Gene IL1B - ENSG00000125538 | NCBI Gene ID: 3553

Details for: IL1B

Gene ID: 3553

Symbol: IL1B

Ensembl ID: ENSG00000125538

Description: interleukin 1 beta

Associated with

C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell recruitment (pro-inflammatory response)
(R-HSA-9664424)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Clec7a/inflammasome pathway
(R-HSA-5660668)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 processing
(R-HSA-448706)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-10 signaling
(R-HSA-6783783)
Leishmania infection
(R-HSA-9658195)
Parasitic infection pathways
(R-HSA-9824443)
Programmed cell death
(R-HSA-5357801)
Purinergic signaling in leishmaniasis infection
(R-HSA-9660826)
Pyroptosis
(R-HSA-5620971)
Regulated necrosis
(R-HSA-5218859)
Signaling by interleukins
(R-HSA-449147)
Apoptotic process
(GO:0006915)
Astrocyte activation
(GO:0048143)
Cell-cell signaling
(GO:0007267)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine activity
(GO:0005125)
Ectopic germ cell programmed cell death
(GO:0035234)
Embryo implantation
(GO:0007566)
Fever generation
(GO:0001660)
Hyaluronan biosynthetic process
(GO:0030213)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Integrin binding
(GO:0005178)
Interleukin-1 receptor binding
(GO:0005149)
Jnk cascade
(GO:0007254)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of glucose transmembrane transport
(GO:0010829)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of lipid metabolic process
(GO:0045833)
Negative regulation of map kinase activity
(GO:0043407)
Neutrophil chemotaxis
(GO:0030593)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of complement activation
(GO:0045917)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of fever generation
(GO:0031622)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of granulocyte macrophage colony-stimulating factor production
(GO:0032725)
Positive regulation of heterotypic cell-cell adhesion
(GO:0034116)
Positive regulation of immature t cell proliferation in thymus
(GO:0033092)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of myosin light chain kinase activity
(GO:0035505)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of prostaglandin biosynthetic process
(GO:0031394)
Positive regulation of prostaglandin secretion
(GO:0032308)
Positive regulation of protein export from nucleus
(GO:0046827)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of t cell mediated immunity
(GO:0002711)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of type ii interferon production
(GO:0032729)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Positive regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030949)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of canonical nf-kappab signal transduction
(GO:0043122)
Regulation of defense response to virus by host
(GO:0050691)
Regulation of neurogenesis
(GO:0050767)
Response to atp
(GO:0033198)
Response to carbohydrate
(GO:0009743)
Response to lipopolysaccharide
(GO:0032496)
Sequestering of triglyceride
(GO:0030730)
Signal transduction
(GO:0007165)
Smooth muscle adaptation
(GO:0014805)
Vascular endothelial growth factor production
(GO:0010573)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.78
Marker Score: 1135
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.79
Marker Score: 99882
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.59
Marker Score: 1618
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.52
Marker Score: 1744
Cell Name: early promyelocyte (CL0002154)
Fold Change: 1.51
Marker Score: 1209
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.47
Marker Score: 473
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.47
Marker Score: 3820
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.4
Marker Score: 2650
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.34
Marker Score: 1336
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.33
Marker Score: 1965
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.31
Marker Score: 3157
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.3
Marker Score: 2530
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.27
Marker Score: 922
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.23
Marker Score: 31561
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.18
Marker Score: 7145.5
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.12
Marker Score: 2318
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.12
Marker Score: 2273
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71783
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48009
Cell Name: macrophage (CL0000235)
Fold Change: 0.99
Marker Score: 1101
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: thymocyte (CL0000893)
Fold Change: 0.97
Marker Score: 1013
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 498
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 453
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.95
Marker Score: 646
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.95
Marker Score: 1360.5
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5260
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2731
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 0.89
Marker Score: 250
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.89
Marker Score: 322.5
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.89
Marker Score: 3686
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 319
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.88
Marker Score: 309
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5276
Cell Name: leukocyte (CL0000738)
Fold Change: 0.81
Marker Score: 465
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 608
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1259
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.76
Marker Score: 305.5
Cell Name: microglial cell (CL0000129)
Fold Change: 0.76
Marker Score: 1376
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.75
Marker Score: 3146
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 388
Cell Name: brush cell (CL0002204)
Fold Change: 0.74
Marker Score: 671
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.72
Marker Score: 380
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.72
Marker Score: 539.5
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.69
Marker Score: 339
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.68
Marker Score: 172
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.66
Marker Score: 666
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.66
Marker Score: 1830
Cell Name: monocyte (CL0000576)
Fold Change: 0.65
Marker Score: 848.5
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.64
Marker Score: 2634
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.64
Marker Score: 774
Cell Name: neutrophil (CL0000775)
Fold Change: 0.61
Marker Score: 372
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.6
Marker Score: 1483
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.58
Marker Score: 155
Cell Name: colon macrophage (CL0009038)
Fold Change: 0.57
Marker Score: 158
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.56
Marker Score: 234
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.55
Marker Score: 139
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.55
Marker Score: 354
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.55
Marker Score: 191
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.54
Marker Score: 867
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.54
Marker Score: 171
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.53
Marker Score: 276
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.51
Marker Score: 353
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.51
Marker Score: 307
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.51
Marker Score: 155
Cell Name: mature T cell (CL0002419)
Fold Change: 0.49
Marker Score: 4804
Cell Name: myelocyte (CL0002193)
Fold Change: 0.48
Marker Score: 207
Cell Name: granulocyte (CL0000094)
Fold Change: 0.46
Marker Score: 208
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.45
Marker Score: 589
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.45
Marker Score: 271
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.45
Marker Score: 7033
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.44
Marker Score: 135
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 0.43
Marker Score: 326
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 0.43
Marker Score: 150
Cell Name: decidual cell (CL2000002)
Fold Change: 0.43
Marker Score: 1840
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.42
Marker Score: 291
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.42
Marker Score: 358
Cell Name: phagocyte (CL0000234)
Fold Change: 0.4
Marker Score: 134
Cell Name: mast cell (CL0000097)
Fold Change: 0.4
Marker Score: 234
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.39
Marker Score: 267
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.39
Marker Score: 161
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.39
Marker Score: 177
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.37
Marker Score: 161
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.36
Marker Score: 3665
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.35
Marker Score: 118
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.35
Marker Score: 2218
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.35
Marker Score: 158
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.34
Marker Score: 331
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.34
Marker Score: 168
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.33
Marker Score: 219
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.33
Marker Score: 178
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.33
Marker Score: 105
Cell Name: eosinophil (CL0000771)
Fold Change: 0.33
Marker Score: 106
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.32
Marker Score: 155
Cell Name: pneumocyte (CL0000322)
Fold Change: 0.32
Marker Score: 517
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.32
Marker Score: 333
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.3
Marker Score: 91

