Details for: FGA
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 15.4303
Cell Significance Index: 259.9200 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 4.9426
Cell Significance Index: 18.6200 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 4.9274
Cell Significance Index: 13.2000 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 4.3116
Cell Significance Index: 15.0000 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 4.0035
Cell Significance Index: 23.0600 - Cell Name: hepatoblast (CL0005026)
Fold Change: 3.8813
Cell Significance Index: 65.2800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 3.6455
Cell Significance Index: 723.4700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.2941
Cell Significance Index: 33.8600 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.9735
Cell Significance Index: 15.5800 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 1.7817
Cell Significance Index: 4.7000 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.5680
Cell Significance Index: 15.4700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.9109
Cell Significance Index: 29.1800 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.8901
Cell Significance Index: 90.9200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.7997
Cell Significance Index: 28.1000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7272
Cell Significance Index: 15.7600 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.4145
Cell Significance Index: 3.9400 - Cell Name: mature B cell (CL0000785)
Fold Change: 0.4083
Cell Significance Index: 2.6600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.3791
Cell Significance Index: 23.2500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2159
Cell Significance Index: 41.0900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1248
Cell Significance Index: 7.4900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0935
Cell Significance Index: 58.4000 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.0751
Cell Significance Index: 0.7800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0487
Cell Significance Index: 36.8600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0479
Cell Significance Index: 5.2100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0405
Cell Significance Index: 4.7200 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.0404
Cell Significance Index: 0.3700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0285
Cell Significance Index: 3.2600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0239
Cell Significance Index: 21.5500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0081
Cell Significance Index: 1.3800 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.0076
Cell Significance Index: 0.1100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0023
Cell Significance Index: 0.3800 - Cell Name: neuron associated cell (CL0000095)
Fold Change: 0.0016
Cell Significance Index: 0.0600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0009
Cell Significance Index: 0.6900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0007
Cell Significance Index: 0.0500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0018
Cell Significance Index: -1.0000 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0027
Cell Significance Index: -0.0700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0079
Cell Significance Index: -1.6700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0111
Cell Significance Index: -0.3200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0136
Cell Significance Index: -0.3400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0194
Cell Significance Index: -14.2300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0212
Cell Significance Index: -2.1000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0240
Cell Significance Index: -2.7400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0261
Cell Significance Index: -0.7000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0286
Cell Significance Index: -3.9300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0309
Cell Significance Index: -6.1900 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: -0.0469
Cell Significance Index: -0.3600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0534
Cell Significance Index: -2.4200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0550
Cell Significance Index: -1.1400 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0565
Cell Significance Index: -0.5900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0694
Cell Significance Index: -3.2400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0836
Cell Significance Index: -3.9300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0930
Cell Significance Index: -1.9800 - Cell Name: plasmablast (CL0000980)
Fold Change: -0.1013
Cell Significance Index: -0.9400 - Cell Name: peg cell (CL4033014)
Fold Change: -0.1162
Cell Significance Index: -2.6900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1272
Cell Significance Index: -3.6500 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1289
Cell Significance Index: -3.2200 - Cell Name: lymphocyte (CL0000542)
Fold Change: -0.1307
Cell Significance Index: -1.7800 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.1338
Cell Significance Index: -1.7500 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.1396
Cell Significance Index: -2.0400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1607
Cell Significance Index: -5.2600 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1619
Cell Significance Index: -2.3200 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.1669
Cell Significance Index: -2.7500 - Cell Name: epithelial cell (CL0000066)
Fold Change: -0.1844
Cell Significance Index: -1.9500 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.1972
Cell Significance Index: -1.6800 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2054
Cell Significance Index: -3.1000 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.2133
Cell Significance Index: -3.3000 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2345
Cell Significance Index: -5.9800 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.2388
Cell Significance Index: -3.0800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2397
Cell Significance Index: -8.8000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2412
Cell Significance Index: -6.4400 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2462
Cell Significance Index: -5.3200 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2464
Cell Significance Index: -6.4800 - Cell Name: thymocyte (CL0000893)
Fold Change: -0.2497
Cell Significance Index: -3.1600 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.2609
Cell Significance Index: -3.1500 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2667
Cell Significance Index: -5.8400 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.2713
Cell Significance Index: -5.4100 - Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.2761
Cell Significance Index: -2.9100 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2784
Cell Significance Index: -4.1100 - Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.2856
Cell Significance Index: -3.2400 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.2899
Cell Significance Index: -3.0000 - Cell Name: naive B cell (CL0000788)
Fold Change: -0.2958
Cell Significance Index: -3.1200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3026
Cell Significance Index: -5.0700 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.3060
Cell Significance Index: -5.2900 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.3135
Cell Significance Index: -4.4000 - Cell Name: monocyte (CL0000576)
Fold Change: -0.3181
Cell Significance Index: -3.6600 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.3210
Cell Significance Index: -4.1900 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.3219
Cell Significance Index: -5.1700 - Cell Name: erythroblast (CL0000765)
Fold Change: -0.3271
Cell Significance Index: -3.9000 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.3283
Cell Significance Index: -4.1600 - Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.3493
Cell Significance Index: -3.7100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3510
Cell Significance Index: -7.4500 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3568
Cell Significance Index: -5.1100 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.3582
Cell Significance Index: -8.6800 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.3775
Cell Significance Index: -7.3800 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3791
Cell Significance Index: -11.1700 - Cell Name: PP cell (CL0000696)
Fold Change: -0.3826
Cell Significance Index: -3.8900 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.3879
Cell Significance Index: -6.6300 - Cell Name: adipocyte (CL0000136)
Fold Change: -0.3923
Cell Significance Index: -5.2300 - Cell Name: myelocyte (CL0002193)
Fold Change: -0.3959
Cell Significance Index: -4.2300 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.4034
Cell Significance Index: -4.1200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1664192174
Symbol: FIBA_HUMAN
Name: Fibrinogen alpha chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1457396
Title: Carboxy-terminal-extended variant of the human fibrinogen alpha subunit: a novel exon conferring marked homology to beta and gamma subunits.
