Details for: FOXP3

Gene ID: 50943

Symbol: FOXP3

Ensembl ID: ENSG00000049768

Description: forkhead box P3

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Runx1 and foxp3 control the development of regulatory t lymphocytes (tregs)
    (R-HSA-8877330)
  • Runx1 regulates transcription of genes involved in wnt signaling
    (R-HSA-8939256)
  • Transcriptional regulation by runx1
    (R-HSA-8878171)
  • B cell homeostasis
    (GO:0001782)
  • Cd4-positive, alpha-beta t cell proliferation
    (GO:0035739)
  • Cd4-positive, cd25-positive, alpha-beta regulatory t cell lineage commitment
    (GO:0002362)
  • Chromatin
    (GO:0000785)
  • Chromatin remodeling
    (GO:0006338)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Establishment of endothelial blood-brain barrier
    (GO:0014045)
  • Histone acetyltransferase binding
    (GO:0035035)
  • Histone deacetylase binding
    (GO:0042826)
  • Immature t cell proliferation in thymus
    (GO:0033080)
  • Inflammatory response
    (GO:0006954)
  • Isotype switching to ige isotypes
    (GO:0048289)
  • Metal ion binding
    (GO:0046872)
  • Myeloid cell homeostasis
    (GO:0002262)
  • Negative regulation of activated t cell proliferation
    (GO:0046007)
  • Negative regulation of cd4-positive, alpha-beta t cell proliferation
    (GO:2000562)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of chronic inflammatory response
    (GO:0002677)
  • Negative regulation of creb transcription factor activity
    (GO:0032792)
  • Negative regulation of cytokine production
    (GO:0001818)
  • Negative regulation of defense response to virus
    (GO:0050687)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of immune response
    (GO:0050777)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of interleukin-4 production
    (GO:0032713)
  • Negative regulation of interleukin-5 production
    (GO:0032714)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of interleukin-10 production
    (GO:0032693)
  • Negative regulation of interleukin-17 production
    (GO:0032700)
  • Negative regulation of isotype switching to ige isotypes
    (GO:0048294)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of t-helper 17 cell differentiation
    (GO:2000320)
  • Negative regulation of t cell cytokine production
    (GO:0002725)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Nf-kappab binding
    (GO:0051059)
  • Nfat protein binding
    (GO:0051525)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cd4-positive, cd25-positive, alpha-beta regulatory t cell differentiation
    (GO:0032831)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of immature t cell proliferation in thymus
    (GO:0033092)
  • Positive regulation of interleukin-4 production
    (GO:0032753)
  • Positive regulation of peripheral t cell tolerance induction
    (GO:0002851)
  • Positive regulation of regulatory t cell differentiation
    (GO:0045591)
  • Positive regulation of t cell anergy
    (GO:0002669)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of transforming growth factor beta1 production
    (GO:0032914)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of isotype switching to igg isotypes
    (GO:0048302)
  • Regulation of t cell anergy
    (GO:0002667)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Regulatory t cell differentiation
    (GO:0045066)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Response to rapamycin
    (GO:1901355)
  • Response to virus
    (GO:0009615)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • T cell activation
    (GO:0042110)
  • T cell anergy
    (GO:0002870)
  • T cell homeostasis
    (GO:0043029)
  • T cell mediated immunity
    (GO:0002456)
  • T cell receptor signaling pathway
    (GO:0050852)
  • Tolerance induction to self antigen
    (GO:0002513)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription corepressor activity
    (GO:0003714)
  • Transforming growth factor beta1 production
    (GO:0032905)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 2.5818
    Cell Significance Index: -2.4700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.5452
    Cell Significance Index: 25.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.8755
    Cell Significance Index: 55.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.8130
    Cell Significance Index: 43.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.2019
    Cell Significance Index: -0.6200
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.0934
    Cell Significance Index: 0.8400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0439
    Cell Significance Index: 0.7400
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.0427
    Cell Significance Index: 0.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0115
    Cell Significance Index: 0.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0095
    Cell Significance Index: 1.8900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0081
    Cell Significance Index: 0.1400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0068
    Cell Significance Index: 0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0053
    Cell Significance Index: 1.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0027
    Cell Significance Index: 1.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0012
    Cell Significance Index: 0.4200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0011
    Cell Significance Index: -0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0014
    Cell Significance Index: -2.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0024
    Cell Significance Index: -1.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0025
    Cell Significance Index: -3.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0029
    Cell Significance Index: -2.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0029
    Cell Significance Index: -1.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0032
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0033
    Cell Significance Index: -2.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0036
    Cell Significance Index: -2.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0036
    Cell Significance Index: -2.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0053
    Cell Significance Index: -0.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0055
    Cell Significance Index: -0.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0056
    Cell Significance Index: -2.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0082
    Cell Significance Index: -2.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0082
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0086
    Cell Significance Index: -1.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0098
    Cell Significance Index: -2.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0109
    Cell Significance Index: -0.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0133
    Cell Significance Index: -0.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0146
    Cell Significance Index: -2.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0147
    Cell Significance Index: -2.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0153
    Cell Significance Index: -1.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0173
    Cell Significance Index: -2.1300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0174
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0179
    Cell Significance Index: -2.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0182
