Details for: EEF1G

Gene ID: 1937

Symbol: EEF1G

Ensembl ID: ENSG00000254772

Description: eukaryotic translation elongation factor 1 gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 143.6406
    Cell Significance Index: -58.3600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 133.3631
    Cell Significance Index: -68.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 64.8656
    Cell Significance Index: -61.9300
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 29.4280
    Cell Significance Index: 22.4600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 26.5973
    Cell Significance Index: 228.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.0135
    Cell Significance Index: -61.6500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 15.8262
    Cell Significance Index: 365.6400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 12.5928
    Cell Significance Index: 90.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.4592
    Cell Significance Index: 299.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 9.5328
    Cell Significance Index: 87.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 9.1161
    Cell Significance Index: 267.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 8.4160
    Cell Significance Index: 95.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 7.1145
    Cell Significance Index: 874.7900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 7.0540
    Cell Significance Index: 32.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 6.9299
    Cell Significance Index: 1249.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.5131
    Cell Significance Index: 706.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 5.2269
    Cell Significance Index: 272.2600
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.3743
    Cell Significance Index: 9.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.9215
    Cell Significance Index: 73.0300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.5922
    Cell Significance Index: 36.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.2062
    Cell Significance Index: 260.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9714
    Cell Significance Index: 214.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.9658
    Cell Significance Index: 51.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6008
    Cell Significance Index: 89.8300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.5280
    Cell Significance Index: 23.6400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.4824
    Cell Significance Index: 18.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3274
    Cell Significance Index: 81.5900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.2371
    Cell Significance Index: 12.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6453
    Cell Significance Index: 582.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5169
    Cell Significance Index: 84.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3960
    Cell Significance Index: 11.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3461
    Cell Significance Index: 34.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3254
    Cell Significance Index: 61.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2996
    Cell Significance Index: 107.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2701
    Cell Significance Index: 54.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1758
    Cell Significance Index: 6.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1483
    Cell Significance Index: 19.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0910
    Cell Significance Index: 12.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0771
    Cell Significance Index: 5.3300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0432
    Cell Significance Index: 0.4500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0232
    Cell Significance Index: 2.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0096
    Cell Significance Index: 5.9700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0037
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0296
    Cell Significance Index: -21.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0322
    Cell Significance Index: -60.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0382
    Cell Significance Index: -70.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0434
    Cell Significance Index: -1.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0459
    Cell Significance Index: -70.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0460
    Cell Significance Index: -25.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0531
    Cell Significance Index: -1.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0570
    Cell Significance Index: -43.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0750
    Cell Significance Index: -1.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0771
    Cell Significance Index: -43.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0785
    Cell Significance Index: -2.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0860
    Cell Significance Index: -14.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0864
    Cell Significance Index: -38.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0901
    Cell Significance Index: -66.0700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1010
    Cell Significance Index: -0.6100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1226
    Cell Significance Index: -0.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1286
    Cell Significance Index: -58.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1289
    Cell Significance Index: -27.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2296
    Cell Significance Index: -11.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2381
    Cell Significance Index: -18.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2713
    Cell Significance Index: -8.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3204
    Cell Significance Index: -37.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3483
    Cell Significance Index: -16.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3491
    Cell Significance Index: -26.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3599
    Cell Significance Index: -36.7700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3645
    Cell Significance Index: -14.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3794
    Cell Significance Index: -43.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3922
    Cell Significance Index: -9.4000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.4359
    Cell Significance Index: -5.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4535
    Cell Significance Index: -12.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5169
    Cell Significance Index: -8.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5540
    Cell Significance Index: -10.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5541
    Cell Significance Index: -20.3400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.5704
    Cell Significance Index: -3.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6252
    Cell Significance Index: -12.9700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.6525
    Cell Significance Index: -4.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6997
    Cell Significance Index: -42.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8398
    Cell Significance Index: -66.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8884
    Cell Significance Index: -18.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8899
    Cell Significance Index: -59.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9520
    Cell Significance Index: -60.0000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.9573
    Cell Significance Index: -8.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.0146
    Cell Significance Index: -65.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.0451
    Cell Significance Index: -73.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1698
    Cell Significance Index: -38.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1807
    Cell Significance Index: -61.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2112
    Cell Significance Index: -53.5800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -1.2133
    Cell Significance Index: -11.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.2805
    Cell Significance Index: -58.0400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.2988
    Cell Significance Index: -8.0700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -1.3464
    Cell Significance Index: -7.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.3551
    Cell Significance Index: -63.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3897
    Cell Significance Index: -44.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.4360
    Cell Significance Index: -14.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.4522
    Cell Significance Index: -54.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.4998
    Cell Significance Index: -52.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5914
    Cell Significance Index: -46.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **EF1G structure and function**: EEF1G is a heterotrimeric protein complex consisting of three subunits: EEF1A1, EEF1A2, and EEF1G. The EEF1G subunit is responsible for binding to elongation factor 1A (EF1A) and facilitating the exchange of GTP for GDP, thereby regulating the elongation phase of translation. 2. **Cellular localization**: EEF1G is predominantly found in the cytosol, where it interacts with ribosomes and other translation machinery components to regulate protein synthesis. 3. **Cell-type specificity**: The expression of EEF1G varies across different cell types, with significant expression observed in immune cells, epithelial cells, and fibroblasts, highlighting its role in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Translation elongation**: EEF1G plays a crucial role in regulating the elongation phase of translation, ensuring accurate and efficient protein synthesis. 2. **Protein quality control**: EEF1G is involved in protein quality control by regulating the translation of misfolded proteins, thereby preventing protein aggregation and promoting cellular homeostasis. 3. **Immune cell function**: EEF1G is highly expressed in immune cells, where it regulates the translation of key proteins involved in immune responses, such as cytokines and chemokines. 4. **Cancer biology**: Alterations in EEF1G expression have been implicated in various cancers, including breast, prostate, and lung cancer, highlighting its potential as a therapeutic target. **Clinical Significance:** 1. **Cancer therapy**: Targeting EEF1G has shown promise in cancer therapy, with several small-molecule inhibitors demonstrating efficacy in preclinical models. 2. **Immunotherapy**: EEF1G's role in regulating immune cell function makes it an attractive target for immunotherapy, with potential applications in treating autoimmune diseases and cancer. 3. **Proteinopathy**: EEF1G's involvement in protein quality control makes it a potential therapeutic target for proteinopathies, such as Alzheimer's disease and Parkinson's disease. 4. **Protein synthesis regulation**: EEF1G's regulation of protein synthesis has implications for understanding the mechanisms underlying various diseases, including metabolic disorders and neurodegenerative diseases. In conclusion, EEF1G is a critical gene that plays a pivotal role in regulating protein synthesis, particularly during the elongation phase of translation. Its involvement in various cellular processes, including immune cell function, protein quality control, and cancer biology, highlights its potential as a therapeutic target and a key player in maintaining cellular homeostasis. Further research is necessary to fully elucidate the mechanisms underlying EEF1G's functions and to explore its therapeutic potential.

