Details for: PPBP

Gene ID: 5473

Symbol: PPBP

Ensembl ID: ENSG00000163736

Description: pro-platelet basic protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162061
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.54
    Marker Score: 4621.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.01
    Marker Score: 839
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.43
    Marker Score: 615
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.36
    Marker Score: 1195.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7417
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.01
    Marker Score: 784
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71812
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48037
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.99
    Marker Score: 2523
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.93
    Marker Score: 700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.85
    Marker Score: 421
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.77
    Marker Score: 429
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 582
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.75
    Marker Score: 41794
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.7
    Marker Score: 583
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.69
    Marker Score: 240
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 431
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.64
    Marker Score: 629
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.57
    Marker Score: 511
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.57
    Marker Score: 477
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.56
    Marker Score: 605
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.55
    Marker Score: 249
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.54
    Marker Score: 324
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.53
    Marker Score: 497
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.52
    Marker Score: 6016
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.51
    Marker Score: 998.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.51
    Marker Score: 180
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.46
    Marker Score: 1447
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 273
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.45
    Marker Score: 187
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.41
    Marker Score: 21930
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.4
    Marker Score: 208
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.37
    Marker Score: 398
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 0.33
    Marker Score: 118
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.3
    Marker Score: 756
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.3
    Marker Score: 130
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.3
    Marker Score: 150
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.29
    Marker Score: 199
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.28
    Marker Score: 161
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.28
    Marker Score: 179.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.27
    Marker Score: 274
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.27
    Marker Score: 125
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.27
    Marker Score: 75
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.27
    Marker Score: 271
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.25
    Marker Score: 1079
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.25
    Marker Score: 143
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.24
    Marker Score: 64
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.24
    Marker Score: 150
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.23
    Marker Score: 164
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.23
    Marker Score: 111
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.23
    Marker Score: 181
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.22
    Marker Score: 196
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.21
    Marker Score: 159
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.21
    Marker Score: 142
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.2
    Marker Score: 154
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.2
    Marker Score: 160
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.2
    Marker Score: 219
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.2
    Marker Score: 208
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.2
    Marker Score: 46
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 105
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.19
    Marker Score: 126
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.19
    Marker Score: 124
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.19
    Marker Score: 42
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.18
    Marker Score: 90
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.18
    Marker Score: 36
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.18
    Marker Score: 129
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.17
    Marker Score: 122
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.17
    Marker Score: 404
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.17
    Marker Score: 110
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.16
    Marker Score: 135
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.16
    Marker Score: 100
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.16
    Marker Score: 211
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.16
    Marker Score: 68
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.16
    Marker Score: 199
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.16
    Marker Score: 108
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.16
    Marker Score: 78
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.16
    Marker Score: 34
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.15
    Marker Score: 154
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.15
    Marker Score: 89.5
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.15
    Marker Score: 35
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.15
    Marker Score: 41
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.15
    Marker Score: 36
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.15
    Marker Score: 100
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.14
    Marker Score: 38
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.14
    Marker Score: 136
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.14
    Marker Score: 103
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.14
    Marker Score: 40
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.14
    Marker Score: 40.5
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.14
    Marker Score: 119

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Other Information

**Key Characteristics** PPBP is a chemokine belonging to the CXC chemokine family, characterized by its ability to induce chemotaxis in target cells. The protein exhibits a unique structure, consisting of four conserved cysteine residues, which are essential for its function. PPBP has been shown to interact with various receptors, including CXCR1, CXCR2, and CXCR3, facilitating its signaling pathways. Its expression is tightly regulated, with a peak in megakaryocytes and other cells involved in immune responses. **Pathways and Functions** PPBP's involvement in immune responses is multifaceted, with its primary functions including: 1. **Neutrophil chemotaxis**: PPBP acts as a chemoattractant for neutrophils, guiding their migration towards sites of inflammation. 2. **Platelet activation**: PPBP is involved in the regulation of platelet activation, signaling, and aggregation, which are crucial for hemostasis and wound repair. 3. **Immune cell trafficking**: PPBP facilitates the recruitment of immune cells, including T cells and natural killer cells, to sites of inflammation. 4. **Inflammation**: PPBP contributes to the regulation of inflammatory responses by modulating the activity of immune cells and the production of pro-inflammatory cytokines. 5. **Cell proliferation**: PPBP has been implicated in the regulation of cell proliferation, particularly in the context of cancer and tissue repair. **Clinical Significance** The dysregulation of PPBP has been implicated in various diseases, including: 1. **Inflammatory disorders**: PPBP's role in regulating inflammation makes it a potential therapeutic target for diseases such as rheumatoid arthritis, asthma, and inflammatory bowel disease. 2. **Cancer**: PPBP's involvement in cell proliferation and tumor growth suggests its potential as a biomarker or therapeutic target for cancer treatment. 3. **Hemostatic disorders**: PPBP's role in platelet activation and aggregation makes it a potential therapeutic target for bleeding disorders, such as thrombocytopenia. 4. **Neurological disorders**: PPBP's expression in neurons and its involvement in neuroinflammation suggest its potential as a biomarker or therapeutic target for neurological disorders, such as Alzheimer's disease. In conclusion, PPBP is a multifunctional chemokine that plays a crucial role in various physiological and pathological processes, including immune responses, hemostasis, and cell proliferation. Further research is necessary to fully elucidate the mechanisms underlying PPBP's functions and to explore its therapeutic potential in diseases characterized by dysregulation of immune responses and inflammation.

