Details for: AMBP

Gene ID: 259

Symbol: AMBP

Ensembl ID: ENSG00000106927

Description: alpha-1-microglobulin/bikunin precursor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 73.4244
    Cell Significance Index: 193.6900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 6.7706
    Cell Significance Index: 25.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 4.5849
    Cell Significance Index: 909.8900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.1630
    Cell Significance Index: 70.1300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.7072
    Cell Significance Index: 15.5900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 2.5160
    Cell Significance Index: 6.7400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.3191
    Cell Significance Index: 34.2300
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.4697
    Cell Significance Index: 14.5000
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.3768
    Cell Significance Index: 4.7900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.1178
    Cell Significance Index: 8.8300
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 1.0155
    Cell Significance Index: 0.5100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.5698
    Cell Significance Index: 8.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4582
    Cell Significance Index: 45.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4426
    Cell Significance Index: 26.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3962
    Cell Significance Index: 357.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3661
    Cell Significance Index: 39.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2630
    Cell Significance Index: 42.7700
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.2491
    Cell Significance Index: 2.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2202
    Cell Significance Index: 41.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1834
    Cell Significance Index: 12.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1247
    Cell Significance Index: 21.3000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1094
    Cell Significance Index: 1.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1034
    Cell Significance Index: 1.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0933
    Cell Significance Index: 10.8700
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.0907
    Cell Significance Index: 0.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0857
    Cell Significance Index: 6.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0616
    Cell Significance Index: 1.6500
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.0523
    Cell Significance Index: 0.5400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0495
    Cell Significance Index: 0.7000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0484
    Cell Significance Index: 0.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0432
    Cell Significance Index: 0.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0260
    Cell Significance Index: 0.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0100
    Cell Significance Index: 1.4600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0068
    Cell Significance Index: 0.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0067
    Cell Significance Index: 4.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0057
    Cell Significance Index: 3.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0033
    Cell Significance Index: 1.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0007
    Cell Significance Index: 0.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0012
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0019
    Cell Significance Index: -1.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0024
    Cell Significance Index: -1.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0033
    Cell Significance Index: -4.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0037
    Cell Significance Index: -0.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0042
    Cell Significance Index: -0.0900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0043
    Cell Significance Index: -0.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0050
    Cell Significance Index: -2.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0059
    Cell Significance Index: -3.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0060
    Cell Significance Index: -2.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0073
    Cell Significance Index: -0.4500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0088
    Cell Significance Index: -0.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0098
    Cell Significance Index: -1.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0108
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0111
    Cell Significance Index: -2.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0121
    Cell Significance Index: -3.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0129
    Cell Significance Index: -2.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0207
    Cell Significance Index: -0.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0210
    Cell Significance Index: -3.7800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0284
    Cell Significance Index: -0.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0303
    Cell Significance Index: -4.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0325
    Cell Significance Index: -3.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0331
    Cell Significance Index: -4.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0372
    Cell Significance Index: -4.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0372
    Cell Significance Index: -0.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0423
    Cell Significance Index: -4.4000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0499
    Cell Significance Index: -0.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0519
    Cell Significance Index: -4.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0530
    Cell Significance Index: -3.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0559
    Cell Significance Index: -3.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0590
    Cell Significance Index: -1.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0605
    Cell Significance Index: -3.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0661
    Cell Significance Index: -5.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0674
    Cell Significance Index: -1.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0691
    Cell Significance Index: -3.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0731
    Cell Significance Index: -3.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0751
    Cell Significance Index: -1.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0758
    Cell Significance Index: -1.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0779
    Cell Significance Index: -3.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0828
    Cell Significance Index: -3.8900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0925
    Cell Significance Index: -3.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0933
    Cell Significance Index: -4.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0964
    Cell Significance Index: -3.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0986
    Cell Significance Index: -4.3600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0998
    Cell Significance Index: -0.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1045
    Cell Significance Index: -3.6600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1058
    Cell Significance Index: -1.5900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1074
    Cell Significance Index: -0.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1137
    Cell Significance Index: -5.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1181
    Cell Significance Index: -6.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1204
    Cell Significance Index: -4.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1228
    Cell Significance Index: -3.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1249
    Cell Significance Index: -4.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1264
    Cell Significance Index: -3.4400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1266
    Cell Significance Index: -3.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1293
    Cell Significance Index: -2.1300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1323
    Cell Significance Index: -1.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1340
    Cell Significance Index: -3.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The AMBP gene encodes a protein that exhibits multiple functional domains, including carbohydrate-binding, protein-binding, and protease-inhibitory activities. It is also involved in the regulation of immune responses, including the negative regulation of the JNK cascade and the scavenging of heme from plasma. The protein's ability to bind to various ligands, including IgA and heme, underscores its role in immune system modulation and cellular homeostasis. **Pathways and Functions:** The AMBP protein is involved in several key pathways, including: 1. **Scavenging of heme from plasma:** AMBP binds to heme, facilitating its removal from the plasma and preventing oxidative damage to tissues. 2. **Regulation of immune response:** AMBP negatively regulates the JNK cascade, a key signaling pathway involved in immune responses, and modulates the activity of immune cells, such as macrophages. 3. **Cell adhesion:** AMBP interacts with various ligands, including collagen and IgA, facilitating cell adhesion and maintaining tissue integrity. 4. **Endoplasmic reticulum and Golgi apparatus:** AMBP is translocated to the endoplasmic reticulum and Golgi apparatus, where it undergoes processing and modification, resulting in the generation of various proteolytic fragments. 5. **Vesicle-mediated transport:** AMBP is transported to the plasma membrane and secreted into the extracellular space, where it can interact with cells and other molecules. **Clinical Significance:** Dysregulation of the AMBP gene has been implicated in various diseases, including: 1. **Liver disease:** Alterations in AMBP expression have been observed in liver diseases, such as hepatitis and cirrhosis, highlighting the protein's role in liver homeostasis. 2. **Kidney disease:** AMBP has been shown to play a role in kidney disease, including the regulation of immune responses and the maintenance of renal function. 3. **Inflammatory disorders:** The protein's ability to modulate immune responses makes it a potential target for the treatment of inflammatory disorders, such as rheumatoid arthritis and atherosclerosis. 4. **Cancer:** AMBP has been implicated in cancer development and progression, particularly in the regulation of cell adhesion and immune responses. In conclusion, the AMBP gene is a multifaceted protein that plays a crucial role in modulating the immune response, regulating cell adhesion, and maintaining tissue integrity. Its dysregulation has been implicated in various diseases, making it a potential target for the development of novel therapeutic strategies.