PubMed ID: 1457396
DOI: 10.1021/bi00163a002
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2102623
Title: Nucleotide sequences of the three genes coding for human fibrinogen.
PubMed ID: 2102623
PubMed ID: 6575389
Title: Partial mRNA sequences for human A alpha, B beta, and gamma fibrinogen chains: evolutionary and functional implications.
PubMed ID: 6575389
PubMed ID: 6688355
Title: Characterization of a complementary deoxyribonucleic acid coding for the alpha chain of human fibrinogen.
PubMed ID: 6688355
DOI: 10.1021/bi00282a031
PubMed ID: 518846
Title: Amino acid sequence studies on the alpha chain of human fibrinogen. Overlapping sequences providing the complete sequence.
PubMed ID: 518846
DOI: 10.1021/bi00591a024
PubMed ID: 6689067
Title: Isolation and characterisation of cDNA clones for the A alpha- and gamma-chains of human fibrinogen.
PubMed ID: 6689067
PubMed ID: 6575700
Title: Cloning of fibrinogen genes and their cDNA.
PubMed ID: 6575700
PubMed ID: 741445
Title: The arrangement of disulfide bonds in fragment D from human fibrinogen.
PubMed ID: 741445
PubMed ID: 518845
Title: Amino acid sequence studies on the alpha chain of human fibrinogen. Exact location of cross-linking acceptor sites.
PubMed ID: 518845
DOI: 10.1021/bi00591a023
PubMed ID: 632262
Title: Localization of the alpha-chain cross-link acceptor sites of human fibrin.
PubMed ID: 632262
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 936108
Title: Disulfide bridges in NH2-terminal part of human fibrinogen.
PubMed ID: 936108
PubMed ID: 6383194
PubMed ID: 2877981
Title: Cross-linking site in fibrinogen for alpha 2-plasmin inhibitor.
PubMed ID: 2877981
PubMed ID: 6318767
Title: Phosphorylation of fibrinogen by casein kinase 1.
PubMed ID: 6318767
PubMed ID: 11418620
Title: Extracellular fibrinogen-binding protein, Efb, from Staphylococcus aureus blocks platelet aggregation due to its binding to the alpha-chain.
PubMed ID: 11418620
PubMed ID: 16807684
Title: Phosphoproteomic analysis of the human pituitary.
PubMed ID: 16807684
PubMed ID: 18088087
PubMed ID: 19696023
Title: Prolyl 4-hydroxylation of alpha-fibrinogen: a novel protein modification revealed by plasma proteomics.
PubMed ID: 19696023
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 2143188
Title: A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule.
PubMed ID: 2143188
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23050552
Title: Glycoproteomic analysis of human fibrinogen reveals novel regions of O-glycosylation.
PubMed ID: 23050552
DOI: 10.1021/pr3005937
PubMed ID: 24348255
Title: Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface.
PubMed ID: 24348255
PubMed ID: 23151259
Title: Characterization of fibrinogen glycosylation and its importance for serum/plasma N-glycome analysis.
PubMed ID: 23151259
DOI: 10.1021/pr300813h
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26091039
Title: A single kinase generates the majority of the secreted phosphoproteome.
PubMed ID: 26091039
PubMed ID: 1560020
Title: The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution.
PubMed ID: 1560020
PubMed ID: 9333233
Title: Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin.
PubMed ID: 9333233
DOI: 10.1038/38947
PubMed ID: 9628725
Title: Crystal structure of fragment double-D from human fibrin with two different bound ligands.