Genular Protein ID: 3930618439

Symbol: CXCL7_HUMAN

Name: Platelet basic protein

UniProtKB Accession Codes:

P02775 B2R5F3 Q6IBJ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2713489

Title: Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library.

PubMed ID: 2713489

PubMed ID: 1826003

Title: Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4.

PubMed ID: 1826003

DOI: 10.1016/s0021-9258(19)67665-9

PubMed ID: 11468158

Title: Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus.

PubMed ID: 11468158

DOI: 10.1182/blood.v98.3.610

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2423119

Title: Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin.

PubMed ID: 2423119

DOI: 10.1021/bi00356a023

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 10877842

Title: Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines.

PubMed ID: 10877842

DOI: 10.1074/jbc.275.27.20374

PubMed ID: 6572368

Title: Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor.

PubMed ID: 6572368

DOI: 10.1073/pnas.80.3.765

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 77677

Title: Complete covalent structure of human beta-thromboglobulin.

PubMed ID: 77677

DOI: 10.1021/bi00602a024

PubMed ID: 8950790

Title: Thrombin-activated human platelets release two NAP-2 variants that stimulate polymorphonuclear leukocytes.

PubMed ID: 8950790

PubMed ID: 2783111

Title: Connective tissue activation. XXXIII. Biologically active cleavage products of CTAP-III from human platelets.

PubMed ID: 2783111

DOI: 10.1016/0006-291x(89)92330-9

PubMed ID: 2522778

Title: A novel cleavage product of beta-thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils.

PubMed ID: 2522778

DOI: 10.1016/0006-291x(89)92203-1

PubMed ID: 7890771

Title: Limited and defined truncation at the C-terminus enhances receptor binding and degranulation activity of the neutrophil-activating peptide 2 (NAP-2). Comparison of native and recombinant NAP-2 variants.

PubMed ID: 7890771

DOI: 10.1074/jbc.270.11.6338

PubMed ID: 2406364

Title: Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases.

PubMed ID: 2406364

DOI: 10.1084/jem.171.2.449

PubMed ID: 2007144

Title: Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide.

PubMed ID: 2007144

DOI: 10.1021/bi00226a021

PubMed ID: 9794434

Title: Novel C-terminally truncated isoforms of the CXC chemokine beta-thromboglobulin and their impact on neutrophil functions.

PubMed ID: 9794434

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 8034022

Title: Purification, crystallization and preliminary X-ray diffraction analysis of recombinant human neutrophil-activating peptide 2 (rhNAP-2).

PubMed ID: 8034022

DOI: 10.1016/0014-5793(94)00573-7

PubMed ID: 7706245

Title: The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution.

PubMed ID: 7706245

DOI: 10.1074/jbc.270.13.7077

Sequence Information:

  • Length: 128
  • Mass: 13894
  • Checksum: BEAB7B75916723D9
  • Sequence:
    • MSLRLDTTPS CNSARPLHAL QVLLLLSLLL TALASSTKGQ TKRNLAKGKE ESLDSDLYAE 
LRCMCIKTTS GIHPKNIQSL EVIGKGTHCN QVEVIATLKD GRKICLDPDA PRIKKIVQKK 
LAGDESAD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.