Details for: MAN2B1

Gene ID: 4125

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: MAN2B1

Ensembl ID: ENSG00000104774

Description: mannosidase alpha class 2B member 1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • plasmacytoid dendritic cell, human CL0001058
    CSI 26.59
    rCSI 18.57%
    PRS 91.84
  • Langerhans cell CL0000453
    CSI 10.05
    rCSI 15.34%
    PRS 95.24
  • bronchus fibroblast of lung CL2000093
    CSI 8.68
    rCSI 7.05%
    PRS 88.04
  • mononuclear phagocyte CL0000113
    CSI 7.4
    rCSI 16.3%
    PRS 91.25
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 7.28
    rCSI 5.61%
    PRS 91.78
  • conventional dendritic cell CL0000990
    CSI 7.1
    rCSI 5.93%
    PRS 84.45
  • immature B cell CL0000816
    CSI 5.24
    rCSI 3.89%
    PRS 95.16
  • plasmacytoid dendritic cell CL0000784
    CSI 5.09
    rCSI 5.15%
    PRS 95
  • secretory cell CL0000151
    CSI 4.3
    rCSI 4.48%
    PRS 87.63
  • stem cell CL0000034
    CSI 4.28
    rCSI 4.12%
    PRS 84.23
  • double negative thymocyte CL0002489
    CSI 4.21
    rCSI 2.93%
    PRS 96.39
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 3.6
    rCSI 2.13%
    PRS 98.01
  • memory B cell CL0000787
    CSI 3.55
    rCSI 3.51%
    PRS 94.93
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 3.28
    rCSI 8.54%
    PRS 90.05
  • elicited macrophage CL0000861
    CSI 3.23
    rCSI 2.97%
    PRS 93.58
  • precursor B cell CL0000817
    CSI 3.01
    rCSI 2.63%
    PRS 93.18
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 2.98
    rCSI 2.14%
    PRS 96.86
  • pancreatic D cell CL0000173
    CSI 2.92
    rCSI 2.88%
    PRS 90.42
  • epithelial cell CL0000066
    CSI 2.87
    rCSI 4.41%
    PRS 77.3
  • T follicular helper cell CL0002038
    CSI 2.81
    rCSI 2.1%
    PRS 96.22
  • mature NK T cell CL0000814
    CSI 2.75
    rCSI 3.51%
    PRS 93.13
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 2.68
    rCSI 1.81%
    PRS 96.82
  • erythrocyte CL0000232
    CSI 2.67
    rCSI 6.05%
    PRS 87.62
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 2.66
    rCSI 2.72%
    PRS 94.37
  • plasmablast CL0000980
    CSI 2.63
    rCSI 2.07%
    PRS 91.44
  • Kupffer cell CL0000091
    CSI 2.59
    rCSI 5.93%
    PRS 89.6
  • lung interstitial macrophage CL4033043
    CSI 2.53
    rCSI 5.69%
    PRS 96.14
  • intermediate monocyte CL0002393
    CSI 2.52
    rCSI 3.8%
    PRS 92.76
  • dendritic cell, human CL0001056
    CSI 2.47
    rCSI 3.79%
    PRS 94.46
  • myeloid leukocyte CL0000766
    CSI 2.4
    rCSI 2.21%
    PRS 89.76
  • dendritic cell CL0000451
    CSI 2.37
    rCSI 2.92%
    PRS 88.72
  • CD14-positive monocyte CL0001054
    CSI 2.32
    rCSI 2.89%
    PRS 94.65
  • nasal mucosa goblet cell CL0002480
    CSI 2.23
    rCSI 2.59%
    PRS 89.67
  • club cell CL0000158
    CSI 2.21
    rCSI 3.24%
    PRS 83.99
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 2.21
    rCSI 3.03%
    PRS 97.11
  • monocyte CL0000576
    CSI 2.19
    rCSI 3.97%
    PRS 90.49
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.16
    rCSI 2.69%
    PRS 72.3
  • mature B cell CL0000785
    CSI 2.15
    rCSI 1.87%
    PRS 95.07
  • common myeloid progenitor CL0000049
    CSI 2.13
    rCSI 1.73%
    PRS 90.41
  • myeloid dendritic cell CL0000782
    CSI 2.12
    rCSI 3.07%
    PRS 96.33
  • alternatively activated macrophage CL0000890
    CSI 2.07
    rCSI 2.6%
    PRS 94.44
  • choroid plexus epithelial cell CL0000706
    CSI 2.05
    rCSI 3.37%
    PRS 80.86
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 2
    rCSI 2.62%
    PRS 95.18
  • pancreatic acinar cell CL0002064
    CSI 1.96
    rCSI 2.6%
    PRS 91.93
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 1.79
    rCSI 2.17%
    PRS 93.73
  • Hofbauer cell CL3000001
    CSI 1.76
    rCSI 3.32%
    PRS 93.96
  • promyelocyte CL0000836
    CSI 1.76
    rCSI 2.54%
    PRS 91.54
  • common dendritic progenitor CL0001029
    CSI 1.68
    rCSI 2.1%
    PRS 94.17
  • acinar cell CL0000622
    CSI 1.62
    rCSI 2.37%
    PRS 94.29
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 1.56
    rCSI 9.46%
    PRS 94.6
  • promonocyte CL0000559
    CSI 1.46
    rCSI 2.51%
    PRS 91.53
  • alveolar macrophage CL0000583
    CSI 1.45
    rCSI 2.39%
    PRS 90.74
  • pancreatic ductal cell CL0002079
    CSI 1.3
    rCSI 2.52%
    PRS 90.47
  • astrocyte of the cerebral cortex CL0002605
    CSI 1.27
    rCSI 2.85%
    PRS 75.13
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 1.22
    rCSI 6.14%
    PRS 96.04
  • lung macrophage CL1001603
    CSI 1.21
    rCSI 2.69%
    PRS 93.34
  • glial cell CL0000125
    CSI 1.2
    rCSI 4.58%
    PRS 81.59
  • innate lymphoid cell CL0001065
    CSI 1
    rCSI 2.06%
    PRS 83.55
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.6
    rCSI 2.15%
    PRS 72.45

