Details for: MAN2B1

Gene ID: 4125

Symbol: MAN2B1

Ensembl ID: ENSG00000104774

Description: mannosidase alpha class 2B member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 84.5413
    Cell Significance Index: -13.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.2029
    Cell Significance Index: -12.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 29.2721
    Cell Significance Index: -13.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 29.1027
    Cell Significance Index: -14.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.7790
    Cell Significance Index: -13.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2485
    Cell Significance Index: -14.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.0693
    Cell Significance Index: -15.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6948
    Cell Significance Index: -10.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4015
    Cell Significance Index: -13.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.2707
    Cell Significance Index: 432.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.5858
    Cell Significance Index: 29.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0922
    Cell Significance Index: 65.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0310
    Cell Significance Index: 30.2800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0208
    Cell Significance Index: 9.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5194
    Cell Significance Index: 93.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5083
    Cell Significance Index: 59.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4804
    Cell Significance Index: 52.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4378
    Cell Significance Index: 53.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4163
    Cell Significance Index: 11.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4023
    Cell Significance Index: 115.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3920
    Cell Significance Index: 78.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2478
    Cell Significance Index: 17.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2336
    Cell Significance Index: 210.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2305
    Cell Significance Index: 26.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2152
    Cell Significance Index: 6.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1885
    Cell Significance Index: 37.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1704
    Cell Significance Index: 4.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1441
    Cell Significance Index: 4.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1431
    Cell Significance Index: 51.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1284
    Cell Significance Index: 2.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0947
    Cell Significance Index: 7.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0946
    Cell Significance Index: 6.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0830
    Cell Significance Index: 13.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0748
    Cell Significance Index: 1.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0472
    Cell Significance Index: 6.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0425
    Cell Significance Index: 5.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0224
    Cell Significance Index: 12.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0158
    Cell Significance Index: 1.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0123
    Cell Significance Index: 23.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0097
    Cell Significance Index: 17.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0055
    Cell Significance Index: 2.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0049
    Cell Significance Index: 0.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0048
    Cell Significance Index: 7.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0012
    Cell Significance Index: 1.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0061
    Cell Significance Index: -3.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0077
    Cell Significance Index: -3.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0093
    Cell Significance Index: -0.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0101
    Cell Significance Index: -0.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0108
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0146
    Cell Significance Index: -10.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0157
    Cell Significance Index: -11.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0176
    Cell Significance Index: -0.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0185
    Cell Significance Index: -13.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0216
    Cell Significance Index: -12.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0224
    Cell Significance Index: -13.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0244
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0281
    Cell Significance Index: -4.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0315
    Cell Significance Index: -1.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0333
    Cell Significance Index: -0.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0336
    Cell Significance Index: -4.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0509
    Cell Significance Index: -2.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0605
    Cell Significance Index: -1.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0640
    Cell Significance Index: -4.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0660
    Cell Significance Index: -13.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0672
    Cell Significance Index: -8.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0721
    Cell Significance Index: -8.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0731
    Cell Significance Index: -3.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0760
    Cell Significance Index: -4.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0813
    Cell Significance Index: -3.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0961
    Cell Significance Index: -4.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1067
    Cell Significance Index: -11.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1109
    Cell Significance Index: -6.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1244
    Cell Significance Index: -2.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1272
    Cell Significance Index: -2.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1347
    Cell Significance Index: -9.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1361
    Cell Significance Index: -10.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1377
    Cell Significance Index: -4.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1533
    Cell Significance Index: -3.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1592
    Cell Significance Index: -9.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1677
    Cell Significance Index: -4.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1730
    Cell Significance Index: -4.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1855
    Cell Significance Index: -14.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2227
    Cell Significance Index: -11.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2463
    Cell Significance Index: -7.0300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2503
    Cell Significance Index: -3.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2689
    Cell Significance Index: -9.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2691
    Cell Significance Index: -8.5700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2716
    Cell Significance Index: -8.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2790
    Cell Significance Index: -9.1400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2954
    Cell Significance Index: -4.7400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2967
    Cell Significance Index: -7.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3023
    Cell Significance Index: -5.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3071
    Cell Significance Index: -4.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3113
    Cell Significance Index: -5.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3291
    Cell Significance Index: -12.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3294
    Cell Significance Index: -7.9000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3434
    Cell Significance Index: -5.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3505
    Cell Significance Index: -9.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3534
    Cell Significance Index: -7.5000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3542
    Cell Significance Index: -6.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MAN2B1 belongs to the alpha-mannosidase family, which is responsible for the degradation of mannose-containing glycoconjugates. The enzyme is characterized by its ability to hydrolyze alpha-1,2-mannose bonds, a critical step in the breakdown of complex carbohydrates. MAN2B1 is a lysosomal enzyme, localized within the lysosomal lumen, where it can access its substrates. The enzyme's substrate specificity and kinetic properties are essential for its function, allowing it to efficiently degrade mannose-containing glycoconjugates. **Pathways and Functions** MAN2B1 is involved in several key pathways, including: 1. **Lysosomal oligosaccharide catabolism**: MAN2B1 plays a critical role in the degradation of complex carbohydrates within lysosomes, facilitating the breakdown of glycoproteins and glycolipids. 2. **Immune system**: As a component of the innate immune system, MAN2B1 is expressed in dendritic cells and monocytes, where it contributes to the recognition and processing of pathogens. 3. **Neutrophil degranulation**: MAN2B1 is also involved in the regulation of neutrophil degranulation, a process critical for the elimination of pathogens. 4. **Learning and memory**: Recent studies have implicated MAN2B1 in the regulation of learning and memory, highlighting its potential role in neurological disorders. **Clinical Significance** Dysregulation of MAN2B1 has been implicated in various disease states, including: 1. **Lysosomal storage disorders**: Mutations in the MAN2B1 gene have been associated with lysosomal storage disorders, such as I-cell disease and Hermansky-Pudlak syndrome. 2. **Immunodeficiency**: MAN2B1 deficiency has been linked to impaired immune function, increasing susceptibility to infections. 3. **Neurological disorders**: Abnormalities in MAN2B1 expression have been observed in neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, MAN2B1 is a critical enzyme involved in the degradation of complex carbohydrates within lysosomes. Its dysregulation has been implicated in various disease states, highlighting its importance in immune system function and cellular development. Further research is necessary to fully elucidate the role of MAN2B1 in human disease and to develop therapeutic strategies for its manipulation.