Hover over a box to see details here...

**Key characteristics:** * IL-1β is a cytokine of the interleukin-1 family. * It is produced by a variety of cell types, including macrophages, dendritic cells, and neutrophils. * IL-1β is a potent activator of the complement system. * It is involved in the regulation of inflammation, cell death, and tissue repair. **Pathways and functions:** * IL-1β binds to its receptor, IL-1R1, on immune cells. * This binding triggers a signaling cascade that involves the adapter protein IL-1R1-associated protein kinase (IL-1R1-AK). * IL-1R1-AK phosphorylates the pro-apoptotic protein Bad, leading to cell death. * IL-1β also activates the complement system, which can lead to inflammation and tissue damage. * It also plays a role in the regulation of inflammation, cell death, and tissue repair. **Clinical significance:** * IL-1β is a key cytokine in the innate immune response. * It is involved in the pathogenesis of various diseases, including inflammation, infection, and cancer. * Antagonization of IL-1β can help to mitigate inflammation and disease progression. **Other important points:** * IL-1β is a highly conserved cytokine that is found in humans, mice, and other animals. * It is a potent inflammatory cytokine that can promote inflammation, cell death, and tissue repair. * IL-1β is a target for therapeutic intervention in inflammatory diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Catabolin

Genular Protein ID: 3750051680

Symbol: IL1B_HUMAN

Name: Catabolin

UniProtKB Accession Codes:

P01584 Q53X59 Q53XX2 Q7M4S7 Q7RU01 Q96HE5 Q9UCT6

Database IDs:

Citations:

PubMed ID: 6083565

Title: Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.