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [MAN2B1](/details-gene/4125) (mannosidase alpha class 2B member 1) is a protein-coding gene located on chromosome 19p13.13 that encodes the lysosomal alpha-mannosidase enzyme. This enzyme plays a crucial role in the catabolism of N-linked glycoproteins by cleaving terminal alpha-mannose residues within the lysosome. Its function is fundamental to the cellular process of protein deglycosylation. Clinically, loss-of-function mutations in [MAN2B1](/details-gene/4125) are the cause of alpha-mannosidosis ([248500](https://omim.org/entry/248500)), a rare lysosomal storage disorder characterized by the accumulation of mannose-rich oligosaccharides, leading to multisystemic complications including immunodeficiency, skeletal abnormalities, and neurological dysfunction [Link](https://doi.org/10.1093/hmg/6.5.717), [Link](https://doi.org/10.1086/302048). Expression data indicate that [MAN2B1](/details-gene/4125) is particularly significant in cells of the innate immune system, with exceptionally high expression in [plasmacytoid dendritic cell, human](/details-cell/CL0001058) and other mononuclear phagocytes. ## Cellular Roles and Expression Landscape The expression profile of [MAN2B1](/details-gene/4125) highlights its critical function within the hematopoietic system, particularly in professional antigen-presenting cells and phagocytes. **Overall**, the gene exhibits its highest significance in [plasmacytoid dendritic cell, human](/details-cell/CL0001058) (CSI: 26.59), a cell type specialized in producing type I interferons in response to viral infections. High significance is also observed in other key dendritic cell subsets, including [Langerhans cell](/details-cell/CL0000453) (CSI: 10.05) and [conventional dendritic cell](/details-cell/CL0000990) (CSI: 7.10), suggesting that proper glycoprotein processing is essential for their surveillance and antigen presentation functions. The gene is also a prominent marker in the broader [mononuclear phagocyte](/details-cell/CL0000113) lineage (CSI: 7.40), including [CD14-low, CD16-positive monocyte](/details-cell/CL0002396) (CSI: 7.28) and various macrophage populations. This pattern is consistent with its role in lysosomal degradation, a central activity in phagocytic cells responsible for processing pathogens and cellular debris. Beyond the core myeloid compartment, [MAN2B1](/details-gene/4125) shows moderate significance in lymphoid cells, such as [immature B cell](/details-cell/CL0000816) (CSI: 5.24) and [double negative thymocyte](/details-cell/CL0002489) (CSI: 4.21), indicating a housekeeping lysosomal role during lymphocyte development. Interestingly, significant expression is also noted in non-hematopoietic cells like [bronchus fibroblast of lung](/details-cell/CL2000093) (CSI: 8.68), which may point to a role in extracellular matrix maintenance or the processing of secreted proteins in structural tissues. ## Pathways and Molecular Function The molecular functions of [MAN2B1](/details-gene/4125) are centered on its enzymatic activity within the lysosome, which is reflected in its associated gene ontology and pathway annotations. The primary molecular function is **alpha-mannosidase activity** ([GO:0004559](https://www.ebi.ac.uk/QuickGO/term/GO:0004559)), enabling the **oligosaccharide catabolic process** ([GO:0009313](https://www.ebi.ac.uk/QuickGO/term/GO:0009313)) and **protein deglycosylation** ([GO:0006517](https://www.ebi.ac.uk/QuickGO/term/GO:0006517)). This activity is dependent on **metal ion binding** ([GO:0046872](https://www.ebi.ac.uk/QuickGO/term/GO:0046872)), as the enzyme requires zinc for its catalytic function [Link](https://doi.org/10.1074/jbc.271.45.28348). Its localization is predominantly in the **lysosome** ([GO:0005764](https://www.ebi.ac.uk/QuickGO/term/GO:0005764)), specifically the **lysosomal