Details for: IMPDH1

Gene ID: 3614

Symbol: IMPDH1

Ensembl ID: ENSG00000106348

Description: inosine monophosphate dehydrogenase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.91
    Marker Score: 3343
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.63
    Marker Score: 91058
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.61
    Marker Score: 4603
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.52
    Marker Score: 453
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.32
    Marker Score: 327
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.3
    Marker Score: 7871
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.27
    Marker Score: 2466
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.21
    Marker Score: 633.5
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.19
    Marker Score: 1207
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.13
    Marker Score: 28885
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.06
    Marker Score: 12373
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15910
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.01
    Marker Score: 6416
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1
    Marker Score: 2503
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71712
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1
    Marker Score: 583
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47935
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.99
    Marker Score: 2246
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30395
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.96
    Marker Score: 1103
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.91
    Marker Score: 261
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2705
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.9
    Marker Score: 1898
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.87
    Marker Score: 9027
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5239
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.86
    Marker Score: 547
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.86
    Marker Score: 1144
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.85
    Marker Score: 1221
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4841
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.84
    Marker Score: 1705
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.8
    Marker Score: 201
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.79
    Marker Score: 5056
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.78
    Marker Score: 431
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 596.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 462
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.77
    Marker Score: 265
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1241
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.76
    Marker Score: 7712
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.76
    Marker Score: 1834
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.76
    Marker Score: 452
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.75
    Marker Score: 810
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.74
    Marker Score: 1683
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.73
    Marker Score: 364
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.71
    Marker Score: 230
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.71
    Marker Score: 519
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.7
    Marker Score: 199
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2883
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.68
    Marker Score: 1391
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.68
    Marker Score: 284
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 618
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.67
    Marker Score: 362
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.67
    Marker Score: 279
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.64
    Marker Score: 990
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.64
    Marker Score: 221
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.64
    Marker Score: 2597
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.63
    Marker Score: 596
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.62
    Marker Score: 2578
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.62
    Marker Score: 418
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.62
    Marker Score: 425
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.61
    Marker Score: 1591
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.61
    Marker Score: 420
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.61
    Marker Score: 536
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.61
    Marker Score: 193
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.6
    Marker Score: 211
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 398
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.6
    Marker Score: 567
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.6
    Marker Score: 2570
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.59
    Marker Score: 743.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.59
    Marker Score: 716
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.59
    Marker Score: 134
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.59
    Marker Score: 1856
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.59
    Marker Score: 431
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.58
    Marker Score: 244
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.58
    Marker Score: 423
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.58
    Marker Score: 924
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.57
    Marker Score: 274
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.57
    Marker Score: 126
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.57
    Marker Score: 3422
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.57
    Marker Score: 281
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.56
    Marker Score: 5307
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.56
    Marker Score: 354.5
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.56
    Marker Score: 528
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.56
    Marker Score: 2930
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.56
    Marker Score: 2160
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.56
    Marker Score: 418
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.56
    Marker Score: 604
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.56
    Marker Score: 402
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.55
    Marker Score: 269
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.55
    Marker Score: 500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.55
    Marker Score: 812
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.55
    Marker Score: 119
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.55
    Marker Score: 122

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Other Information

**Key characteristics:** * IMPDH1 is a member of the inosine monophosphate dehydrogenase family of enzymes. * It is a ubiquitin-dependent protein that is regulated by the proteasome. * It is a key enzyme in the purine salvage pathway, which is responsible for maintaining purine nucleotide levels in the body. * It also plays a role in the regulation of innate immunity and inflammation. **Pathways and functions:** * The main pathway activated by IMPDH1 is the purine salvage pathway, which is responsible for recycling purines and pyrimidines. * It also plays a role in the regulation of innate immunity and inflammation. * It is involved in the clearance of apoptotic cells and in the regulation of immune responses to pathogens. **Clinical significance:** * Mutations in IMPDH1 have been linked to a number of human diseases, including systemic sclerosis, lupus, and sars. * In sars, mutations in IMPDH1 can lead to the accumulation of damaged purines and pyrimidines, which can damage DNA and tissues. * Targeting IMPDH1 with drugs is a potential therapeutic strategy for sars and other diseases that are caused by mutations in the gene. **Additional information:** * The gene is located on chromosome 15q21.1. * It is a highly conserved gene, with a similar gene found in humans, mice, and rats. * It is a key enzyme in the purine salvage pathway, which is responsible for maintaining purine nucleotide levels in the body.

Genular Protein ID: 3649824902

Symbol: IMDH1_HUMAN

Name: IMPDH-I

UniProtKB Accession Codes:

P20839 A4D0Z6 A4D0Z7 A6NDW5 A6NNI6 B3KNP7 B3KVM8 B4DE09 C9JV30 J3KNX8 Q8N194 Q96NU2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 2 CTD 1 ChEBI 20 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EC 1 EMBL 11 EMDB 12 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HAMAP 1 HAMAP-Rule 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 13 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 4 RefSeq 9 Rhea 1 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1969416

Title: Two distinct cDNAs for human IMP dehydrogenase.

PubMed ID: 1969416

DOI: 10.1016/s0021-9258(19)34120-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7903306

Title: Characterization of human type I and type II IMP dehydrogenases.

PubMed ID: 7903306

DOI: 10.1016/s0021-9258(19)74247-1

PubMed ID: 15028279

Title: PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.

PubMed ID: 15028279

DOI: 10.1016/j.ygeno.2003.09.023

PubMed ID: 7763314

Title: Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding.

PubMed ID: 7763314

DOI: 10.1016/0006-2952(95)00026-v

PubMed ID: 14766016

Title: Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo.

