Details for: KLRD1

Gene ID: 3824

Symbol: KLRD1

Ensembl ID: ENSG00000134539

Description: killer cell lectin like receptor D1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 113.7290
    Cell Significance Index: -17.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.9120
    Cell Significance Index: -18.2400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 45.4182
    Cell Significance Index: 121.6700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.1024
    Cell Significance Index: -23.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.2746
    Cell Significance Index: -17.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.2503
    Cell Significance Index: 647.4700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.1284
    Cell Significance Index: 32.9300
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.0903
    Cell Significance Index: 22.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5480
    Cell Significance Index: 70.1700
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.4174
    Cell Significance Index: 8.2200
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 1.3515
    Cell Significance Index: 3.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.1547
    Cell Significance Index: 167.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1115
    Cell Significance Index: 211.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1049
    Cell Significance Index: 84.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1002
    Cell Significance Index: 28.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8931
    Cell Significance Index: 88.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7451
    Cell Significance Index: 672.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5660
    Cell Significance Index: 15.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4300
    Cell Significance Index: 28.9200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3802
    Cell Significance Index: 6.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3628
    Cell Significance Index: 59.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3314
    Cell Significance Index: 12.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2832
    Cell Significance Index: 101.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2748
    Cell Significance Index: 171.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2509
    Cell Significance Index: 11.1000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2434
    Cell Significance Index: 3.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2420
    Cell Significance Index: 26.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1791
    Cell Significance Index: 113.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1783
    Cell Significance Index: 3.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1556
    Cell Significance Index: 31.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1366
    Cell Significance Index: 6.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0793
    Cell Significance Index: 15.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0718
    Cell Significance Index: 4.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0660
    Cell Significance Index: 124.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0188
    Cell Significance Index: 0.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0140
    Cell Significance Index: 6.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0066
    Cell Significance Index: 0.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0024
    Cell Significance Index: 3.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0023
    Cell Significance Index: 4.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0026
    Cell Significance Index: -0.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0060
    Cell Significance Index: -4.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0077
    Cell Significance Index: -5.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0077
    Cell Significance Index: -10.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0100
    Cell Significance Index: -0.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0114
    Cell Significance Index: -1.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0144
    Cell Significance Index: -10.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0183
    Cell Significance Index: -3.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0191
    Cell Significance Index: -10.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0200
    Cell Significance Index: -3.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0295
    Cell Significance Index: -16.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0300
    Cell Significance Index: -22.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0309
    Cell Significance Index: -0.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0438
    Cell Significance Index: -19.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0452
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0536
    Cell Significance Index: -9.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0651
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1039
    Cell Significance Index: -11.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1074
    Cell Significance Index: -12.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1105
    Cell Significance Index: -15.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1132
    Cell Significance Index: -1.9400
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: -0.1153
    Cell Significance Index: -0.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1167
    Cell Significance Index: -14.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1259
    Cell Significance Index: -13.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1352
    Cell Significance Index: -4.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1418
    Cell Significance Index: -8.7200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1511
    Cell Significance Index: -6.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1519
    Cell Significance Index: -15.5200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1606
    Cell Significance Index: -2.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1659
    Cell Significance Index: -19.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1683
    Cell Significance Index: -21.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1905
    Cell Significance Index: -22.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1946
    Cell Significance Index: -11.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1953
    Cell Significance Index: -9.1800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2417
    Cell Significance Index: -1.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2506
    Cell Significance Index: -3.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2781
    Cell Significance Index: -19.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2889
    Cell Significance Index: -21.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2980
    Cell Significance Index: -18.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3038
    Cell Significance Index: -17.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3386
    Cell Significance Index: -21.8500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3396
    Cell Significance Index: -3.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3445
    Cell Significance Index: -18.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3538
    Cell Significance Index: -18.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3650
    Cell Significance Index: -17.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3809
    Cell Significance Index: -10.1900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3842
    Cell Significance Index: -4.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3995
    Cell Significance Index: -12.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4111
    Cell Significance Index: -14.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4133
    Cell Significance Index: -21.5300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.4183
    Cell Significance Index: -3.0100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4276
    Cell Significance Index: -8.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4279
    Cell Significance Index: -14.0100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.4381
    Cell Significance Index: -3.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4441
    Cell Significance Index: -12.4100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4473
    Cell Significance Index: -6.7400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4631
    Cell Significance Index: -6.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4686
    Cell Significance Index: -9.9800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4699
    Cell Significance Index: -5.8600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4718
    Cell Significance Index: -6.0500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.4842
    Cell Significance Index: -4.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** KLRD1 is a type II transmembrane glycoprotein, consisting of an extracellular domain with a lectin-like binding site and an intracellular domain with immunoreceptor tyrosine-based inhibitory motif (ITIM) and tyrosine-based activation motifs (TAMs). 2. **Ligand Recognition:** KLRD1 binds to specific ligands, including HLA-E and HLA-G, which are expressed on the surface of target cells. This interaction triggers a signaling cascade that modulates NK cell activity. 3. **Immunoregulatory Functions:** KLRD1's dual role in regulating NK cell-mediated immunity is evident from its involvement in both negative (inhibitory) and positive (stimulatory) signaling pathways. 4. **Expression:** KLRD1 is expressed in various immune cells, including NK cells, T cells, innate lymphoid cells, and decidual NK cells. **Pathways and Functions:** 1. **Dap12 Signaling Pathway:** KLRD1 interacts with Dap12, a signaling protein that transduces signals from the KLRD1 ligand binding site to the intracellular domain, triggering a signaling cascade that regulates NK cell activation and cytotoxicity. 2. **Stimulatory C-Type Lectin Receptor Signaling Pathway:** KLRD1's interaction with specific ligands triggers a signaling cascade that activates the stimulatory c-type lectin receptor signaling pathway, leading to the activation of NF-κB and the induction of pro-inflammatory cytokines. 3. **Negative Regulation of NK Cell-Mediated Cytotoxicity:** KLRD1's interaction with HLA-E and HLA-G ligands triggers a signaling cascade that inhibits NK cell-mediated cytotoxicity, preventing excessive tissue damage. 4. **Regulation of NK Cell Activation:** KLRD1's positive regulation of NK cell activation is mediated through the activation of the stimulatory c-type lectin receptor signaling pathway, leading to the induction of pro-inflammatory cytokines and the activation of NF-κB. **Clinical Significance:** 1. **Cancer Immunotherapy:** KLRD1's role in regulating NK cell-mediated immunity makes it a potential target for cancer immunotherapy. Inhibiting KLRD1 may enhance NK cell-mediated cytotoxicity against tumor cells. 2. **Autoimmune Diseases:** KLRD1's involvement in regulating NK cell-mediated immunity may also contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. Understanding KLRD1's role in immune homeostasis may provide insights into the pathogenesis of these diseases. 3. **Infectious Diseases:** KLRD1's role in regulating NK cell-mediated immunity makes it a potential target for the treatment of infectious diseases, such as HIV and tuberculosis. In conclusion, KLRD1 is a key regulator of natural killer cell immunity and immune homeostasis. Its dual role in modulating NK cell activation and cytotoxicity, as well as its involvement in negative regulation of NK cell-mediated cytotoxicity, highlights its importance in maintaining immune tolerance and preventing tissue damage. Further research into KLRD1's mechanisms of action and clinical significance may provide new insights into the development of immunotherapies for cancer and autoimmune diseases.