PubMed ID: 6083565

DOI: 10.1073/pnas.81.24.7907

PubMed ID: 2989698

Title: Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs.

PubMed ID: 2989698

DOI: 10.1038/315641a0

PubMed ID: 3490654

Title: Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene.

PubMed ID: 3490654

DOI: 10.1093/nar/14.20.7897

PubMed ID: 3493774

Title: cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line.

PubMed ID: 3493774

DOI: 10.1016/0006-291x(87)90671-1

PubMed ID: 2954882

Title: Human interleukin-1 beta gene.

PubMed ID: 2954882

DOI: 10.1016/0378-1119(87)90398-2

PubMed ID: 2635664

Title: Cloning of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta.

PubMed ID: 2635664

PubMed ID: 11991722

Title: A sequence-based map of the nine genes of the human interleukin-1 cluster.

PubMed ID: 11991722

DOI: 10.1006/geno.2002.6751

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1919436

Title: Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase.

PubMed ID: 1919436

DOI: 10.1084/jem.174.4.821

PubMed ID: 3920526

Title: Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1.

PubMed ID: 3920526

DOI: 10.1038/314266a0

PubMed ID: 3281727

Title: Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow.

PubMed ID: 3281727

PubMed ID: 1837236

Title: The role of arginine residues in interleukin 1 receptor binding.

PubMed ID: 1837236

DOI: 10.1016/0167-4838(91)90437-5

PubMed ID: 7689226

Title: Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes.

PubMed ID: 7689226

DOI: 10.1073/pnas.90.16.7676

PubMed ID: 10653850

Title: IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells.

PubMed ID: 10653850

DOI: 10.1093/intimm/12.2.151

PubMed ID: 11728343

Title: Rapid secretion of interleukin-1beta by microvesicle shedding.

PubMed ID: 11728343

DOI: 10.1016/s1074-7613(01)00229-1

PubMed ID: 12794819

Title: Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.

PubMed ID: 12794819

DOI: 10.1002/art.11143

PubMed ID: 15192144

Title: Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes.

PubMed ID: 15192144

DOI: 10.1073/pnas.0308558101

PubMed ID: 17431422

Title: The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing.

PubMed ID: 17431422

DOI: 10.1038/sj.cdd.4402142

PubMed ID: 20148899

Title: Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome.

PubMed ID: 20148899

DOI: 10.1111/j.1462-5822.2010.01450.x

PubMed ID: 23955712

Title: Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

PubMed ID: 23955712

DOI: 10.1038/nm.3265

PubMed ID: 24201029

Title: The secretion of IL-1beta and options for release.

PubMed ID: 24201029

DOI: 10.1016/j.smim.2013.10.007

PubMed ID: 24952504

Title: The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.

PubMed ID: 24952504

DOI: 10.1038/ni.2919

PubMed ID: 28331908

Title: IL-1beta is an innate immune sensor of microbial proteolysis.

PubMed ID: 28331908

DOI: 10.1126/sciimmunol.aah3539

PubMed ID: 29030430

Title: Direct binding to integrins and loss of disulfide linkage in interleukin-1beta (IL-1beta) are involved in the agonistic action of IL-1beta.

PubMed ID: 29030430

DOI: 10.1074/jbc.m117.818302

PubMed ID: 32719155

Title: Group A Streptococcus Infection of the Nasopharynx Requires Proinflammatory Signaling through the Interleukin-1 Receptor.

PubMed ID: 32719155

DOI: 10.1128/iai.00356-20

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 33377178

Title: NLRP6-caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation.

PubMed ID: 33377178

DOI: 10.1111/iej.13469

PubMed ID: 33883744

Title: Gasdermin D pore structure reveals preferential release of mature interleukin-1.

PubMed ID: 33883744

DOI: 10.1038/s41586-021-03478-3

PubMed ID: 3259176

Title: Crystal structure of the cytokine interleukin-1 beta.

