Details for: REM1

Gene ID: 28954

Symbol: REM1

Ensembl ID: ENSG00000088320

Description: RRAD and GEM like GTPase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 12.2346
    Cell Significance Index: -5.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 10.3151
    Cell Significance Index: -4.8700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.8090
    Cell Significance Index: 23.5700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.4518
    Cell Significance Index: 20.6000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.7606
    Cell Significance Index: 8.7600
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.5750
    Cell Significance Index: 5.8700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2552
    Cell Significance Index: 3.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0775
    Cell Significance Index: 9.9400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0606
    Cell Significance Index: 1.4000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0371
    Cell Significance Index: 0.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0333
    Cell Significance Index: 1.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0242
    Cell Significance Index: 10.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0100
    Cell Significance Index: 1.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0030
    Cell Significance Index: -4.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0031
    Cell Significance Index: -4.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0063
    Cell Significance Index: -4.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0074
    Cell Significance Index: -5.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0077
    Cell Significance Index: -5.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0096
    Cell Significance Index: -5.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0109
    Cell Significance Index: -4.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0115
    Cell Significance Index: -6.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0120
    Cell Significance Index: -1.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0155
    Cell Significance Index: -5.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0190
    Cell Significance Index: -5.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0229
    Cell Significance Index: -2.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0243
    Cell Significance Index: -4.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0257
    Cell Significance Index: -4.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0260
    Cell Significance Index: -0.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0264
    Cell Significance Index: -5.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0266
    Cell Significance Index: -5.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0355
    Cell Significance Index: -4.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0391
    Cell Significance Index: -4.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0402
    Cell Significance Index: -4.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0403
    Cell Significance Index: -4.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0428
    Cell Significance Index: -4.3700
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.0457
    Cell Significance Index: -0.2700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0550
    Cell Significance Index: -0.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0561
    Cell Significance Index: -5.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0573
    Cell Significance Index: -2.6700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0604
    Cell Significance Index: -2.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0655
    Cell Significance Index: -4.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0672
    Cell Significance Index: -3.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0698
    Cell Significance Index: -1.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0812
    Cell Significance Index: -2.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0868
    Cell Significance Index: -6.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0873
    Cell Significance Index: -5.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0914
    Cell Significance Index: -5.6200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0962
    Cell Significance Index: -1.7000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0996
    Cell Significance Index: -0.4600
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1084
    Cell Significance Index: -1.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1101
    Cell Significance Index: -2.8300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1126
    Cell Significance Index: -1.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1158
    Cell Significance Index: -3.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1173
    Cell Significance Index: -2.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1268
    Cell Significance Index: -1.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1308
    Cell Significance Index: -7.3400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1338
    Cell Significance Index: -2.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1413
    Cell Significance Index: -6.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1418
    Cell Significance Index: -3.8000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1440
    Cell Significance Index: -6.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1467
    Cell Significance Index: -7.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1508
    Cell Significance Index: -4.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1531
    Cell Significance Index: -4.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1637
    Cell Significance Index: -6.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1644
    Cell Significance Index: -5.7600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1801
    Cell Significance Index: -3.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1801
    Cell Significance Index: -4.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1808
    Cell Significance Index: -5.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1848
    Cell Significance Index: -5.8900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1928
    Cell Significance Index: -4.6700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1989
    Cell Significance Index: -7.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2000
    Cell Significance Index: -4.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2071
    Cell Significance Index: -5.9100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2087
    Cell Significance Index: -4.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2095
    Cell Significance Index: -5.5100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2096
    Cell Significance Index: -5.3400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2112
    Cell Significance Index: -3.6400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2116
    Cell Significance Index: -3.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2135
    Cell Significance Index: -5.8100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2202
    Cell Significance Index: -2.8200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2313
    Cell Significance Index: -3.6700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2381
    Cell Significance Index: -5.9400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2402
    Cell Significance Index: -3.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2431
    Cell Significance Index: -5.8300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2454
    Cell Significance Index: -6.1300
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.2573
    Cell Significance Index: -2.6900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2578
    Cell Significance Index: -5.2500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.2604
    Cell Significance Index: -2.4100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2621
    Cell Significance Index: -3.8200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2630
    Cell Significance Index: -4.2200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2640
    Cell Significance Index: -8.3500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2670
    Cell Significance Index: -4.4900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2733
    Cell Significance Index: -3.2200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2740
    Cell Significance Index: -5.9200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2743
    Cell Significance Index: -4.6200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2787
    Cell Significance Index: -3.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2799
    Cell Significance Index: -5.9400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2829
    Cell Significance Index: -2.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** REM1 is a member of the RRAD and GEM like GTPase 1 family, characterized by its high sequence homology to these proteins. Its expression is widespread across various cell types, including pulmonary interstitial fibroblasts, mural cells, granulocyte monocyte progenitor cells, goblet cells, and early T lineage precursors. This broad expression pattern suggests that REM1 plays a multifaceted role in different cellular contexts. **Pathways and Functions:** REM1's primary function is associated with calcium signaling, which is crucial for various cellular processes, including muscle contraction, cell proliferation, and differentiation. It is involved in the regulation of calcium ion transmembrane transport via high-voltage-gated calcium channels, which is essential for maintaining calcium homeostasis within cells. Furthermore, REM1 is implicated in the negative regulation of calcium ion signaling, which is a critical mechanism for preventing excessive calcium influx and subsequent cellular damage. This regulatory function is mediated through its interaction with calmodulin, a calcium-binding protein that modulates various cellular processes. In addition to its role in calcium signaling, REM1 is also involved in the regulation of skeletal muscle contraction by modulating calcium ion signaling. This function is critical for maintaining muscle function and overall physiological homeostasis. **Clinical Significance:** The clinical significance of REM1 is an area of ongoing research, with potential implications in various diseases. Dysregulation of REM1 has been implicated in conditions such as: 1. **Muscular dystrophy:** REM1's role in regulating calcium signaling may be critical in maintaining muscle function, and its dysregulation may contribute to the pathogenesis of muscular dystrophy. 2. **Immune disorders:** REM1's expression in immune cells, such as granulocyte monocyte progenitor cells, suggests that it may play a role in immune regulation and the development of immune disorders, such as autoimmune diseases. 3. **Cancer:** REM1's involvement in cell proliferation and differentiation may also have implications for cancer development and progression. In conclusion, REM1 is a complex gene with far-reaching implications in immune regulation and calcium signaling. Further research is necessary to fully elucidate its role in various diseases and to explore its therapeutic potential. **Recommendations:** 1. **Further research on REM1's role in disease:** Investigate the specific mechanisms by which REM1 contributes to disease pathogenesis and identify potential therapeutic targets. 2. **Expression analysis:** Conduct detailed expression analysis to elucidate REM1's role in different cell types and tissues. 3. **Functional studies:** Perform functional studies to confirm REM1's role in calcium signaling and immune regulation. By advancing our understanding of REM1, we can unlock new avenues for treating a range of diseases and improving human health.

