Details for: AGTRAP

Gene ID: 57085

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: AGTRAP

Ensembl ID: ENSG00000177674

Description: angiotensin II receptor associated protein

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • promonocyte CL0000559
    CSI 22.53
    rCSI 38.59%
    PRS 91.78
  • ciliated epithelial cell CL0000067
    CSI 15.5
    rCSI 13.63%
    PRS 80.3
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 15.26
    rCSI 11.76%
    PRS 92.23
  • classical monocyte CL0000860
    CSI 10.7
    rCSI 15.86%
    PRS 94.27
  • common myeloid progenitor CL0000049
    CSI 10.39
    rCSI 8.4%
    PRS 90.64
  • acinar cell CL0000622
    CSI 9.56
    rCSI 14.03%
    PRS 94.51
  • CD14-positive monocyte CL0001054
    CSI 7.57
    rCSI 9.42%
    PRS 94.95
  • granulocyte monocyte progenitor cell CL0000557
    CSI 7.41
    rCSI 6.42%
    PRS 91.38
  • CD16-positive, CD56-dim natural killer cell, human CL0000939
    CSI 7.31
    rCSI 4.87%
    PRS 95.02
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 6.82
    rCSI 41.24%
    PRS 94.92
  • ependymal cell CL0000065
    CSI 6.81
    rCSI 13.82%
    PRS 70.91
  • multi-ciliated epithelial cell CL0005012
    CSI 6.01
    rCSI 6%
    PRS 83.5
  • bronchus fibroblast of lung CL2000093
    CSI 5.55
    rCSI 4.51%
    PRS 88.44
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 5.35
    rCSI 4.01%
    PRS 97.2
  • helper T cell CL0000912
    CSI 5.32
    rCSI 7.52%
    PRS 85.45
  • pulmonary artery endothelial cell CL1001568
    CSI 5.14
    rCSI 6.99%
    PRS 93.96
  • mesenchymal cell CL0008019
    CSI 4.65
    rCSI 11.82%
    PRS 83.92
  • activated type II NK T cell CL0000931
    CSI 4.65
    rCSI 5.24%
    PRS 96.46
  • myofibroblast cell CL0000186
    CSI 4.62
    rCSI 6.4%
    PRS 85.84
  • epithelial cell of lung CL0000082
    CSI 4.59
    rCSI 3.81%
    PRS 89.96
  • mature NK T cell CL0000814
    CSI 4.56
    rCSI 5.83%
    PRS 93.6
  • Hofbauer cell CL3000001
    CSI 4.52
    rCSI 8.54%
    PRS 94.13
  • non-classical monocyte CL0000875
    CSI 4.41
    rCSI 7.06%
    PRS 94.33
  • glioblast CL0000030
    CSI 4.27
    rCSI 6.81%
    PRS 81.54
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 4.13
    rCSI 3.14%
    PRS 97.12
  • fallopian tube secretory epithelial cell CL4030006
    CSI 4.12
    rCSI 3.96%
    PRS 87.8
  • stem cell CL0000034
    CSI 3.98
    rCSI 3.83%
    PRS 84.72
  • fibroblast of lung CL0002553
    CSI 3.93
    rCSI 3.66%
    PRS 90.31
  • conventional dendritic cell CL0000990
    CSI 3.87
    rCSI 3.23%
    PRS 84.78
  • mammary gland epithelial cell CL0002327
    CSI 3.82
    rCSI 13.41%
    PRS 93.23
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 3.66
    rCSI 2.46%
    PRS 97.08
  • double negative thymocyte CL0002489
    CSI 3.65
    rCSI 2.53%
    PRS 96.52
  • mesodermal cell CL0000222
    CSI 3.61
    rCSI 4.34%
    PRS 87.84
  • innate lymphoid cell CL0001065
    CSI 3.55
    rCSI 7.32%
    PRS 83.97
  • monocyte CL0000576
    CSI 3.51
    rCSI 6.35%
    PRS 90.87
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 3.31
    rCSI 2.99%
    PRS 88.02
  • cytotoxic T cell CL0000910
    CSI 3.22
    rCSI 18.43%
    PRS 88.83
  • inflammatory macrophage CL0000863
    CSI 3.16
    rCSI 5.4%
    PRS 96.74
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 3.13
    rCSI 3.78%
    PRS 93.97
  • hematopoietic stem cell CL0000037
    CSI 3.11
    rCSI 2.06%
    PRS 90.82
  • ciliated cell CL0000064
    CSI 3.1
    rCSI 5.02%
    PRS 83.54
  • pulmonary capillary endothelial cell CL4028001
    CSI 3.09
    rCSI 5.89%
    PRS 94.94
  • naive T cell CL0000898
    CSI 3.05
    rCSI 2.12%
    PRS 97.27
  • basal cell CL0000646
    CSI 3.03
    rCSI 4.05%
    PRS 86.48
  • immature B cell CL0000816
    CSI 3.02
    rCSI 2.24%
    PRS 95.4
  • pancreatic ductal cell CL0002079
    CSI 2.95
    rCSI 5.73%
    PRS 90.86
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 2.95