PubMed ID: 9628725
DOI: 10.1021/bi9804129
PubMed ID: 9689040
Title: Crystal structure of a recombinant alphaEC domain from human fibrinogen-420.
PubMed ID: 9689040
PubMed ID: 10074346
Title: Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.
PubMed ID: 10074346
DOI: 10.1021/bi982626w
PubMed ID: 19296670
PubMed ID: 2070049
Title: Fibrinogen Kyoto II, a new congenitally abnormal molecule, characterized by the replacement of A alpha proline-18 by leucine.
PubMed ID: 2070049
PubMed ID: 1634621
Title: Fibrinogen Lima: a homozygous dysfibrinogen with an A alpha-arginine-141 to serine substitution associated with extra N-glycosylation at A alpha-asparagine-139. Impaired fibrin gel formation but normal fibrin-facilitated plasminogen activation catalyzed by tissue-type plasminogen activator.
PubMed ID: 1634621
DOI: 10.1172/jci115857
PubMed ID: 1675636
Title: An A alpha Ser-434 to N-glycosylated Asn substitution in a dysfibrinogen, fibrinogen Caracas II, characterized by impaired fibrin gel formation.
PubMed ID: 1675636
PubMed ID: 8473507
Title: Molecular basis for fibrinogen Dusart (A alpha 554 Arg-->Cys) and its association with abnormal fibrin polymerization and thrombophilia.
PubMed ID: 8473507
DOI: 10.1172/jci116371
PubMed ID: 8097946
Title: Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain.
PubMed ID: 8097946
DOI: 10.1038/ng0393-252
PubMed ID: 8461606
Title: Fibrinogen Osaka IV: a congenital dysfibrinogenemia found in a patient originally reported in relation to surgery, now defined to have an A alpha arginine-16 to histidine substitution.
PubMed ID: 8461606
DOI: 10.1007/bf00308999
PubMed ID: 8675656
Title: Aberrant hepatic processing causes removal of activation peptide and primary polymerisation site from fibrinogen Canterbury (A-alpha 20 Val-to-Asp).
PubMed ID: 8675656
DOI: 10.1172/jci118356
PubMed ID: 10391209
Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.
PubMed ID: 10391209
DOI: 10.1038/10290
PubMed ID: 16846481
Title: The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance.
PubMed ID: 16846481
PubMed ID: 25427968
Title: Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency.
PubMed ID: 25427968
DOI: 10.1160/th14-07-0629
Sequence Information:
- Length: 866
- Mass: 94973
- Checksum: EA73A81204D8AEC4
- Sequence:
MFSMRIVCLV LSVVGTAWTA DSGEGDFLAE GGGVRGPRVV ERHQSACKDS DWPFCSDEDW NYKCPSGCRM KGLIDEVNQD FTNRINKLKN SLFEYQKNNK DSHSLTTNIM EILRGDFSSA NNRDNTYNRV SEDLRSRIEV LKRKVIEKVQ HIQLLQKNVR AQLVDMKRLE VDIDIKIRSC RGSCSRALAR EVDLKDYEDQ QKQLEQVIAK DLLPSRDRQH LPLIKMKPVP DLVPGNFKSQ LQKVPPEWKA LTDMPQMRME LERPGGNEIT RGGSTSYGTG SETESPRNPS SAGSWNSGSS GPGSTGNRNP GSSGTGGTAT WKPGSSGPGS TGSWNSGSSG TGSTGNQNPG SPRPGSTGTW NPGSSERGSA GHWTSESSVS GSTGQWHSES GSFRPDSPGS GNARPNNPDW GTFEEVSGNV SPGTRREYHT EKLVTSKGDK ELRTGKEKVT SGSTTTTRRS CSKTVTKTVI GPDGHKEVTK EVVTSEDGSD CPEAMDLGTL SGIGTLDGFR HRHPDEAAFF DTASTGKTFP GFFSPMLGEF VSETESRGSE SGIFTNTKES SSHHPGIAEF PSRGKSSSYS KQFTSSTSYN RGDSTFESKS YKMADEAGSE ADHEGTHSTK RGHAKSRPVR DCDDVLQTHP SGTQSGIFNI KLPGSSKIFS VYCDQETSLG GWLLIQQRMD GSLNFNRTWQ DYKRGFGSLN DEGEGEFWLG NDYLHLLTQR GSVLRVELED WAGNEAYAEY HFRVGSEAEG YALQVSSYEG TAGDALIEGS VEEGAEYTSH NNMQFSTFDR DADQWEENCA EVYGGGWWYN NCQAANLNGI YYPGGSYDPR NNSPYEIENG VVWVSFRGAD YSLRAVRMKI RPLVTQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.