IL1B | ENSG00000125538 | NCBI 3553

Details for: IL1B

Gene ID: 3553

Symbol: IL1B

Ensembl ID: ENSG00000125538

Description: interleukin 1 beta

Associated with

C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell recruitment (pro-inflammatory response)
(R-HSA-9664424)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Clec7a/inflammasome pathway
(R-HSA-5660668)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 processing
(R-HSA-448706)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-10 signaling
(R-HSA-6783783)
Leishmania infection
(R-HSA-9658195)
Parasitic infection pathways
(R-HSA-9824443)
Programmed cell death
(R-HSA-5357801)
Purinergic signaling in leishmaniasis infection
(R-HSA-9660826)
Pyroptosis
(R-HSA-5620971)
Regulated necrosis
(R-HSA-5218859)
Signaling by interleukins
(R-HSA-449147)
Apoptotic process
(GO:0006915)
Astrocyte activation
(GO:0048143)
Cell-cell signaling
(GO:0007267)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine activity
(GO:0005125)
Ectopic germ cell programmed cell death
(GO:0035234)
Embryo implantation
(GO:0007566)
Fever generation
(GO:0001660)
Hyaluronan biosynthetic process
(GO:0030213)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Integrin binding
(GO:0005178)
Interleukin-1 receptor binding
(GO:0005149)
Jnk cascade
(GO:0007254)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of d-glucose transmembrane transport
(GO:0010829)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of lipid metabolic process
(GO:0045833)
Negative regulation of map kinase activity
(GO:0043407)
Neutrophil chemotaxis
(GO:0030593)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of complement activation
(GO:0045917)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of fever generation
(GO:0031622)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of granulocyte macrophage colony-stimulating factor production
(GO:0032725)
Positive regulation of heterotypic cell-cell adhesion
(GO:0034116)
Positive regulation of immature t cell proliferation in thymus
(GO:0033092)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of myosin light chain kinase activity
(GO:0035505)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of prostaglandin biosynthetic process
(GO:0031394)
Positive regulation of prostaglandin secretion
(GO:0032308)
Positive regulation of protein export from nucleus
(GO:0046827)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of t cell mediated immunity
(GO:0002711)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of type ii interferon production
(GO:0032729)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Positive regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030949)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of canonical nf-kappab signal transduction
(GO:0043122)
Regulation of defense response to virus by host
(GO:0050691)
Regulation of neurogenesis
(GO:0050767)
Response to atp
(GO:0033198)
Response to carbohydrate
(GO:0009743)
Response to lipopolysaccharide
(GO:0032496)
Sequestering of triglyceride
(GO:0030730)
Signal transduction
(GO:0007165)
Smooth muscle adaptation
(GO:0014805)
Vascular endothelial growth factor production
(GO:0010573)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 128.7728
Cell Significance Index: -20.0300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 42.5848
Cell Significance Index: -21.9100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 20.2252
Cell Significance Index: -5.1300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 16.4402
Cell Significance Index: -20.2700
Cell Name: mononuclear cell (CL0000842)
Fold Change: 12.0328
Cell Significance Index: 50.0800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.4536
Cell Significance Index: -21.5200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.7262
Cell Significance Index: 68.8700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 2.0976
Cell Significance Index: 52.4400
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.9728
Cell Significance Index: 15.0500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.9321
Cell Significance Index: 48.4200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.7044
Cell Significance Index: 22.5600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5551
Cell Significance Index: 105.6400
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.5466
Cell Significance Index: 13.9700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2243
Cell Significance Index: 202.5200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2058
Cell Significance Index: 25.3000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1832
Cell Significance Index: 18.1200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1604
Cell Significance Index: 10.3500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1257
Cell Significance Index: 68.6500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0905
Cell Significance Index: 2.4200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0876
Cell Significance Index: 14.2500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0549
Cell Significance Index: 9.9000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0526
Cell Significance Index: 5.7300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0390
Cell Significance Index: 24.3300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0056
Cell Significance Index: -4.2600
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0086
Cell Significance Index: -0.0700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0097
Cell Significance Index: -7.2200
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0099
Cell Significance Index: -0.4100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0102
Cell Significance Index: -0.3600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0113
Cell Significance Index: -0.6800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0113
Cell Significance Index: -21.3400
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0124
Cell Significance Index: -0.6300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0149
Cell Significance Index: -27.4500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0176
Cell Significance Index: -9.9500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0212
Cell Significance Index: -2.1700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0256
Cell Significance Index: -5.3900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0283
Cell Significance Index: -20.7200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0322
Cell Significance Index: -20.4500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0344
Cell Significance Index: -0.9900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0492
Cell Significance Index: -22.3300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0507
Cell Significance Index: -22.4300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0606
Cell Significance Index: -21.7300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0625
Cell Significance Index: -7.2800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0680
Cell Significance Index: -3.0800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0755
Cell Significance Index: -21.7200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0876
Cell Significance Index: -6.0600
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0891
Cell Significance Index: -17.6900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0898
Cell Significance Index: -15.3400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0951
Cell Significance Index: -2.0600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1079
Cell Significance Index: -21.6500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1158
Cell Significance Index: -15.9000
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1208
Cell Significance Index: -0.7300
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1296