    rCSI 8.45%
    PRS 98.21
  • lung macrophage CL1001603
    CSI 2.94
    rCSI 6.57%
    PRS 93.55
  • interstitial cell of Cajal CL0002088
    CSI 2.91
    rCSI 3.71%
    PRS 92.91
  • elicited macrophage CL0000861
    CSI 2.76
    rCSI 2.53%
    PRS 93.81
  • enteric smooth muscle cell CL0002504
    CSI 2.7
    rCSI 3.86%
    PRS 89.45
  • pancreatic acinar cell CL0002064
    CSI 2.68
    rCSI 3.56%
    PRS 92.22
  • myeloid leukocyte CL0000766
    CSI 2.68
    rCSI 2.47%
    PRS 90.2
  • skin fibroblast CL0002620
    CSI 2.67
    rCSI 2.3%
    PRS 88.72
  • respiratory hillock cell CL4030023
    CSI 2.63
    rCSI 4.68%
    PRS 93.2
  • deuterosomal cell CL4033044
    CSI 2.56
    rCSI 8.64%
    PRS 84.5
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 2.48
    rCSI 2.44%
    PRS 97.14
  • radial glial cell CL0000681
    CSI 2.45
    rCSI 3.41%
    PRS 87.66
  • neural crest cell CL0011012
    CSI 2.43
    rCSI 1.92%
    PRS 81.48
  • ionocyte CL0005006
    CSI 2.39
    rCSI 2.56%
    PRS 90.66
  • conjunctival epithelial cell CL1000432
    CSI 2.38
    rCSI 3.64%
    PRS 88.49
  • adventitial cell CL0002503
    CSI 2.35
    rCSI 5.62%
    PRS 91.55
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 2.31
    rCSI 3.17%
    PRS 97.36
  • intestinal epithelial cell CL0002563
    CSI 2.3
    rCSI 2.41%
    PRS 86.8
  • granulocyte CL0000094
    CSI 2.25
    rCSI 3.44%
    PRS 93.66
  • extravillous trophoblast CL0008036
    CSI 2.24
    rCSI 2.78%
    PRS 87.54
  • promyelocyte CL0000836
    CSI 2.18
    rCSI 3.14%
    PRS 91.72
  • club cell CL0000158
    CSI 2.16
    rCSI 3.16%
    PRS 84.39
  • alveolar macrophage CL0000583
    CSI 2.16
    rCSI 3.56%
    PRS 91.09
  • luminal epithelial cell of mammary gland CL0002326
    CSI 2.16
    rCSI 3.92%
    PRS 94.37
  • duct epithelial cell CL0000068
    CSI 2.14
    rCSI 3.13%
    PRS 92.6
  • pulmonary ionocyte CL0017000
    CSI 2.12
    rCSI 2.58%
    PRS 93.03
  • dendritic cell, human CL0001056
    CSI 2.06
    rCSI 3.17%
    PRS 94.63
  • intermediate monocyte CL0002393
    CSI 2.06
    rCSI 3.11%
    PRS 93.07
  • alveolar type 1 fibroblast cell CL4028004
    CSI 2.06
    rCSI 2.25%
    PRS 90.66
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 2.03
    rCSI 2.43%
    PRS 97.12
  • lung ciliated cell CL1000271
    CSI 2
    rCSI 2.31%
    PRS 83.36
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 1.88
    rCSI 9.46%
    PRS 96.32
  • choroid plexus epithelial cell CL0000706
    CSI 1.84
    rCSI 3.02%
    PRS 81.46
  • mononuclear phagocyte CL0000113
    CSI 1.81
    rCSI 3.98%
    PRS 91.6
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 1.81
    rCSI 2.37%
    PRS 95.42
  • myeloid dendritic cell CL0000782
    CSI 1.75
    rCSI 2.54%
    PRS 96.52
  • epithelial cell of proximal tubule CL0002306
    CSI 1.72
    rCSI 4.21%
    PRS 82.24
  • alternatively activated macrophage CL0000890
    CSI 1.69
    rCSI 2.13%
    PRS 94.62
  • glandular epithelial cell CL0000150
    CSI 1.57
    rCSI 4.14%
    PRS 95.41
  • alveolar adventitial fibroblast CL4028006
    CSI 1.44
    rCSI 2.28%
    PRS 90
  • myelocyte CL0002193
    CSI 1.41
    rCSI 9.28%
    PRS 95.54
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 1.36
    rCSI 3.09%
    PRS 82.41
  • professional antigen presenting cell CL0000145
    CSI 1.15
    rCSI 3.94%
    PRS 93.62
  • type B pancreatic cell CL0000169
    CSI 1.12
    rCSI 2.49%
    PRS 89.05
  • pancreatic stellate cell CL0002410
    CSI 0.91
    rCSI 5.27%
    PRS 90.92
  • luminal cell of prostate epithelium CL0002340
    CSI 0.8
    rCSI 4.29%
    PRS 93.39
  • podocyte CL0000653
    CSI 0.76
    rCSI 3.38%
    PRS 89.69
  • decidual natural killer cell, human CL0002343
    CSI 0.52
    rCSI 5.24%
    PRS 94.54
  • erythroid progenitor cell CL0000038
    CSI 0.39
    rCSI 2.26%
    PRS 91.53
  • pluripotent stem cell CL0002248
    CSI 0.2
    rCSI 6.03%
    PRS 94.26