lumen** ([GO:0043202](https://www.ebi.ac.uk/QuickGO/term/GO:0043202)). Its identification in the **azurophil granule lumen** ([GO:0035578](https://www.ebi.ac.uk/QuickGO/term/GO:0035578)) of neutrophils directly aligns with its involvement in the **Neutrophil degranulation** pathway ([R-HSA-6798695](https://reactome.org/content/detail/R-HSA-6798695)). The central metabolic pathway for [MAN2B1](/details-gene/4125) is **Lysosomal oligosaccharide catabolism** ([R-HSA-8853383](https://reactome.org/content/detail/R-HSA-8853383)). Its strong expression in myeloid cells underscores its relevance to the **Innate immune system** ([R-HSA-168249](https://reactome.org/content/detail/R-HSA-168249)), where lysosomal processing is critical for pathogen clearance and antigen presentation. The association with **Learning or memory** ([GO:0007611](https://www.ebi.ac.uk/QuickGO/term/GO:0007611)) is likely a reflection of the severe neurological deficits that arise from its dysfunction in alpha-mannosidosis, highlighting the importance of proper glycoprotein turnover for neuronal health. ## Research Directions The specific expression pattern of [MAN2B1](/details-gene/4125) and the pathophysiology of alpha-mannosidosis suggest several avenues for future investigation. ### Proposed Hypotheses: 1. **[MAN2B1](/details-gene/4125) is essential for the specialized function of plasmacytoid dendritic cells (pDCs).** The exceptionally high CSI score in [pDCs](/details-cell/CL0001058) suggests that the accumulation of mannosylated glycoproteins in [MAN2B1](/details-gene/4125)-deficient cells may impair the trafficking or function of Toll-like receptors (e.g., TLR7/9), leading to a blunted type I interferon response and contributing to the immunodeficiency observed in alpha-mannosidosis patients. 2. **Dysfunctional glycoprotein processing by [MAN2B1](/details-gene/4125) in fibroblasts directly contributes to the connective tissue and skeletal pathology of alpha-mannosidosis.** The high significance of [MAN2B1](/details-gene/4125) in [bronchus fibroblast of lung](/details-cell/CL2000093) suggests a critical role in processing secreted glycoproteins or components of the extracellular matrix. Its deficiency may lead to the secretion of aberrantly glycosylated matrix proteins, compromising tissue integrity and resulting in the characteristic skeletal dysplasia of the disease. ### Key Experimental Approach: To test the first hypothesis regarding the role of [MAN2B1](/details-gene/4125) in pDC function, a targeted experiment could be designed. One could use CRISPR-Cas9 to knock out [MAN2B1](/details-gene/4125) in primary human hematopoietic stem and progenitor cells, followed by *in vitro* differentiation into [pDCs](/details-cell/CL0001058). These knockout pDCs, along with isogenic controls, would then be stimulated with specific TLR agonists (e.g., CpG-A for TLR9). The primary readouts would be the quantification of IFN-alpha secretion via ELISA and the analysis of interferon-stimulated gene expression by RT-qPCR or RNA-seq. A significant reduction in the type I interferon response in knockout cells would confirm that [MAN2B1](/details-gene/4125) is functionally critical for the primary effector function of this cell type. ### Therapeutic Potential: As alpha-mannosidosis is a monogenic, loss-of-function lysosomal storage disorder, the therapeutic strategy is focused on **restoration or replacement** of the enzyme, not inhibition. [MAN2B1](/details-gene/4125) is an excellent candidate for enzyme replacement therapy (ERT), where a recombinant form of the enzyme is administered intravenously to restore lysosomal function. Indeed, an ERT (velmanase alfa) has been developed and approved for this condition. Future therapeutic avenues could include hematopoietic stem cell transplantation or gene therapy aimed at providing a permanent, endogenous source of functional alpha-mannosidase.

