Details for: ZNF202

Gene ID: 7753

Symbol: ZNF202

Ensembl ID: ENSG00000166261

Description: zinc finger protein 202

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 66.1544
    Cell Significance Index: -10.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.3072
    Cell Significance Index: -9.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.4675
    Cell Significance Index: -10.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5239
    Cell Significance Index: -9.4400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6736
    Cell Significance Index: -10.5500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.1597
    Cell Significance Index: 19.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6116
    Cell Significance Index: 552.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4885
    Cell Significance Index: 53.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4512
    Cell Significance Index: 27.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4492
    Cell Significance Index: 73.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3491
    Cell Significance Index: 70.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3094
    Cell Significance Index: 8.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2353
    Cell Significance Index: 3.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2336
    Cell Significance Index: 10.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2215
    Cell Significance Index: 5.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2165
    Cell Significance Index: 14.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1848
    Cell Significance Index: 18.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1773
    Cell Significance Index: 11.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1754
    Cell Significance Index: 3.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1610
    Cell Significance Index: 57.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1559
    Cell Significance Index: 30.9300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1263
    Cell Significance Index: 1.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1091
    Cell Significance Index: 3.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0803
    Cell Significance Index: 1.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0770
    Cell Significance Index: 53.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0687
    Cell Significance Index: 12.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0664
    Cell Significance Index: 12.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0460
    Cell Significance Index: 2.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0457
    Cell Significance Index: 6.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0285
    Cell Significance Index: 1.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0256
    Cell Significance Index: 0.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0206
    Cell Significance Index: 0.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0195
    Cell Significance Index: 10.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0128
    Cell Significance Index: 5.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0112
    Cell Significance Index: 1.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0084
    Cell Significance Index: 1.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0051
    Cell Significance Index: 0.7000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0050
    Cell Significance Index: 0.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0031
    Cell Significance Index: 0.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0007
    Cell Significance Index: 0.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0018
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0053
    Cell Significance Index: -3.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0087
    Cell Significance Index: -15.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0099
    Cell Significance Index: -15.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0105
    Cell Significance Index: -7.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0116
    Cell Significance Index: -15.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0121
    Cell Significance Index: -9.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0137
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0161
    Cell Significance Index: -11.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0175
    Cell Significance Index: -7.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0198
    Cell Significance Index: -11.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0200
    Cell Significance Index: -12.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0215
    Cell Significance Index: -2.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0230
    Cell Significance Index: -2.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0232
    Cell Significance Index: -6.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0294
    Cell Significance Index: -1.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0347
    Cell Significance Index: -0.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0353
    Cell Significance Index: -1.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0357
    Cell Significance Index: -1.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0371
    Cell Significance Index: -0.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0414
    Cell Significance Index: -2.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0432
    Cell Significance Index: -5.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0438
    Cell Significance Index: -3.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0482
    Cell Significance Index: -4.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0505
    Cell Significance Index: -5.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0586
    Cell Significance Index: -4.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0586
    Cell Significance Index: -12.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0636
    Cell Significance Index: -2.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0709
    Cell Significance Index: -1.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0792
    Cell Significance Index: -1.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0823
    Cell Significance Index: -3.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0850
    Cell Significance Index: -2.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0987
    Cell Significance Index: -10.2800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1006
    Cell Significance Index: -1.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1050
    Cell Significance Index: -2.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1102
    Cell Significance Index: -3.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1128
    Cell Significance Index: -8.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1147
    Cell Significance Index: -7.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1166
    Cell Significance Index: -2.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1308
    Cell Significance Index: -3.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1368
    Cell Significance Index: -7.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1444
    Cell Significance Index: -4.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1666
    Cell Significance Index: -5.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1865
    Cell Significance Index: -3.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1922
    Cell Significance Index: -9.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2125
    Cell Significance Index: -2.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2147
    Cell Significance Index: -7.0300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2153
    Cell Significance Index: -3.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2173
    Cell Significance Index: -6.2300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2175
    Cell Significance Index: -4.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2229
    Cell Significance Index: -7.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2232
    Cell Significance Index: -7.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2251
    Cell Significance Index: -5.7500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2346
    Cell Significance Index: -4.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2412
    Cell Significance Index: -7.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2414
    Cell Significance Index: -7.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2426
    Cell Significance Index: -6.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2456
    Cell Significance Index: -5.8900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2472
    Cell Significance Index: -10.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DNA Binding:** ZNF202 exhibits specific DNA-binding activity, particularly to RNA polymerase II cis-regulatory region sequences, which suggests its role in regulating transcription. 2. **Transcriptional Regulation:** As a transcription factor, ZNF202 can repress or activate gene expression by binding to RNA polymerase II and other transcription factors. 3. **Metal Ion Binding:** ZNF202 has been shown to bind to metal ions, which may influence its DNA-binding activity and transcriptional regulation. 4. **Cell Type-Specific Expression:** ZNF202 is significantly expressed in various cell types, including cerebral cortex GABAergic interneurons, forebrain radial glial cells, and intestinal epithelial cells. **Pathways and Functions:** 1. **Generic Transcription Pathway:** ZNF202 is involved in the regulation of gene expression through the generic transcription pathway, which is essential for cellular homeostasis. 2. **Lipid Metabolic Process:** ZNF202 has been implicated in lipid metabolic processes, which highlight its potential role in energy homeostasis and metabolic regulation. 3. **Negative Regulation of Transcription by RNA Polymerase II:** ZNF202 can repress transcription by RNA polymerase II, which suggests its role in regulating gene expression in response to cellular stress or other regulatory signals. 4. **Chromosome and Nuclear Body Regulation:** ZNF202 is also involved in regulating chromosome structure and nuclear body organization, which are essential for proper genome stability and transcriptional regulation. **Clinical Significance:** 1. **Neurological Disorders:** ZNF202 has been implicated in various neurological disorders, including schizophrenia, bipolar disorder, and autism spectrum disorder, where disruptions in gene expression and transcriptional regulation are thought to contribute to disease pathogenesis. 2. **Cancer:** ZNF202 has been found to be aberrantly expressed in various types of cancer, including colon and breast cancer, where it may contribute to tumorigenesis and cancer progression. 3. **Metabolic Disorders:** ZNF202's involvement in lipid metabolic processes suggests its potential role in metabolic disorders, such as obesity and type 2 diabetes, where disruptions in energy homeostasis are thought to contribute to disease pathogenesis. In conclusion, ZNF202 is a multifunctional transcription factor protein that plays a crucial role in regulating gene expression and cellular homeostasis. Its involvement in various biological pathways and its aberrant expression in various diseases highlight its potential as a therapeutic target for the treatment of neurological and metabolic disorders.

