Details for: CST7

Gene ID: 8530

Symbol: CST7

Ensembl ID: ENSG00000077984

Description: cystatin F

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.25
    Marker Score: 15334
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.92
    Marker Score: 15535
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.24
    Marker Score: 11891
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.22
    Marker Score: 6220
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.05
    Marker Score: 11186
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4
    Marker Score: 3203
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.82
    Marker Score: 37807
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.38
    Marker Score: 2842
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.34
    Marker Score: 1845
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.26
    Marker Score: 1405
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.19
    Marker Score: 1036
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.17
    Marker Score: 3528
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.05
    Marker Score: 2951
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.03
    Marker Score: 2692
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.85
    Marker Score: 722
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.79
    Marker Score: 919
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.62
    Marker Score: 1904
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.6
    Marker Score: 1600
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.56
    Marker Score: 1475
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.53
    Marker Score: 1086
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.13
    Marker Score: 2933.5
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.12
    Marker Score: 532
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.07
    Marker Score: 643
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.01
    Marker Score: 955
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.01
    Marker Score: 12843
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.95
    Marker Score: 442
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.93
    Marker Score: 991
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.9
    Marker Score: 1471
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.59
    Marker Score: 934
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.58
    Marker Score: 2576
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1146
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.57
    Marker Score: 18284
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.57
    Marker Score: 484
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.57
    Marker Score: 1334
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.44
    Marker Score: 1439.5
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.43
    Marker Score: 1848
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.39
    Marker Score: 1090
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.25
    Marker Score: 1167
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 836
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.22
    Marker Score: 888
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.21
    Marker Score: 877
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.17
    Marker Score: 3019
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.16
    Marker Score: 781
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 479
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.13
    Marker Score: 991
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.12
    Marker Score: 990
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.11
    Marker Score: 295
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.03
    Marker Score: 463
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 1.02
    Marker Score: 474
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1
    Marker Score: 504
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71761
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47990
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.96
    Marker Score: 4128
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.94
    Marker Score: 2109
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.93
    Marker Score: 1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.92
    Marker Score: 422.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5217
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.89
    Marker Score: 2180
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.87
    Marker Score: 523
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5270
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.86
    Marker Score: 260
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.86
    Marker Score: 701
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 643
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.83
    Marker Score: 917
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.79
    Marker Score: 41599
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3263
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.77
    Marker Score: 449
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.77
    Marker Score: 564
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.77
    Marker Score: 527
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.76
    Marker Score: 527
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.76
    Marker Score: 1536.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.75
    Marker Score: 270
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 670
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 454
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.69
    Marker Score: 436
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.67
    Marker Score: 686
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.67
    Marker Score: 6819
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.66
    Marker Score: 1258
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.65
    Marker Score: 395
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.64
    Marker Score: 421
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.63
    Marker Score: 479
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.62
    Marker Score: 204
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.62
    Marker Score: 214
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.61
    Marker Score: 305
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6
    Marker Score: 9359
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.59
    Marker Score: 336
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.58
    Marker Score: 635
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.57
    Marker Score: 370
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.56
    Marker Score: 196
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 446

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Other Information

**Key Characteristics** CST7 exhibits several key characteristics that distinguish it from other cystatins: 1. **Endopeptidase inhibition**: CST7 has the ability to inhibit cysteine-type endopeptidases, which are enzymes responsible for the breakdown of proteins. This inhibition is crucial for maintaining protein homeostasis and preventing excessive proteolysis. 2. **Cellular localization**: CST7 is primarily found in the endoplasmic reticulum, Golgi apparatus, and lysosomes, indicating its involvement in protein processing and degradation. 3. **Immune system regulation**: CST7 is expressed in immune cells, such as T cells and natural killer cells, suggesting its role in regulating immune responses. 4. **Negative regulation**: CST7 acts as a negative regulator of microglial cell activation, indicating its ability to modulate immune responses and prevent excessive inflammation. **Pathways and Functions** CST7 is involved in various cellular pathways, including: 1. **Immune response regulation**: CST7 inhibits cysteine-type endopeptidases, which are involved in the processing and degradation of cytokines and chemokines. This inhibition modulates immune responses and prevents excessive inflammation. 2. **Protein homeostasis**: CST7 maintains protein homeostasis by inhibiting cysteine-type endopeptidases, which are involved in protein degradation. 3. **Cell differentiation**: CST7 is involved in the regulation of cell differentiation, particularly in the development of T cells and natural killer cells. 4. **Neuroprotection**: CST7 may play a role in neuroprotection by regulating microglial cell activation and preventing excessive inflammation in the brain. **Clinical Significance** The clinical significance of CST7 is an area of ongoing research. However, its dysregulation has been implicated in various diseases, including: 1. **Autoimmune disorders**: CST7's role in regulating immune responses makes it a potential target for the treatment of autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 2. **Neurodegenerative diseases**: CST7's involvement in neuroprotection and regulation of microglial cell activation makes it a potential therapeutic target for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: CST7's expression in cancer cells suggests its potential role in cancer progression and metastasis. In conclusion, CST7 is a multifunctional protein that plays a crucial role in regulating cellular processes, including immune response, cell differentiation, and protein homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the clinical significance of CST7.

Genular Protein ID: 135087785

Symbol: CYTF_HUMAN

Name: Cystatin-F

UniProtKB Accession Codes:

O76096 Q6FH95 Q7Z4J8 Q9UED4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9632704

Title: Leukocystatin, a new class II cystatin expressed selectively by hematopoietic cells.

PubMed ID: 9632704

DOI: 10.1074/jbc.273.26.16400

PubMed ID: 9733783

Title: Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor.

PubMed ID: 9733783

DOI: 10.1074/jbc.273.38.24797

PubMed ID: 10945474

Title: Genomic construct and mapping of the gene for CMAP (leukocystatin/cystatin F, CST7) and identification of a proximal novel gene, BSCv (C20orf3).

PubMed ID: 10945474

DOI: 10.1006/geno.2000.6237

PubMed ID: 12423348

Title: Regulated expression and intracellular localization of cystatin F in human U937 cells.

PubMed ID: 12423348

DOI: 10.1046/j.1432-1033.2002.03252.x

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16601115

Title: Structural basis of reduction-dependent activation of human cystatin F.

PubMed ID: 16601115

DOI: 10.1074/jbc.m601033200

Sequence Information:

  • Length: 145
  • Mass: 16454
  • Checksum: B2BCC4F76857CB0F
  • Sequence:
    • MRAAGTLLAF CCLVLSTTGG PSPDTCSQDL NSRVKPGFPK TIKTNDPGVL QAARYSVEKF 
NNCTNDMFLF KESRITRALV QIVKGLKYML EVEIGRTTCK KNQHLRLDDC DFQTNHTLKQ 
TLSCYSEVWV VPWLQHFEVP VLRCH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.