Details for: MARCO

Gene ID: 8685

Symbol: MARCO

Ensembl ID: ENSG00000019169

Description: macrophage receptor with collagenous structure

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 62.5542
    Cell Significance Index: -9.7300
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 20.5766
    Cell Significance Index: 54.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 18.9741
    Cell Significance Index: -9.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.8916
    Cell Significance Index: -9.7300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.9713
    Cell Significance Index: 45.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7120
    Cell Significance Index: 13.1600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.4636
    Cell Significance Index: 5.7400
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.1009
    Cell Significance Index: 0.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0354
    Cell Significance Index: 1.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0317
    Cell Significance Index: 4.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0062
    Cell Significance Index: 2.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0002
    Cell Significance Index: -0.1600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0044
    Cell Significance Index: -8.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0085
    Cell Significance Index: -15.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0102
    Cell Significance Index: -15.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0109
    Cell Significance Index: -14.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0115
    Cell Significance Index: -8.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0128
    Cell Significance Index: -8.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0131
    Cell Significance Index: -9.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0142
    Cell Significance Index: -4.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0188
    Cell Significance Index: -8.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0208
    Cell Significance Index: -11.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0264
    Cell Significance Index: -9.4600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0278
    Cell Significance Index: -0.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0319
    Cell Significance Index: -3.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0439
    Cell Significance Index: -8.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0477
    Cell Significance Index: -8.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0492
    Cell Significance Index: -9.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0511
    Cell Significance Index: -7.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0586
    Cell Significance Index: -7.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0613
    Cell Significance Index: -3.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0660
    Cell Significance Index: -11.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0738
    Cell Significance Index: -9.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0804
    Cell Significance Index: -9.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0880
    Cell Significance Index: -12.0800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0899
    Cell Significance Index: -3.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0950
    Cell Significance Index: -9.8900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1005
    Cell Significance Index: -1.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1026
    Cell Significance Index: -11.7500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1091
    Cell Significance Index: -0.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1145
    Cell Significance Index: -8.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1180
    Cell Significance Index: -6.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1312
    Cell Significance Index: -10.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1339
    Cell Significance Index: -9.4700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1456
    Cell Significance Index: -2.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1482
    Cell Significance Index: -9.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1490
    Cell Significance Index: -10.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1517
    Cell Significance Index: -9.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1572
    Cell Significance Index: -8.1900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1607
    Cell Significance Index: -2.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1629
    Cell Significance Index: -10.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1681
    Cell Significance Index: -4.7000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1701
    Cell Significance Index: -2.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1832
    Cell Significance Index: -4.9000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1857
    Cell Significance Index: -3.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1980
    Cell Significance Index: -5.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2008
    Cell Significance Index: -8.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2145
    Cell Significance Index: -10.0000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2228
    Cell Significance Index: -3.1900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2238
    Cell Significance Index: -3.7700
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.2240
    Cell Significance Index: -2.0500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2284
    Cell Significance Index: -1.9300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2320
    Cell Significance Index: -5.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2385
    Cell Significance Index: -10.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2411
    Cell Significance Index: -13.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2596
    Cell Significance Index: -13.6300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.2765
    Cell Significance Index: -2.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2789
    Cell Significance Index: -10.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2854
    Cell Significance Index: -7.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2904
    Cell Significance Index: -10.6600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2909
    Cell Significance Index: -2.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2933
    Cell Significance Index: -8.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2933
    Cell Significance Index: -10.2800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.3084
    Cell Significance Index: -3.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3140
    Cell Significance Index: -10.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3195
    Cell Significance Index: -8.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3240
    Cell Significance Index: -10.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3338
    Cell Significance Index: -9.5700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.3510
    Cell Significance Index: -6.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3518
    Cell Significance Index: -10.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3587
    Cell Significance Index: -7.0000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3662
    Cell Significance Index: -3.4100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3673
    Cell Significance Index: -9.1600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3767
    Cell Significance Index: -5.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3812
    Cell Significance Index: -7.9800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3864
    Cell Significance Index: -9.8500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4025
    Cell Significance Index: -8.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4125
    Cell Significance Index: -10.2900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.4154
    Cell Significance Index: -4.9100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4177
    Cell Significance Index: -8.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4206
    Cell Significance Index: -9.2100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4455
    Cell Significance Index: -5.7700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4484
    Cell Significance Index: -7.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4532
    Cell Significance Index: -10.8700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4655
    Cell Significance Index: -6.6700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.4688
    Cell Significance Index: -4.9800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4730
    Cell Significance Index: -10.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4825
    Cell Significance Index: -10.2400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4885
    Cell Significance Index: -15.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MARCO is a transmembrane receptor with a collagenous structure, consisting of 10 collagen-like domains and a single Ig-like domain. Its extracellular domain is rich in collagen, allowing it to bind to various ligands, including amyloid-beta, collagen, and other glycoproteins. The intracellular domain of MARCO is characterized by the presence of seven transmembrane segments, which are typical of G protein-coupled receptors. This allows MARCO to activate various signaling pathways upon ligand binding. **Pathways and Functions:** MARCO is involved in multiple signaling pathways, including: 1. **Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway**: MARCO activates this pathway, which regulates various cellular processes, including cell proliferation and differentiation. 2. **Apoptotic cell clearance**: MARCO plays a critical role in the clearance of apoptotic cells, which helps maintain tissue homeostasis and prevent autoimmune responses. 3. **Amyloid-beta binding and clearance**: MARCO binds to amyloid-beta, a key component of Alzheimer's disease, and facilitates its clearance from the brain. 4. **Scavenger receptor activity**: MARCO is a member of the scavenger receptor family, which recognizes and binds to various ligands, including pathogens, dead cells, and other foreign substances. 5. **Receptor-mediated endocytosis**: MARCO regulates the uptake of ligands by endocytic vesicles, which is essential for the clearance of pathogens and other foreign substances. **Signaling pathways activated by MARCO:** 1. **Positive regulation of erk1 and erk2 cascade**: MARCO activates the mitogen-activated protein kinase (MAPK) pathway, which regulates cell proliferation, differentiation, and survival. 2. **Positive regulation of protein phosphorylation**: MARCO activates various kinases, including protein kinase C (PKC) and protein kinase B (Akt), which regulate cell signaling and survival pathways. 3. **Vesicle-mediated transport**: MARCO regulates the transport of ligands and signaling molecules within endocytic vesicles, which is essential for the clearance of pathogens and other foreign substances. **Significantly Expressed Cells:** MARCO is expressed on various cell types, including: 1. **Elicited macrophage**: MARCO is induced on macrophages in response to inflammatory stimuli, allowing them to recognize and clear pathogens. 2. **Alveolar macrophage**: MARCO is expressed on alveolar macrophages, which play a critical role in the clearance of pathogens and other foreign substances in the lungs. 3. **Kupffer cell**: MARCO is expressed on Kupffer cells, which are resident macrophages in the liver and play a critical role in the clearance of pathogens and other foreign substances. 4. **Capillary endothelial cell**: MARCO is expressed on capillary endothelial cells, which play a critical role in the regulation of immune responses and the clearance of pathogens. **Clinical Significance:** MARCO has been implicated in various diseases, including: 1. **Alzheimer's disease**: MARCO has been shown to play a critical role in the clearance of amyloid-beta, which is a hallmark of Alzheimer's disease. 2. **Atherosclerosis**: MARCO has been implicated in the development of atherosclerosis, a condition characterized by the buildup of plaque in the arteries. 3. **Autoimmune diseases**: MARCO has been shown to play a critical role in the clearance of apoptotic cells, which helps maintain tissue homeostasis and prevent autoimmune responses. In conclusion, the MARCO gene is a critical component of the immune system's scavenger receptor network, playing a pivotal role in the recognition and clearance of pathogens, apoptotic cells, and other foreign substances. Its unique collagenous structure allows it to bind to a wide range of ligands, including amyloid-beta, which is a hallmark of Alzheimer's disease. Further research is needed to fully elucidate the mechanisms by which MARCO regulates immune responses and to explore its therapeutic potential in various diseases.