Genular Protein ID: 3626551294

Symbol: KLRD1_HUMAN

Name: Natural killer cells antigen CD94

UniProtKB Accession Codes:

Q13241 O43321 O43773 Q9UBE3 Q9UEQ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7589107

Title: Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily.

PubMed ID: 7589107

DOI: 10.1002/eji.1830250904

PubMed ID: 9472066

Title: Structure of the human CD94 C-type lectin gene.

PubMed ID: 9472066

DOI: 10.1007/s002510050362

PubMed ID: 9601951

Title: A alternatively spliced form of the human CD94 gene.

PubMed ID: 9601951

DOI: 10.1007/s002510050407

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9430220

Title: Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors.

PubMed ID: 9430220

DOI: 10.1016/s1074-7613(00)80393-3

PubMed ID: 9485206

Title: Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases.

PubMed ID: 9485206

DOI: 10.1002/(sici)1521-4141(199801)28:01<264::aid-immu264>3.0.co;2-o

PubMed ID: 9754572

Title: HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer.

PubMed ID: 9754572

DOI: 10.1002/(sici)1521-4141(199809)28:09<2854::aid-immu2854>3.0.co;2-w

PubMed ID: 9655483

Title: Association of DAP12 with activating CD94/NKG2C NK cell receptors.

PubMed ID: 9655483

DOI: 10.1016/s1074-7613(00)80574-9

PubMed ID: 9486650

Title: HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.

