Details for: FGA

Gene ID: 2243

Symbol: FGA

Ensembl ID: ENSG00000171560

Description: fibrinogen alpha chain

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 9.51
    Marker Score: 31,147
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.95
    Marker Score: 21,240
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.67
    Marker Score: 4,109
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.53
    Marker Score: 2,707
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.37
    Marker Score: 15,220
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 2.36
    Marker Score: 733
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.35
    Marker Score: 10,160
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1,997
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.92
    Marker Score: 1,201
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.65
    Marker Score: 454
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,172
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.51
    Marker Score: 1,509
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.37
    Marker Score: 301
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.34
    Marker Score: 914
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,817
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.13
    Marker Score: 427
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.07
    Marker Score: 7,139
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1
    Marker Score: 678
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,349
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.92
    Marker Score: 423
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.9
    Marker Score: 375
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.62
    Marker Score: 467
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 391
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.59
    Marker Score: 521
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 457
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.52
    Marker Score: 7,039
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.48
    Marker Score: 180
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.44
    Marker Score: 702
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.43
    Marker Score: 197
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.4
    Marker Score: 382
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.38
    Marker Score: 779
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.35
    Marker Score: 194
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.32
    Marker Score: 137
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.29
    Marker Score: 303
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.28
    Marker Score: 1,851
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.25
    Marker Score: 476
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.25
    Marker Score: 85
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.24
    Marker Score: 270
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.24
    Marker Score: 160
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.23
    Marker Score: 376
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.22
    Marker Score: 102
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.22
    Marker Score: 243
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.21
    Marker Score: 435
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.21
    Marker Score: 337
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.2
    Marker Score: 374
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.2
    Marker Score: 220
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.18
    Marker Score: 183
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.18
    Marker Score: 180
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 162
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.18
    Marker Score: 65
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.18
    Marker Score: 64
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.18
    Marker Score: 169
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.15
    Marker Score: 88
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.15
    Marker Score: 213
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.14
    Marker Score: 228
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.14
    Marker Score: 2,233
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.14
    Marker Score: 31
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.14
    Marker Score: 85
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.14
    Marker Score: 79
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.14
    Marker Score: 286
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.13
    Marker Score: 237
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.13
    Marker Score: 853
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.13
    Marker Score: 767
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.13
    Marker Score: 135
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.12
    Marker Score: 126
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.12
    Marker Score: 378
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.12
    Marker Score: 50
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.12
    Marker Score: 99
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.11
    Marker Score: 94
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 98
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.11
    Marker Score: 261
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.11
    Marker Score: 241
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.1
    Marker Score: 54
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.1
    Marker Score: 353
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.1
    Marker Score: 126
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.1
    Marker Score: 185
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.09
    Marker Score: 45
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 91
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.09
    Marker Score: 48
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.09
    Marker Score: 69
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.08
    Marker Score: 62
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.08
    Marker Score: 40

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: Fibrinogen is a tetrameric glycoprotein composed of three polypeptide chains: alpha, beta, and gamma. 2. **Function**: Fibrinogen plays a central role in blood coagulation, regulating the conversion of soluble fibrinogen to insoluble fibrin. 3. **Synthesis**: Fibrinogen is synthesized in the liver and released into the bloodstream. 4. **Expression**: Fibrinogen is expressed in various cells, including hepatoblasts, endothelial cells, and inflammatory macrophages. 5. **Binding**: Fibrinogen binds to other proteins, including thrombin, factor XIII, and integrins, to regulate coagulation and cellular processes. **Pathways and Functions** 1. **Blood Coagulation**: Fibrinogen is converted into fibrin by thrombin, forming a fibrin clot that helps to stop bleeding. 2. **Cell-Matrix Adhesion**: Fibrinogen interacts with integrins and other proteins to regulate cell-matrix adhesion and signaling. 3. **Adaptive Immune Response**: Fibrinogen is involved in the adaptive immune response, regulating the activation of immune cells and the production of cytokines. 4. **Amyloid Fiber Formation**: Fibrinogen can form amyloid fibers, which are associated with various diseases, including Alzheimer's and Parkinson's. 5. **Signaling Pathways**: Fibrinogen interacts with various signaling pathways, including MAPK, PI3K, and JAK/STAT, to regulate cellular processes. **Clinical Significance** 1. **Thrombotic Disorders**: Fibrinogen dysregulation is associated with thrombotic disorders, including deep vein thrombosis and pulmonary embolism. 2. **Hemostasis**: Fibrinogen plays a critical role in hemostasis, regulating the formation of fibrin clots that help to stop bleeding. 3. **Inflammatory Diseases**: Fibrinogen is involved in the regulation of inflammatory responses, including the activation of immune cells and the production of cytokines. 4. **Cancer**: Fibrinogen is overexpressed in various cancers, including breast, lung, and colon cancer, and is associated with poor prognosis. 5. **Infectious Diseases**: Fibrinogen is involved in the regulation of the innate immune response, including the activation of immune cells and the production of cytokines. In conclusion, fibrinogen alpha chain is a multifunctional protein that plays a critical role in blood coagulation, cellular processes, and the regulation of the immune response. Its dysregulation is associated with various diseases, including thrombotic disorders, hemostasis, inflammatory diseases, cancer, and infectious diseases.

