PDGFA | ENSG00000197461 | NCBI 5154

Details for: PDGFA

Gene ID: 5154

Symbol: PDGFA

Ensembl ID: ENSG00000197461

Description: platelet derived growth factor subunit A

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signal transduction
(R-HSA-186763)
Extracellular matrix organization
(R-HSA-1474244)
Hemostasis
(R-HSA-109582)
Intracellular signaling by second messengers
(R-HSA-9006925)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nfe2l2 regulating tumorigenic genes
(R-HSA-9818030)
Non-integrin membrane-ecm interactions
(R-HSA-3000171)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Raf/map kinase cascade
(R-HSA-5673001)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Signaling by pdgf
(R-HSA-186797)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Actin cytoskeleton organization
(GO:0030036)
Angiogenesis
(GO:0001525)
Animal organ morphogenesis
(GO:0009887)
Cell-cell signaling
(GO:0007267)
Cell activation
(GO:0001775)
Cell projection assembly
(GO:0030031)
Cell surface
(GO:0009986)
Collagen binding
(GO:0005518)
Embryonic lung development
(GO:1990401)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi lumen
(GO:0005796)
Golgi membrane
(GO:0000139)
Growth factor activity
(GO:0008083)
Hair follicle development
(GO:0001942)
Identical protein binding
(GO:0042802)
Lung alveolus development
(GO:0048286)
Microvillus
(GO:0005902)
Negative chemotaxis
(GO:0050919)
Negative regulation of phosphatidylinositol biosynthetic process
(GO:0010512)
Negative regulation of platelet activation
(GO:0010544)
Platelet-derived growth factor binding
(GO:0048407)
Platelet-derived growth factor complex
(GO:1990265)
Platelet-derived growth factor receptor-alpha signaling pathway
(GO:0035790)
Platelet-derived growth factor receptor binding
(GO:0005161)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Platelet alpha granule lumen
(GO:0031093)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of mesenchymal cell proliferation
(GO:0002053)
Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
(GO:0035793)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein autophosphorylation
(GO:0031954)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
(GO:0060683)
Regulation of dna biosynthetic process
(GO:2000278)
Regulation of glomerular mesangial cell proliferation
(GO:0072124)
Regulation of peptidyl-tyrosine phosphorylation
(GO:0050730)
Regulation of smooth muscle cell migration
(GO:0014910)
Response to wounding
(GO:0009611)
Skin development
(GO:0043588)
Wound healing
(GO:0042060)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 138.0949
Cell Significance Index: -21.4800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 84.7647
Cell Significance Index: -21.5000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 45.5254
Cell Significance Index: -18.5000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 44.9671
Cell Significance Index: -21.2300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 42.6334
Cell Significance Index: -21.9300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 19.5550
Cell Significance Index: -18.6700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 17.4702
Cell Significance Index: -21.5400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.2572
Cell Significance Index: -22.1200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.4536
Cell Significance Index: -21.5200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 3.4011
Cell Significance Index: 154.1600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 3.3094
Cell Significance Index: 95.3500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 2.3899
Cell Significance Index: 35.8100
Cell Name: perivascular cell (CL4033054)
Fold Change: 2.3412
Cell Significance Index: 10.8100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.3296
Cell Significance Index: 144.6300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8753
Cell Significance Index: 142.3600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.8115
Cell Significance Index: 138.5800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.8085
Cell Significance Index: 8.7900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.7375
Cell Significance Index: 51.0000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.7259
Cell Significance Index: 15.4600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6760
Cell Significance Index: 18.4000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6406
Cell Significance Index: 283.2200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.6083
Cell Significance Index: 8.3000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5027
Cell Significance Index: 35.5500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4933
Cell Significance Index: 445.4300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4556
Cell Significance Index: 23.6700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3791
Cell Significance Index: 76.0500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3614
Cell Significance Index: 12.7000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3490
Cell Significance Index: 190.5700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3428
Cell Significance Index: 68.0200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3017
Cell Significance Index: 37.1000
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.2841
Cell Significance Index: 2.3500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2836
Cell Significance Index: 7.0900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2299
Cell Significance Index: 22.7400
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.1907
Cell Significance Index: 2.9500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1906
Cell Significance Index: 8.8900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1864
Cell Significance Index: 33.6000
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.1707
Cell Significance Index: 1.8500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1613
Cell Significance Index: 57.8700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1391
Cell Significance Index: 8.9800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1345
Cell Significance Index: 253.2300
Cell Name: kidney cell (CL1000497)
Fold Change: 0.1265
Cell Significance Index: 1.0100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0704
Cell Significance Index: 1.5300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0616
Cell Significance Index: 11.7300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0584
Cell Significance Index: 37.0900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0530
Cell Significance Index: 4.0700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0255
Cell Significance Index: 18.7100
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0142
Cell Significance Index: 26.2400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0005
Cell Significance Index: 0.8400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0002
Cell Significance Index: -0.0100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0008
Cell Significance Index: -0.0200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0059
Cell Significance Index: -4.3900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0062