PubMed ID: 14766016

DOI: 10.1042/bj20031585

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 11875049

Title: Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas of wild-type and Rho(-/-) mice.

PubMed ID: 11875049

DOI: 10.1093/hmg/11.5.547

PubMed ID: 11875050

Title: Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa.

PubMed ID: 11875050

DOI: 10.1093/hmg/11.5.559

PubMed ID: 16384941

Title: Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and Leber congenital amaurosis.

PubMed ID: 16384941

DOI: 10.1167/iovs.05-0868

Sequence Information:

  • Length: 514
  • Mass: 55406
  • Checksum: ABAC654A9091BE62
  • Sequence:
    • MADYLISGGT GYVPEDGLTA QQLFASADGL TYNDFLILPG FIDFIADEVD LTSALTRKIT 
LKTPLISSPM DTVTEADMAI AMALMGGIGF IHHNCTPEFQ ANEVRKVKKF EQGFITDPVV 
LSPSHTVGDV LEAKMRHGFS GIPITETGTM GSKLVGIVTS RDIDFLAEKD HTTLLSEVMT 
PRIELVVAPA GVTLKEANEI LQRSKKGKLP IVNDCDELVA IIARTDLKKN RDYPLASKDS 
QKQLLCGAAV GTREDDKYRL DLLTQAGVDV IVLDSSQGNS VYQIAMVHYI KQKYPHLQVI 
GGNVVTAAQA KNLIDAGVDG LRVGMGCGSI CITQEVMACG RPQGTAVYKV AEYARRFGVP 
IIADGGIQTV GHVVKALALG ASTVMMGSLL AATTEAPGEY FFSDGVRLKK YRGMGSLDAM 
EKSSSSQKRY FSEGDKVKIA QGVSGSIQDK GSIQKFVPYL IAGIQHGCQD IGARSLSVLR 
SMMYSGELKF EKRTMSAQIE GGVHGLHSYE KRLY

Genular Protein ID: 876879802

Symbol: B3KRZ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KRZ3

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 18 DNASU 1 EC 1 EMBL 2 GO 6 Gene3D 1 Genevisible 1 GenomeRNAi 1 HAMAP 1 HAMAP-Rule 1 InterPro 5 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 Rhea 1 RuleBase 2 SMART 2 SUPFAM 1 UniPathway 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 522
  • Mass: 56366
  • Checksum: 539CB029594FA082
  • Sequence:
    • MDRLRRASMA DYLISGGTGY VPEDGLTAQQ LFASADGLTY NDFLILPGFI DFIADEVDLT 
SALTRKITLK TPLISSPMDT VTEADMAIAM ALMGGIGFIH HNCTPEFQAN EVRKVKKFEQ 
GFITDPVVLS PSHTVGDVLE AKMRHGFSGI PITETGTMGS KLVGIVTSRD IDFLAEKDHT 
TLLSEVMTPR IELVVAPAGV TLKEANEILQ RSKKGKLPIV NDCDELVAII ARTDLKKNRD 
YPLASKDSQK QLLCGAAVGT REDDKYRLDL LTQAGVDVIV LDSSQGNSVY QIAMVHYIKQ 
KYPHLQVIGG NVVTAAQAKN LIDAGVDGLR VGMGCGSICI TQEVMACGRP QGTAVYKVAE 
YARRFGVPII ADGGIQTVGH VVKALALGAS TVMMGSLLAA TTEAPGEYFF SDGVRLKKYR 
GMGSLDAMEK SSSSQKRYFS EGDKVKIAQG VSGSIQDKGS IQKFVPHLIA GIQHGCQDIG 
ARSLSVLRSM MYSGELKFEK RTMSAQIEGG VHGLHSYEKR LY

Genular Protein ID: 674284723

Symbol: Q6ZNB1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6ZNB1

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 18 DNASU 1 EC 1 EMBL 2 GO 6 Gene3D 1 GenomeRNAi 1 HAMAP 1 HAMAP-Rule 1 InterPro 5 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PROSITE 3 PROSITE-ProRule 1 Pfam 2 RefSeq 1 Rhea 1 RuleBase 2 SAM 1 SMART 2 SUPFAM 1 UniPathway 1

Sequence Information:

  • Length: 530
  • Mass: 57050
  • Checksum: F4517075D4DF140E
  • Sequence:
    • MEGPLTPPPL QGGGAAAVPE PGARQHPGHE TAAQRYSARL LQAGYEPESD FLILPGFIDF 
IADEVDLTSA LTRKITLKTP LISSPMDTVT EADMAFAMAL MGGIGFIHHN CTPEFQANEV 
RKVKKFEQGF ITDPVVLSPS HTVGDVLEAK MRHGFSGIPI TETGTMGSKL VGIVTSRDID 
FLAEKDHTTL LSEVMTPRIE LVVAPAGVTL KEANEILQRS KKGKLPIVND CDELVAIIAR 
TDLKKNRDYP LASKDSQKQL LCGAAVGTRE DDKYRLDLLT QAGVDVIVLD SSQGNSVYQI 
AMVHYIKQKY PHLQVIGGNV VTAAQAKNLI DAGVDGLRVG MGCGSICITQ EVMACGRPQG 
TAVYKVAEYA RRFGVPIIAD GGIQTVGHVV KALALGASTV MMGSLLAATT EAPGEYFFSD 
GVRLKKYRGM GSLDAMEKSS SSQKRYFSEG DKVKIAQGVS GSIQDKGSIQ KFVPYLIAGI 
QHGCQDIGAR SLSVLRSMMY SGELKFEKRT MSAQIEGGVH GLHSYEKRLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.