    Cell Significance Index: -2.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0195
    Cell Significance Index: -1.9900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0197
    Cell Significance Index: -0.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0222
    Cell Significance Index: -1.3300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0241
    Cell Significance Index: -0.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0241
    Cell Significance Index: -0.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0247
    Cell Significance Index: -1.6600
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0250
    Cell Significance Index: -0.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0269
    Cell Significance Index: -1.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0310
    Cell Significance Index: -1.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0311
    Cell Significance Index: -2.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0317
    Cell Significance Index: -2.4300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0349
    Cell Significance Index: -0.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0350
    Cell Significance Index: -0.9800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0350
    Cell Significance Index: -1.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0358
    Cell Significance Index: -2.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0364
    Cell Significance Index: -0.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0374
    Cell Significance Index: -1.9500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0376
    Cell Significance Index: -0.3900
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.0380
    Cell Significance Index: -0.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0382
    Cell Significance Index: -2.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0394
    Cell Significance Index: -2.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0397
    Cell Significance Index: -1.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0415
    Cell Significance Index: -2.6800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0440
    Cell Significance Index: -0.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0480
    Cell Significance Index: -1.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0485
    Cell Significance Index: -1.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0492
    Cell Significance Index: -1.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0500
    Cell Significance Index: -2.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0510
    Cell Significance Index: -2.6800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0511
    Cell Significance Index: -0.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0516
    Cell Significance Index: -1.0800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0523
    Cell Significance Index: -0.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0526
    Cell Significance Index: -2.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0578
    Cell Significance Index: -1.2700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0593
    Cell Significance Index: -0.7900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0611
    Cell Significance Index: -0.6700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0615
    Cell Significance Index: -1.0500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0646
    Cell Significance Index: -0.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0651
    Cell Significance Index: -2.4700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0652
    Cell Significance Index: -1.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0653
    Cell Significance Index: -3.3900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0706
    Cell Significance Index: -1.7600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0708
    Cell Significance Index: -2.0200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0715
    Cell Significance Index: -1.0700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0718
    Cell Significance Index: -1.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0731
    Cell Significance Index: -1.5800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0734
    Cell Significance Index: -0.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0742
    Cell Significance Index: -2.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0749
    Cell Significance Index: -1.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0763
    Cell Significance Index: -2.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0765
    Cell Significance Index: -2.6600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0767
    Cell Significance Index: -1.5600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0769
    Cell Significance Index: -0.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0785
    Cell Significance Index: -2.2500
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0790
    Cell Significance Index: -1.0000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0790
    Cell Significance Index: -1.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FOXP3 is a transcription factor that belongs to the forkhead box (FOX) family of proteins. It is characterized by its ability to bind to specific DNA sequences and regulate gene expression. FOXP3 is specifically expressed in Tregs and is required for their proper development, maintenance, and function. The protein has a unique structure, consisting of three domains: the forkhead domain, the helix-loop-helix domain, and the C-terminal domain. FOXP3 is highly conserved across species, suggesting its critical role in immune regulation. **Pathways and Functions** FOXP3 regulates immune responses through several pathways: 1. **Treg differentiation and function**: FOXP3 is essential for the development and maintenance of Tregs, which are critical for preventing autoimmunity and suppressing excessive immune responses. 2. **Transcriptional regulation**: FOXP3 regulates the expression of genes involved in Treg function, including those involved in cytokine production, cell proliferation, and survival. 3. **Immune tolerance**: FOXP3 promotes immune tolerance by suppressing the activation and proliferation of effector T cells, thereby preventing autoimmune responses. 4. **Inflammation regulation**: FOXP3 regulates the production of anti-inflammatory cytokines, such as TGF-β, which helps to resolve inflammation and prevent tissue damage. **Clinical Significance** Dysregulation of FOXP3 has been implicated in various autoimmune and inflammatory diseases, including: 1. **Rheumatoid arthritis**: FOXP3 deficiency has been associated with an increased risk of developing rheumatoid arthritis. 2. **Type 1 diabetes**: FOXP3 deficiency has been linked to an increased risk of developing type 1 diabetes. 3. **Multiple sclerosis**: FOXP3 has been implicated in the pathogenesis of multiple sclerosis, a chronic autoimmune disease affecting the central nervous system. 4. **Cancer**: FOXP3 has been shown to suppress tumor growth and immune evasion in certain types of cancer, such as melanoma and lung cancer. In summary, FOXP3 is a critical transcription factor that plays a central role in regulating immune responses, particularly in the context of Treg function and immune tolerance. Its dysregulation has been implicated in various autoimmune and inflammatory diseases, highlighting the importance of FOXP3 in maintaining immune homeostasis.