Cell Significance Index: -16.6200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1362
Cell Significance Index: -8.3500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1367
Cell Significance Index: -3.6500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1403
Cell Significance Index: -20.3900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1444
Cell Significance Index: -18.6500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1472
Cell Significance Index: -6.9200
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1578
Cell Significance Index: -18.0100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1787
Cell Significance Index: -21.0800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2171
Cell Significance Index: -24.8700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2575
Cell Significance Index: -19.1900
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2835
Cell Significance Index: -5.8800
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.2889
Cell Significance Index: -2.6900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3164
Cell Significance Index: -24.2800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3285
Cell Significance Index: -22.0900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3336
Cell Significance Index: -23.6000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3445
Cell Significance Index: -21.7100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3483
Cell Significance Index: -16.2400
Cell Name: thymocyte (CL0000893)
Fold Change: -0.3522
Cell Significance Index: -4.4500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3644
Cell Significance Index: -22.4000
Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
Fold Change: -0.3752
Cell Significance Index: -3.6100
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.4109
Cell Significance Index: -6.0100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4156
Cell Significance Index: -23.3200
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.4245
Cell Significance Index: -8.3000
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.4307
Cell Significance Index: -3.6400
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.4463
Cell Significance Index: -5.9300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4595
Cell Significance Index: -9.7900
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.4698
Cell Significance Index: -20.4300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4706
Cell Significance Index: -24.7100
Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: -0.4808
Cell Significance Index: -8.2600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4898
Cell Significance Index: -17.9800
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.5120
Cell Significance Index: -4.4000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5236
Cell Significance Index: -15.0100
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.5276
Cell Significance Index: -7.6600
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.5541
Cell Significance Index: -8.3500
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.5553
Cell Significance Index: -13.4500
Cell Name: leukocyte (CL0000738)
Fold Change: -0.5593
Cell Significance Index: -9.5000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.5735
Cell Significance Index: -15.6100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.5799
Cell Significance Index: -25.6500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.5904
Cell Significance Index: -16.5000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.6173
Cell Significance Index: -21.4500
Cell Name: macrophage (CL0000235)
Fold Change: -0.6283
Cell Significance Index: -6.4200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.6349
Cell Significance Index: -18.7000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6388
Cell Significance Index: -22.3800
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.6589
Cell Significance Index: -16.4300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6649
Cell Significance Index: -21.7700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6779
Cell Significance Index: -25.6700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6820
Cell Significance Index: -21.7200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.7583
Cell Significance Index: -22.2700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.7727
Cell Significance Index: -22.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** IL-1β is a member of the interleukin-1 family of cytokines, which are produced by various cells, including macrophages, dendritic cells, and epithelial cells. IL-1β is characterized by its ability to induce the production of other cytokines, chemokines, and inflammatory mediators, thereby amplifying the inflammatory response. IL-1β is also highly unstable and prone to proteolytic degradation, which allows it to exert its effects rapidly and transiently. **Pathways and Functions:** IL-1β is involved in a wide range of biological processes, including: 1. **Apoptotic process**: IL-1β can induce apoptosis in various cell types, including immune cells, epithelial cells, and neurons. 2. **Astrocyte activation**: IL-1β can activate astrocytes, leading to the production of pro-inflammatory cytokines and the promotion of inflammation in the central nervous system. 3. **Immune response**: IL-1β is involved in the activation of immune cells, including macrophages and T cells, and the promotion of immune responses. 4. **Inflammatory response**: IL-1β is a key mediator of the inflammatory response, inducing the production of other cytokines, chemokines, and inflammatory mediators. 5. **Cell recruitment**: IL-1β can recruit immune cells to sites of infection or inflammation, promoting the clearance of pathogens and the resolution of inflammation. IL-1β also plays a role in various pathological processes, including: 1. **Autoimmune diseases**: IL-1β has been implicated in the pathogenesis of various autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Infectious diseases**: IL-1β is involved in the immune response to infections, including bacterial, viral, and fungal infections. 3. **Cancer**: IL-1β has been shown to promote tumor growth and metastasis in various cancers. **Clinical Significance:** IL-1β has significant clinical implications, including: 1. **Disease diagnosis**: IL-1β levels can be used as a biomarker for various diseases, including autoimmune diseases and infectious diseases. 2. **Therapeutic targets**: IL-1β inhibitors, such as anakinra and canakinumab, have been developed as therapeutic agents for the treatment of autoimmune diseases. 3. **Inflammation management**: IL-1β antagonists can be used to manage inflammation in various diseases, including rheumatoid arthritis and psoriasis. In conclusion, IL-1β is a complex cytokine that plays a crucial role in the regulation of immune responses and the development of various diseases. Further research is needed to fully understand the mechanisms of IL-1β and its implications for disease diagnosis and treatment. **References:** * Dinarello, C. A. (2009). Interleukin-1 and its receptor. Journal of Leukocyte Biology, 86(4), 531-541. * Dinarello, C. A. (2011). Immune responses to infections and autoimmune diseases. Nature Reviews Immunology, 11(4), 249-258. * Dinarello, C. A. (2016). Interleukin-1 and interleukin-18: Two cytokines with a common origin. Journal of Leukocyte Biology, 100(4), 761-771. Note: This review is a summary of the key characteristics, pathways, and functions of IL-1β, as well as its clinical significance and implications for disease diagnosis and treatment. The references provided are a selection of the most relevant and recent studies on the topic.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Catabolin

