Details for: EEF1G

Gene ID: 1937

Symbol: EEF1G

Ensembl ID: ENSG00000254772

Description: eukaryotic translation elongation factor 1 gamma

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 5.86
    Marker Score: 28777
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 5.47
    Marker Score: 6735
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.92
    Marker Score: 3473
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.6
    Marker Score: 156452
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.29
    Marker Score: 3656
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 4.26
    Marker Score: 10386
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 4.08
    Marker Score: 3833
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.94
    Marker Score: 11040
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.92
    Marker Score: 2298
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.74
    Marker Score: 6414.5
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.57
    Marker Score: 1697
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.49
    Marker Score: 1454
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.48
    Marker Score: 2043
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.31
    Marker Score: 1829
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 3.21
    Marker Score: 6647.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.19
    Marker Score: 4702
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.18
    Marker Score: 27870
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.14
    Marker Score: 1032
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.1
    Marker Score: 2720
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.02
    Marker Score: 3154
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.96
    Marker Score: 18899
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.92
    Marker Score: 154602
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.73
    Marker Score: 1975
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.63
    Marker Score: 934
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.51
    Marker Score: 10744
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.49
    Marker Score: 7850
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.47
    Marker Score: 909
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.45
    Marker Score: 4651
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.41
    Marker Score: 773
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.4
    Marker Score: 1477
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.39
    Marker Score: 1375
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.33
    Marker Score: 1907
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.24
    Marker Score: 4005
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.21
    Marker Score: 2670
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 2.21
    Marker Score: 891
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.19
    Marker Score: 1605
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.19
    Marker Score: 6490
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 2.18
    Marker Score: 699
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.14
    Marker Score: 627
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.13
    Marker Score: 21094
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.11
    Marker Score: 2809
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.08
    Marker Score: 3017
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.05
    Marker Score: 713
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 2.03
    Marker Score: 712
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.03
    Marker Score: 1359
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.03
    Marker Score: 998
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 2.02
    Marker Score: 572
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.95
    Marker Score: 10265
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.95
    Marker Score: 1616
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.92
    Marker Score: 1299
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.82
    Marker Score: 1323
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.81
    Marker Score: 2264
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.8
    Marker Score: 1514.5
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.74
    Marker Score: 444
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.71
    Marker Score: 2782
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.71
    Marker Score: 3245.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.68
    Marker Score: 22225
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.63
    Marker Score: 907
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.62
    Marker Score: 21753
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.58
    Marker Score: 415
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.56
    Marker Score: 859
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.55
    Marker Score: 3791
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.54
    Marker Score: 86305
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.54
    Marker Score: 11479
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.53
    Marker Score: 9047
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.46
    Marker Score: 1488.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.45
    Marker Score: 417
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.43
    Marker Score: 9342
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.38
    Marker Score: 3574
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.38
    Marker Score: 8951
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.38
    Marker Score: 1521
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.37
    Marker Score: 942
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.37
    Marker Score: 2388
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.36
    Marker Score: 622.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.36
    Marker Score: 975
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.35
    Marker Score: 320
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.34
    Marker Score: 1403.5
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.34
    Marker Score: 1652
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.34
    Marker Score: 1892
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.33
    Marker Score: 837
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.33
    Marker Score: 596
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.31
    Marker Score: 525
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.31
    Marker Score: 815
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.31
    Marker Score: 548.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.31
    Marker Score: 1199
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.29
    Marker Score: 730
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.29
    Marker Score: 561
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.29
    Marker Score: 463
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.28
    Marker Score: 325
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.28
    Marker Score: 3487
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.27
    Marker Score: 753
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.26
    Marker Score: 1121
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.24
    Marker Score: 2983
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.23
    Marker Score: 4220
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.23
    Marker Score: 1055
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.23
    Marker Score: 845
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.19
    Marker Score: 849
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.18
    Marker Score: 1426
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.18
    Marker Score: 1377
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.17
    Marker Score: 3063

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Other Information

**Key characteristics:** - EEF1G is a transmembrane protein that is composed of two extracellular domains and a central coiled-coil domain. - The extracellular domains interact with the cytoplasmic domain of EF2, which is an elongation factor. - EEF1G is a key regulator of epithelial cell growth and differentiation. - It is upregulated in breast cancer cells, where it promotes cell proliferation and survival. **Pathways and functions:** - EEF1G is a key regulator of epithelial cell growth and differentiation. - It is involved in the formation of the epithelial barrier and the maintenance of epithelial cell polarity. - It also plays a role in the regulation of cell migration and proliferation. - EEF1G is upregulated in breast cancer cells, where it promotes cell proliferation and survival. **Clinical significance:** - EEF1G is a promising target for the treatment of breast cancer. - Inhibition of EEF1G has been shown to inhibit breast cancer cell growth and metastasis in preclinical models. - Clinical trials are currently testing EEF1G inhibitors as cancer drugs.

Genular Protein ID: 1948024018

Symbol: EF1G_HUMAN

Name: Elongation factor 1-gamma

UniProtKB Accession Codes:

P26641 B4DTG2 Q6PJ62 Q6PK31 Q96CU2 Q9P196

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SFLD 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1461723

Title: Elongation factor-1 messenger-RNA levels in cultured cells are high compared to tissue and are not drastically affected further by oncogenic transformation.

PubMed ID: 1461723

DOI: 10.1093/nar/20.22.5907

PubMed ID: 1598220

Title: Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19.

PubMed ID: 1598220

DOI: 10.1093/nar/20.10.2598

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1372736

Title: Expression of elongation factor-1 gamma-related sequence in human pancreatic cancer.

PubMed ID: 1372736

DOI: 10.1097/00006676-199203000-00003

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 12766415

Title: 1H, 15N and 13C resonance assignments of the highly conserved 19 kDa C-terminal domain from human elongation factor 1Bgamma.

PubMed ID: 12766415

DOI: 10.1023/a:1023504611632

Sequence Information:

  • Length: 437
  • Mass: 50119
  • Checksum: A6110663110CF3FC
  • Sequence:
    • MAAGTLYTYP ENWRAFKALI AAQYSGAQVR VLSAPPHFHF GQTNRTPEFL RKFPAGKVPA 
FEGDDGFCVF ESNAIAYYVS NEELRGSTPE AAAQVVQWVS FADSDIVPPA STWVFPTLGI 
MHHNKQATEN AKEEVRRILG LLDAYLKTRT FLVGERVTLA DITVVCTLLW LYKQVLEPSF 
RQAFPNTNRW FLTCINQPQF RAVLGEVKLC EKMAQFDAKK FAETQPKKDT PRKEKGSREE 
KQKPQAERKE EKKAAAPAPE EEMDECEQAL AAEPKAKDPF AHLPKSTFVL DEFKRKYSNE 
DTLSVALPYF WEHFDKDGWS LWYSEYRFPE ELTQTFMSCN LITGMFQRLD KLRKNAFASV 
ILFGTNNSSS ISGVWVFRGQ ELAFPLSPDW QVDYESYTWR KLDPGSEETQ TLVREYFSWE 
GAFQHVGKAF NQGKIFK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.