Details for: TMEM176B

Gene ID: 28959

Symbol: TMEM176B

Ensembl ID: ENSG00000106565

Description: transmembrane protein 176B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 219.9360
    Cell Significance Index: -34.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 133.2580
    Cell Significance Index: -33.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 86.2385
    Cell Significance Index: -35.0400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 79.2305
    Cell Significance Index: -40.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 75.9019
    Cell Significance Index: -35.8400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 54.4468
    Cell Significance Index: -36.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.8241
    Cell Significance Index: -35.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.7463
    Cell Significance Index: -34.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.0321
    Cell Significance Index: -37.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.5402
    Cell Significance Index: -33.7000
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 5.0949
    Cell Significance Index: 13.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.3398
    Cell Significance Index: 35.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.1334
    Cell Significance Index: 61.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.0745
    Cell Significance Index: 205.2100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.9474
    Cell Significance Index: 19.6500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.8448
    Cell Significance Index: 15.6800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.8210
    Cell Significance Index: 30.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.8174
    Cell Significance Index: 33.5900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.1111
    Cell Significance Index: 16.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8292
    Cell Significance Index: 107.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7959
    Cell Significance Index: 36.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7733
    Cell Significance Index: 147.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7554
    Cell Significance Index: 21.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6800
    Cell Significance Index: 93.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6470
    Cell Significance Index: 33.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5960
    Cell Significance Index: 41.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5866
    Cell Significance Index: 15.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5626
    Cell Significance Index: 111.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4837
    Cell Significance Index: 9.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4195
    Cell Significance Index: 48.8900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2647
    Cell Significance Index: 2.0400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2042
    Cell Significance Index: 3.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1902
    Cell Significance Index: 8.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1884
    Cell Significance Index: 6.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1789
    Cell Significance Index: 9.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1652
    Cell Significance Index: 121.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1140
    Cell Significance Index: 4.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0754
    Cell Significance Index: 5.6200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0500
    Cell Significance Index: 0.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0479
    Cell Significance Index: 90.1800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0368
    Cell Significance Index: 0.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0312
    Cell Significance Index: 4.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0030
    Cell Significance Index: 0.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0014
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0086
    Cell Significance Index: -5.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0238
    Cell Significance Index: -43.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0275
    Cell Significance Index: -17.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0280
    Cell Significance Index: -43.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0283
    Cell Significance Index: -19.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0286
    Cell Significance Index: -6.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0326
    Cell Significance Index: -44.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0344
    Cell Significance Index: -19.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0364
    Cell Significance Index: -3.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0393
    Cell Significance Index: -29.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0418
    Cell Significance Index: -18.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0434
    Cell Significance Index: -23.7000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0486
    Cell Significance Index: -0.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0590
    Cell Significance Index: -26.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0662
    Cell Significance Index: -9.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0997
    Cell Significance Index: -35.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1168
    Cell Significance Index: -33.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1205
    Cell Significance Index: -2.6100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1276
    Cell Significance Index: -14.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1427
    Cell Significance Index: -16.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1546
    Cell Significance Index: -11.8600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1661
    Cell Significance Index: -1.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1760
    Cell Significance Index: -35.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1776
    Cell Significance Index: -32.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2413
    Cell Significance Index: -5.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2456
    Cell Significance Index: -4.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2742
    Cell Significance Index: -33.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2956
    Cell Significance Index: -8.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3042
    Cell Significance Index: -24.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3204
    Cell Significance Index: -33.3600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3307
    Cell Significance Index: -13.5500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.3311
    Cell Significance Index: -3.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3355
    Cell Significance Index: -39.5700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3547
    Cell Significance Index: -4.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4274
    Cell Significance Index: -10.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4646
    Cell Significance Index: -24.2000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4661
    Cell Significance Index: -7.8400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5048
    Cell Significance Index: -3.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5441
    Cell Significance Index: -34.2900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.5483
    Cell Significance Index: -9.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5506
    Cell Significance Index: -5.7000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5565
    Cell Significance Index: -7.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5663
    Cell Significance Index: -38.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6161
    Cell Significance Index: -37.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6231
    Cell Significance Index: -38.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6284
    Cell Significance Index: -29.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6320
    Cell Significance Index: -7.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6324
    Cell Significance Index: -40.8000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.6513
    Cell Significance Index: -5.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6520
    Cell Significance Index: -16.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6994
    Cell Significance Index: -39.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7051
    Cell Significance Index: -36.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7099
    Cell Significance Index: -18.9900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.7479
    Cell Significance Index: -4.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7757
    Cell Significance Index: -34.3100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.8793
    Cell Significance Index: -7.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMEM176B is a transmembrane protein composed of 10 transmembrane domains, with a TIR (Toll/IL-1 receptor) domain that interacts with the adaptor protein TIRAP. This protein is highly expressed in various tissues, including epithelial cells, fibroblasts, and immune cells, such as dendritic cells. TMEM176B is also involved in negative regulation of dendritic cell differentiation, suggesting its potential role in modulating the immune response. **Pathways and Functions:** TMEM176B is implicated in several key signaling pathways, including: 1. **Animal Organ Morphogenesis:** TMEM176B is involved in the regulation of cell differentiation and morphogenesis in various tissues, including the kidney, colon, and lung. 2. **Cell Differentiation:** TMEM176B interacts with other proteins to regulate the differentiation of epithelial cells, fibroblasts, and immune cells. 3. **Negative Regulation of Dendritic Cell Differentiation:** TMEM176B inhibits the differentiation of dendritic cells, which are critical for the initiation of immune responses. 4. **Protein Binding:** TMEM176B interacts with various proteins, including TIRAP, to regulate signaling pathways. **Functions:** TMEM176B plays a crucial role in regulating cellular processes, including: 1. **Immune Response:** TMEM176B modulates the immune response by regulating dendritic cell differentiation and function. 2. **Cellular Morphogenesis:** TMEM176B is involved in the regulation of cell shape and morphology in various tissues. 3. **Tissue Homeostasis:** TMEM176B maintains tissue homeostasis by regulating the differentiation and function of epithelial cells and fibroblasts. **Clinical Significance:** TMEM176B has been implicated in various diseases, including: 1. **Autoimmune Diseases:** TMEM176B dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** TMEM176B has been identified as a potential oncogene in certain types of cancer, including breast and lung cancer. 3. **Immunodeficiency Disorders:** TMEM176B mutations have been associated with immunodeficiency disorders, such as chronic granulomatous disease. In conclusion, TMEM176B is a critical transmembrane protein that plays a pivotal role in regulating cellular processes, including morphogenesis, differentiation, and immune responses. Further research is needed to fully elucidate the functions of TMEM176B and its involvement in various diseases. **References:** * [Insert references here] Note: The references section should be populated with relevant studies and research papers on TMEM176B.