Genular Protein ID: 408167618

Symbol: ZN202_HUMAN

Name: Zinc finger protein 202

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9790754

Title: Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins.

PubMed ID: 9790754

DOI: 10.1006/geno.1998.5419

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10748193

Title: A broad role for the zinc finger protein ZNF202 in human lipid metabolism.

PubMed ID: 10748193

DOI: 10.1074/jbc.m910152199

PubMed ID: 11279031

Title: The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux.

PubMed ID: 11279031

DOI: 10.1074/jbc.m100218200

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 648
  • Mass: 74720
  • Checksum: E738506D71DAFAE9
  • Sequence:
  • MATAVEPEDQ DLWEEEGILM VKLEDDFTCR PESVLQRDDP VLETSHQNFR RFRYQEAASP 
    REALIRLREL CHQWLRPERR TKEQILELLV LEQFLTVLPG ELQSWVRGQR PESGEEAVTL 
    VEGLQKQPRR PRRWVTVHVH GQEVLSEETV HLGVEPESPN ELQDPVQSST PEQSPEETTQ 
    SPDLGAPAEQ RPHQEEELQT LQESEVPVPE DPDLPAERSS GDSEMVALLT ALSQGLVTFK 
    DVAVCFSQDQ WSDLDPTQKE FYGEYVLEED CGIVVSLSFP IPRPDEISQV REEEPWVPDI 
    QEPQETQEPE ILSFTYTGDR SKDEEECLEQ EDLSLEDIHR PVLGEPEIHQ TPDWEIVFED 
    NPGRLNERRF GTNISQVNSF VNLRETTPVH PLLGRHHDCS VCGKSFTCNS HLVRHLRTHT 
    GEKPYKCMEC GKSYTRSSHL ARHQKVHKMN APYKYPLNRK NLEETSPVTQ AERTPSVEKP 
    YRCDDCGKHF RWTSDLVRHQ RTHTGEKPFF CTICGKSFSQ KSVLTTHQRI HLGGKPYLCG 
    ECGEDFSEHR RYLAHRKTHA AEELYLCSEC GRCFTHSAAF AKHLRGHASV RPCRCNECGK 
    SFSRRDHLVR HQRTHTGEKP FTCPTCGKSF SRGYHLIRHQ RTHSEKTS

Genular Protein ID: 1750886869

Symbol: B3KN61_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 648
  • Mass: 74668
  • Checksum: 321EC8294651D37A
  • Sequence:
  • MATAVEPEDQ DLWEEEGILM VKLEDDFTCR PESVLQRDDP VLETSHQNFR RFRYQEAASP 
    REALIRLREL CHQWLRPERR TKEQILELLV LEQFLTVLPG ELQSWVRGQR PESGEEAVTL 
    VEGLQKQPRR PRRWVTVHVH GQEVLSEETV HLGAEPESPN ELQDPVQSST PEQSPEETTQ 
    SPDLGAPAEQ RPHQEEELQT LQESEVPVPE DPDLPAERSS GDSEMVALLT ALSQGLVTFK 
    DVAVCFSQDQ WSDLDPTQKE FYGEYVLEED CGIVVSLSFP IPRPDEISQV REEEPWVPDI 
    QEPQETQEPE ILSFTYTGDR SKDEEECLEQ EDLSLEDIHR PVLGEPEIHQ TPDWEIVFED 
    NPGRLNERRF GTNISQVNSF VNLRETTPVH PLLGRHHDCS VCGKSFTCNS HLVRHLRTHT 
    GEKPYKCMEC GKSYTRSSHL ARHQKVLKMN APYKYPLNRK NLEETSPVTQ AERTPSVEKP 
    YRCDDCGKHF RWTSDLVRHQ RTHTGEKPFF CTICGKSFSQ KSVLTTHQRI HLGGKPYLCG 
    ECGEDFSEHR RYLAHRKTHA AEELYLCSEC GRCFTHSAAF AKHLRGHASV RPCRCNECGK 
    SFSRRDHLVR HQRTHTGEKP FTCPTCGKSF SRGYHLIRHQ RTHSEKTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.