Details for: PLAG1

Gene ID: 5324

Symbol: PLAG1

Ensembl ID: ENSG00000181690

Description: PLAG1 zinc finger

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 102.9283
    Cell Significance Index: -16.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 62.9624
    Cell Significance Index: -15.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.2608
    Cell Significance Index: -16.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1966
    Cell Significance Index: -16.5600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.5776
    Cell Significance Index: 42.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6768
    Cell Significance Index: 332.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5652
    Cell Significance Index: 87.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4243
    Cell Significance Index: 271.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1704
    Cell Significance Index: 89.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8947
    Cell Significance Index: 23.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8115
    Cell Significance Index: 80.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7285
    Cell Significance Index: 118.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6827
    Cell Significance Index: 14.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6804
    Cell Significance Index: 614.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5763
    Cell Significance Index: 115.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5366
    Cell Significance Index: 33.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5119
    Cell Significance Index: 30.7300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4916
    Cell Significance Index: 5.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4845
    Cell Significance Index: 52.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4148
    Cell Significance Index: 148.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3454
    Cell Significance Index: 17.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2615
    Cell Significance Index: 7.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2372
    Cell Significance Index: 10.4900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2096
    Cell Significance Index: 2.6000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.1991
    Cell Significance Index: 2.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1875
    Cell Significance Index: 9.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1731
    Cell Significance Index: 94.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1605
    Cell Significance Index: 2.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1519
    Cell Significance Index: 3.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1308
    Cell Significance Index: 6.1000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1132
    Cell Significance Index: 1.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1064
    Cell Significance Index: 7.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1034
    Cell Significance Index: 3.9200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1027
    Cell Significance Index: 0.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0930
    Cell Significance Index: 64.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0904
    Cell Significance Index: 16.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0837
    Cell Significance Index: 2.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0776
    Cell Significance Index: 35.2100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0765
    Cell Significance Index: 0.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0623
    Cell Significance Index: 114.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0555
    Cell Significance Index: 1.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0440
    Cell Significance Index: 1.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0394
    Cell Significance Index: 17.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0381
    Cell Significance Index: 4.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0305
    Cell Significance Index: 57.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0271
    Cell Significance Index: 17.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0218
    Cell Significance Index: 33.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0216
    Cell Significance Index: 0.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0216
    Cell Significance Index: 0.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0210
    Cell Significance Index: 0.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0011
    Cell Significance Index: 0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0049
    Cell Significance Index: -6.6700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0101
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0119
    Cell Significance Index: -8.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0143
    Cell Significance Index: -10.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0182
    Cell Significance Index: -13.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0205
    Cell Significance Index: -11.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0242
    Cell Significance Index: -3.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0300
    Cell Significance Index: -18.7300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0350
    Cell Significance Index: -0.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0372
    Cell Significance Index: -0.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0427
    Cell Significance Index: -0.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0458
    Cell Significance Index: -13.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0481
    Cell Significance Index: -6.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0510
    Cell Significance Index: -7.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0606
    Cell Significance Index: -10.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0762
    Cell Significance Index: -8.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0781
    Cell Significance Index: -16.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0791
    Cell Significance Index: -9.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0885
    Cell Significance Index: -5.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0999
    Cell Significance Index: -3.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1061
    Cell Significance Index: -11.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1176
    Cell Significance Index: -5.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1206
    Cell Significance Index: -13.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1300
    Cell Significance Index: -16.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1352
    Cell Significance Index: -9.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1359
    Cell Significance Index: -13.8800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1493
    Cell Significance Index: -2.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1686
    Cell Significance Index: -3.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1753
    Cell Significance Index: -1.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1792
    Cell Significance Index: -1.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1820
    Cell Significance Index: -11.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1822
    Cell Significance Index: -12.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1928
    Cell Significance Index: -15.2700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1965
    Cell Significance Index: -1.2300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1988
    Cell Significance Index: -3.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2198
    Cell Significance Index: -16.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2297
    Cell Significance Index: -14.0800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2303
    Cell Significance Index: -3.4700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2342
    Cell Significance Index: -1.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2448
    Cell Significance Index: -8.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2568
    Cell Significance Index: -8.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2906
    Cell Significance Index: -7.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2963
    Cell Significance Index: -7.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3012
    Cell Significance Index: -14.1600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3015
    Cell Significance Index: -3.7600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3084
    Cell Significance Index: -3.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3219
    Cell Significance Index: -9.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3240
    Cell Significance Index: -11.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3356
    Cell Significance Index: -8.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain:** PLAG1 contains a highly conserved zinc finger domain, which is essential for its DNA-binding activity and transcriptional regulation. 2. **Wide Expression Profile:** PLAG1 is expressed in various cell types, including mesenchymal cells, cardiac myocytes, and glial cells, underscoring its importance in multiple cellular processes. 3. **Transcriptional Activation and Repression:** PLAG1 can act as a transcriptional activator or repressor, depending on the context and target genes. 4. **Regulation of Gene Expression:** PLAG1 modulates gene expression by interacting with specific DNA sequences, influencing transcriptional activity and cellular differentiation. **Pathways and Functions:** 1. **Centrosome and Cytoskeleton Organization:** PLAG1 regulates centrosome formation and cytoskeleton organization, crucial for cell division and cellular morphology. 2. **Gland Morphogenesis:** PLAG1 is essential for the development and differentiation of glandular tissues, including the prostate gland. 3. **Cardiac Development:** PLAG1 plays a critical role in cardiac development, influencing the formation and function of cardiac myocytes. 4. **Glial Cell Proliferation:** PLAG1 promotes glial cell proliferation, contributing to the maintenance of the central nervous system. 5. **Transcriptional Regulation:** PLAG1 interacts with RNA polymerase II to regulate transcriptional activity, influencing the expression of target genes. **Clinical Significance:** 1. **Cancer Progression:** PLAG1 is overexpressed in various cancers, including prostate, breast, and colon cancers, suggesting its role in tumorigenesis and cancer progression. 2. **Cardiac Disease:** PLAG1 alterations have been linked to cardiac hypertrophy, cardiomyopathy, and arrhythmias, highlighting its importance in cardiac development and function. 3. **Neurological Disorders:** PLAG1 expression is altered in neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, suggesting its involvement in neurodegeneration. 4. **Regenerative Medicine:** PLAG1's role in tissue development and differentiation makes it a potential target for regenerative medicine applications, such as tissue engineering and stem cell therapy. In conclusion, the PLAG1 gene is a multifunctional transcriptional regulator that plays a critical role in various cellular processes, including development, differentiation, and proliferation. Its involvement in multiple diseases and disorders underscores its importance as a therapeutic target and a valuable tool for understanding the molecular mechanisms underlying complex biological processes.