Genular Protein ID: 3844281567

Symbol: T176B_HUMAN

Name: Transmembrane protein 176B

UniProtKB Accession Codes:

Q3YBM2 B2RDK2 D3DWZ7 E9PAV4 Q5BJI2 Q9BT42 Q9Y609

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 5 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 5 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9922225

Title: Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display.

PubMed ID: 9922225

DOI: 10.1165/ajrcmb.20.2.3368

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16095493

Title: Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts.

PubMed ID: 16095493

DOI: 10.1111/j.1600-6143.2005.01007.x

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 270
  • Mass: 29056
  • Checksum: 6D27B2A384709FDD
  • Sequence:
    • MTQNTVIVNG VAMASRPSQP THVNVHIHQE SALTQLLKAG GSLKKFLFHP GDTVPSTARI 
GYEQLALGVT QILLGVVSCV LGVCLSLGPW TVLSASGCAF WAGSVVIAAG AGAIVHEKHP 
GKLAGYISSL LTLAGFATAM AAVVLCVNSF IWQTEPFLYI DTVCDRSDPV FPTTGYRWMR 
RSQENQWQKE ECRAYMQMLR KLFTAIRALF LAVCVLKVIV SLVSLGVGLR NLCGQSSQPL 
NEEGSEKRLL GENSVPPSPS REQTSTAIVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.