Genular Protein ID: 3295938753

Symbol: MARCO_HUMAN

Name: Macrophage receptor MARCO

UniProtKB Accession Codes:

Q9UEW3 B4DW79 Q9Y5S3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 19 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9468508

Title: Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region.

PubMed ID: 9468508

DOI: 10.1074/jbc.273.8.4530

PubMed ID: 10331948

Title: Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor.

PubMed ID: 10331948

DOI: 10.1006/geno.1999.5811

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10224290

Title: Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles.

PubMed ID: 10224290

DOI: 10.1084/jem.189.9.1497

PubMed ID: 12847263

Title: Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair.

PubMed ID: 12847263

DOI: 10.4049/jimmunol.171.2.924

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 520
  • Mass: 52658
  • Checksum: 8CFC5F6F99EEBA8D
  • Sequence:
    • MRNKKILKED ELLSETQQAA FHQIAMEPFE INVPKPKRRN GVNFSLAVVV IYLILLTAGA 
GLLVVQVLNL QARLRVLEMY FLNDTLAAED SPSFSLLQSA HPGEHLAQGA SRLQVLQAQL 
TWVRVSHEHL LQRVDNFTQN PGMFRIKGEQ GAPGLQGHKG AMGMPGAPGP PGPPAEKGAK 
GAMGRDGATG PSGPQGPPGV KGEAGLQGPQ GAPGKQGATG TPGPQGEKGS KGDGGLIGPK 
GETGTKGEKG DLGLPGSKGD RGMKGDAGVM GPPGAQGSKG DFGRPGPPGL AGFPGAKGDQ 
GQPGLQGVPG PPGAVGHPGA KGEPGSAGSP GRAGLPGSPG SPGATGLKGS KGDTGLQGQQ 
GRKGESGVPG PAGVKGEQGS PGLAGPKGAP GQAGQKGDQG VKGSSGEQGV KGEKGERGEN 
SVSVRIVGSS NRGRAEVYYS GTWGTICDDE WQNSDAIVFC RMLGYSKGRA LYKVGAGTGQ 
IWLDNVQCRG TESTLWSCTK NSWGHHDCSH EEDAGVECSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.