII GGNEVTPHSR PYMVLLSLDR KTICAGALIA 
KDWVLTAAHC NLNKRSQVIL GAHSITREEP TKQIMLVKKE FPYPCYDPAT REGDLKLLQL 
MEKAKINKYV TILHLPKKGD DVKPGTMCQV AGWGRTHNSA SWSDTLREVN ITIIDRKVCN 
DRNHYNFNPV IGMNMVCAGS LRGGRDSCNG DSGSPLLCEG VFRGVTSFGL ENKCGDPRGP 
GVYILLSKKH LNWIIMTIKG AV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.