Genular Protein ID: 1948024018

Symbol: EF1G_HUMAN

Name: Elongation factor 1-gamma

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1461723

Title: Elongation factor-1 messenger-RNA levels in cultured cells are high compared to tissue and are not drastically affected further by oncogenic transformation.

PubMed ID: 1461723

DOI: 10.1093/nar/20.22.5907

PubMed ID: 1598220

Title: Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19.

PubMed ID: 1598220

DOI: 10.1093/nar/20.10.2598

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1372736

Title: Expression of elongation factor-1 gamma-related sequence in human pancreatic cancer.

PubMed ID: 1372736

DOI: 10.1097/00006676-199203000-00003

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 12766415

Title: 1H, 15N and 13C resonance assignments of the highly conserved 19 kDa C-terminal domain from human elongation factor 1Bgamma.

PubMed ID: 12766415

DOI: 10.1023/a:1023504611632

Sequence Information:

  • Length: 437
  • Mass: 50119
  • Checksum: A6110663110CF3FC
  • Sequence:
  • MAAGTLYTYP ENWRAFKALI AAQYSGAQVR VLSAPPHFHF GQTNRTPEFL RKFPAGKVPA 
    FEGDDGFCVF ESNAIAYYVS NEELRGSTPE AAAQVVQWVS FADSDIVPPA STWVFPTLGI 
    MHHNKQATEN AKEEVRRILG LLDAYLKTRT FLVGERVTLA DITVVCTLLW LYKQVLEPSF 
    RQAFPNTNRW FLTCINQPQF RAVLGEVKLC EKMAQFDAKK FAETQPKKDT PRKEKGSREE 
    KQKPQAERKE EKKAAAPAPE EEMDECEQAL AAEPKAKDPF AHLPKSTFVL DEFKRKYSNE 
    DTLSVALPYF WEHFDKDGWS LWYSEYRFPE ELTQTFMSCN LITGMFQRLD KLRKNAFASV 
    ILFGTNNSSS ISGVWVFRGQ ELAFPLSPDW QVDYESYTWR KLDPGSEETQ TLVREYFSWE 
    GAFQHVGKAF NQGKIFK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.