Genular Protein ID: 3270159851

Symbol: MA2B1_HUMAN

Name: Lysosomal alpha-mannosidase

UniProtKB Accession Codes:

O00754 G5E928 O15330 Q16680 Q93094 Q9BW13

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CDD 1 CPTAC 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 21 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8166692

Title: Human lysosomal alpha-mannosidase: isolation and nucleotide sequence of the full-length cDNA.

PubMed ID: 8166692

DOI: 10.1006/bbrc.1994.1440

PubMed ID: 9158146

Title: Alpha-mannosidosis: functional cloning of the lysosomal alpha-mannosidase cDNA and identification of a mutation in two affected siblings.

PubMed ID: 9158146

DOI: 10.1093/hmg/6.5.717

PubMed ID: 9192839

Title: Genomic structure of the human lysosomal alpha-mannosidase gene (MANB).

PubMed ID: 9192839

DOI: 10.1006/geno.1997.4668

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8910458

Title: Cloning, expression, purification, and characterization of the human broad specificity lysosomal acid alpha-mannosidase.

PubMed ID: 8910458

DOI: 10.1074/jbc.271.45.28348

PubMed ID: 7832746

Title: Partial sequence of the purified protein confirms the identity of cDNA coding for human lysosomal alpha-mannosidase B.

PubMed ID: 7832746

DOI: 10.1042/bj3050363

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9758606

Title: Missense and nonsense mutations in the lysosomal alpha-mannosidase gene (MANB) in severe and mild forms of alpha-mannosidosis.

PubMed ID: 9758606

DOI: 10.1086/302048

PubMed ID: 9915946

Title: Spectrum of mutations in alpha-mannosidosis.

PubMed ID: 9915946

DOI: 10.1086/302183

PubMed ID: 12718372

Title: Alpha-mannosidosis and mutational analysis in a Turkish patient.

PubMed ID: 12718372

PubMed ID: 15712269

Title: Identification and characterization of five novel MAN2B1 mutations in Italian patients with alpha-mannosidosis.

PubMed ID: 15712269

DOI: 10.1002/humu.9310

PubMed ID: 22161967

Title: Identification of 83 novel alpha-mannosidosis-associated sequence variants: functional analysis of MAN2B1 missense mutations.

PubMed ID: 22161967

DOI: 10.1002/humu.22005

Sequence Information:

  • Length: 1011
  • Mass: 113744
  • Checksum: E11C77C19D8BD88C
  • Sequence:
    • MGAYARASGV CARGCLDSAG PWTMSRALRP PLPPLCFFLL LLAAAGARAG GYETCPTVQP 
NMLNVHLLPH THDDVGWLKT VDQYFYGIKN DIQHAGVQYI LDSVISALLA DPTRRFIYVE 
IAFFSRWWHQ QTNATQEVVR DLVRQGRLEF ANGGWVMNDE AATHYGAIVD QMTLGLRFLE 
DTFGNDGRPR VAWHIDPFGH SREQASLFAQ MGFDGFFFGR LDYQDKWVRM QKLEMEQVWR 
ASTSLKPPTA DLFTGVLPNG YNPPRNLCWD VLCVDQPLVE DPRSPEYNAK ELVDYFLNVA 
TAQGRYYRTN HTVMTMGSDF QYENANMWFK NLDKLIRLVN AQQAKGSSVH VLYSTPACYL 
WELNKANLTW SVKHDDFFPY ADGPHQFWTG YFSSRPALKR YERLSYNFLQ VCNQLEALVG 
LAANVGPYGS GDSAPLNEAM AVLQHHDAVS GTSRQHVAND YARQLAAGWG PCEVLLSNAL 
ARLRGFKDHF TFCQQLNISI CPLSQTAARF QVIVYNPLGR KVNWMVRLPV SEGVFVVKDP 
NGRTVPSDVV IFPSSDSQAH PPELLFSASL PALGFSTYSV AQVPRWKPQA RAPQPIPRRS 
WSPALTIENE HIRATFDPDT GLLMEIMNMN QQLLLPVRQT FFWYNASIGD NESDQASGAY 
IFRPNQQKPL PVSRWAQIHL VKTPLVQEVH QNFSAWCSQV VRLYPGQRHL ELEWSVGPIP 
VGDTWGKEVI SRFDTPLETK GRFYTDSNGR EILERRRDYR PTWKLNQTEP VAGNYYPVNT 
RIYITDGNMQ LTVLTDRSQG GSSLRDGSLE LMVHRRLLKD DGRGVSEPLM ENGSGAWVRG 
RHLVLLDTAQ AAAAGHRLLA EQEVLAPQVV LAPGGGAAYN LGAPPRTQFS GLRRDLPPSV 
HLLTLASWGP EMVLLRLEHQ FAVGEDSGRN LSAPVTLNLR DLFSTFTITR LQETTLVANQ 
LREAASRLKW TTNTGPTPHQ TPYQLDPANI TLEPMEIRTF LASVQWKEVD G

Genular Protein ID: 2156892087

Symbol: A8K6A7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K6A7

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 4 Gene3D 4 InterPro 12 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 5 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 1011
  • Mass: 113792
  • Checksum: 1B4C73D4DCDBD33C
  • Sequence:
    • MGAYARASGV CARGCLDSAG PWTMSRALRP PLPPLCFFLL LLAAAGARAG GYETCPTVQP 
NMLNVHLLPH THDDVGWLKT VDQYFYGIKN DIQHAGVQYI LDSVISALLA DPTRRFIYVE 
IAFFSRWWHQ QTNATQEVVR DLVRQGRLEF ANGGWVMNDE AATHYGAIVD QMTLGLRFLE 
DTFGNDGRPR VAWHIDPFGH SREQASLFAQ MGFDGFFFGR LDYQDKWVRM QKLEMEQVWR 
ASTSLKPPTA DLFTGVLPNG YNPPRNLCWD VLCVDQPLVE DPRSPEYNAK ELVDYFLNVA 
TAQGRYYRTN HTVMTMGSDF QYENANMWFK NLDKLIRLVN AQQAKGSSVH VLYSTPACYL 
WELNKANLTW SVKHDDFFPY ADGPHQFWTG YFSSRPALKR YERLSYNFLQ VCNQLEALVG 
LAANVGPYGS GDSAPLNEAM AVLQHHDAVS GTSRQHVAND YARQLAAGWG PCEVLLSNAL 
ARLRGFKDHF TFCQQLNISI CPLSQTAARF QVIVYNPLGR KVNWMVRLPV SEGVFVVKDP 
NGRTVPSDVV IFPSSDSQAH PPELLFSASL PALGFSTYSV AQVPRWKPQA RAPQPIPRRS 
WSPALTIENE HIRATFDPDT GLLMEIMNMN QQLLLPVRQT FFWYNASIGD NESDQASGAY 
IFRPNQQKPL PVSRWAQIHL VKTPLVQEVH QNFSAWCSQV VRLYPGQRHL ELEWSVGPIP 
VGDTWGKEFI SRFDTPLETK GRFYTDSNGR EILERRRDYR PTWKLNQTEP VAGNYYPVNT 
RIYITDGNMQ LTVLTDRSQG GSSLRDGSLE LMVHRRLLKD DGRGVSEPLM ENGSGAWVRG 
RHLVLLDTAQ AAAAGHRLLA EQEVLAPQVV LAPGGGAAYN LGAPPRTQFS GLRRDLPPSV 
HLLTLASWGP EMVLLRLEHQ FAVGEDSGRN LSAPVTLNLR DLFSTFTITR LQETTLVANQ 
LREAASRLKW TTNTGPTPHQ TPYQLDPANI TLEPMEIRTF LASVQWKEVD G