Genular Protein ID: 2155462579

Symbol: PLAG1_HUMAN

Name: Zinc finger protein PLAG1

UniProtKB Accession Codes:

Q6DJT9 B4DLC2 Q59GH8 Q9Y4L2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9020842

Title: Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations.

PubMed ID: 9020842

DOI: 10.1038/ng0297-170

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9722527

Title: Transcriptional activation capacity of the novel PLAG family of zinc finger proteins.

PubMed ID: 9722527

DOI: 10.1074/jbc.273.36.23026

PubMed ID: 9525740

Title: The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter.

PubMed ID: 9525740

DOI: 10.1038/sj.onc.1201660

PubMed ID: 10029085

Title: Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene.

PubMed ID: 10029085

PubMed ID: 10646861

Title: PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II.

PubMed ID: 10646861

PubMed ID: 10987300

Title: PLAG1 fusion oncogenes in lipoblastoma.

PubMed ID: 10987300

PubMed ID: 11888928

Title: The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities.

PubMed ID: 11888928

PubMed ID: 11882654

Title: Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal.

PubMed ID: 11882654

DOI: 10.1074/jbc.m112112200

PubMed ID: 14695992

Title: Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma.

PubMed ID: 14695992

DOI: 10.1002/gcc.10307

PubMed ID: 15208321

Title: Repression of the transactivating capacity of the oncoprotein PLAG1 by SUMOylation.

PubMed ID: 15208321

DOI: 10.1074/jbc.m401753200

PubMed ID: 14712223

Title: Microarray screening for target genes of the proto-oncogene PLAG1.

PubMed ID: 14712223

DOI: 10.1038/sj.onc.1207013

PubMed ID: 15642402

Title: PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement.

PubMed ID: 15642402

DOI: 10.1016/j.cancergencyto.2004.04.017

PubMed ID: 16207715

Title: Sumoylation and acetylation play opposite roles in the transactivation of PLAG1 and PLAGL2.

PubMed ID: 16207715

DOI: 10.1074/jbc.m504334200

PubMed ID: 16736500

Title: CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas.

PubMed ID: 16736500

DOI: 10.1002/gcc.20346

PubMed ID: 28796236

Title: Genetic disruption of the oncogenic HMGA2-PLAG1-IGF2 pathway causes fetal growth restriction.

PubMed ID: 28796236

DOI: 10.1038/gim.2017.105

Sequence Information:

  • Length: 500
  • Mass: 55909
  • Checksum: CF022A132A1BFD43
  • Sequence:
    • MATVIPGDLS EVRDTQKVPS GKRKRGETKP RKNFPCQLCD KAFNSVEKLK VHSYSHTGER 
PYKCIQQDCT KAFVSKYKLQ RHMATHSPEK THKCNYCEKM FHRKDHLKNH LHTHDPNKET 
FKCEECGKNY NTKLGFKRHL ALHAATSGDL TCKVCLQTFE STGVLLEHLK SHAGKSSGGV 
KEKKHQCEHC DRRFYTRKDV RRHMVVHTGR KDFLCQYCAQ RFGRKDHLTR HMKKSHNQEL 
LKVKTEPVDF LDPFTCNVSV PIKDELLPVM SLPSSELLSK PFTNTLQLNL YNTPFQSMQS 
SGSAHQMITT LPLGMTCPID MDTVHPSHHL SFKYPFSSTS YAISIPEKEQ PLKGEIESYL 
MELQGGVPSS SQDSQASSSS KLGLDPQIGS LDDGAGDLSL SKSSISISDP LNTPALDFSQ 
LFNFIPLNGP PYNPLSVGSL GMSYSQEEAH SSVSQLPPQT QDLQDPANTI GLGSLHSLSA 
AFTSSLSTST TLPRFHQAFQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.