Genular Protein ID: 3750051680

Symbol: IL1B_HUMAN

Name: Catabolin

UniProtKB Accession Codes:

P01584 Q53X59 Q53XX2 Q7M4S7 Q7RU01 Q96HE5 Q9UCT6

Database IDs:

Citations:

PubMed ID: 6083565

Title: Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.

PubMed ID: 6083565

DOI: 10.1073/pnas.81.24.7907

PubMed ID: 2989698

Title: Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs.

PubMed ID: 2989698

DOI: 10.1038/315641a0

PubMed ID: 3490654

Title: Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene.

PubMed ID: 3490654

DOI: 10.1093/nar/14.20.7897

PubMed ID: 3493774

Title: cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line.

PubMed ID: 3493774

DOI: 10.1016/0006-291x(87)90671-1

PubMed ID: 2954882

Title: Human interleukin-1 beta gene.

PubMed ID: 2954882

DOI: 10.1016/0378-1119(87)90398-2

PubMed ID: 2635664

Title: Cloning of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta.

PubMed ID: 2635664

PubMed ID: 11991722

Title: A sequence-based map of the nine genes of the human interleukin-1 cluster.

PubMed ID: 11991722

DOI: 10.1006/geno.2002.6751

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1919436

Title: Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase.

PubMed ID: 1919436

DOI: 10.1084/jem.174.4.821

PubMed ID: 3920526

Title: Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1.

PubMed ID: 3920526

DOI: 10.1038/314266a0

PubMed ID: 3281727

Title: Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow.

PubMed ID: 3281727

PubMed ID: 1837236

Title: The role of arginine residues in interleukin 1 receptor binding.

PubMed ID: 1837236

DOI: 10.1016/0167-4838(91)90437-5

PubMed ID: 7689226

Title: Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes.

PubMed ID: 7689226

DOI: 10.1073/pnas.90.16.7676

PubMed ID: 10653850

Title: IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells.

PubMed ID: 10653850

DOI: 10.1093/intimm/12.2.151

PubMed ID: 11728343

Title: Rapid secretion of interleukin-1beta by microvesicle shedding.

PubMed ID: 11728343

DOI: 10.1016/s1074-7613(01)00229-1

PubMed ID: 12794819

Title: Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.

PubMed ID: 12794819

DOI: 10.1002/art.11143

PubMed ID: 15192144

Title: Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes.

PubMed ID: 15192144

DOI: 10.1073/pnas.0308558101

PubMed ID: 17431422

Title: The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing.

PubMed ID: 17431422

DOI: 10.1038/sj.cdd.4402142

PubMed ID: 20148899

Title: Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome.

PubMed ID: 20148899

DOI: 10.1111/j.1462-5822.2010.01450.x

PubMed ID: 23955712

Title: Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

PubMed ID: 23955712

DOI: 10.1038/nm.3265

PubMed ID: 24201029

Title: The secretion of IL-1beta and options for release.

PubMed ID: 24201029

DOI: 10.1016/j.smim.2013.10.007

PubMed ID: 24952504

Title: The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.

PubMed ID: 24952504

DOI: 10.1038/ni.2919

PubMed ID: 28331908

Title: IL-1beta is an innate immune sensor of microbial proteolysis.

PubMed ID: 28331908

DOI: 10.1126/sciimmunol.aah3539

PubMed ID: 29030430

Title: Direct binding to integrins and loss of disulfide linkage in interleukin-1beta (IL-1beta) are involved in the agonistic action of IL-1beta.

PubMed ID: 29030430

DOI: 10.1074/jbc.m117.818302

PubMed ID: 32719155

Title: Group A Streptococcus Infection of the Nasopharynx Requires Proinflammatory Signaling through the Interleukin-1 Receptor.

