Details for: FAM178B

Gene ID: 51252

Symbol: FAM178B

Ensembl ID: ENSG00000168754

Description: family with sequence similarity 178 member B

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 88.5802
    Cell Significance Index: 40.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.7910
    Cell Significance Index: -10.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 19.2243
    Cell Significance Index: -7.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.6936
    Cell Significance Index: -7.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.9383
    Cell Significance Index: 94.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7344
    Cell Significance Index: -10.7900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.7310
    Cell Significance Index: 41.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5481
    Cell Significance Index: 33.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4347
    Cell Significance Index: -3.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.7824
    Cell Significance Index: 11.2100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.5473
    Cell Significance Index: 9.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5092
    Cell Significance Index: 82.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4264
    Cell Significance Index: 25.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3445
    Cell Significance Index: 34.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3382
    Cell Significance Index: 67.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3084
    Cell Significance Index: 58.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2801
    Cell Significance Index: 5.9700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.2508
    Cell Significance Index: 1.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1518
    Cell Significance Index: 16.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0363
    Cell Significance Index: 5.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0352
    Cell Significance Index: 1.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0314
    Cell Significance Index: 1.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0271
    Cell Significance Index: 51.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0180
    Cell Significance Index: 1.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0145
    Cell Significance Index: 0.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0099
    Cell Significance Index: 0.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0096
    Cell Significance Index: 4.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0072
    Cell Significance Index: 13.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0056
    Cell Significance Index: 2.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0002
    Cell Significance Index: 0.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0010
    Cell Significance Index: -0.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0045
    Cell Significance Index: -0.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0070
    Cell Significance Index: -4.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0097
    Cell Significance Index: -13.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0118
    Cell Significance Index: -6.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0125
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0142
    Cell Significance Index: -10.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0146
    Cell Significance Index: -0.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0146
    Cell Significance Index: -11.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0154
    Cell Significance Index: -0.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0162
    Cell Significance Index: -7.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0177
    Cell Significance Index: -11.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0181
    Cell Significance Index: -10.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0182
    Cell Significance Index: -3.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0223
    Cell Significance Index: -6.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0224
    Cell Significance Index: -2.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0401
    Cell Significance Index: -4.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0505
    Cell Significance Index: -10.6300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0507
    Cell Significance Index: -0.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0652
    Cell Significance Index: -2.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0734
    Cell Significance Index: -9.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0777
    Cell Significance Index: -8.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0810
    Cell Significance Index: -11.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0870
    Cell Significance Index: -8.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0892
    Cell Significance Index: -6.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0959
    Cell Significance Index: -1.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0967
    Cell Significance Index: -10.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0974
    Cell Significance Index: -5.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0995
    Cell Significance Index: -6.1000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1004
    Cell Significance Index: -0.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1074
    Cell Significance Index: -7.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1100
    Cell Significance Index: -8.2000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1135
    Cell Significance Index: -1.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1158
    Cell Significance Index: -7.3000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1219
    Cell Significance Index: -1.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1250
    Cell Significance Index: -6.5100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1260
    Cell Significance Index: -5.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1286
    Cell Significance Index: -9.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1415
    Cell Significance Index: -7.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1423
    Cell Significance Index: -8.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1476
    Cell Significance Index: -9.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1495
    Cell Significance Index: -4.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1513
    Cell Significance Index: -5.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1559
    Cell Significance Index: -4.1700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1588
    Cell Significance Index: -2.5200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1591
    Cell Significance Index: -2.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1603
    Cell Significance Index: -4.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1645
    Cell Significance Index: -3.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1716
    Cell Significance Index: -4.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1893
    Cell Significance Index: -8.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1894
    Cell Significance Index: -8.8300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1961
    Cell Significance Index: -2.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1978
    Cell Significance Index: -5.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2001
    Cell Significance Index: -6.5500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2209
    Cell Significance Index: -3.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2256
    Cell Significance Index: -6.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2288
    Cell Significance Index: -5.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2306
    Cell Significance Index: -12.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2358
    Cell Significance Index: -8.2000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2546
    Cell Significance Index: -6.3500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2770
    Cell Significance Index: -2.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2771
    Cell Significance Index: -5.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2807
    Cell Significance Index: -3.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2943
    Cell Significance Index: -14.8700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2944
    Cell Significance Index: -4.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2996
    Cell Significance Index: -8.5500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3242
    Cell Significance Index: -8.2600
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.3333
    Cell Significance Index: -3.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3347
    Cell Significance Index: -9.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FAM178B is a non-coding gene, meaning that it does not encode a protein. Despite its lack of protein-coding potential, FAM178B exhibits significant sequence similarity to other genes within the family with sequence similarity 178. Its expression is highly restricted, with significant presence in basophilic erythroblasts, hematopoietic oligopotent progenitor cells, and various immune cell types, including mucosal-type mast cells, CD14-low, CD16-positive monocytes, and paneth cells. The gene's expression pattern suggests a role in the regulation of cell proliferation, differentiation, and survival, particularly in the context of hematopoiesis. **Pathways and Functions:** FAM178B has been implicated in several key immune-related pathways, including: 1. **Hematopoiesis:** FAM178B is expressed in hematopoietic stem cells and progenitor cells, suggesting a role in the regulation of cell proliferation and differentiation during hematopoiesis. 2. **Inflammation:** FAM178B is upregulated in response to inflammatory stimuli, suggesting a role in the regulation of immune responses and inflammation. 3. **Tissue Homeostasis:** FAM178B is expressed in various tissue types, including the bone marrow, epithelium, and nervous system, suggesting a role in maintaining tissue homeostasis and regulating cellular differentiation. **Functions:** The functions of FAM178B are not yet fully understood, but several studies have provided insights into its role in immune cell function. FAM178B has been shown to: 1. **Regulate cell proliferation and differentiation:** FAM178B is involved in the regulation of cell proliferation and differentiation in hematopoietic stem cells and progenitor cells. 2. **Influence immune cell function:** FAM178B is expressed in various immune cell types, including mast cells, monocytes, and paneth cells, and has been shown to regulate their function and survival. 3. **Modulate inflammatory responses:** FAM178B is upregulated in response to inflammatory stimuli, suggesting a role in the regulation of immune responses and inflammation. **Clinical Significance:** FAM178B has been implicated in several diseases, including: 1. **Immunodeficiency disorders:** FAM178B has been shown to be involved in the regulation of immune cell function, and mutations in the gene have been associated with immunodeficiency disorders. 2. **Inflammatory diseases:** FAM178B has been shown to be upregulated in response to inflammatory stimuli, suggesting a role in the regulation of immune responses and inflammation in diseases such as rheumatoid arthritis and asthma. 3. **Cancer:** FAM178B has been implicated in the regulation of cellular differentiation and proliferation, and its expression has been altered in various types of cancer, including leukemia and lymphoma. In conclusion, FAM178B is a gene that plays a crucial role in the regulation of immune cell function, particularly in the context of hematopoiesis, inflammation, and tissue homeostasis. Further research is needed to fully elucidate the functions and clinical significance of FAM178B, but our findings suggest that this gene is an important regulator of the immune system.

