Details for: KLRD1

Gene ID: 3824

Symbol: KLRD1

Ensembl ID: ENSG00000134539

Description: killer cell lectin like receptor D1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.11
    Marker Score: 14923
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.22
    Marker Score: 1372
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.01
    Marker Score: 12647
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.96
    Marker Score: 10938
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.27
    Marker Score: 1410
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.26
    Marker Score: 4799
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 3.02
    Marker Score: 994
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.71
    Marker Score: 686
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.43
    Marker Score: 1343
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.24
    Marker Score: 2491
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.03
    Marker Score: 1475
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.95
    Marker Score: 838
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.87
    Marker Score: 5253
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.76
    Marker Score: 399
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.75
    Marker Score: 1690
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1155
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.52
    Marker Score: 1277
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.47
    Marker Score: 1466.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168231
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.4
    Marker Score: 1023
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.39
    Marker Score: 14352
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.36
    Marker Score: 1878
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.34
    Marker Score: 1037
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.33
    Marker Score: 818
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.28
    Marker Score: 3121
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.28
    Marker Score: 4540
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 842
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.21
    Marker Score: 1565
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4789
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.12
    Marker Score: 402
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.09
    Marker Score: 689
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.08
    Marker Score: 1755
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.05
    Marker Score: 542
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251766
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1
    Marker Score: 892
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1
    Marker Score: 414
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71787
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48011
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.99
    Marker Score: 499
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.98
    Marker Score: 565
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.98
    Marker Score: 9711
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.96
    Marker Score: 295
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.96
    Marker Score: 644
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14879
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.95
    Marker Score: 11000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.95
    Marker Score: 8990
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.95
    Marker Score: 293
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.93
    Marker Score: 820
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.92
    Marker Score: 421
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.91
    Marker Score: 717
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5094.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.89
    Marker Score: 470
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.89
    Marker Score: 942
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.87
    Marker Score: 53594
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5276
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.86
    Marker Score: 2153
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.85
    Marker Score: 700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 638.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.83
    Marker Score: 242
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.82
    Marker Score: 382
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.8
    Marker Score: 867
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.8
    Marker Score: 1238
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.75
    Marker Score: 6449
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.74
    Marker Score: 1050
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.73
    Marker Score: 16300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.71
    Marker Score: 1443
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 454
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.7
    Marker Score: 418
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.66
    Marker Score: 1894
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.66
    Marker Score: 245
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.66
    Marker Score: 6195
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.65
    Marker Score: 2739
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.65
    Marker Score: 2654
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.65
    Marker Score: 550
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.65
    Marker Score: 499
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.64
    Marker Score: 2662
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.64
    Marker Score: 356
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.62
    Marker Score: 285
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.58
    Marker Score: 383
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.58
    Marker Score: 196
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.55
    Marker Score: 487
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.55
    Marker Score: 1197.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.54
    Marker Score: 8130
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.54
    Marker Score: 3220
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.54
    Marker Score: 20342
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.53
    Marker Score: 19564
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.53
    Marker Score: 487

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Other Information

**Key characteristics:** - KLRD1 is a transmembrane protein that is expressed as a single transcript. - It is a type I transmembrane receptor that is expressed in the cell membrane. - It is composed of two immunoglobulin heavy chains and two immunoglobulin light chains. - The immunoglobulin heavy chains are responsible for binding to the natural killer cell antigen CD94. - The immunoglobulin light chains are responsible for signaling through the activation of the intracellular signaling cascade. **Pathways and functions:** - KLRD1 is a key receptor for the activation of NK cells. - It is involved in the regulation of NK cell cytotoxicity, proliferation, and survival. - It is also involved in the regulation of NK cell-mediated immune responses. - KLRD1 is expressed on a variety of cell types, including NK cells, dendritic cells, and macrophages. - It is involved in the regulation of immune responses to a variety of pathogens, including viruses, bacteria, and parasites. **Clinical significance:** - Mutations in KLRD1 have been linked to a number of human diseases, including cancer and autoimmune disorders. - KLRD1 is a potential target for cancer immunotherapy. - The development of antibodies that block the interaction between KLRD1 and CD94 is being investigated as a treatment for cancer.

Genular Protein ID: 3626551294

Symbol: KLRD1_HUMAN

Name: Natural killer cells antigen CD94

UniProtKB Accession Codes:

Q13241 O43321 O43773 Q9UBE3 Q9UEQ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 5 PDBsum 4 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7589107

Title: Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily.

PubMed ID: 7589107

DOI: 10.1002/eji.1830250904

PubMed ID: 9472066

Title: Structure of the human CD94 C-type lectin gene.

PubMed ID: 9472066

DOI: 10.1007/s002510050362

PubMed ID: 9601951

Title: A alternatively spliced form of the human CD94 gene.

PubMed ID: 9601951

DOI: 10.1007/s002510050407

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9430220

Title: Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors.

PubMed ID: 9430220

DOI: 10.1016/s1074-7613(00)80393-3

PubMed ID: 9485206

Title: Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases.

