Details for: P2RY2

Gene ID: 5029

Symbol: P2RY2

Ensembl ID: ENSG00000175591

Description: purinergic receptor P2Y2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 58.6968
    Cell Significance Index: -9.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.2714
    Cell Significance Index: -9.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 13.7105
    Cell Significance Index: -5.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.4131
    Cell Significance Index: -9.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.8026
    Cell Significance Index: -5.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5252
    Cell Significance Index: 20.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8701
    Cell Significance Index: 165.5900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.8424
    Cell Significance Index: 11.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8205
    Cell Significance Index: 42.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7381
    Cell Significance Index: 19.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5533
    Cell Significance Index: 8.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5187
    Cell Significance Index: 51.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4967
    Cell Significance Index: 13.3100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.4954
    Cell Significance Index: 5.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4335
    Cell Significance Index: 391.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3967
    Cell Significance Index: 11.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3530
    Cell Significance Index: 16.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3260
    Cell Significance Index: 8.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3236
    Cell Significance Index: 19.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2949
    Cell Significance Index: 32.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2694
    Cell Significance Index: 43.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2179
    Cell Significance Index: 6.0900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.2131
    Cell Significance Index: 2.2100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1895
    Cell Significance Index: 2.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1714
    Cell Significance Index: 11.8600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1703
    Cell Significance Index: 1.1300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.1669
    Cell Significance Index: 2.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1255
    Cell Significance Index: 3.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1195
    Cell Significance Index: 2.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1162
    Cell Significance Index: 20.9600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.1111
    Cell Significance Index: 1.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0777
    Cell Significance Index: 9.5500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0619
    Cell Significance Index: 0.5700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0330
    Cell Significance Index: 0.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0270
    Cell Significance Index: 0.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0232
    Cell Significance Index: 12.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0216
    Cell Significance Index: 0.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0079
    Cell Significance Index: 3.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0060
    Cell Significance Index: 1.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0007
    Cell Significance Index: 0.0500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0080
    Cell Significance Index: -5.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0084
    Cell Significance Index: -6.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0092
    Cell Significance Index: -5.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0100
    Cell Significance Index: -0.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0116
    Cell Significance Index: -0.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0127
    Cell Significance Index: -23.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0127
    Cell Significance Index: -0.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0130
    Cell Significance Index: -19.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0150
    Cell Significance Index: -11.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0165
    Cell Significance Index: -0.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0168
    Cell Significance Index: -22.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0227
    Cell Significance Index: -10.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0237
    Cell Significance Index: -13.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0276
    Cell Significance Index: -3.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0279
    Cell Significance Index: -8.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0283
    Cell Significance Index: -1.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0286
    Cell Significance Index: -0.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0345
    Cell Significance Index: -5.0200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0349
    Cell Significance Index: -0.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0387
    Cell Significance Index: -1.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0410
    Cell Significance Index: -0.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0442
    Cell Significance Index: -8.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0476
    Cell Significance Index: -5.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0502
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0594
    Cell Significance Index: -10.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0641
    Cell Significance Index: -6.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0662
    Cell Significance Index: -4.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0664
    Cell Significance Index: -7.6100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0738
    Cell Significance Index: -0.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0808
    Cell Significance Index: -6.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0848
    Cell Significance Index: -11.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0954
    Cell Significance Index: -4.4500
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0969
    Cell Significance Index: -0.6000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0976
    Cell Significance Index: -0.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1049
    Cell Significance Index: -7.8200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1092
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1115
    Cell Significance Index: -23.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1135
    Cell Significance Index: -7.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1205
    Cell Significance Index: -15.5700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1209
    Cell Significance Index: -2.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1253
    Cell Significance Index: -7.7000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1316
    Cell Significance Index: -0.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1330
    Cell Significance Index: -8.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1428
    Cell Significance Index: -2.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1507
    Cell Significance Index: -4.4400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1511
    Cell Significance Index: -6.5700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1705
    Cell Significance Index: -2.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1778
    Cell Significance Index: -9.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1783
    Cell Significance Index: -8.3800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1921
    Cell Significance Index: -2.8000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1938
    Cell Significance Index: -4.8400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2004
    Cell Significance Index: -2.7800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2097
    Cell Significance Index: -3.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2220
    Cell Significance Index: -9.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2326
    Cell Significance Index: -4.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2378
    Cell Significance Index: -8.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2411
    Cell Significance Index: -8.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G-protein coupled receptor**: The P2RY2 receptor is a member of the G-protein coupled receptor family, which is characterized by its ability to bind to extracellular ligands and activate downstream signaling pathways. 2. **Purinergic receptor**: The P2RY2 receptor is a purinergic receptor, which responds to extracellular ATP and UTP. 3. **High expression in immune cells**: The P2RY2 gene is highly expressed in mature NK T cells, immature innate lymphoid cells, and other immune cells, suggesting its critical role in immune response. 4. **Expression in non-immune cells**: The P2RY2 gene is also expressed in non-immune cells, including cardiac endothelial cells, cardiac muscle myoblasts, and intestinal epithelial cells, indicating its involvement in various physiological processes. **Pathways and Functions:** 1. **G-protein coupled receptor signaling pathway**: The P2RY2 receptor activates the G-protein coupled receptor signaling pathway, which leads to the activation of downstream effectors, including phospholipase C and protein kinase C. 2. **Intracellular signaling**: The P2RY2 receptor activates intracellular signaling pathways, including the phospholipase C-activating G-protein coupled receptor signaling pathway, which regulates various cellular processes, including metabolism, protein binding, and surfactant metabolism. 3. **Immune response**: The P2RY2 receptor plays a critical role in the immune response, particularly in the activation of mature NK T cells and the regulation of mucus secretion. 4. **Cardiovascular function**: The P2RY2 receptor is also involved in cardiovascular function, including the regulation of blood vessel diameter and the maintenance of cardiovascular homeostasis. **Clinical Significance:** 1. **Cardiovascular disease**: The P2RY2 gene has been implicated in cardiovascular disease, including hypertension, atherosclerosis, and cardiac failure. 2. **Diabetes**: The P2RY2 gene has been shown to play a role in the development of diabetes, particularly in the regulation of glucose metabolism. 3. **Cancer**: The P2RY2 gene has been implicated in cancer, particularly in the regulation of tumor growth and metastasis. 4. **Neurological disorders**: The P2RY2 gene has been shown to play a role in various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the P2RY2 gene is a critical component of the immune system and plays a significant role in various physiological processes. Its dysregulation has been implicated in various diseases, including cardiovascular disease, diabetes, and cancer. Further research is needed to fully understand the role of the P2RY2 gene in human health and disease.