Genular Protein ID: 2434001786

Symbol: AMBP_HUMAN

Name: Alpha-1 microglycoprotein

UniProtKB Accession Codes:

P02760 P00977 P02759 P78491 Q2TU33 Q5TBD7 Q9UC58 Q9UDI8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 2 CTD 1 CarbonylDB 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRINTS 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2428011

Title: Sequence of a full length cDNA coding for human protein HC (alpha 1 microglobulin).

PubMed ID: 2428011

DOI: 10.1093/nar/14.15.6340

PubMed ID: 2430261

Title: The mRNA for a proteinase inhibitor related to the HI-30 domain of inter-alpha-trypsin inhibitor also encodes alpha-1-microglobulin (protein HC).

PubMed ID: 2430261

DOI: 10.1093/nar/14.20.7839

PubMed ID: 1708673

Title: Structure of the human alpha 1-microglobulin-bikunin gene.

PubMed ID: 1708673

DOI: 10.1515/bchm3.1990.371.2.1185

PubMed ID: 1696200

Title: Structural analysis of the human inter-alpha-trypsin inhibitor light-chain gene.

PubMed ID: 1696200

DOI: 10.1111/j.1432-1033.1990.tb19102.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6198962

Title: The complete amino acid sequence of human complex-forming glycoprotein heterogeneous in charge (protein HC) from one individual.

PubMed ID: 6198962

DOI: 10.1016/0003-9861(84)90021-3

PubMed ID: 6164372

Title: Complete amino acid sequence of human alpha 1-microglobulin.

PubMed ID: 6164372

DOI: 10.1016/0006-291x(81)91209-2

PubMed ID: 7506257

Title: Location of a novel type of interpolypeptide chain linkage in the human protein HC-IgA complex (HC-IgA) and identification of a heterogeneous chromophore associated with the complex.

PubMed ID: 7506257

DOI: 10.1016/s0021-9258(17)42361-1

PubMed ID: 2408638

Title: Human inter-alpha-trypsin inhibitor: localization of the Kunitz-type domains in the N-terminal part of the molecule and their release by a trypsin-like proteinase.