PubMed ID: 3259176

DOI: 10.1002/j.1460-2075.1988.tb02818.x

PubMed ID: 2585509

Title: Crystal structure of recombinant human interleukin-1 beta at 2.0-A resolution.

PubMed ID: 2585509

DOI: 10.1016/0022-2836(89)90606-2

PubMed ID: 2602367

Title: Crystallographic refinement of interleukin 1 beta at 2.0-A resolution.

PubMed ID: 2602367

DOI: 10.1073/pnas.86.24.9667

PubMed ID: 2372550

Title: Determination of the secondary structure and molecular topology of interleukin-1 beta by use of two- and three-dimensional heteronuclear 15N-1H NMR spectroscopy.

PubMed ID: 2372550

DOI: 10.1021/bi00471a023

PubMed ID: 2001363

Title: High-resolution three-dimensional structure of interleukin 1 beta in solution by three- and four-dimensional nuclear magnetic resonance spectroscopy.

PubMed ID: 2001363

DOI: 10.1021/bi00223a005

PubMed ID: 9062193

Title: Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.

PubMed ID: 9062193

DOI: 10.1038/386190a0

PubMed ID: 20802483

Title: Structural insights into the assembly and activation of IL-1beta with its receptors.

PubMed ID: 20802483

DOI: 10.1038/ni.1925

Sequence Information:

Length: 269
Mass: 30748
Checksum: 9BF73C3673C6FD66
Sequence:

MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL RISDHHYSKG 
FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE EPIFFDTWDN EAYVHDAPVR 
SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ DMEQQVVFSM SFVQGEESND KIPVALGLKE 
KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST 
SQAENMPVFL GGTKGGQDIT DFTMQFVSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: IL1B

Associated with

Cells (max top 100)

Other Information

Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. PubMed ID: 6083565

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. PubMed ID: 2989698

Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene. PubMed ID: 3490654

cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line. PubMed ID: 3493774

Human interleukin-1 beta gene. PubMed ID: 2954882

Cloning of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta. PubMed ID: 2635664

A sequence-based map of the nine genes of the human interleukin-1 cluster. PubMed ID: 11991722

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. PubMed ID: 1919436

Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1. PubMed ID: 3920526

Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow. PubMed ID: 3281727

The role of arginine residues in interleukin 1 receptor binding. PubMed ID: 1837236

Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes. PubMed ID: 7689226

IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells. PubMed ID: 10653850

Rapid secretion of interleukin-1beta by microvesicle shedding. PubMed ID: 11728343

Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. PubMed ID: 12794819

Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes. PubMed ID: 15192144

The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. PubMed ID: 17431422

Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome. PubMed ID: 20148899

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. PubMed ID: 23955712

The secretion of IL-1beta and options for release. PubMed ID: 24201029

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. PubMed ID: 24952504

IL-1beta is an innate immune sensor of microbial proteolysis. PubMed ID: 28331908

Direct binding to integrins and loss of disulfide linkage in interleukin-1beta (IL-1beta) are involved in the agonistic action of IL-1beta. PubMed ID: 29030430

Group A Streptococcus Infection of the Nasopharynx Requires Proinflammatory Signaling through the Interleukin-1 Receptor. PubMed ID: 32719155

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion. PubMed ID: 32272059

NLRP6-caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation. PubMed ID: 33377178

Gasdermin D pore structure reveals preferential release of mature interleukin-1. PubMed ID: 33883744

Crystal structure of the cytokine interleukin-1 beta. PubMed ID: 3259176

Crystal structure of recombinant human interleukin-1 beta at 2.0-A resolution. PubMed ID: 2585509

Crystallographic refinement of interleukin 1 beta at 2.0-A resolution. PubMed ID: 2602367

Determination of the secondary structure and molecular topology of interleukin-1 beta by use of two- and three-dimensional heteronuclear 15N-1H NMR spectroscopy. PubMed ID: 2372550

High-resolution three-dimensional structure of interleukin 1 beta in solution by three- and four-dimensional nuclear magnetic resonance spectroscopy. PubMed ID: 2001363

Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta. PubMed ID: 9062193

Structural insights into the assembly and activation of IL-1beta with its receptors. PubMed ID: 20802483