Cell Significance Index: -3.8500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0112
Cell Significance Index: -0.3000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0128
Cell Significance Index: -5.8300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0149
Cell Significance Index: -20.3100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0173
Cell Significance Index: -13.0900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0288
Cell Significance Index: -16.2600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0556
Cell Significance Index: -6.4800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0581
Cell Significance Index: -12.2400
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.0583
Cell Significance Index: -0.4900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0624
Cell Significance Index: -17.9500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0670
Cell Significance Index: -9.7400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0727
Cell Significance Index: -8.3300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0889
Cell Significance Index: -3.0900
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1030
Cell Significance Index: -13.2000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1098
Cell Significance Index: -2.0300
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1125
Cell Significance Index: -14.5400
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1181
Cell Significance Index: -13.4800
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.1192
Cell Significance Index: -0.6500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1212
Cell Significance Index: -12.3900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1242
Cell Significance Index: -3.4700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1244
Cell Significance Index: -17.0800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1257
Cell Significance Index: -13.0900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1548
Cell Significance Index: -9.5200
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.1590
Cell Significance Index: -1.6600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1925
Cell Significance Index: -22.7000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2001
Cell Significance Index: -13.4600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2199
Cell Significance Index: -17.4200
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2270
Cell Significance Index: -2.3500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2421
Cell Significance Index: -18.0400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2486
Cell Significance Index: -15.2400
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2624
Cell Significance Index: -10.7500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3019
Cell Significance Index: -9.6700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3054
Cell Significance Index: -15.4300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3059
Cell Significance Index: -16.0600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3154
Cell Significance Index: -16.4300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.3211
Cell Significance Index: -1.9400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3475
Cell Significance Index: -9.9600
Cell Name: peg cell (CL4033014)
Fold Change: -0.3653
Cell Significance Index: -8.4400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3775
Cell Significance Index: -7.8300
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3803
Cell Significance Index: -10.0000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4123
Cell Significance Index: -18.2400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4248
Cell Significance Index: -23.8400
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.4345
Cell Significance Index: -12.4000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4346
Cell Significance Index: -13.8400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.4357
Cell Significance Index: -4.9500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4739
Cell Significance Index: -16.6000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4896
Cell Significance Index: -18.5400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4918
Cell Significance Index: -16.1000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.5467
Cell Significance Index: -9.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Gene Expression:** PDGFA is significantly expressed in various cell types, including CD14-positive, CD16-negative classical monocytes, mature gamma-delta T cells, mature alpha-beta T cells, Paneth cells of the epithelium of the small intestine, skeletal muscle satellite stem cells, cortical thymic epithelial cells, renal interstitial pericytes, mural cells, kidney interstitial cells, and peptic cells. 2. **Protein Structure:** PDGFA is a 19-kDa protein that forms a heterodimer with the PDGFB subunit to form the PDGF complex. 3. **Function:** PDGFA plays a critical role in cell growth, differentiation, migration, and survival by binding to the PDGFR-alpha receptor, triggering a cascade of signaling pathways that regulate various cellular processes. **Pathways and Functions:** 1. **Cell Signaling:** PDGFA binds to the PDGFR-alpha receptor, triggering the activation of various signaling pathways, including the PI3K/AKT, MAPK, and ERK cascades, which regulate cell growth, differentiation, migration, and survival. 2. **Angiogenesis:** PDGFA promotes angiogenesis by regulating the expression of vascular endothelial growth factor (VEGF) and other angiogenic factors. 3. **Inflammation:** PDGFA has anti-inflammatory properties by regulating the expression of inflammatory cytokines and chemokines. 4. **Wound Healing:** PDGFA plays a crucial role in wound healing by promoting the migration and proliferation of fibroblasts and other cell types involved in the wound healing process. 5. **Cancer:** PDGFA has been implicated in various cancers, including breast, lung, and colon cancer, where it promotes tumor growth, metastasis, and angiogenesis. **Clinical Significance:** 1. **Cancer:** Elevated PDGFA levels have been associated with poor prognosis and increased risk of recurrence in various cancers. 2. **Inflammatory Diseases:** PDGFA has been implicated in the pathogenesis of inflammatory diseases, such as arthritis and asthma, where it regulates the expression of inflammatory cytokines and chemokines. 3. **Neurological Disorders:** PDGFA has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates the expression of neurotrophic factors and neuroinflammatory cytokines. 4. **Cardiovascular Disease:** PDGFA has been implicated in the pathogenesis of cardiovascular disease, where it regulates the expression of angiogenic factors and promotes vascular remodeling. In conclusion, the PDGFA gene plays a critical role in various physiological and pathological processes, including cell signaling, angiogenesis, inflammation, wound healing, and cancer. Understanding the mechanisms of PDGFA function and its clinical significance is essential for the development of novel therapeutic strategies for various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Platelet-derived growth factor subunit A