PubMed ID: 9486650

DOI: 10.1038/35869

PubMed ID: 10428963

Title: Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E.

PubMed ID: 10428963

DOI: 10.1093/emboj/18.15.4250

PubMed ID: 10669413

Title: Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40.

PubMed ID: 10669413

DOI: 10.1126/science.287.5455.1031

PubMed ID: 12387742

Title: TCR specificity dictates CD94/NKG2A expression by human CTL.

PubMed ID: 12387742

DOI: 10.1016/s1074-7613(02)00427-2

PubMed ID: 12165520

Title: Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal.

PubMed ID: 12165520

DOI: 10.4049/jimmunol.169.4.1948

PubMed ID: 15751767

Title: HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells.

PubMed ID: 15751767

DOI: 10.1177/135965350501000107

PubMed ID: 15940674

Title: The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells.

PubMed ID: 15940674

DOI: 10.1002/eji.200425843

PubMed ID: 18064301

Title: Small intestinal CD8+TCRgammadelta+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease.

PubMed ID: 18064301

DOI: 10.1172/jci30989

PubMed ID: 20952657

Title: NKG2A inhibits NKG2C effector functions of gammadelta T cells: implications in health and disease.

PubMed ID: 20952657

DOI: 10.1189/jlb.0710413

PubMed ID: 21825173

Title: Expansion of a unique CD57-positive NKG2Chi natural killer cell subset during acute human cytomegalovirus infection.

PubMed ID: 21825173

DOI: 10.1073/pnas.1110900108

PubMed ID: 23335510

Title: Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells.

PubMed ID: 23335510

DOI: 10.1074/jbc.m112.409672

PubMed ID: 30503213

Title: Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells.

PubMed ID: 30503213

DOI: 10.1016/j.cell.2018.10.014

PubMed ID: 30134159

Title: Distinct HLA-E Peptide Complexes Modify Antibody-Driven Effector Functions of Adaptive NK Cells.

PubMed ID: 30134159

DOI: 10.1016/j.celrep.2018.07.069

PubMed ID: 30860984

Title: Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells.

PubMed ID: 30860984

DOI: 10.1172/jci123955

PubMed ID: 32859121

Title: SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway.

PubMed ID: 32859121

DOI: 10.3390/cells9091975

PubMed ID: 37264229

Title: HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.

PubMed ID: 37264229

DOI: 10.1038/s41590-023-01523-z

PubMed ID: 10023772

Title: Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors.

PubMed ID: 10023772

DOI: 10.1016/s1074-7613(00)80008-4

PubMed ID: 18083576

Title: The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition.

PubMed ID: 18083576

DOI: 10.1016/j.immuni.2007.10.013

PubMed ID: 18448674

Title: Structural basis for NKG2A/CD94 recognition of HLA-E.

PubMed ID: 18448674

DOI: 10.1073/pnas.0802736105

PubMed ID: 18332182

Title: CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence.

PubMed ID: 18332182

DOI: 10.1084/jem.20072525

Sequence Information:

  • Length: 179
  • Mass: 20513
  • Checksum: 01634D3832D4B1A7
  • Sequence:
    • MAVFKTTLWR LISGTLGIIC LSLMSTLGIL LKNSFTKLSI EPAFTPGPNI ELQKDSDCCS 
CQEKWVGYRC NCYFISSEQK TWNESRHLCA SQKSSLLQLQ NTDELDFMSS SQQFYWIGLS 
YSEEHTAWLW ENGSALSQYL FPSFETFNTK NCIAYNPNGN ALDESCEDKN RYICKQQLI

Genular Protein ID: 2693758215

Symbol: Q53ZY6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53ZY6

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 GO 5 Gene3D 1 IntAct 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 Pfam 1 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14607929

Title: Human CD94 gene expression: dual promoters differing in responsiveness to IL-2 or IL-15.

PubMed ID: 14607929

Sequence Information:

  • Length: 179
  • Mass: 20497
  • Checksum: 1884D99E8D9583A7
  • Sequence:
    • MAVFKTTLWR LISGTLGIIC LSLMATLGIL LKNSFTKLSI EPAFTPGPNI ELQKDSDCCS 
CQEKWVGYRC NCYFISSEQK TWNESRHLCA SQKSSLLQLQ NTDELDFMSS SQQFYWIGLS 
YSEEHTAWLW ENGSALSQYL FPSFETFNTK NCIAYNPNGN ALDESCEDKN RYICKQQLI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.