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [AGTRAP](/details-gene/57085), or Angiotensin II Receptor Associated Protein, is a protein-coding gene located on chromosome 1p36.22. It functions as a key modulator of the angiotensin II signaling pathway, which is critical for processes such as the `[regulation of blood pressure](/details-go/GO:0008217)`. Research indicates that it is a transmembrane protein that interacts with the type-1 angiotensin II receptor to attenuate its signaling, suggesting a role as a negative regulator `[Link](https://doi.org/10.1091/mbc.e03-06-0383)`. **Overall**, expression data reveals its highest significance in cells of the myeloid lineage, particularly in the `[promonocyte](/details-cell/CL0000559)` and `[classical monocyte](/details-cell/CL0000860)` populations. It is also notably expressed in specialized cell types like `[ciliated epithelial cell](/details-cell/CL0000067)`, pointing to a diverse, yet specific, set of biological roles. ## Cellular Roles and Expression Landscape The expression profile of `[AGTRAP](/details-gene/57085)` highlights its prominent role within the hematopoietic system, specifically in myeloid cell development and function. **Overall**, its highest significance is observed in `[promonocyte](/details-cell/CL0000559)` (CSI: 22.53), followed by various monocyte subsets including `[CD14-low, CD16-positive monocyte](/details-cell/CL0002396)` and `[classical monocyte](/details-cell/CL0000860)`. Its consistent high ranking in progenitor cells like the `[common myeloid progenitor](/details-cell/CL0000049)` and `[granulocyte monocyte progenitor cell](/details-cell/CL0000557)` suggests an integral role beginning early in myeloid differentiation. Beyond the myeloid compartment, `[AGTRAP](/details-gene/57085)` shows significant expression in several non-immune cell types. It is a key marker in `[ciliated epithelial cell](/details-cell/CL0000067)`, `[acinar cell](/details-cell/CL0000622)`, and `[ependymal cell](/details-cell/CL0000065)`. This pattern suggests its function in angiotensin signaling may be important for processes related to fluid transport, secretion, and barrier function in these specialized tissues. The gene also shows moderate significance in lymphoid cells such as `[CD16-positive, CD56-dim natural killer cell, human](/details-cell/CL0000939)` and `[helper T cell](/details-cell/CL0000912)`, indicating a broader, albeit less prominent, role in the immune system. ## Pathways and Molecular Function Functional annotation corroborates the role of `[AGTRAP](/details-gene/57085)` as a direct participant in the `[Angiotensin-activated signaling pathway](/details-go/GO:0038166)`. Its molecular function is defined by its ability to bind the angiotensin type II receptor (`[GO:0004945](/details-go/GO:0004945)`) and other proteins (`[GO:0005515](/details-go/GO:0005515)`). As a transmembrane protein localized to the `[plasma membrane](/details-go/GO:0005886)`, `[endoplasmic reticulum membrane](/details-go/GO:0005789)`, and `[Golgi apparatus](/details-go/GO:0005794)`, it is positioned to modulate receptor trafficking and signaling cascades at multiple cellular locations `[Link](https://doi.org/10.1091/mbc.e03-06-0383)`. The association of `[AGTRAP](/details-gene/57085)` with Reactome pathways such as `[Oncogenic mapk signaling](/details-reactome/R-HSA-6802957)` is noteworthy. This link suggests that beyond its established role in cardiovascular regulation, the angiotensin signaling