Genular Protein ID: 3955993075

Symbol: P2RY2_HUMAN

Name: P2Y purinoceptor 2

UniProtKB Accession Codes:

P41231 B2R9W3 Q96EM8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 7 Ensembl 3 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 8 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8159738

Title: Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.

PubMed ID: 8159738

DOI: 10.1073/pnas.91.8.3275

PubMed ID: 7809171

Title: Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.

PubMed ID: 7809171

DOI: 10.1073/pnas.91.26.13067

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 377
  • Mass: 42273
  • Checksum: F71DAF4A8DCB4062
  • Sequence:
    • MAADLGPWND TINGTWDGDE LGYRCRFNED FKYVLLPVSY GVVCVPGLCL NAVALYIFLC 
RLKTWNASTT YMFHLAVSDA LYAASLPLLV YYYARGDHWP FSTVLCKLVR FLFYTNLYCS 
ILFLTCISVH RCLGVLRPLR SLRWGRARYA RRVAGAVWVL VLACQAPVLY FVTTSARGGR 
VTCHDTSAPE LFSRFVAYSS VMLGLLFAVP FAVILVCYVL MARRLLKPAY GTSGGLPRAK 
RKSVRTIAVV LAVFALCFLP FHVTRTLYYS FRSLDLSCHT LNAINMAYKV TRPLASANSC 
LDPVLYFLAG QRLVRFARDA KPPTGPSPAT PARRRLGLRR SDRTDMQRIE DVLGSSEDSR 
RTESTPAGSE NTKDIRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.