Details for: CST7

Gene ID: 8530

Symbol: CST7

Ensembl ID: ENSG00000077984

Description: cystatin F

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 110.1287
    Cell Significance Index: -17.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.5465
    Cell Significance Index: -17.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.8544
    Cell Significance Index: -23.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 48.8156
    Cell Significance Index: -25.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.8202
    Cell Significance Index: -18.8000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 39.8020
    Cell Significance Index: 106.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.8042
    Cell Significance Index: -17.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.3265
    Cell Significance Index: -16.3600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 5.2032
    Cell Significance Index: 89.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.8183
    Cell Significance Index: 120.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.7976
    Cell Significance Index: -10.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7262
    Cell Significance Index: -18.6500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.9964
    Cell Significance Index: 61.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.9351
    Cell Significance Index: 115.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.8924
    Cell Significance Index: 77.3700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.7500
    Cell Significance Index: 17.5600
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 2.1015
    Cell Significance Index: 5.3800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.9279
    Cell Significance Index: 12.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2319
    Cell Significance Index: 234.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0165
    Cell Significance Index: 100.5600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.8285
    Cell Significance Index: 6.4500
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.8132
    Cell Significance Index: 8.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8085
    Cell Significance Index: 730.0400
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.6500
    Cell Significance Index: 5.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5895
    Cell Significance Index: 38.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4806
    Cell Significance Index: 78.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2982
    Cell Significance Index: 32.4400
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.1807
    Cell Significance Index: 1.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0883
    Cell Significance Index: 6.1100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0743
    Cell Significance Index: 0.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0003
    Cell Significance Index: 0.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0083
    Cell Significance Index: -0.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0084
    Cell Significance Index: -0.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0089
    Cell Significance Index: -16.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0097
    Cell Significance Index: -0.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0109
    Cell Significance Index: -8.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0119
    Cell Significance Index: -21.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0141
    Cell Significance Index: -9.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0142
    Cell Significance Index: -21.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0165
    Cell Significance Index: -22.4000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0213
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0253
    Cell Significance Index: -18.7600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0338
    Cell Significance Index: -0.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0367
    Cell Significance Index: -20.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0372
    Cell Significance Index: -23.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0384
    Cell Significance Index: -1.5700
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: -0.0397
    Cell Significance Index: -0.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0402
    Cell Significance Index: -1.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0498
    Cell Significance Index: -22.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0512
    Cell Significance Index: -18.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0527
    Cell Significance Index: -1.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0720
    Cell Significance Index: -20.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0723
    Cell Significance Index: -14.3400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0788
    Cell Significance Index: -0.6300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0828
    Cell Significance Index: -0.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0926
    Cell Significance Index: -18.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1036
    Cell Significance Index: -10.5800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1043
    Cell Significance Index: -1.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1188
    Cell Significance Index: -21.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1199
    Cell Significance Index: -3.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1208
    Cell Significance Index: -20.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1270
    Cell Significance Index: -2.7100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1325
    Cell Significance Index: -5.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1424
    Cell Significance Index: -8.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1448
    Cell Significance Index: -19.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1556
    Cell Significance Index: -19.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1567
    Cell Significance Index: -22.7800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1601
    Cell Significance Index: -2.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1686
    Cell Significance Index: -21.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1687
    Cell Significance Index: -19.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1721
    Cell Significance Index: -3.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1733
    Cell Significance Index: -21.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1749
    Cell Significance Index: -8.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1804
    Cell Significance Index: -20.6700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.2314
    Cell Significance Index: -2.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2684
    Cell Significance Index: -20.6000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2712
    Cell Significance Index: -3.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2881
    Cell Significance Index: -19.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2895
    Cell Significance Index: -18.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2913
    Cell Significance Index: -21.7100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3254
    Cell Significance Index: -5.6100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3258
    Cell Significance Index: -4.9100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.3365
    Cell Significance Index: -3.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3454
    Cell Significance Index: -21.2300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3765
    Cell Significance Index: -3.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3983
    Cell Significance Index: -22.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4068
    Cell Significance Index: -21.1300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.4072
    Cell Significance Index: -4.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4131
    Cell Significance Index: -11.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4176
    Cell Significance Index: -18.4700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4210
    Cell Significance Index: -4.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4565
    Cell Significance Index: -23.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4802
    Cell Significance Index: -22.3900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.4841
    Cell Significance Index: -4.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4915
    Cell Significance Index: -18.6100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.4964
    Cell Significance Index: -4.0200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5364
    Cell Significance Index: -18.7900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.5422
    Cell Significance Index: -7.6100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.5608
    Cell Significance Index: -5.6900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5910
    Cell Significance Index: -19.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CST7 exhibits several key characteristics that distinguish it from other cystatins: 1. **Endopeptidase inhibition**: CST7 has the ability to inhibit cysteine-type endopeptidases, which are enzymes responsible for the breakdown of proteins. This inhibition is crucial for maintaining protein homeostasis and preventing excessive proteolysis. 2. **Cellular localization**: CST7 is primarily found in the endoplasmic reticulum, Golgi apparatus, and lysosomes, indicating its involvement in protein processing and degradation. 3. **Immune system regulation**: CST7 is expressed in immune cells, such as T cells and natural killer cells, suggesting its role in regulating immune responses. 4. **Negative regulation**: CST7 acts as a negative regulator of microglial cell activation, indicating its ability to modulate immune responses and prevent excessive inflammation. **Pathways and Functions** CST7 is involved in various cellular pathways, including: 1. **Immune response regulation**: CST7 inhibits cysteine-type endopeptidases, which are involved in the processing and degradation of cytokines and chemokines. This inhibition modulates immune responses and prevents excessive inflammation. 2. **Protein homeostasis**: CST7 maintains protein homeostasis by inhibiting cysteine-type endopeptidases, which are involved in protein degradation. 3. **Cell differentiation**: CST7 is involved in the regulation of cell differentiation, particularly in the development of T cells and natural killer cells. 4. **Neuroprotection**: CST7 may play a role in neuroprotection by regulating microglial cell activation and preventing excessive inflammation in the brain. **Clinical Significance** The clinical significance of CST7 is an area of ongoing research. However, its dysregulation has been implicated in various diseases, including: 1. **Autoimmune disorders**: CST7's role in regulating immune responses makes it a potential target for the treatment of autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 2. **Neurodegenerative diseases**: CST7's involvement in neuroprotection and regulation of microglial cell activation makes it a potential therapeutic target for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: CST7's expression in cancer cells suggests its potential role in cancer progression and metastasis. In conclusion, CST7 is a multifunctional protein that plays a crucial role in regulating cellular processes, including immune response, cell differentiation, and protein homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the clinical significance of CST7.