PubMed ID: 2408638

DOI: 10.1515/bchm3.1985.366.1.479

PubMed ID: 1469060

Title: Cancer-related urinary proteinase inhibitor, EDC1: a new method for its isolation and evidence for multiple forms.

PubMed ID: 1469060

DOI: 10.1002/jcb.240500303

PubMed ID: 1898736

Title: Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor.

PubMed ID: 1898736

DOI: 10.1016/s0021-9258(17)35235-3

PubMed ID: 7682553

Title: Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin.

PubMed ID: 7682553

DOI: 10.1016/s0021-9258(18)52933-1

PubMed ID: 7676539

Title: Characterization of uronic-acid-rich inhibitor of calcium oxalate crystallization isolated from rat urine.

PubMed ID: 7676539

DOI: 10.1007/bf00307939

PubMed ID: 7513643

Title: Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor.

PubMed ID: 7513643

DOI: 10.1111/j.1432-1033.1994.tb18803.x

PubMed ID: 6171497

Title: Kunitz-type proteinase inhibitors derived by limited proteolysis of the inter-alpha-trypsin inhibitor, V. Attachments of carbohydrates in the human urinary trypsin inhibitor isolated by affinity chromatography.

PubMed ID: 6171497

DOI: 10.1515/bchm2.1981.362.2.1357

PubMed ID: 3890890

Title: The reactive site of human inter-alpha-trypsin inhibitor is in the amino-terminal half of the protein.

PubMed ID: 3890890

DOI: 10.1515/bchm3.1985.366.1.19

PubMed ID: 2476436

Title: Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan.

PubMed ID: 2476436

DOI: 10.1016/s0021-9258(18)71575-5

PubMed ID: 1694784

Title: Location and characterization of the three carbohydrate prosthetic groups of human protein HC.

PubMed ID: 1694784

DOI: 10.1016/0014-5793(90)81531-r

PubMed ID: 1714898

Title: The protein HC chromophore is linked to the cysteine residue at position 34 of the polypeptide chain by a reduction-resistant bond and causes the charge heterogeneity of protein HC.

PubMed ID: 1714898

DOI: 10.1016/s0021-9258(18)98474-7

PubMed ID: 7535251

Title: Formation of the alpha 1-microglobulin chromophore in mammalian and insect cells: a novel post-translational mechanism?

PubMed ID: 7535251

DOI: 10.1016/0014-5793(95)00206-o

PubMed ID: 9183005

Title: Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma.

PubMed ID: 9183005

DOI: 10.1111/j.1432-1033.1997.00676.x

PubMed ID: 10480954

Title: Generation of catalytically active granzyme K from Escherichia coli inclusion bodies and identification of efficient granzyme K inhibitors in human plasma.

PubMed ID: 10480954

DOI: 10.1074/jbc.274.38.27331

PubMed ID: 10631976

Title: Alpha1-microglobulin chromophores are located to three lysine residues semiburied in the lipocalin pocket and associated with a novel lipophilic compound.

PubMed ID: 10631976

DOI: 10.1110/ps.8.12.2611

PubMed ID: 11877257

Title: Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties.

PubMed ID: 11877257

DOI: 10.1182/blood.v99.6.1894

PubMed ID: 15452109

Title: Human alpha-1-microglobulin is covalently bound to kynurenine-derived chromophores.

PubMed ID: 15452109

DOI: 10.1074/jbc.m408242200

PubMed ID: 15037615

Title: The ORF3 protein of hepatitis E virus interacts with liver-specific alpha1-microglobulin and its precursor alpha1-microglobulin/bikunin precursor (AMBP) and expedites their export from the hepatocyte.

PubMed ID: 15037615

DOI: 10.1074/jbc.m402017200

PubMed ID: 15683711

Title: Redox properties of the lipocalin alpha1-microglobulin: reduction of cytochrome c, hemoglobin, and free iron.

PubMed ID: 15683711

DOI: 10.1016/j.freeradbiomed.2004.12.013

PubMed ID: 15917224

Title: Characterization of the interaction between tumor necrosis factor-stimulated gene-6 and heparin: implications for the inhibition of plasmin in extracellular matrix microenvironments.

PubMed ID: 15917224

DOI: 10.1074/jbc.m502068200

PubMed ID: 16140784

Title: The 41-amino-acid C-terminal region of the hepatitis E virus ORF3 protein interacts with bikunin, a Kunitz-type serine protease inhibitor.