axis modulated by `[AGTRAP](/details-gene/57085)` may be co-opted in pathological contexts like cancer. This is consistent with the known roles of angiotensin II in promoting proliferation and inflammation, processes that are central to tumorigenesis. ## Research Directions The specific and high expression of `[AGTRAP](/details-gene/57085)` in monocytes and its link to MAPK signaling pathways present compelling avenues for future research, particularly in the context of inflammation-driven diseases and cancer. Based on the available data, several testable hypotheses can be proposed: 1. The high expression of `[AGTRAP](/details-gene/57085)` in monocytes serves as a key feedback mechanism to prevent excessive inflammation in response to angiotensin II. Its downregulation in chronic inflammatory states, such as atherosclerosis, may contribute to persistent monocyte activation and plaque formation. 2. In the tumor microenvironment, `[AGTRAP](/details-gene/57085)` expression in tumor-associated macrophages (TAMs) dictates their polarization state. Loss of `[AGTRAP](/details-gene/57085)` could enhance pro-tumorigenic angiotensin II signaling, skewing TAMs towards an M2-like, pro-angiogenic phenotype. To test the second hypothesis, a key experiment could be designed. A myeloid-specific knockout of `[AGTRAP](/details-gene/57085)` could be generated in mice (e.g., using a LysM-Cre driver). These mice and their wild-type littermates would be implanted with syngeneic tumor cells (e.g., MC38 colorectal cancer model). Tumor growth would be monitored, and upon sacrifice, tumors would be analyzed by single-cell RNA sequencing and flow cytometry to specifically assess the transcriptional and phenotypic changes in the TAM population, focusing on M1/M2 markers and angiogenesis-related gene signatures. Regarding its therapeutic potential, `[AGTRAP](/details-gene/57085)` presents an interesting target. Because its function is to attenuate angiotensin II receptor signaling `[Link](https://doi.org/10.1091/mbc.e03-06-0383)`, it acts as an endogenous negative regulator. Therefore, therapeutic strategies would likely focus on the **activation** of `[AGTRAP](/details-gene/57085)` or enhancement of its interaction with the receptor. Small molecules that stabilize the AGTRAP-receptor complex could offer a novel approach to dampen pathological angiotensin II signaling in hypertension, chronic kidney disease, or certain cancers, potentially with greater specificity than systemic receptor blockade.

Genular Protein ID: 686790051

Symbol: ATRAP_HUMAN

Name: Type-1 angiotensin II receptor-associated protein

UniProtKB Accession Codes:

Q6RW13 A8MVQ5 Q5SNV4 Q5SNV5 Q96AC0 Q96PL4 Q9NRW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 5 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11733189

Title: Identification and characterization of AGTRAP, a human homolog of murine angiotensin II receptor-associated protein (Agtrap).

PubMed ID: 11733189

DOI: 10.1016/s1357-2725(01)00094-2

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12960423

Title: The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling.

PubMed ID: 12960423

DOI: 10.1091/mbc.e03-06-0383

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 159
  • Mass: 17419
  • Checksum: 7E1D5C7E79AE6BC5
  • Sequence:
    • MELPAVNLKV ILLGHWLLTT WGCIVFSGSY AWANFTILAL GVWAVAQRDS IDAISMFLGG 
LLATIFLDIV HISIFYPRVS LTDTGRFGVG MAILSLLLKP LSCCFVYHMY RERGGELLVH 
TGFLGSSQDR SAYQTIDSAE APADPFAVPE GRSQDARGY