Genular Protein ID: 135087785

Symbol: CYTF_HUMAN

Name: Cystatin-F

UniProtKB Accession Codes:

O76096 Q6FH95 Q7Z4J8 Q9UED4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 1 EvolutionaryTrace 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9632704

Title: Leukocystatin, a new class II cystatin expressed selectively by hematopoietic cells.

PubMed ID: 9632704

DOI: 10.1074/jbc.273.26.16400

PubMed ID: 9733783

Title: Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor.

PubMed ID: 9733783

DOI: 10.1074/jbc.273.38.24797

PubMed ID: 10945474

Title: Genomic construct and mapping of the gene for CMAP (leukocystatin/cystatin F, CST7) and identification of a proximal novel gene, BSCv (C20orf3).

PubMed ID: 10945474

DOI: 10.1006/geno.2000.6237

PubMed ID: 12423348

Title: Regulated expression and intracellular localization of cystatin F in human U937 cells.

PubMed ID: 12423348

DOI: 10.1046/j.1432-1033.2002.03252.x

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16601115

Title: Structural basis of reduction-dependent activation of human cystatin F.

PubMed ID: 16601115

DOI: 10.1074/jbc.m601033200

Sequence Information:

  • Length: 145
  • Mass: 16454
  • Checksum: B2BCC4F76857CB0F
  • Sequence:
    • MRAAGTLLAF CCLVLSTTGG PSPDTCSQDL NSRVKPGFPK TIKTNDPGVL QAARYSVEKF 
NNCTNDMFLF KESRITRALV QIVKGLKYML EVEIGRTTCK KNQHLRLDDC DFQTNHTLKQ 
TLSCYSEVWV VPWLQHFEVP VLRCH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.