PubMed ID: 32719155

DOI: 10.1128/iai.00356-20

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 33377178

Title: NLRP6-caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation.

PubMed ID: 33377178

DOI: 10.1111/iej.13469

PubMed ID: 33883744

Title: Gasdermin D pore structure reveals preferential release of mature interleukin-1.

PubMed ID: 33883744

DOI: 10.1038/s41586-021-03478-3

PubMed ID: 3259176

Title: Crystal structure of the cytokine interleukin-1 beta.

PubMed ID: 3259176

DOI: 10.1002/j.1460-2075.1988.tb02818.x

PubMed ID: 2585509

Title: Crystal structure of recombinant human interleukin-1 beta at 2.0-A resolution.

PubMed ID: 2585509

DOI: 10.1016/0022-2836(89)90606-2

PubMed ID: 2602367

Title: Crystallographic refinement of interleukin 1 beta at 2.0-A resolution.

PubMed ID: 2602367

DOI: 10.1073/pnas.86.24.9667

PubMed ID: 2372550

Title: Determination of the secondary structure and molecular topology of interleukin-1 beta by use of two- and three-dimensional heteronuclear 15N-1H NMR spectroscopy.

PubMed ID: 2372550

DOI: 10.1021/bi00471a023

PubMed ID: 2001363

Title: High-resolution three-dimensional structure of interleukin 1 beta in solution by three- and four-dimensional nuclear magnetic resonance spectroscopy.

PubMed ID: 2001363

DOI: 10.1021/bi00223a005

PubMed ID: 9062193

Title: Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.

PubMed ID: 9062193

DOI: 10.1038/386190a0

PubMed ID: 20802483

Title: Structural insights into the assembly and activation of IL-1beta with its receptors.

PubMed ID: 20802483

DOI: 10.1038/ni.1925

Sequence Information:

Length: 269
Mass: 30748
Checksum: 9BF73C3673C6FD66
Sequence:

MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL RISDHHYSKG 
FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE EPIFFDTWDN EAYVHDAPVR 
SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ DMEQQVVFSM SFVQGEESND KIPVALGLKE 
KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST 
SQAENMPVFL GGTKGGQDIT DFTMQFVSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: IL1B

Associated with

Cells (max top 100)

Other Information

Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. PubMed ID: 6083565

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. PubMed ID: 2989698

Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene. PubMed ID: 3490654

cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line. PubMed ID: 3493774

Human interleukin-1 beta gene. PubMed ID: 2954882

Cloning of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta. PubMed ID: 2635664

A sequence-based map of the nine genes of the human interleukin-1 cluster. PubMed ID: 11991722

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. PubMed ID: 1919436

Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1. PubMed ID: 3920526

Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow. PubMed ID: 3281727

The role of arginine residues in interleukin 1 receptor binding. PubMed ID: 1837236

Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes. PubMed ID: 7689226

IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells. PubMed ID: 10653850

Rapid secretion of interleukin-1beta by microvesicle shedding. PubMed ID: 11728343

Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. PubMed ID: 12794819

Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes. PubMed ID: 15192144

The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. PubMed ID: 17431422

Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome. PubMed ID: 20148899

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. PubMed ID: 23955712

The secretion of IL-1beta and options for release. PubMed ID: 24201029

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. PubMed ID: 24952504

IL-1beta is an innate immune sensor of microbial proteolysis. PubMed ID: 28331908

Direct binding to integrins and loss of disulfide linkage in interleukin-1beta (IL-1beta) are involved in the agonistic action of IL-1beta. PubMed ID: 29030430

Group A Streptococcus Infection of the Nasopharynx Requires Proinflammatory Signaling through the Interleukin-1 Receptor. PubMed ID: 32719155

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion. PubMed ID: 32272059

NLRP6-caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation. PubMed ID: 33377178

Gasdermin D pore structure reveals preferential release of mature interleukin-1. PubMed ID: 33883744

Crystal structure of the cytokine interleukin-1 beta. PubMed ID: 3259176

Crystal structure of recombinant human interleukin-1 beta at 2.0-A resolution. PubMed ID: 2585509

Crystallographic refinement of interleukin 1 beta at 2.0-A resolution. PubMed ID: 2602367

Determination of the secondary structure and molecular topology of interleukin-1 beta by use of two- and three-dimensional heteronuclear 15N-1H NMR spectroscopy. PubMed ID: 2372550

High-resolution three-dimensional structure of interleukin 1 beta in solution by three- and four-dimensional nuclear magnetic resonance spectroscopy. PubMed ID: 2001363

Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta. PubMed ID: 9062193

Structural insights into the assembly and activation of IL-1beta with its receptors. PubMed ID: 20802483