Genular Protein ID: 1457934326

Symbol: REM1_HUMAN

Name: GTP-binding protein REM 1

UniProtKB Accession Codes:

O75628 E1P5L1 Q5TZR7 Q5TZR8 Q9NP57

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10831614

Title: Ges, a human GTPase of the Rad/Gem/Kir family, promotes endothelial cell sprouting and cytoskeleton reorganization.

PubMed ID: 10831614

DOI: 10.1083/jcb.149.5.1107

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 298
  • Mass: 32947
  • Checksum: E7CCE776FFD42CD7
  • Sequence:
    • MTLNTEQEAK TPLHRRASTP LPLSPRGHQP GRLSTVPSTQ SQHPRLGQSA SLNPPTQKPS 
PAPDDWSSES SDSEGSWEAL YRVVLLGDPG VGKTSLASLF AGKQERDLHE QLGEDVYERT 
LTVDGEDTTL VVVDTWEAEK LDKSWSQESC LQGGSAYVIV YSIADRGSFE SASELRIQLR 
RTHQADHVPI ILVGNKADLA RCREVSVEEG RACAVVFDCK FIETSATLQH NVAELFEGVV 
RQLRLRRRDS AAKEPPAPRR PASLAQRARR FLARLTARSA RRRALKARSK SCHNLAVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.