Genular Protein ID: 4158722382

Symbol: FOXP3_HUMAN

Name: Forkhead box protein P3

UniProtKB Accession Codes:

Q9BZS1 A5HJT1 B7ZLG0 B9UN80 O60827 Q14DD8 Q4ZH51

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 78 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11138001

Title: Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.

PubMed ID: 11138001

DOI: 10.1038/83784

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15790681

Title: Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells.

PubMed ID: 15790681

DOI: 10.1073/pnas.0501675102

PubMed ID: 17377532

Title: Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.

PubMed ID: 17377532

DOI: 10.1038/nature05673

PubMed ID: 17360565

Title: FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression.

PubMed ID: 17360565

DOI: 10.1073/pnas.0700298104

PubMed ID: 18354202

Title: Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3.

PubMed ID: 18354202

DOI: 10.4049/jimmunol.180.7.4785

PubMed ID: 18368049

Title: TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.

PubMed ID: 18368049

DOI: 10.1038/nature06878

PubMed ID: 19117830

Title: Foxp3 processing by proprotein convertases and control of regulatory T cell function.

PubMed ID: 19117830

DOI: 10.1074/jbc.m807322200

PubMed ID: 20676092

Title: Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells.

PubMed ID: 20676092

DOI: 10.1038/ni.1915

PubMed ID: 22678915

Title: Subcellular localization of FOXP3 in human regulatory and nonregulatory T cells.

PubMed ID: 22678915

DOI: 10.1002/eji.201141838

PubMed ID: 22312127

Title: Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells.

PubMed ID: 22312127

DOI: 10.4049/jimmunol.1100903

PubMed ID: 23169781

Title: A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells.

PubMed ID: 23169781

DOI: 10.1182/blood-2012-05-431023

PubMed ID: 24350059

Title: Searching for the Achilles Heel of FOXP3.