Genular Protein ID: 1664192174

Symbol: FIBA_HUMAN

Name: Fibrinogen alpha chain

UniProtKB Accession Codes:

P02671 A8K3E4 D3DP14 D3DP15 Q4QQH7 Q9BX62 Q9UCH2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CTD 1 CarbonylDB 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 18 EMBL 19 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 39 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 2 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 48 PDBsum 39 PIR 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 21 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniLectin 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1457396

Title: Carboxy-terminal-extended variant of the human fibrinogen alpha subunit: a novel exon conferring marked homology to beta and gamma subunits.

PubMed ID: 1457396

DOI: 10.1021/bi00163a002

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2102623

Title: Nucleotide sequences of the three genes coding for human fibrinogen.

PubMed ID: 2102623

DOI: 10.1007/978-1-4615-3806-6_3

PubMed ID: 6575389

Title: Partial mRNA sequences for human A alpha, B beta, and gamma fibrinogen chains: evolutionary and functional implications.

PubMed ID: 6575389

DOI: 10.1073/pnas.80.13.3953

PubMed ID: 6688355

Title: Characterization of a complementary deoxyribonucleic acid coding for the alpha chain of human fibrinogen.

PubMed ID: 6688355

DOI: 10.1021/bi00282a031

PubMed ID: 518846

Title: Amino acid sequence studies on the alpha chain of human fibrinogen. Overlapping sequences providing the complete sequence.

PubMed ID: 518846

DOI: 10.1021/bi00591a024

PubMed ID: 6689067

Title: Isolation and characterisation of cDNA clones for the A alpha- and gamma-chains of human fibrinogen.

PubMed ID: 6689067

DOI: 10.1093/nar/11.21.7427

PubMed ID: 6575700

Title: Cloning of fibrinogen genes and their cDNA.

PubMed ID: 6575700

DOI: 10.1111/j.1749-6632.1983.tb23265.x

PubMed ID: 741445

Title: The arrangement of disulfide bonds in fragment D from human fibrinogen.

PubMed ID: 741445

DOI: 10.1016/0049-3848(78)90142-1

PubMed ID: 518845

Title: Amino acid sequence studies on the alpha chain of human fibrinogen. Exact location of cross-linking acceptor sites.

PubMed ID: 518845

DOI: 10.1021/bi00591a023

PubMed ID: 632262

Title: Localization of the alpha-chain cross-link acceptor sites of human fibrin.

PubMed ID: 632262

DOI: 10.1016/s0021-9258(17)38057-2

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 936108

Title: Disulfide bridges in NH2-terminal part of human fibrinogen.

PubMed ID: 936108

DOI: 10.1016/0049-3848(76)90245-0

PubMed ID: 6383194

Title: Fibrinogen and fibrin.

PubMed ID: 6383194

DOI: 10.1146/annurev.bi.53.070184.001211

PubMed ID: 2877981

Title: Cross-linking site in fibrinogen for alpha 2-plasmin inhibitor.

PubMed ID: 2877981

DOI: 10.1016/s0021-9258(18)66755-9

PubMed ID: 6318767

Title: Phosphorylation of fibrinogen by casein kinase 1.

PubMed ID: 6318767

DOI: 10.1016/0006-291x(83)91247-0

PubMed ID: 11418620

Title: Extracellular fibrinogen-binding protein, Efb, from Staphylococcus aureus blocks platelet aggregation due to its binding to the alpha-chain.

PubMed ID: 11418620

DOI: 10.1074/jbc.m104554200

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19696023

Title: Prolyl 4-hydroxylation of alpha-fibrinogen: a novel protein modification revealed by plasma proteomics.

PubMed ID: 19696023

DOI: 10.1074/jbc.m109.041749

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 2143188

Title: A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule.

PubMed ID: 2143188

DOI: 10.1016/s0021-9258(18)77401-2

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23050552

Title: Glycoproteomic analysis of human fibrinogen reveals novel regions of O-glycosylation.

PubMed ID: 23050552

DOI: 10.1021/pr3005937

PubMed ID: 24348255

Title: Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface.

PubMed ID: 24348255

DOI: 10.1371/journal.ppat.1003816

PubMed ID: 23151259

Title: Characterization of fibrinogen glycosylation and its importance for serum/plasma N-glycome analysis.

PubMed ID: 23151259

DOI: 10.1021/pr300813h

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 1560020

Title: The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution.

PubMed ID: 1560020

DOI: 10.1016/s0021-9258(18)42599-9

PubMed ID: 9333233

Title: Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin.

PubMed ID: 9333233

DOI: 10.1038/38947

PubMed ID: 9628725

Title: Crystal structure of fragment double-D from human fibrin with two different bound ligands.