Genular Protein ID: 3270159851

Symbol: MA2B1_HUMAN

Name: Lysosomal alpha-mannosidase

UniProtKB Accession Codes:

O00754 G5E928 O15330 Q16680 Q93094 Q9BW13

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CDD 1 CPTAC 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 21 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8166692

Title: Human lysosomal alpha-mannosidase: isolation and nucleotide sequence of the full-length cDNA.

PubMed ID: 8166692

DOI: 10.1006/bbrc.1994.1440

PubMed ID: 9158146

Title: Alpha-mannosidosis: functional cloning of the lysosomal alpha-mannosidase cDNA and identification of a mutation in two affected siblings.

PubMed ID: 9158146

DOI: 10.1093/hmg/6.5.717

PubMed ID: 9192839

Title: Genomic structure of the human lysosomal alpha-mannosidase gene (MANB).

PubMed ID: 9192839

DOI: 10.1006/geno.1997.4668

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8910458

Title: Cloning, expression, purification, and characterization of the human broad specificity lysosomal acid alpha-mannosidase.

PubMed ID: 8910458

DOI: 10.1074/jbc.271.45.28348

PubMed ID: 7832746

Title: Partial sequence of the purified protein confirms the identity of cDNA coding for human lysosomal alpha-mannosidase B.

PubMed ID: 7832746

DOI: 10.1042/bj3050363

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9758606

Title: Missense and nonsense mutations in the lysosomal alpha-mannosidase gene (MANB) in severe and mild forms of alpha-mannosidosis.

PubMed ID: 9758606

DOI: 10.1086/302048

PubMed ID: 9915946

Title: Spectrum of mutations in alpha-mannosidosis.

PubMed ID: 9915946

DOI: 10.1086/302183

PubMed ID: 12718372

Title: Alpha-mannosidosis and mutational analysis in a Turkish patient.

PubMed ID: 12718372

PubMed ID: 15712269

Title: Identification and characterization of five novel MAN2B1 mutations in Italian patients with alpha-mannosidosis.

PubMed ID: 15712269

DOI: 10.1002/humu.9310

PubMed ID: 22161967

Title: Identification of 83 novel alpha-mannosidosis-associated sequence variants: functional analysis of MAN2B1 missense mutations.

PubMed ID: 22161967

DOI: 10.1002/humu.22005

Sequence Information:

  • Length: 1011
  • Mass: 113744
  • Checksum: E11C77C19D8BD88C
  • Sequence:
    • MGAYARASGV CARGCLDSAG PWTMSRALRP PLPPLCFFLL LLAAAGARAG GYETCPTVQP 
NMLNVHLLPH THDDVGWLKT VDQYFYGIKN DIQHAGVQYI LDSVISALLA DPTRRFIYVE 
IAFFSRWWHQ QTNATQEVVR DLVRQGRLEF ANGGWVMNDE AATHYGAIVD QMTLGLRFLE 
DTFGNDGRPR VAWHIDPFGH SREQASLFAQ MGFDGFFFGR LDYQDKWVRM QKLEMEQVWR 
ASTSLKPPTA DLFTGVLPNG YNPPRNLCWD VLCVDQPLVE DPRSPEYNAK ELVDYFLNVA 
TAQGRYYRTN HTVMTMGSDF QYENANMWFK NLDKLIRLVN AQQAKGSSVH VLYSTPACYL 
WELNKANLTW SVKHDDFFPY ADGPHQFWTG YFSSRPALKR YERLSYNFLQ VCNQLEALVG 
LAANVGPYGS GDSAPLNEAM AVLQHHDAVS GTSRQHVAND YARQLAAGWG PCEVLLSNAL 
ARLRGFKDHF TFCQQLNISI CPLSQTAARF QVIVYNPLGR KVNWMVRLPV SEGVFVVKDP 
NGRTVPSDVV IFPSSDSQAH PPELLFSASL PALGFSTYSV AQVPRWKPQA RAPQPIPRRS 
WSPALTIENE HIRATFDPDT GLLMEIMNMN QQLLLPVRQT FFWYNASIGD NESDQASGAY 
IFRPNQQKPL PVSRWAQIHL VKTPLVQEVH QNFSAWCSQV VRLYPGQRHL ELEWSVGPIP 
VGDTWGKEVI SRFDTPLETK GRFYTDSNGR EILERRRDYR PTWKLNQTEP VAGNYYPVNT 
RIYITDGNMQ LTVLTDRSQG GSSLRDGSLE LMVHRRLLKD DGRGVSEPLM ENGSGAWVRG 
RHLVLLDTAQ AAAAGHRLLA EQEVLAPQVV LAPGGGAAYN LGAPPRTQFS GLRRDLPPSV 
HLLTLASWGP EMVLLRLEHQ FAVGEDSGRN LSAPVTLNLR DLFSTFTITR LQETTLVANQ 
LREAASRLKW TTNTGPTPHQ TPYQLDPANI TLEPMEIRTF LASVQWKEVD G

Genular Protein ID: 2156892087

Symbol: A8K6A7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K6A7

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 4 Gene3D 4 InterPro 12 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 5 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 1011
  • Mass: 113792
  • Checksum: 1B4C73D4DCDBD33C
  • Sequence:
    • MGAYARASGV CARGCLDSAG PWTMSRALRP PLPPLCFFLL LLAAAGARAG GYETCPTVQP 
NMLNVHLLPH THDDVGWLKT VDQYFYGIKN DIQHAGVQYI LDSVISALLA DPTRRFIYVE 
IAFFSRWWHQ QTNATQEVVR DLVRQGRLEF ANGGWVMNDE AATHYGAIVD QMTLGLRFLE 
DTFGNDGRPR VAWHIDPFGH SREQASLFAQ MGFDGFFFGR LDYQDKWVRM QKLEMEQVWR 
ASTSLKPPTA DLFTGVLPNG YNPPRNLCWD VLCVDQPLVE DPRSPEYNAK ELVDYFLNVA 
TAQGRYYRTN HTVMTMGSDF QYENANMWFK NLDKLIRLVN AQQAKGSSVH VLYSTPACYL 
WELNKANLTW SVKHDDFFPY ADGPHQFWTG YFSSRPALKR YERLSYNFLQ VCNQLEALVG 
LAANVGPYGS GDSAPLNEAM AVLQHHDAVS GTSRQHVAND YARQLAAGWG PCEVLLSNAL 
ARLRGFKDHF TFCQQLNISI CPLSQTAARF QVIVYNPLGR KVNWMVRLPV SEGVFVVKDP 
NGRTVPSDVV IFPSSDSQAH PPELLFSASL PALGFSTYSV AQVPRWKPQA RAPQPIPRRS 
WSPALTIENE HIRATFDPDT GLLMEIMNMN QQLLLPVRQT FFWYNASIGD NESDQASGAY 
IFRPNQQKPL PVSRWAQIHL VKTPLVQEVH QNFSAWCSQV VRLYPGQRHL ELEWSVGPIP 
VGDTWGKEFI SRFDTPLETK GRFYTDSNGR EILERRRDYR PTWKLNQTEP VAGNYYPVNT 
RIYITDGNMQ LTVLTDRSQG GSSLRDGSLE LMVHRRLLKD DGRGVSEPLM ENGSGAWVRG 
RHLVLLDTAQ AAAAGHRLLA EQEVLAPQVV LAPGGGAAYN LGAPPRTQFS GLRRDLPPSV 
HLLTLASWGP EMVLLRLEHQ FAVGEDSGRN LSAPVTLNLR DLFSTFTITR LQETTLVANQ 
LREAASRLKW TTNTGPTPHQ TPYQLDPANI TLEPMEIRTF LASVQWKEVD G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.