PubMed ID: 24350059

DOI: 10.3389/fonc.2013.00294

PubMed ID: 23973222

Title: Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.

PubMed ID: 23973222

DOI: 10.1016/j.immuni.2013.05.018

PubMed ID: 23973223

Title: The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.

PubMed ID: 23973223

DOI: 10.1016/j.immuni.2013.08.006

PubMed ID: 23543754

Title: Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28.

PubMed ID: 23543754

DOI: 10.4049/jimmunol.1203561

PubMed ID: 23396208

Title: Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis.

PubMed ID: 23396208

DOI: 10.1038/nm.3085

PubMed ID: 24835996

Title: Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60.

PubMed ID: 24835996

DOI: 10.1016/j.celrep.2014.04.021

PubMed ID: 23947341

Title: The role of FOXP3 in regulating immune responses.

PubMed ID: 23947341

DOI: 10.3109/08830185.2013.811657

PubMed ID: 24354325

Title: Forkhead box P3: the peacekeeper of the immune system.

PubMed ID: 24354325

DOI: 10.3109/08830185.2013.863303

PubMed ID: 24722479

Title: FOXP3 and scurfy: how it all began.

PubMed ID: 24722479

DOI: 10.1038/nri3650

PubMed ID: 25047417

Title: Post-translational modification networks regulating FOXP3 function.

PubMed ID: 25047417

DOI: 10.1016/j.it.2014.06.005

PubMed ID: 30513302

Title: AMBRA1 controls regulatory T-cell differentiation and homeostasis upstream of the FOXO3-FOXP3 axis.

PubMed ID: 30513302

DOI: 10.1016/j.devcel.2018.11.010

PubMed ID: 32644293

Title: The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation.

PubMed ID: 32644293

DOI: 10.15252/embr.202050308

PubMed ID: 21458306

Title: Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells.

PubMed ID: 21458306

DOI: 10.1016/j.immuni.2011.02.017

PubMed ID: 25567984

Title: DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions.

PubMed ID: 25567984

DOI: 10.1093/nar/gku1373

PubMed ID: 11120765

Title: JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome.

PubMed ID: 11120765

DOI: 10.1172/jci11679

PubMed ID: 11768393

Title: Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX).

PubMed ID: 11768393

DOI: 10.1136/jmg.38.12.874

PubMed ID: 11137992

Title: X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy.

PubMed ID: 11137992

DOI: 10.1038/83707

PubMed ID: 11137993

Title: The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.

PubMed ID: 11137993

DOI: 10.1038/83713

PubMed ID: 18951619

Title: Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between forkhead box protein 3 expression and disease severity.

PubMed ID: 18951619

DOI: 10.1016/j.jaci.2008.09.027

Sequence Information:

  • Length: 431
  • Mass: 47244
  • Checksum: 91737C3CEA665A15
  • Sequence:
    • MPNPRPGKPS APSLALGPSP GASPSWRAAP KASDLLGARG PGGTFQGRDL RGGAHASSSS 
LNPMPPSQLQ LPTLPLVMVA PSGARLGPLP HLQALLQDRP HFMHQLSTVD AHARTPVLQV 
HPLESPAMIS LTPPTTATGV FSLKARPGLP PGINVASLEW VSREPALLCT FPNPSAPRKD 
STLSAVPQSS YPLLANGVCK WPGCEKVFEE PEDFLKHCQA DHLLDEKGRA QCLLQREMVQ 
SLEQQLVLEK EKLSAMQAHL AGKMALTKAS SVASSDKGSC CIVAAGSQGP VVPAWSGPRE 
APDSLFAVRR HLWGSHGNST FPEFLHNMDY FKFHNMRPPF TYATLIRWAI LEAPEKQRTL 
NEIYHWFTRM FAFFRNHPAT WKNAIRHNLS LHKCFVRVES EKGAVWTVDE LEFRKKRSQR 
PSRCSNPTPG P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.