Details for: CTBP1 DT

Gene ID: 92070

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: CTBP1 DT

Ensembl ID: ENSG00000196810

Description: CTBP1 divergent transcript

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 6.61
    rCSI 8.01%
    PRS 90.19
  • regulatory T cell CL0000815
    CSI 4.8
    rCSI 5.57%
    PRS 95.24
  • basal cell of epidermis CL0002187
    CSI 3.02
    rCSI 5.36%
    PRS 86.66
  • melanocyte of skin CL1000458
    CSI 2.71
    rCSI 3.69%
    PRS 87.78
  • innate lymphoid cell CL0001065
    CSI 2.33
    rCSI 4.81%
    PRS 95.78
  • retinal pigment epithelial cell CL0002586
    CSI 2.26
    rCSI 4.48%
    PRS 97.86
  • cytotoxic T cell CL0000910
    CSI 2.22
    rCSI 12.75%
    PRS 96.69
  • helper T cell CL0000912
    CSI 2.07
    rCSI 2.93%
    PRS 96.12
  • suprabasal keratinocyte CL4033013
    CSI 1.41
    rCSI 2.29%
    PRS 88.43

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CTBP1 DT](/details-gene/92070) is a non-coding RNA (ncRNA) gene located on human chromosome 4p16.3. Functional annotations suggest its involvement in crucial nuclear processes, specifically in protein binding and the maintenance of genomic integrity through postreplication and recombinational DNA repair. **Overall**, its expression profile indicates a significant role in both the adaptive immune system and cutaneous tissues, with particularly high significance in [CD8-positive, alpha-beta memory T cell, CD45RO-positive](/details-cell/CL0001203) and [basal cell of epidermis](/details-cell/CL0002187). ## Cellular Roles and Expression Landscape The expression pattern of [CTBP1 DT](/details-gene/92070) highlights its importance in two primary biological systems: the immune system and the skin. Within the immune system, [CTBP1 DT](/details-gene/92070) shows the highest significance in long-lived lymphocyte populations. It is most prominent in [CD8-positive, alpha-beta memory T cell, CD45RO-positive](/details-cell/CL0001203) (CSI: 6.61), suggesting a potential role in the maintenance and survival of this critical cell type. Its significance is also notable in [regulatory T cell](/details-cell/CL0000815) (CSI: 4.80), [innate lymphoid cell](/details-cell/CL0001065) (CSI: 2.33), [cytotoxic T cell](/details-cell/CL0000910) (CSI: 2.22), and [helper T cell](/details-cell/CL0000912) (CSI: 2.07), underscoring a broad involvement in T cell biology. Concurrently, [CTBP1 DT](/details-gene/92070) is highly significant in various skin cell types. It is a key marker for [basal cell of epidermis](/details-cell/CL0002187) (CSI: 3.02), the proliferative layer of the skin, as well as [melanocyte of skin](/details-cell/CL1000458) (CSI: 2.71) and [suprabasal keratinocyte](/details-cell/CL4033013) (CSI: 1.41). This expression pattern suggests a role in maintaining the integrity of tissues that are subject to constant turnover and environmental stress. Its expression in [retinal pigment epithelial cell](/details-cell/CL0002586) (CSI: 2.26) further supports a function in specialized epithelial tissues. ## Pathways and Molecular Function The functional annotations for [CTBP1 DT](/details-gene/92070) are consistent with its expression in long-lived and proliferative cell populations. Its localization to the [nucleus](/details-go/GO:0005634) and [chromosome](/details-go/GO:0005694) points to a direct role in regulating genomic events. The gene's association with biological processes such as [postreplication repair](/details-go/GO:0006301) and [recombinational repair](/details-go/GO:0000725) is particularly relevant for cells like memory T cells, which must maintain genomic stability over long periods, and for epidermal basal cells, which undergo frequent division and are exposed to mutagens like UV radiation. The annotated molecular function of [protein binding](/details-go/GO:0005515) suggests that [CTBP1 DT](/details-gene/92070) likely acts as a scaffold or guide, recruiting protein complexes to specific chromatin locations to facilitate DNA repair. ## Research Directions The specific expression of [CTBP1 DT](/details-gene/92070) in cell types requiring robust DNA maintenance mechanisms suggests several avenues for future investigation. **Proposed Hypotheses:** 1. **Role in Memory T Cell Longevity:** Given its top expression in [CD8-positive, alpha-beta memory T cell, CD45RO-positive](/details-cell/CL0001203) and its link to DNA repair, [CTBP1 DT](/details-gene/92070) may be essential for the long-term survival and genomic integrity of the memory T cell pool. Its downregulation could lead to accelerated cellular senescence or increased apoptosis, compromising long-term immunity. 2. **Protection Against Genotoxic Stress in Skin:** The high significance of [CTBP1 DT](/details-gene/92070) in epidermal cells, including [basal cell of epidermis](/details-cell/CL0002187) and [melanocyte of skin](/details-cell/CL1000458), suggests it plays a protective role against environmental mutagens, particularly UV radiation. Loss of [CTBP1 DT](/details-gene/92070) function may increase susceptibility to DNA damage, elevating the risk of photoaging and skin carcinogenesis. **Key Experimental Approach:** To test the hypothesis that [CTBP1 DT](/details-gene/92070) protects skin cells from genotoxic stress, a loss-of-function study could be performed. Primary human keratinocytes could be treated with antisense oligonucleotides (ASOs) or siRNA to specifically knock down [CTBP1 DT](/details-gene/92070) expression. These cells, alongside non-targeting controls, would then be exposed to controlled doses of UVB radiation. The impact of the knockdown could be assessed by quantifying DNA damage markers, such as cyclobutane pyrimidine dimers (CPDs), via immunofluorescence, and by measuring cell viability and apoptosis rates using flow cytometry. A significant increase in DNA damage and cell death in the knockdown group would validate its protective role. **Therapeutic Potential:** As an ncRNA with a putative role in preserving genomic stability, [CTBP1 DT](/details-gene/92070) represents a potential therapeutic target. Rather than inhibition, **activation** or supplementation of its function could be beneficial. For example, developing synthetic mimetics or delivery systems to enhance its expression in the skin might offer a novel strategy for photoprotection. Conversely, in a cancer context where tumor cells may exploit DNA repair pathways for survival, inhibiting [CTBP1 DT](/details-gene/92070) could serve as a chemosensitization or radiosensitization strategy.