PubMed ID: 9485206

DOI: 10.1002/(sici)1521-4141(199801)28:01<264::aid-immu264>3.0.co;2-o

PubMed ID: 9754572

Title: HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer.

PubMed ID: 9754572

DOI: 10.1002/(sici)1521-4141(199809)28:09<2854::aid-immu2854>3.0.co;2-w

PubMed ID: 9655483

Title: Association of DAP12 with activating CD94/NKG2C NK cell receptors.

PubMed ID: 9655483

DOI: 10.1016/s1074-7613(00)80574-9

PubMed ID: 9486650

Title: HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.

PubMed ID: 9486650

DOI: 10.1038/35869

PubMed ID: 10428963

Title: Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E.

PubMed ID: 10428963

DOI: 10.1093/emboj/18.15.4250

PubMed ID: 10669413

Title: Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40.

PubMed ID: 10669413

DOI: 10.1126/science.287.5455.1031

PubMed ID: 12387742

Title: TCR specificity dictates CD94/NKG2A expression by human CTL.

PubMed ID: 12387742

DOI: 10.1016/s1074-7613(02)00427-2

PubMed ID: 12165520

Title: Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal.

PubMed ID: 12165520

DOI: 10.4049/jimmunol.169.4.1948

PubMed ID: 15751767

Title: HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells.

PubMed ID: 15751767

DOI: 10.1177/135965350501000107

PubMed ID: 15940674

Title: The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells.

PubMed ID: 15940674

DOI: 10.1002/eji.200425843

PubMed ID: 18064301

Title: Small intestinal CD8+TCRgammadelta+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease.

PubMed ID: 18064301

DOI: 10.1172/jci30989

PubMed ID: 20952657

Title: NKG2A inhibits NKG2C effector functions of gammadelta T cells: implications in health and disease.

PubMed ID: 20952657

DOI: 10.1189/jlb.0710413

PubMed ID: 21825173

Title: Expansion of a unique CD57-positive NKG2Chi natural killer cell subset during acute human cytomegalovirus infection.

PubMed ID: 21825173

DOI: 10.1073/pnas.1110900108

PubMed ID: 23335510

Title: Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells.

PubMed ID: 23335510

DOI: 10.1074/jbc.m112.409672

PubMed ID: 30503213

Title: Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells.

PubMed ID: 30503213

DOI: 10.1016/j.cell.2018.10.014

PubMed ID: 30134159

Title: Distinct HLA-E Peptide Complexes Modify Antibody-Driven Effector Functions of Adaptive NK Cells.

PubMed ID: 30134159

DOI: 10.1016/j.celrep.2018.07.069

PubMed ID: 30860984

Title: Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells.

PubMed ID: 30860984

DOI: 10.1172/jci123955

PubMed ID: 32859121

Title: SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway.

PubMed ID: 32859121

DOI: 10.3390/cells9091975

PubMed ID: 37264229

Title: HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.

PubMed ID: 37264229

DOI: 10.1038/s41590-023-01523-z

PubMed ID: 10023772

Title: Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors.

PubMed ID: 10023772

DOI: 10.1016/s1074-7613(00)80008-4

PubMed ID: 18083576

Title: The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition.

PubMed ID: 18083576

DOI: 10.1016/j.immuni.2007.10.013

PubMed ID: 18448674

Title: Structural basis for NKG2A/CD94 recognition of HLA-E.

PubMed ID: 18448674

DOI: 10.1073/pnas.0802736105

PubMed ID: 18332182

Title: CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence.

PubMed ID: 18332182

DOI: 10.1084/jem.20072525

Sequence Information:

  • Length: 179
  • Mass: 20513
  • Checksum: 01634D3832D4B1A7
  • Sequence:
    • MAVFKTTLWR LISGTLGIIC LSLMSTLGIL LKNSFTKLSI EPAFTPGPNI ELQKDSDCCS 
CQEKWVGYRC NCYFISSEQK TWNESRHLCA SQKSSLLQLQ NTDELDFMSS SQQFYWIGLS 
YSEEHTAWLW ENGSALSQYL FPSFETFNTK NCIAYNPNGN ALDESCEDKN RYICKQQLI

Genular Protein ID: 2693758215

Symbol: Q53ZY6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53ZY6

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 GO 2 Gene3D 1 GenomeRNAi 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 Pfam 1 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14607929

Title: Human CD94 gene expression: dual promoters differing in responsiveness to IL-2 or IL-15.

PubMed ID: 14607929

Sequence Information:

  • Length: 179
  • Mass: 20497
  • Checksum: 1884D99E8D9583A7
  • Sequence:
    • MAVFKTTLWR LISGTLGIIC LSLMATLGIL LKNSFTKLSI EPAFTPGPNI ELQKDSDCCS 
CQEKWVGYRC NCYFISSEQK TWNESRHLCA SQKSSLLQLQ NTDELDFMSS SQQFYWIGLS 
YSEEHTAWLW ENGSALSQYL FPSFETFNTK NCIAYNPNGN ALDESCEDKN RYICKQQLI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.