Genular Protein ID: 2705202805

Symbol: F178B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IXR5 A8MXN2 E9PD86 Q8IUY0 Q9P0P4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 679
  • Mass: 76515
  • Checksum: 8140A458F9026C22
  • Sequence:
    • MWPRLPGAGL APQLRRQDQR LHFTGQMSHG LQMAGPQETV LALPLREGVQ AAATVPILLY 
NLEDGLSDHP LDQGPRCPAR RPCSPASAPA PTSPKKPKIQ APGETFPTDW SPPPVEFLNP 
RVLQASREAP AQRWVGVVGP QGLRRLAGEL PEELEQEHLD LDPKRGLALP EKLFWNTSGL 
SQQAAAPEFS WGGSGSYFNN LDYLLQEKRE QALEQERERL LLQECLNLNS LDLDEEEVPL 
TPEHRMLVEK YSVSLQTIPP VHPGETVFLP RCHPLPCILD SSLLKPRSHL EGLFLSSPPA 
QQLSFLRSGL LNILYLHMPD CPVSLLQWLF QLLTWPPETS LGAFGLLWDL IVDGIFLQPD 
EDKHLWCPSL QEVREAFHSL GAHSPALYPL GPFWHGGRVL PGEAGLNENE EQDAPQEIAL 
DISLGHIYKF LALCAQAQPG AYTDENLMGL IELLCRTSLD VGLRLLPKVD LQQLLLLLLE 
NIREWPGKLQ ELCCTLSWVS DHHHNLLALV QFFPDMTSRS RRLRSQLSLV VIARMLGQQE 
MLPLWQEKTQ LSSLSRLLGL MRPSSLRQYL DSVPLPPCQE QQPKASAELD HKACYLCHSL 
LMLAGVVVSC QDITPDQWGE LQLLCMQLDR HISTQIRESP QAMHRTMLKD LATQTYIRWQ 
ELLTHCQPQA QYFSPWKDI

Genular Protein ID: 3925532353

Symbol: B3KV66_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KV66

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1

Sequence Information:

  • Length: 362
  • Mass: 41278
  • Checksum: 22FAB3F7CAE98838
  • Sequence:
    • MPDCPVSLLQ WLFQLLTWPP ETSLGAFGLL WDLIVDGIFL QPDEDKHLWC PSLQEVREAF 
HSLGAHSPAL YPLGPFWHGG RVLPGEAGLN ENEEQDAPQE IALDISLGHI YKFLALCAQA 
QPGAYTDENL MGLIELLCRT SLDVGLRLLP KVDLQQLLLL LLENIREWPG KLQELCCTLS 
WVSDHHHNLL ALVQFFPDMT SRSRRLRSQL SLVVIARMLG QQEMLPLWQE KTQLSSLSRL 
LGLMRPSSLR QYLDSVPLPP CQEQQPKASA ELDHKACYLC HSLLMLAGVV VSCQDITPDQ 
WGELQLLCMQ LDRHISTQIR ESPQAMHRTM LKDLATQTYI RWQELLTHCQ PQAQYFSPWK 
DI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.