PubMed ID: 9628725

DOI: 10.1021/bi9804129

PubMed ID: 9689040

Title: Crystal structure of a recombinant alphaEC domain from human fibrinogen-420.

PubMed ID: 9689040

DOI: 10.1073/pnas.95.16.9099

PubMed ID: 10074346

Title: Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.

PubMed ID: 10074346

DOI: 10.1021/bi982626w

PubMed ID: 19296670

Title: Crystal structure of human fibrinogen.

PubMed ID: 19296670

DOI: 10.1021/bi802205g

PubMed ID: 2070049

Title: Fibrinogen Kyoto II, a new congenitally abnormal molecule, characterized by the replacement of A alpha proline-18 by leucine.

PubMed ID: 2070049

PubMed ID: 1634621

Title: Fibrinogen Lima: a homozygous dysfibrinogen with an A alpha-arginine-141 to serine substitution associated with extra N-glycosylation at A alpha-asparagine-139. Impaired fibrin gel formation but normal fibrin-facilitated plasminogen activation catalyzed by tissue-type plasminogen activator.

PubMed ID: 1634621

DOI: 10.1172/jci115857

PubMed ID: 1675636

Title: An A alpha Ser-434 to N-glycosylated Asn substitution in a dysfibrinogen, fibrinogen Caracas II, characterized by impaired fibrin gel formation.

PubMed ID: 1675636

DOI: 10.1016/s0021-9258(18)98995-7

PubMed ID: 8473507

Title: Molecular basis for fibrinogen Dusart (A alpha 554 Arg-->Cys) and its association with abnormal fibrin polymerization and thrombophilia.

PubMed ID: 8473507

DOI: 10.1172/jci116371

PubMed ID: 8097946

Title: Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain.

PubMed ID: 8097946

DOI: 10.1038/ng0393-252

PubMed ID: 8461606

Title: Fibrinogen Osaka IV: a congenital dysfibrinogenemia found in a patient originally reported in relation to surgery, now defined to have an A alpha arginine-16 to histidine substitution.

PubMed ID: 8461606

DOI: 10.1007/bf00308999

PubMed ID: 8675656

Title: Aberrant hepatic processing causes removal of activation peptide and primary polymerisation site from fibrinogen Canterbury (A-alpha 20 Val-to-Asp).

PubMed ID: 8675656

DOI: 10.1172/jci118356

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 16846481

Title: The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance.

PubMed ID: 16846481

DOI: 10.1111/j.1365-2141.2006.06129.x

PubMed ID: 25427968

Title: Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency.

PubMed ID: 25427968

DOI: 10.1160/th14-07-0629

Sequence Information:

  • Length: 866
  • Mass: 94973
  • Checksum: EA73A81204D8AEC4
  • Sequence:
    • MFSMRIVCLV LSVVGTAWTA DSGEGDFLAE GGGVRGPRVV ERHQSACKDS DWPFCSDEDW 
NYKCPSGCRM KGLIDEVNQD FTNRINKLKN SLFEYQKNNK DSHSLTTNIM EILRGDFSSA 
NNRDNTYNRV SEDLRSRIEV LKRKVIEKVQ HIQLLQKNVR AQLVDMKRLE VDIDIKIRSC 
RGSCSRALAR EVDLKDYEDQ QKQLEQVIAK DLLPSRDRQH LPLIKMKPVP DLVPGNFKSQ 
LQKVPPEWKA LTDMPQMRME LERPGGNEIT RGGSTSYGTG SETESPRNPS SAGSWNSGSS 
GPGSTGNRNP GSSGTGGTAT WKPGSSGPGS TGSWNSGSSG TGSTGNQNPG SPRPGSTGTW 
NPGSSERGSA GHWTSESSVS GSTGQWHSES GSFRPDSPGS GNARPNNPDW GTFEEVSGNV 
SPGTRREYHT EKLVTSKGDK ELRTGKEKVT SGSTTTTRRS CSKTVTKTVI GPDGHKEVTK 
EVVTSEDGSD CPEAMDLGTL SGIGTLDGFR HRHPDEAAFF DTASTGKTFP GFFSPMLGEF 
VSETESRGSE SGIFTNTKES SSHHPGIAEF PSRGKSSSYS KQFTSSTSYN RGDSTFESKS 
YKMADEAGSE ADHEGTHSTK RGHAKSRPVR DCDDVLQTHP SGTQSGIFNI KLPGSSKIFS 
VYCDQETSLG GWLLIQQRMD GSLNFNRTWQ DYKRGFGSLN DEGEGEFWLG NDYLHLLTQR 
GSVLRVELED WAGNEAYAEY HFRVGSEAEG YALQVSSYEG TAGDALIEGS VEEGAEYTSH 
NNMQFSTFDR DADQWEENCA EVYGGGWWYN NCQAANLNGI YYPGGSYDPR NNSPYEIENG 
VVWVSFRGAD YSLRAVRMKI RPLVTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.