Details for: HP

Gene ID: 3240

Symbol: HP

Ensembl ID: ENSG00000257017

Description: haptoglobin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 183.6047
    Cell Significance Index: 484.3400
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 55.3537
    Cell Significance Index: -8.6100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 7.5203
    Cell Significance Index: 126.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.9913
    Cell Significance Index: -8.6200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 5.4612
    Cell Significance Index: 14.6300
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 3.0886
    Cell Significance Index: 10.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.0612
    Cell Significance Index: 98.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.9058
    Cell Significance Index: 42.8900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.3697
    Cell Significance Index: 25.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1211
    Cell Significance Index: -8.3700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.9489
    Cell Significance Index: 7.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9306
    Cell Significance Index: 41.8300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.7657
    Cell Significance Index: 13.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7203
    Cell Significance Index: 341.3900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.6523
    Cell Significance Index: 9.5200
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.6329
    Cell Significance Index: 16.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.2677
    Cell Significance Index: 959.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5398
    Cell Significance Index: 102.7300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.3454
    Cell Significance Index: 5.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3038
    Cell Significance Index: 6.4700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.2735
    Cell Significance Index: 2.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2723
    Cell Significance Index: 26.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2670
    Cell Significance Index: 16.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2252
    Cell Significance Index: 24.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2175
    Cell Significance Index: 196.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1611
    Cell Significance Index: 26.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0737
    Cell Significance Index: 5.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0366
    Cell Significance Index: 1.0200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0103
    Cell Significance Index: 0.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0021
    Cell Significance Index: 1.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0044
    Cell Significance Index: -8.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0060
    Cell Significance Index: -0.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0068
    Cell Significance Index: -0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0069
    Cell Significance Index: -12.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0084
    Cell Significance Index: -12.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0096
    Cell Significance Index: -13.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0102
    Cell Significance Index: -0.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0115
    Cell Significance Index: -0.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0142
    Cell Significance Index: -10.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0160
    Cell Significance Index: -10.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0170
    Cell Significance Index: -12.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0190
    Cell Significance Index: -10.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0204
    Cell Significance Index: -2.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0208
    Cell Significance Index: -0.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0225
    Cell Significance Index: -1.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0228
    Cell Significance Index: -10.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0231
    Cell Significance Index: -8.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0254
    Cell Significance Index: -7.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0280
    Cell Significance Index: -1.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0281
    Cell Significance Index: -1.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0284
    Cell Significance Index: -3.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0322
    Cell Significance Index: -0.8300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0352
    Cell Significance Index: -0.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0426
    Cell Significance Index: -8.5400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0476
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0537
    Cell Significance Index: -11.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0541
    Cell Significance Index: -9.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0628
    Cell Significance Index: -6.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0636
    Cell Significance Index: -8.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0699
    Cell Significance Index: -10.1600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0708
    Cell Significance Index: -0.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0715
    Cell Significance Index: -5.4900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0737
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0748
    Cell Significance Index: -12.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0765
    Cell Significance Index: -9.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0818
    Cell Significance Index: -10.0600
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.0833
    Cell Significance Index: -0.6400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0836
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0883
    Cell Significance Index: -10.1200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0994
    Cell Significance Index: -1.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1052
    Cell Significance Index: -4.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1143
    Cell Significance Index: -5.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1147
    Cell Significance Index: -2.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1224
    Cell Significance Index: -1.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1265
    Cell Significance Index: -7.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1322
    Cell Significance Index: -8.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1394
    Cell Significance Index: -10.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1419
    Cell Significance Index: -9.5400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1508
    Cell Significance Index: -2.1900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1521
    Cell Significance Index: -1.3400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1539
    Cell Significance Index: -2.1600
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1582
    Cell Significance Index: -2.2500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1608
    Cell Significance Index: -1.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1693
    Cell Significance Index: -9.5000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1706
    Cell Significance Index: -3.3300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1718
    Cell Significance Index: -1.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1810
    Cell Significance Index: -11.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1899
    Cell Significance Index: -9.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1956
    Cell Significance Index: -7.1800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1981
    Cell Significance Index: -2.5400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1989
    Cell Significance Index: -1.8200
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.2024
    Cell Significance Index: -1.0600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2100
    Cell Significance Index: -2.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2180
    Cell Significance Index: -2.3700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2192
    Cell Significance Index: -5.3100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.2327
    Cell Significance Index: -2.9800
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.2340
    Cell Significance Index: -2.2900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2351
    Cell Significance Index: -3.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2450
    Cell Significance Index: -10.8400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2550
    Cell Significance Index: -3.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** HP consists of two identical subunits, each with a molecular weight of approximately 15 kDa. It binds to free hemoglobin, forming a 1:1 complex that sequesters it from oxidative damage. 2. **Expression and Regulation:** HP is primarily expressed in the liver, but also in endothelial cells, macrophages, and other cell types involved in immune responses. 3. **Scavenging Mechanism:** HP binds to free hemoglobin through its N-terminal domain, preventing its interaction with oxidative enzymes and subsequent oxidative damage to tissues. 4. **Antioxidant Activity:** HP has been shown to have antioxidant properties, neutralizing reactive oxygen species (ROS) and reducing oxidative stress in tissues. **Pathways and Functions:** 1. **Acute-Phase Response:** HP is upregulated in response to inflammation, serving as a marker of acute-phase response and oxidative stress. 2. **Antioxidant Activity:** HP's antioxidant properties help protect tissues from oxidative damage, modulating the activity of ROS-reducing enzymes. 3. **Immune Response:** HP interacts with scavenger receptors on macrophages, influencing their phagocytic activity and cytokine production. 4. **Hemoglobin Binding:** HP binds to free hemoglobin, preventing its interaction with oxidative enzymes and subsequent oxidative damage to tissues. 5. **Negative Regulation of Oxidative Stress:** HP's binding to hemoglobin reduces oxidative stress, modulating the activity of ROS-reducing enzymes. **Clinical Significance:** Dysregulation of HP has been implicated in various diseases, including: 1. **Hemolytic Uremic Syndrome (HUS):** HP's inability to bind free hemoglobin leads to oxidative damage and inflammation, contributing to HUS. 2. **Cancer:** Altered HP expression and function have been linked to cancer progression and metastasis. 3. **Cardiovascular Disease:** HP's antioxidant properties may protect against cardiovascular disease by reducing oxidative stress and inflammation. 4. **Neurodegenerative Diseases:** HP's role in oxidative stress and inflammation may contribute to the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, haptoglobin plays a multifaceted role in regulating oxidative stress and immune response, making it an important gene in the context of disease pathology. Further research into the mechanisms of HP's function and dysregulation is essential for understanding its clinical significance and developing therapeutic strategies to modulate its activity.