PubMed ID: 16140784

DOI: 10.1128/jvi.79.18.12081-12087.2005

PubMed ID: 16873769

Title: TSG-6 potentiates the antitissue kallikrein activity of inter-alpha-inhibitor through bikunin release.

PubMed ID: 16873769

DOI: 10.1165/rcmb.2006-0018oc

PubMed ID: 20463016

Title: The TSG-6/HC2-mediated transfer is a dynamic process shuffling heavy chains between glycosaminoglycans.

PubMed ID: 20463016

DOI: 10.1074/jbc.m109.041046

PubMed ID: 21356557

Title: Perfusion of human placenta with hemoglobin introduces preeclampsia-like injuries that are prevented by alpha1-microglobulin.

PubMed ID: 21356557

DOI: 10.1016/j.placenta.2011.01.017

PubMed ID: 22096585

Title: Up-regulation of A1M/alpha1-microglobulin in skin by heme and reactive oxygen species gives protection from oxidative damage.

PubMed ID: 22096585

DOI: 10.1371/journal.pone.0027505

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 23157686

Title: The radical-binding lipocalin A1M binds to a Complex I subunit and protects mitochondrial structure and function.

PubMed ID: 23157686

DOI: 10.1089/ars.2012.4658

PubMed ID: 23642167

Title: The cysteine 34 residue of A1M/alpha1-microglobulin is essential for protection of irradiated cell cultures and reduction of carbonyl groups.

PubMed ID: 23642167

DOI: 10.3109/10715762.2013.801555

PubMed ID: 25301953

Title: Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin.

PubMed ID: 25301953

DOI: 10.1074/jbc.m114.609560

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25698971

Title: A1M/alpha1-microglobulin is proteolytically activated by myeloperoxidase, binds its heme group and inhibits low density lipoprotein oxidation.

PubMed ID: 25698971

DOI: 10.3389/fphys.2015.00011

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 32823731

Title: alpha1-Microglobulin (A1M) Protects Human Proximal Tubule Epithelial Cells from Heme-Induced Damage In Vitro.

PubMed ID: 32823731

DOI: 10.3390/ijms21165825

PubMed ID: 32092412

Title: Human radical scavenger alpha1-microglobulin protects against hemolysis in vitro and alpha1-microglobulin knockout mice exhibit a macrocytic anemia phenotype.

PubMed ID: 32092412

DOI: 10.1016/j.freeradbiomed.2020.02.018

PubMed ID: 36213313

Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.

PubMed ID: 36213313

DOI: 10.1007/s42485-022-00092-3

PubMed ID: 37453717

Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

PubMed ID: 37453717

DOI: 10.1016/j.mcpro.2023.100617

PubMed ID: 9566199

Title: The crystal structure of bikunin from the inter-alpha-inhibitor complex: a serine protease inhibitor with two Kunitz domains.

PubMed ID: 9566199

DOI: 10.1006/jmbi.1997.1582

PubMed ID: 22512701

Title: The crystal structure of human alpha(1)-microglobulin reveals a potential haem-binding site.

PubMed ID: 22512701

DOI: 10.1042/bj20120448

PubMed ID: 11058759

Title: Alpha(1)-microglobulin: a yellow-brown lipocalin.

PubMed ID: 11058759

DOI: 10.1016/s0167-4838(00)00157-6

Sequence Information:

  • Length: 352
  • Mass: 38999
  • Checksum: BC001780094CBD06
  • Sequence:
    • MRSLGALLLL LSACLAVSAG PVPTPPDNIQ VQENFNISRI YGKWYNLAIG STCPWLKKIM 
DRMTVSTLVL GEGATEAEIS MTSTRWRKGV CEETSGAYEK TDTDGKFLYH KSKWNITMES 
YVVHTNYDEY AIFLTKKFSR HHGPTITAKL YGRAPQLRET LLQDFRVVAQ GVGIPEDSIF 
TMADRGECVP GEQEPEPILI PRVRRAVLPQ EEEGSGGGQL VTEVTKKEDS CQLGYSAGPC 
MGMTSRYFYN GTSMACETFQ YGGCMGNGNN FVTEKECLQT CRTVAACNLP IVRGPCRAFI 
QLWAFDAVKG KCVLFPYGGC QGNGNKFYSE KECREYCGVP GDGDEELLRF SN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.