Genular Protein ID: 3645918631

Symbol: PDGFA_HUMAN

Name: Platelet-derived growth factor subunit A

UniProtKB Accession Codes:

P04085 B5BU73

Database IDs:

Citations:

PubMed ID: 3422746

Title: Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.

PubMed ID: 3422746

DOI: 10.1073/pnas.85.5.1492

PubMed ID: 2832727

Title: Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins.

PubMed ID: 2832727

DOI: 10.1128/mcb.8.2.571-577.1988

PubMed ID: 3754619

Title: cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines.

PubMed ID: 3754619

DOI: 10.1038/320695a0

PubMed ID: 3666150

Title: The long 3'-untranslated regions of the PDGF-A and -B mRNAs are only distantly related.

PubMed ID: 3666150

DOI: 10.1016/0014-5793(87)80297-1

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 8486521

Title: Nucleotide sequence of the 5' region of the human platelet-derived growth factor A-chain gene.

PubMed ID: 8486521

PubMed ID: 1612586

Title: Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite.

PubMed ID: 1612586

DOI: 10.1016/0888-7543(92)90240-s

PubMed ID: 3614363

Title: cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains.

PubMed ID: 3614363

DOI: 10.1038/328619a0

PubMed ID: 3614364

Title: Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain.

PubMed ID: 3614364

DOI: 10.1038/328621a0

PubMed ID: 1317862

Title: Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF.

PubMed ID: 1317862

DOI: 10.1016/s0021-9258(19)49905-5

PubMed ID: 10358027

Title: High-affinity binding of basic fibroblast growth factor and platelet-derived growth factor-AA to the core protein of the NG2 proteoglycan.

PubMed ID: 10358027

DOI: 10.1074/jbc.274.24.16831

PubMed ID: 18483217

Title: Role of platelet-derived growth factors in physiology and medicine.

PubMed ID: 18483217

DOI: 10.1101/gad.1653708

PubMed ID: 20534510

Title: Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.

PubMed ID: 20534510

DOI: 10.1073/pnas.1000806107

Sequence Information:

Length: 211
Mass: 24043
Checksum: 48633DDE558EFA43
Sequence:

MRTLACLLLL GCGYLAHVLA EEAEIPREVI ERLARSQIHS IRDLQRLLEI DSVGSEDSLD 
TSLRAHGVHA TKHVPEKRPL PIRRKRSIEE AVPAVCKTRT VIYEIPRSQV DPTSANFLIW 
PPCVEVKRCT GCCNTSSVKC QPSRVHHRSV KVAKVEYVRK KPKLKEVQVR LEEHLECACA 
TTSLNPDYRE EDTGRPRESG KKRKRKRLKP T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PDGFA

Associated with

Cells (max top 100)

Other Information

Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing. PubMed ID: 3422746

Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins. PubMed ID: 2832727

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. PubMed ID: 3754619

The long 3'-untranslated regions of the PDGF-A and -B mRNAs are only distantly related. PubMed ID: 3666150

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The DNA sequence of human chromosome 7. PubMed ID: 12853948

Nucleotide sequence of the 5' region of the human platelet-derived growth factor A-chain gene. PubMed ID: 8486521

Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite. PubMed ID: 1612586

cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains. PubMed ID: 3614363

Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain. PubMed ID: 3614364

Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF. PubMed ID: 1317862

High-affinity binding of basic fibroblast growth factor and platelet-derived growth factor-AA to the core protein of the NG2 proteoglycan. PubMed ID: 10358027

Role of platelet-derived growth factors in physiology and medicine. PubMed ID: 18483217

Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. PubMed ID: 20534510