Genular Protein ID: 963343575

Symbol: HPT_HUMAN

Name: Haptoglobin

UniProtKB Accession Codes:

P00738 B0AZL5 P00737 Q0VAC4 Q0VAC5 Q2PP15 Q3B7J0 Q6LBY9 Q9UC67

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CPTAC 3 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 20 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6688992

Title: Molecular cloning of human haptoglobin cDNA: evidence for a single mRNA coding for alpha 2 and beta chains.

PubMed ID: 6688992

DOI: 10.1002/j.1460-2075.1983.tb01534.x

PubMed ID: 6310599

Title: Identification and characterization of human haptoglobin cDNA.

PubMed ID: 6310599

DOI: 10.1073/pnas.80.19.5875

PubMed ID: 6546723

Title: Characterization of human haptoglobin cDNAs coding for alpha 2FS beta and alpha 1S beta variants.

PubMed ID: 6546723

DOI: 10.1016/0014-5793(84)80215-x

PubMed ID: 6330675

Title: Evolution of haptoglobin: comparison of complementary DNA encoding Hp alpha 1S and Hp alpha 2FS.

PubMed ID: 6330675

DOI: 10.1093/nar/12.11.4531

PubMed ID: 4018023

Title: Structure and expression of the human haptoglobin locus.

PubMed ID: 4018023

DOI: 10.1002/j.1460-2075.1985.tb02325.x

PubMed ID: 2987228

Title: Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element.

PubMed ID: 2987228

DOI: 10.1016/s0021-9258(18)88836-6

PubMed ID: 1478675

Title: Junctions between genes in the haptoglobin gene cluster of primates.

PubMed ID: 1478675

DOI: 10.1016/s0888-7543(05)80116-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3519135

Title: Expression of cloned human haptoglobin and alpha 1-antitrypsin complementary DNAs in Saccharomyces cerevisiae.

PubMed ID: 3519135

DOI: 10.1089/dna.1986.5.129

PubMed ID: 6310515

Title: Sequence of human haptoglobin cDNA: evidence that the alpha and beta subunits are coded by the same mRNA.

PubMed ID: 6310515

DOI: 10.1093/nar/11.17.5811

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 6325933

Title: Duplication within the haptoglobin Hp2 gene.

PubMed ID: 6325933

DOI: 10.1038/309131a0

PubMed ID: 6997877

Title: Covalent structure of human haptoglobin: a serine protease homolog.

PubMed ID: 6997877

DOI: 10.1073/pnas.77.6.3388

PubMed ID: 7637327

Title: Protein analysis of human maculae in relation to age-related maculopathy.

PubMed ID: 7637327

PubMed ID: 4573324

Title: Studies on the interchain disulfides of human haptoglobins.

PubMed ID: 4573324

DOI: 10.1139/o73-032

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 19805376

Title: Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2.

PubMed ID: 19805376

DOI: 10.1073/pnas.0906773106

PubMed ID: 19659435

Title: Haptoglobin: basic and clinical aspects.

PubMed ID: 19659435

DOI: 10.1089/ars.2009.2793

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21248165

Title: Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer.

PubMed ID: 21248165

DOI: 10.1152/physrev.00003.2008

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31142615

Title: The E3 ubiquitin ligase MARCH2 regulates ERGIC3-dependent trafficking of secretory proteins.

PubMed ID: 31142615

DOI: 10.1074/jbc.ra119.007435

PubMed ID: 14999562

Title: A novel I247T missense mutation in the haptoglobin 2 beta-chain decreases the expression of the protein and is associated with ahaptoglobinemia.

PubMed ID: 14999562

DOI: 10.1007/s00439-004-1098-6

Sequence Information:

  • Length: 406
  • Mass: 45205
  • Checksum: A98B56B2B1BE891E
  • Sequence:
    • MSALGAVIAL LLWGQLFAVD SGNDVTDIAD DGCPKPPEIA HGYVEHSVRY QCKNYYKLRT 
EGDGVYTLND KKQWINKAVG DKLPECEADD GCPKPPEIAH GYVEHSVRYQ CKNYYKLRTE 
GDGVYTLNNE KQWINKAVGD KLPECEAVCG KPKNPANPVQ RILGGHLDAK GSFPWQAKMV 
SHHNLTTGAT LINEQWLLTT AKNLFLNHSE NATAKDIAPT LTLYVGKKQL VEIEKVVLHP 
NYSQVDIGLI KLKQKVSVNE RVMPICLPSK DYAEVGRVGY VSGWGRNANF KFTDHLKYVM 
LPVADQDQCI RHYEGSTVPE KKTPKSPVGV QPILNEHTFC AGMSKYQEDT CYGDAGSAFA 
VHDLEEDTWY ATGILSFDKS CAVAEYGVYV KVTSIQDWVQ KTIAEN

Genular Protein ID: 653375965

Symbol: A0A0C4DGL8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DGL8

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 7 MEROPS 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 1 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 347
  • Mass: 38452
  • Checksum: C3A92A17BD401718
  • Sequence:
    • MSALGAVIAL LLWGQLFAVD SGNDVTDIAD DGCPKPPEIA HGYVEHSVRY QCKNYYKLRT 
EGDGVYTLND KKQWINKAVG DKLPECEAVC GKPKNPANPV QRILGGHLDA KGSFPWQAKM 
VSHHNLTTGA TLINEQWLLT TAKNLFLNHS ENATAKDIAP TLTLYVGKKQ LVEIEKVVLH 
PNYSQVDIGL IKLKQKVSVN ERVMPICLPS KDYAEVGRVG YVSGWGRNAN FKFTDHLKYV 
MLPVADQDQC IRHYEGSTVP EKKTPKSPVG VQPILNEHTF CAGMSKYQED TCYGDAGSAF 
AVHDLEEDTW YATGILSFDK SCAVAEYGVY VKVTSIQDWV QKTIAEN

Genular Protein ID: 1625413079

Symbol: Q6PEJ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PEJ8

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 3 Gene3D 1 InterPro 4 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 3 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 228
  • Mass: 25458
  • Checksum: 82D0E68C4584E8E9
  • Sequence:
    • MVSHHNLTTG ATLINEQWLL TTAKNLFLNH SENATAKDIA PTLTLYVGKK QLVEIEKVVL 
HPNYSQVDIG LIKLKQKVSV NERVMPICLP SKDYAEVGRV GYVSGWGRNA NFKFTDHLKY 
VMLPVADQDQ CIRHYEGSTV PEKKTPKSPV GVQPILNEHT FCAGMSKYQE DTCYGDAGSA 
FAVHDLEEDT WYATGILSFD KSCAVAEYGV YVKVTSIQDW VQKTIAEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.